메뉴 건너뛰기




Volumn 18, Issue 3-4, 2007, Pages 313-325

The emerging role of adipokines as mediators of inflammation and immune responses

Author keywords

Adipokines; Articular degenerative diseases; Atherosclerosis; Immune system; Inflammation

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; APELIN; HEPCIDIN; LEPTIN; RESISTIN; UNCLASSIFIED DRUG; VASPIN; VISFATIN;

EID: 34249983235     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2007.04.007     Document Type: Review
Times cited : (312)

References (108)
  • 1
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 6505 (1994) 425-432
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 3
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: inflammation and the pleiotropic role of white adipose tissue
    • Trayhurn P., and Wood I.S. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92 3 (2004) 347-355
    • (2004) Br J Nutr , vol.92 , Issue.3 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 4
    • 27844545767 scopus 로고    scopus 로고
    • Signalling role of adipose tissue: adipokines and inflammation in obesity
    • Trayhurn P., and Wood I.S. Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 33 Pt 5 (2005) 1078-1081
    • (2005) Biochem Soc Trans , vol.33 , Issue.PART 5 , pp. 1078-1081
    • Trayhurn, P.1    Wood, I.S.2
  • 6
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil G.S., Shargill N.S., and Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 5091 (1993) 87-91
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 7
    • 33745646751 scopus 로고    scopus 로고
    • Adipose tissue and adipokines-energy regulation from the human perspective
    • Trayhurn P., Bing C., and Wood I.S. Adipose tissue and adipokines-energy regulation from the human perspective. J Nutr 136 7 (2006) 1935S-1939S
    • (2006) J Nutr , vol.136 , Issue.7
    • Trayhurn, P.1    Bing, C.2    Wood, I.S.3
  • 9
    • 0037651108 scopus 로고    scopus 로고
    • The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
    • Chan J.L., Heist K., DePaoli A.M., Veldhuis J.D., and Mantzoros C.S. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest 111 (2003) 1409-1421
    • (2003) J Clin Invest , vol.111 , pp. 1409-1421
    • Chan, J.L.1    Heist, K.2    DePaoli, A.M.3    Veldhuis, J.D.4    Mantzoros, C.S.5
  • 10
    • 0030903264 scopus 로고    scopus 로고
    • Glucocorticoids as counterregulatory hormones of leptin: toward an understanding of leptin resistance
    • Zakrzewska K.E., Cusin I., Sainsbury A., Rohner-Jeanrenaud F., and Jeanrenaud B. Glucocorticoids as counterregulatory hormones of leptin: toward an understanding of leptin resistance. Diabetes 46 (1997) 717-719
    • (1997) Diabetes , vol.46 , pp. 717-719
    • Zakrzewska, K.E.1    Cusin, I.2    Sainsbury, A.3    Rohner-Jeanrenaud, F.4    Jeanrenaud, B.5
  • 11
    • 0030883332 scopus 로고    scopus 로고
    • Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects
    • Boden G., Chen X., Kolaczynski J.W., and Polansky M. Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects. J Clin Inv 100 (1997) 1107-1113
    • (1997) J Clin Inv , vol.100 , pp. 1107-1113
    • Boden, G.1    Chen, X.2    Kolaczynski, J.W.3    Polansky, M.4
  • 12
    • 17344384196 scopus 로고    scopus 로고
    • Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia
    • Sarraf P., Frederich R.C., Turner E.M., Ma G., Jaskowiak N.T., Rivet III D.J., et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med 185 (1997) 171-175
    • (1997) J Exp Med , vol.185 , pp. 171-175
    • Sarraf, P.1    Frederich, R.C.2    Turner, E.M.3    Ma, G.4    Jaskowiak, N.T.5    Rivet III, D.J.6
  • 13
    • 0034613023 scopus 로고    scopus 로고
    • Elevated serum leptin concentrations induced by experimental acute inflammation
    • Gualillo O., Eiras S., Lago F., Dieguez C., and Casanueva F.F. Elevated serum leptin concentrations induced by experimental acute inflammation. Life Sci 67 (2000) 2433-2441
    • (2000) Life Sci , vol.67 , pp. 2433-2441
    • Gualillo, O.1    Eiras, S.2    Lago, F.3    Dieguez, C.4    Casanueva, F.F.5
  • 14
    • 9844227914 scopus 로고    scopus 로고
    • Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone
    • Blum W.F., Englaro P., Hanitsch S., Juul A., Hertel N.T., Muller J., et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. Clin Endocrinol Metab 82 (1997) 2904-2910
    • (1997) Clin Endocrinol Metab , vol.82 , pp. 2904-2910
    • Blum, W.F.1    Englaro, P.2    Hanitsch, S.3    Juul, A.4    Hertel, N.T.5    Muller, J.6
  • 16
    • 30044434035 scopus 로고    scopus 로고
    • Intracellular signalling pathways activated by leptin
    • Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem J 393 (2006) 7-20
    • (2006) Biochem J , vol.393 , pp. 7-20
    • Fruhbeck, G.1
  • 17
    • 0037456304 scopus 로고    scopus 로고
    • STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    • Bates S.H., Stearns W.H., Dundon T.A., Schubert M., Tso A.W., Wang Y., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421 6925 (2003) 856-859
    • (2003) Nature , vol.421 , Issue.6925 , pp. 856-859
    • Bates, S.H.1    Stearns, W.H.2    Dundon, T.A.3    Schubert, M.4    Tso, A.W.5    Wang, Y.6
  • 18
    • 0037171447 scopus 로고    scopus 로고
    • Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2
    • Gualillo O., Eiras S., White D.W., Dieguez C., and Casanueva F.F. Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2. Mol Cell Endocrinol 190 (2002) 83-89
    • (2002) Mol Cell Endocrinol , vol.190 , pp. 83-89
    • Gualillo, O.1    Eiras, S.2    White, D.W.3    Dieguez, C.4    Casanueva, F.F.5
  • 19
    • 33646780203 scopus 로고    scopus 로고
    • The brain as a molecular target for diabetic therapy
    • Prodi F., and Obici S. The brain as a molecular target for diabetic therapy. Endocrinology 147 6 (2006) 2664-2669
    • (2006) Endocrinology , vol.147 , Issue.6 , pp. 2664-2669
    • Prodi, F.1    Obici, S.2
  • 20
    • 0033569730 scopus 로고    scopus 로고
    • The role of SOCS3 in leptin signalling and leptin resistance
    • Bjorbaek C., Elmquist J.K., Frantz J.D., and Flier J.S. The role of SOCS3 in leptin signalling and leptin resistance. J Biol Chem 274 (1999) 30059-30065
    • (1999) J Biol Chem , vol.274 , pp. 30059-30065
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Flier, J.S.4
  • 21
    • 18744435491 scopus 로고    scopus 로고
    • T lymphopenia in obese diabetic (db/db) mice is non-selective and thymus independent
    • Kimura M., Tanaka S., Isoda F., Sekigawa K., Yamakawa T., and Sekihara H. T lymphopenia in obese diabetic (db/db) mice is non-selective and thymus independent. Life Sci 62 (1998) 1243-1250
    • (1998) Life Sci , vol.62 , pp. 1243-1250
    • Kimura, M.1    Tanaka, S.2    Isoda, F.3    Sekigawa, K.4    Yamakawa, T.5    Sekihara, H.6
  • 22
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: mediators linking adipose tissue, inflammation and immunity
    • Tilg H., and Moschen A.R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6 (2006) 772-783
    • (2006) Nat Rev Immunol , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 25
    • 4143146273 scopus 로고    scopus 로고
    • Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression
    • Mancuso P., Canetti C., Gottschalk A., Tithof P.K., and Peters-Golden M. Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression. Am J Physiol Lung Cell Mol Physiol 287 (2004) 497-502
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287 , pp. 497-502
    • Mancuso, P.1    Canetti, C.2    Gottschalk, A.3    Tithof, P.K.4    Peters-Golden, M.5
  • 26
    • 0036854487 scopus 로고    scopus 로고
    • Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A. 1
    • Raso G.M., Pacilio M., Esposito E., Coppola A., Di Carlo R., and Meli R. Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A. 1. Br J Pharmacol 137 (2002) 799-804
    • (2002) Br J Pharmacol , vol.137 , pp. 799-804
    • Raso, G.M.1    Pacilio, M.2    Esposito, E.3    Coppola, A.4    Di Carlo, R.5    Meli, R.6
  • 27
    • 0035109175 scopus 로고    scopus 로고
    • Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?
    • Caldefie-Chezet F., Poulin A., Tridon A., Sion B., and Vasson M.P. Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?. J Leukoc Biol 69 (2001) 414-418
    • (2001) J Leukoc Biol , vol.69 , pp. 414-418
    • Caldefie-Chezet, F.1    Poulin, A.2    Tridon, A.3    Sion, B.4    Vasson, M.P.5
  • 28
    • 0043198155 scopus 로고    scopus 로고
    • Leptin regulates functional capacities of polymorphonuclear neutrophils
    • Caldefie-Chezet F., Poulin A., and Vasson M.P. Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radic Res 37 (2003) 809-814
    • (2003) Free Radic Res , vol.37 , pp. 809-814
    • Caldefie-Chezet, F.1    Poulin, A.2    Vasson, M.P.3
  • 29
    • 0036431034 scopus 로고    scopus 로고
    • Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation
    • Tian Z., Sun R., Wei H., and Gao B. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem Biophys Res Commun 298 (2002) 297-302
    • (2002) Biochem Biophys Res Commun , vol.298 , pp. 297-302
    • Tian, Z.1    Sun, R.2    Wei, H.3    Gao, B.4
  • 30
    • 33845566273 scopus 로고    scopus 로고
    • Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells
    • Lam Q.L.K., Liu S., Cao X., and Lu L. Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur J Immunol 36 12 (2006) 3118-3130
    • (2006) Eur J Immunol , vol.36 , Issue.12 , pp. 3118-3130
    • Lam, Q.L.K.1    Liu, S.2    Cao, X.3    Lu, L.4
  • 31
    • 0036800760 scopus 로고    scopus 로고
    • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    • Farooqi I.S., Matarese G., Lord G.M., Keogh J.M., Lawrence E., Agwu C., et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110 (2002) 1093-1103
    • (2002) J Clin Invest , vol.110 , pp. 1093-1103
    • Farooqi, I.S.1    Matarese, G.2    Lord, G.M.3    Keogh, J.M.4    Lawrence, E.5    Agwu, C.6
  • 32
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    • Lord G.M., Matarese G., Howard J.K., Baker R.J., Bloom S.R., and Lechler R.I. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394 (1998) 897-901
    • (1998) Nature , vol.394 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3    Baker, R.J.4    Bloom, S.R.5    Lechler, R.I.6
  • 33
    • 0032741972 scopus 로고    scopus 로고
    • Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
    • Howard J.K., Lord G.M., Matarese G., Vendetti S., Ghatei M.A., Ritter M.A., et al. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 104 (1999) 1051-1059
    • (1999) J Clin Invest , vol.104 , pp. 1051-1059
    • Howard, J.K.1    Lord, G.M.2    Matarese, G.3    Vendetti, S.4    Ghatei, M.A.5    Ritter, M.A.6
  • 34
    • 3242779514 scopus 로고    scopus 로고
    • Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient mice
    • Ruter J., Hoffmann T., Demuth H.U., Moschansky P., Klapp B.F., and Hildebrandt M. Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient mice. Biol Chem 385 (2004) 537-541
    • (2004) Biol Chem , vol.385 , pp. 537-541
    • Ruter, J.1    Hoffmann, T.2    Demuth, H.U.3    Moschansky, P.4    Klapp, B.F.5    Hildebrandt, M.6
  • 35
    • 0037241113 scopus 로고    scopus 로고
    • Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses
    • Sanna V., Di Giacomo A., La Cava A., Lechler R.I., Fontana S., Zappacosta S., et al. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest 111 (2003) 241-250
    • (2003) J Clin Invest , vol.111 , pp. 241-250
    • Sanna, V.1    Di Giacomo, A.2    La Cava, A.3    Lechler, R.I.4    Fontana, S.5    Zappacosta, S.6
  • 36
    • 0035195887 scopus 로고    scopus 로고
    • Leptin regulation of the immune response and the immunodeficiency of malnutrition
    • Faggioni R., Feingold K.R., and Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 14 (2001) 2565-2571
    • (2001) FASEB J , vol.14 , pp. 2565-2571
    • Faggioni, R.1    Feingold, K.R.2    Grunfeld, C.3
  • 38
    • 0346103717 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages
    • Williams L., Bradley L., Smith A., and Foxwell B. Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages. J Immunol 172 (2004) 567-576
    • (2004) J Immunol , vol.172 , pp. 567-576
    • Williams, L.1    Bradley, L.2    Smith, A.3    Foxwell, B.4
  • 39
    • 0037080196 scopus 로고    scopus 로고
    • Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis
    • Busso N., So A., Chobaz-Peclat V., Morard C., Martinez-Soria E., Talabot-Ayer D., et al. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol 168 (2002) 875-882
    • (2002) J Immunol , vol.168 , pp. 875-882
    • Busso, N.1    So, A.2    Chobaz-Peclat, V.3    Morard, C.4    Martinez-Soria, E.5    Talabot-Ayer, D.6
  • 40
    • 3042661014 scopus 로고    scopus 로고
    • Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice
    • Siegmund B., Sennello J.A., Jones-Carson J., Gamboni-Robertson F., Lehr H.A., Batra A., et al. Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice. Gut 53 (2004) 965-972
    • (2004) Gut , vol.53 , pp. 965-972
    • Siegmund, B.1    Sennello, J.A.2    Jones-Carson, J.3    Gamboni-Robertson, F.4    Lehr, H.A.5    Batra, A.6
  • 41
    • 0031768795 scopus 로고    scopus 로고
    • Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats
    • Barbier M., Cherbut C., Aube A.C., Blottiere H.M., and Galmiche J.P. Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats. Gut 43 (1998) 783-790
    • (1998) Gut , vol.43 , pp. 783-790
    • Barbier, M.1    Cherbut, C.2    Aube, A.C.3    Blottiere, H.M.4    Galmiche, J.P.5
  • 43
    • 17044381726 scopus 로고    scopus 로고
    • Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells
    • Matarese G., Carrieri P.B., La Cava A., Perna F., Sanna V., De Rosa V., et al. Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells. Proc Natl Acad Sci 102 (2005) 5150-5155
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 5150-5155
    • Matarese, G.1    Carrieri, P.B.2    La Cava, A.3    Perna, F.4    Sanna, V.5    De Rosa, V.6
  • 44
    • 0035873418 scopus 로고    scopus 로고
    • Requirement for leptin in the induction and progression of autoimmune encephalomyelitis
    • Matarese G., Di Giacomo A., Sanna V., Lord G.M., Howard J.K., Di Tuoro A., et al. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol 166 (2001) 5909-5916
    • (2001) J Immunol , vol.166 , pp. 5909-5916
    • Matarese, G.1    Di Giacomo, A.2    Sanna, V.3    Lord, G.M.4    Howard, J.K.5    Di Tuoro, A.6
  • 45
    • 25444481288 scopus 로고    scopus 로고
    • Defining the role of T cell-derived leptin in the modulation of hepatic or intestinal inflammation in mice
    • Fantuzzi G., Sennello J.A., Batra A., Fedke I., Lehr H.A., Zeitz M., et al. Defining the role of T cell-derived leptin in the modulation of hepatic or intestinal inflammation in mice. Clin Exp Immunol 142 (2005) 31-38
    • (2005) Clin Exp Immunol , vol.142 , pp. 31-38
    • Fantuzzi, G.1    Sennello, J.A.2    Batra, A.3    Fedke, I.4    Lehr, H.A.5    Zeitz, M.6
  • 47
    • 33747799996 scopus 로고    scopus 로고
    • Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice
    • Sep 1
    • Palmer G., Aurrand-Lions M., Contassot E., Talabot-Ayer D., Ducrest-Gay D., Vesin C., et al. Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice. J Immunol 177 5 (2006) 2899-2907 Sep 1
    • (2006) J Immunol , vol.177 , Issue.5 , pp. 2899-2907
    • Palmer, G.1    Aurrand-Lions, M.2    Contassot, E.3    Talabot-Ayer, D.4    Ducrest-Gay, D.5    Vesin, C.6
  • 48
    • 26244437056 scopus 로고    scopus 로고
    • Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation
    • Canavan B., Salem R.O., Schurgin S., Koutkia P., Lipinska I., Laposata M., et al. Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation. J Clin Endocrinol Metab 90 (2005) 5779-5785
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5779-5785
    • Canavan, B.1    Salem, R.O.2    Schurgin, S.3    Koutkia, P.4    Lipinska, I.5    Laposata, M.6
  • 49
    • 17744367852 scopus 로고    scopus 로고
    • Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin
    • Sennello J.A., Fayad R., Morris A.M., Eckel R.H., Asilmaz E., Montez J., et al. Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin. Endocrinology 146 (2005) 2157-2164
    • (2005) Endocrinology , vol.146 , pp. 2157-2164
    • Sennello, J.A.1    Fayad, R.2    Morris, A.M.3    Eckel, R.H.4    Asilmaz, E.5    Montez, J.6
  • 50
    • 0032880663 scopus 로고    scopus 로고
    • Decreased CD4+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation
    • Fraser D.A., Thoen J., Reseland J.E., Forre O., and Kjeldsen-Kragh J. Decreased CD4+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation. Clin Rheumatol 18 (1999) 394-401
    • (1999) Clin Rheumatol , vol.18 , pp. 394-401
    • Fraser, D.A.1    Thoen, J.2    Reseland, J.E.3    Forre, O.4    Kjeldsen-Kragh, J.5
  • 51
    • 33747786726 scopus 로고    scopus 로고
    • Changes in fat-derived hormones plasma concentrations: adiponectin, leptin, resistin and visfatin in rheumatoid arthritis subjects
    • Otero M., Lago R., Gomez R., Lago F., Dieguez C., Gomez-Reino J.J., et al. Changes in fat-derived hormones plasma concentrations: adiponectin, leptin, resistin and visfatin in rheumatoid arthritis subjects. Ann Rheum Dis 65 9 (2006) 1198-1201
    • (2006) Ann Rheum Dis , vol.65 , Issue.9 , pp. 1198-1201
    • Otero, M.1    Lago, R.2    Gomez, R.3    Lago, F.4    Dieguez, C.5    Gomez-Reino, J.J.6
  • 52
    • 0141762514 scopus 로고    scopus 로고
    • Leptin consumption in the inflamed joints of patients with rheumatoid arthritis
    • Bokarewa M., Bokarew D., Hultgren O., and Tarkowski A. Leptin consumption in the inflamed joints of patients with rheumatoid arthritis. Ann Rheum Dis 62 (2003) 952-956
    • (2003) Ann Rheum Dis , vol.62 , pp. 952-956
    • Bokarewa, M.1    Bokarew, D.2    Hultgren, O.3    Tarkowski, A.4
  • 53
    • 0033712395 scopus 로고    scopus 로고
    • The role of the chondrocyte in osteoarthritis
    • Goldring M.B. The role of the chondrocyte in osteoarthritis. Arthritis Rheum 43 (2000) 1916-1926
    • (2000) Arthritis Rheum , vol.43 , pp. 1916-1926
    • Goldring, M.B.1
  • 54
    • 5444259084 scopus 로고    scopus 로고
    • The regulation of chondrocyte function by pro-inflammatory mediators: prostaglandins and nitric oxide
    • Goldring M.B., and Berenbaum F. The regulation of chondrocyte function by pro-inflammatory mediators: prostaglandins and nitric oxide. Clin Orthop Relat Res 427 (2004) 37-46
    • (2004) Clin Orthop Relat Res , vol.427 , pp. 37-46
    • Goldring, M.B.1    Berenbaum, F.2
  • 56
    • 19744361964 scopus 로고    scopus 로고
    • Obesity and the female sex, risk factors for knee osteoarthritis that may be attributable to systemic or local leptin biosynthesis and its cellular effects
    • Teichtahl A.J., Wluka A.E., Proietto J., and Cicuttini F.M. Obesity and the female sex, risk factors for knee osteoarthritis that may be attributable to systemic or local leptin biosynthesis and its cellular effects. Med Hypotheses 65 (2005) 312-315
    • (2005) Med Hypotheses , vol.65 , pp. 312-315
    • Teichtahl, A.J.1    Wluka, A.E.2    Proietto, J.3    Cicuttini, F.M.4
  • 57
    • 0037332229 scopus 로고    scopus 로고
    • Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells
    • Otero M., Gomez Reino J.J., and Gualillo O. Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells. Arthritis Rheum 48 (2003) 404-409
    • (2003) Arthritis Rheum , vol.48 , pp. 404-409
    • Otero, M.1    Gomez Reino, J.J.2    Gualillo, O.3
  • 58
    • 30344486078 scopus 로고    scopus 로고
    • Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1
    • Otero M., Lago R., Lago F., Reino J.J., and Gualillo O. Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res Ther 7 (2005) 581-591
    • (2005) Arthritis Res Ther , vol.7 , pp. 581-591
    • Otero, M.1    Lago, R.2    Lago, F.3    Reino, J.J.4    Gualillo, O.5
  • 59
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • Kadowaki T., Yamauchi T., Kubota N., Hara K., Ueki K., and Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116 7 (2006) 1784-1792
    • (2006) J Clin Invest , vol.116 , Issue.7 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5    Tobe, K.6
  • 60
    • 33644911756 scopus 로고    scopus 로고
    • The endocrine role of adipose tissue: an update
    • Ronti T., Lupattelli G., and Mannarino E. The endocrine role of adipose tissue: an update. Clin Endocrinol 64 (2006) 355-365
    • (2006) Clin Endocrinol , vol.64 , pp. 355-365
    • Ronti, T.1    Lupattelli, G.2    Mannarino, E.3
  • 61
    • 19044393872 scopus 로고    scopus 로고
    • Adipose tissue, inflammation, and cardiovascular disease
    • Berg A.H., and Scherer P.E. Adipose tissue, inflammation, and cardiovascular disease. Circ Res 96 9 (2005) 939-949
    • (2005) Circ Res , vol.96 , Issue.9 , pp. 939-949
    • Berg, A.H.1    Scherer, P.E.2
  • 63
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • Kadowaki T., and Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 26 (2005) 439-451
    • (2005) Endocr Rev , vol.26 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 64
    • 1442327754 scopus 로고    scopus 로고
    • Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation
    • Tan K.C., Xu C., Chow W.S., Lam M.C., Ai V.H., Tam S.C., et al. Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation. J Clin Endocrinol Metab 89 (2004) 760-765
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 760-765
    • Tan, K.C.1    Xu, C.2    Chow, W.S.3    Lam, M.C.4    Ai, V.H.5    Tam, S.C.6
  • 66
    • 0042466384 scopus 로고    scopus 로고
    • Regulation of adiponectin by adipose tissue derived cytokines: in vivo and in vitro investigations in humans
    • Bruun J.M., Lihn A.S., Verdich C., Pedersen S.B., Toubro S., Astrup A., et al. Regulation of adiponectin by adipose tissue derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 285 (2003) E527-E533
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Bruun, J.M.1    Lihn, A.S.2    Verdich, C.3    Pedersen, S.B.4    Toubro, S.5    Astrup, A.6
  • 67
    • 33846784058 scopus 로고    scopus 로고
    • Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies
    • 10.1172/JCI29709
    • Takemura Y., Ouchi N., Shibata R., Aprahamian T., Kirber M.T., Summer R.S., et al. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest (2007, 25 January) 10.1172/JCI29709
    • (2007) J Clin Invest
    • Takemura, Y.1    Ouchi, N.2    Shibata, R.3    Aprahamian, T.4    Kirber, M.T.5    Summer, R.S.6
  • 68
    • 0035462629 scopus 로고    scopus 로고
    • PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    • Maeda N., Takahashi M., Funahashi T., Kihara S., Nishizawa H., Kishida K., et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 50 9 (2001) 2094-2099
    • (2001) Diabetes , vol.50 , Issue.9 , pp. 2094-2099
    • Maeda, N.1    Takahashi, M.2    Funahashi, T.3    Kihara, S.4    Nishizawa, H.5    Kishida, K.6
  • 69
    • 0033071540 scopus 로고    scopus 로고
    • Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity
    • Funahashi T., Nakamura T., Shimomura I., Maeda K., Kuriyama H., Takahashi M., et al. Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. Intern Med 38 2 (1999) 202-206
    • (1999) Intern Med , vol.38 , Issue.2 , pp. 202-206
    • Funahashi, T.1    Nakamura, T.2    Shimomura, I.3    Maeda, K.4    Kuriyama, H.5    Takahashi, M.6
  • 70
    • 1842864234 scopus 로고    scopus 로고
    • Plasma adiponectin levels and risk of myocardial infarction in men
    • Pischon T., Girman C.J., Hotamisligil G.S., Rifai N., Hu F.B., and Rimm E.B. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 291 14 (2004) 1730-1737
    • (2004) JAMA , vol.291 , Issue.14 , pp. 1730-1737
    • Pischon, T.1    Girman, C.J.2    Hotamisligil, G.S.3    Rifai, N.4    Hu, F.B.5    Rimm, E.B.6
  • 73
    • 18144408371 scopus 로고    scopus 로고
    • Adipose tissue, adipokines, and inflammation
    • Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115 5 (2005) 911-919
    • (2005) J Allergy Clin Immunol , vol.115 , Issue.5 , pp. 911-919
    • Fantuzzi, G.1
  • 74
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu A., Wang Y., Keshaw H., Xu L.Y., Lam K.S., and Cooper G.J. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 112 1 (2003) 91-100
    • (2003) J Clin Invest , vol.112 , Issue.1 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 75
    • 10744228583 scopus 로고    scopus 로고
    • Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin
    • Kamada Y., Tamura S., Kiso S., Matsumoto H., Saji Y., Yoshida Y., et al. Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. Gastroenterology 125 6 (2003) 1796-1807
    • (2003) Gastroenterology , vol.125 , Issue.6 , pp. 1796-1807
    • Kamada, Y.1    Tamura, S.2    Kiso, S.3    Matsumoto, H.4    Saji, Y.5    Yoshida, Y.6
  • 76
    • 3042699353 scopus 로고    scopus 로고
    • Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice
    • Masaki T., Chiba S., Tatsukawa H., Yasuda T., Noguchi H., Seike M., et al. Adiponectin protects LPS-induced liver injury through modulation of TNF-alpha in KK-Ay obese mice. Hepatology 40 1 (2004) 177-184
    • (2004) Hepatology , vol.40 , Issue.1 , pp. 177-184
    • Masaki, T.1    Chiba, S.2    Tatsukawa, H.3    Yasuda, T.4    Noguchi, H.5    Seike, M.6
  • 79
    • 0034254655 scopus 로고    scopus 로고
    • FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family
    • Holcomb I.N., Kabakoff R.C., Chan B., Baker T.W., Gurney A., Henzel W., et al. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J 19 15 (2000) 4046-4055
    • (2000) EMBO J , vol.19 , Issue.15 , pp. 4046-4055
    • Holcomb, I.N.1    Kabakoff, R.C.2    Chan, B.3    Baker, T.W.4    Gurney, A.5    Henzel, W.6
  • 80
    • 0037241112 scopus 로고    scopus 로고
    • Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production
    • Rajala M.W., Obici S., Scherer P.E., and Rossetti L. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J Clin Invest 111 2 (2003) 225-230
    • (2003) J Clin Invest , vol.111 , Issue.2 , pp. 225-230
    • Rajala, M.W.1    Obici, S.2    Scherer, P.E.3    Rossetti, L.4
  • 81
    • 0037686319 scopus 로고    scopus 로고
    • Identification of RELM gamma, a novel resistin-like molecule with a distinct expression pattern
    • Gerstmayer B., Kusters D., Gebel S., Muller T., Van Miert E., Hofmann K., et al. Identification of RELM gamma, a novel resistin-like molecule with a distinct expression pattern. Genomics 81 6 (2003) 588-595
    • (2003) Genomics , vol.81 , Issue.6 , pp. 588-595
    • Gerstmayer, B.1    Kusters, D.2    Gebel, S.3    Muller, T.4    Van Miert, E.5    Hofmann, K.6
  • 82
    • 29244476240 scopus 로고    scopus 로고
    • Adipocytokines: leptin - the classical. Resistin - the controversical, adiponectin - the promising, and more to come
    • Koerner A., Kratzsch J., and Kiess W. Adipocytokines: leptin - the classical. Resistin - the controversical, adiponectin - the promising, and more to come. Best Pract Res Clin Endocrinol Metab 19 (2005) 525-546
    • (2005) Best Pract Res Clin Endocrinol Metab , vol.19 , pp. 525-546
    • Koerner, A.1    Kratzsch, J.2    Kiess, W.3
  • 84
    • 33745171469 scopus 로고    scopus 로고
    • Role of Resistin in inflammation and inflammation related diseases
    • Pang S., and Le Y. Role of Resistin in inflammation and inflammation related diseases. Cell Mol Immunol 3 1 (2006) 29-34
    • (2006) Cell Mol Immunol , vol.3 , Issue.1 , pp. 29-34
    • Pang, S.1    Le, Y.2
  • 85
    • 17844392652 scopus 로고    scopus 로고
    • Resistin an adipokine with potent pro-inflammatory properties
    • Bokarewa M., Nagaev I., Dahlberg L., Smith U., and Tarkowski A. Resistin an adipokine with potent pro-inflammatory properties. J Immunol 174 9 (2005) 5789-5795
    • (2005) J Immunol , vol.174 , Issue.9 , pp. 5789-5795
    • Bokarewa, M.1    Nagaev, I.2    Dahlberg, L.3    Smith, U.4    Tarkowski, A.5
  • 87
    • 4644285153 scopus 로고    scopus 로고
    • Resistin levels in patients with obstructive sleep apnoea syndrome-the link to subclinical inflammation?
    • Harsch I.A., Koebnick C., Wallaschofski H., Schahin S.P., Hahn E.G., Ficker J.H., et al. Resistin levels in patients with obstructive sleep apnoea syndrome-the link to subclinical inflammation?. Med Sci Monit 10 9 (2004) CR510-CR515
    • (2004) Med Sci Monit , vol.10 , Issue.9
    • Harsch, I.A.1    Koebnick, C.2    Wallaschofski, H.3    Schahin, S.P.4    Hahn, E.G.5    Ficker, J.H.6
  • 89
    • 0043164953 scopus 로고    scopus 로고
    • Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction
    • Verma S., Li S.H., Wang C.H., Fedak P.W., Li R.K., Weisel R.D., et al. Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation 108 6 (2003) 736-740
    • (2003) Circulation , vol.108 , Issue.6 , pp. 736-740
    • Verma, S.1    Li, S.H.2    Wang, C.H.3    Fedak, P.W.4    Li, R.K.5    Weisel, R.D.6
  • 90
    • 0347004641 scopus 로고    scopus 로고
    • Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions
    • Kawanami D., Maemura K., Takeda N., Harada T., Nojiri T., Imai Y., et al. Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. Biochem Biophys Res Commun 314 2 (2004) 415-419
    • (2004) Biochem Biophys Res Commun , vol.314 , Issue.2 , pp. 415-419
    • Kawanami, D.1    Maemura, K.2    Takeda, N.3    Harada, T.4    Nojiri, T.5    Imai, Y.6
  • 92
    • 34147205638 scopus 로고    scopus 로고
    • Resistin is abundantly present in rheumatoid arthritis synovial tissue, synovial fluid, and elevated serum resistin reflects disease activity
    • Senolt L., Housa D., Vernerova Z., Jirasek T., Svobodova R., Veigl D., et al. Resistin is abundantly present in rheumatoid arthritis synovial tissue, synovial fluid, and elevated serum resistin reflects disease activity. Ann Rheum Dis 66 4 (2007) 458-463
    • (2007) Ann Rheum Dis , vol.66 , Issue.4 , pp. 458-463
    • Senolt, L.1    Housa, D.2    Vernerova, Z.3    Jirasek, T.4    Svobodova, R.5    Veigl, D.6
  • 94
    • 19944433652 scopus 로고    scopus 로고
    • Visfatin: a protein secreted by visceral fat that mimics the effects of insulin
    • Fukuhara A., Matsuda M., Nishizawa M., Segawa K., Tanaka M., Kishimoto K., et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307 5708 (2005) 426-430
    • (2005) Science , vol.307 , Issue.5708 , pp. 426-430
    • Fukuhara, A.1    Matsuda, M.2    Nishizawa, M.3    Segawa, K.4    Tanaka, M.5    Kishimoto, K.6
  • 95
    • 85047693796 scopus 로고    scopus 로고
    • Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis
    • Jia S.H., Li Y., Parodo J., Kapus A., Fan L., Rotstein O.D., et al. Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest 113 9 (2004) 1318-1327
    • (2004) J Clin Invest , vol.113 , Issue.9 , pp. 1318-1327
    • Jia, S.H.1    Li, Y.2    Parodo, J.3    Kapus, A.4    Fan, L.5    Rotstein, O.D.6
  • 96
    • 33846527541 scopus 로고    scopus 로고
    • Visfatin an adipocytokine with pro-inflammatory and immunomodulating properties
    • Moschen A.R., Kaser A., Enrich B., Mosheimer B., Theurl M., Niederegger H., et al. Visfatin an adipocytokine with pro-inflammatory and immunomodulating properties. J Immunol 178 3 (2007) 1748-1758
    • (2007) J Immunol , vol.178 , Issue.3 , pp. 1748-1758
    • Moschen, A.R.1    Kaser, A.2    Enrich, B.3    Mosheimer, B.4    Theurl, M.5    Niederegger, H.6
  • 97
    • 0032552988 scopus 로고    scopus 로고
    • Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor
    • Tatemoto K., Hosoya M., Habata Y., Fujii R., Kakegawa T., Zou M.X., et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 251 (1998) 471-476
    • (1998) Biochem Biophys Res Commun , vol.251 , pp. 471-476
    • Tatemoto, K.1    Hosoya, M.2    Habata, Y.3    Fujii, R.4    Kakegawa, T.5    Zou, M.X.6
  • 99
    • 33845682441 scopus 로고    scopus 로고
    • TNFalpha up-regulates apelin expression in human and mouse adipose tissue
    • Daviaud D., Boucher J., Gesta S., Dray C., Guigne C., Quilliot D., et al. TNFalpha up-regulates apelin expression in human and mouse adipose tissue. FASEB J 20 9 (2006) 1528-1530
    • (2006) FASEB J , vol.20 , Issue.9 , pp. 1528-1530
    • Daviaud, D.1    Boucher, J.2    Gesta, S.3    Dray, C.4    Guigne, C.5    Quilliot, D.6
  • 100
    • 22044453852 scopus 로고    scopus 로고
    • Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding
    • Heinonen M.V., Purhonen A.K., Miettinen P., Paakkonen M., Pirinen E., Alhava E., et al. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Regul Pept 130 (2005) 7-13
    • (2005) Regul Pept , vol.130 , pp. 7-13
    • Heinonen, M.V.1    Purhonen, A.K.2    Miettinen, P.3    Paakkonen, M.4    Pirinen, E.5    Alhava, E.6
  • 101
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H., Barnes G.T., Yang Q., Tan G., Yang D., Chou C.J., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112 (2003) 1821-1830
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4    Yang, D.5    Chou, C.J.6
  • 102
    • 23044473651 scopus 로고    scopus 로고
    • Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity
    • Hida K., Wada J., Eguchi J., Zhang H., Baba M., Seida A., et al. Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA 102 (2005) 10610-10615
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 10610-10615
    • Hida, K.1    Wada, J.2    Eguchi, J.3    Zhang, H.4    Baba, M.5    Seida, A.6
  • 103
    • 28144450841 scopus 로고    scopus 로고
    • Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes
    • Kloting N., Berndt J., Kralisch S., Kovacs P., Fasshauer M., Schon M.R., et al. Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes. Biochem Biophys Res Commun 339 1 (2006) 430-436
    • (2006) Biochem Biophys Res Commun , vol.339 , Issue.1 , pp. 430-436
    • Kloting, N.1    Berndt, J.2    Kralisch, S.3    Kovacs, P.4    Fasshauer, M.5    Schon, M.R.6
  • 104
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin a urinary antimicrobial peptide synthesized in the liver
    • Park C.H., Valore E.V., Waring A.J., and Ganz T. Hepcidin a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276 (2001) 7806-7810
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 105
    • 33748265283 scopus 로고    scopus 로고
    • Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH
    • Bekri S., Gual P., Anty R., Luciani N., Dahman M., Ramesh B., et al. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 131 3 (2006) 788-796
    • (2006) Gastroenterology , vol.131 , Issue.3 , pp. 788-796
    • Bekri, S.1    Gual, P.2    Anty, R.3    Luciani, N.4    Dahman, M.5    Ramesh, B.6
  • 106
    • 0035902586 scopus 로고    scopus 로고
    • Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease
    • Fleming R.E., and Sly W.S. Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease. Proc Natl Acad Sci U S A 98 (2001) 8160-8162
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8160-8162
    • Fleming, R.E.1    Sly, W.S.2
  • 107
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E., Valore E.V., Territo M., Schiller G., Lichtenstein A., and Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101 (2003) 2461-2463
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 108
    • 33748102856 scopus 로고    scopus 로고
    • Hepcidin: a peptide hormone at the interface of innate immunity and iron metabolism
    • Ganz T. Hepcidin: a peptide hormone at the interface of innate immunity and iron metabolism. Curr Top Microbiol Immunol 306 (2006) 183-198
    • (2006) Curr Top Microbiol Immunol , vol.306 , pp. 183-198
    • Ganz, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.