Selective capacity of metreleptin administration to reconstitute CD4 + T-cell number in females with acquired hypoleptinemia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 9, 2013, Pages

  Matarese, Giuseppe ^a,b   La Rocca, Claudia ^a,b   Moon, Hyun Seuk ^c   Huh, Joo Young ^c   Brinkoetter, Mary T ^c   Chou, Sharon ^c   Perna, Francesco ^d   Greco, Dario ^e   Kilim, Holly P ^c   Gao, Chuanyun ^c   Arampatzi, Kalliope ^c   Wang, Zhaoxi ^f   Mantzoros, Christos S ^c  

^a UNIVERSITY OF SALERNO   (Italy)

^b CNR   (Italy)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e KAROLINSKA INSTITUTE   (Sweden)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

CD4 cells; Metabolism; Nutritional status

Indexed keywords

LEPTIN; METRELEPTIN; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; STAT3 PROTEIN;

ACQUIRED HYPOLEPTINEMIA; ADAPTIVE IMMUNITY; ADULT; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL COUNT; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENERGY BALANCE; GENE CONTROL; GENETIC REGULATION; HORMONE RESPONSE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; HYPOTHALAMIC AMENORRHEA; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IN VIVO STUDY; LEPTIN DEFICIENCY; PERIPHERAL BLOOD MONONUCLEAR CELL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIGNAL TRANSDUCTION; TUBERCULOSIS;

ADOLESCENT; ADULT; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CYTOKINES; DOWN-REGULATION; FEMALE; GENE EXPRESSION PROFILING; HORMONES; HUMANS; INFLAMMATION; LEPTIN; METABOLIC DISEASES; PHENOTYPE; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TREATMENT OUTCOME; UP-REGULATION; YOUNG ADULT;

EID: 84874480871     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1214554110     Document Type: Article

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