A role for leptin in sustaining lymphopoiesis and myelopoiesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 6, 2008, Pages 2017-2021

  Claycombe, Kate ^a   King, Louis E ^b   Fraker, Pamela J ^a,b  

^a Michigan State University   (United States)

^b Michigan State University   (United States)

Author keywords

ob ob mouse; Obesity; Pre B cell; Pre T cell

Indexed keywords

LEPTIN;

ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFECT; FOOD INTAKE; GRANULOCYTE; IN VIVO STUDY; LYMPHOPOIESIS; MALE; MONOCYTE; MOUSE; MYELOPOIESIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BODY WEIGHT; FEEDING BEHAVIOR; HEMATOPOIESIS; LEPTIN; MICE; MICE, INBRED C57BL; OBESITY;

MUS;

EID: 41149162617     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0712053105     Document Type: Article

References (28)

1. Halaas JL, et al. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546.
2. Campfield LA, et al. (1995) Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549.
3. Lee GH, et al. (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635.
4. Chen H, et al. (1996) Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495.
5. Ikejima S, et al. (2005) Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice. Diabetes 54:182-189.
6. Mancuso P, et al. (2006) Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia. Am J Respir Crit Care Med 173:212-218.
7. La Cava A, Matarese G (2004) The weight of leptin in immunity. Nat Rev Immunol 4:371-379.
8. Busso N, et al. (2002) Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol 168:875-882.
9. Mancuso P, et al. (2002) Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol 168:4018-4024.
10. Mattioli B, et al. (2005) Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. J Immunol 174:6820-6828.
11. Sanna V, et al. (2003) Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest 111:241-250.
12. Bennett BD, et al. (1996) A role for leptin and its cognate receptor in hematopoiesis. Curr Biol 6:1170-1180.
13. Fantuzzi G, Faggioni R (2000) Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 68:437-446.
14. Gainsford T, et al. (1996) Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 93:14564-14568.
15. Tartaglia LA, et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271.
16. van Dielen FM, et al. (2001) Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals. Int J Obes Relat Metab Disord 25:1759-1766.
17. Matarese G, Moschos S, Mantzoros CS (2005) Leptin in immunology. J Immunol 174:3137-3142.
18. Umemoto Y, et al. (1997) Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells. Blood 90:3438-3443.
19. Hick RW, et al. (2006) Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy. J Immunol 177:169-176.
20. Palmer G, et al. (2006) Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice. J Immunol 177:2899-2907.
21. Fraker P, King L (1998) Changes in regulation of lymphopoiesis and myelopoiesis in the zinc-deficient mouse. Nutr Rev 56:S65-S69.
22. King LE, Fraker PJ (2002) Zinc deficiency in mice alters myelopoiesis and hematopoiesis. J Nutr 132:3301-3307.
23. Hardy RR, et al. (2000) B-cell commitment, development and selection. Immunol Rev 175:23-32.
24. Laakko T, Fraker P (2002) Rapid changes in the lymphopoietic and granulopoietic compartments of the marrow caused by stress levels of corticosterone. Immunology 105:111-119.
25. Fraker PJ, King LE (2004) Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr 24:277-298.
26. King LE, Osati-Ashtiani F, Fraker PJ (2002) Apoptosis plays a distinct role in the loss of precursor lymphocytes during zinc deficiency in mice. J Nutr 132:974-979.
27. Hsu A, et al. (2007) Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia. Clin Exp Immunol 150:332-339.
28. Smith AG, Sheridan PA, Harp JB, Beck MA (2007) Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus. J Nutr 137:1236-1243.