-
1
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
-
2
-
-
11844253254
-
Leptin, from fat to inflammation: Old questions and new insights
-
Otero M et al. (2005) Leptin, from fat to inflammation: Old questions and new insights. FEBS Lett 579: 295-301
-
(2005)
FEBS Lett
, vol.579
, pp. 295-301
-
-
Otero, M.1
-
3
-
-
18144408371
-
Adipose tissue, adipokines, and inflammation
-
Fantuzzi G (2005) Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115: 911-919
-
(2005)
J Allergy Clin Immunol
, vol.115
, pp. 911-919
-
-
Fantuzzi, G.1
-
4
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS et al. (1993) Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 259: 87-91
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
-
5
-
-
33748992313
-
Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
-
Tilg H et al. (2006) Adipocytokines: Mediators linking adipose tissue, inflammation and immunity. Nature Rev Immunol 6: 772-783
-
(2006)
Nature Rev Immunol
, vol.6
, pp. 772-783
-
-
Tilg, H.1
-
6
-
-
33745592735
-
Adipose tissue has anti-inflammatory properties
-
Dayer JM et al. (2006) Adipose tissue has anti-inflammatory properties. Ann NY Acad Sci 1069: 444-453
-
(2006)
Ann NY Acad Sci
, vol.1069
, pp. 444-453
-
-
Dayer, J.M.1
-
7
-
-
33747830880
-
Towards a pro-inflammatory and immunomodulatory emerging role of leptin
-
Otero M et al. (2006) Towards a pro-inflammatory and immunomodulatory emerging role of leptin. Rheumatology (Oxford) 45: 944-950
-
(2006)
Rheumatology (Oxford)
, vol.45
, pp. 944-950
-
-
Otero, M.1
-
8
-
-
30044434035
-
Intracellular signalling pathways activated by leptin
-
Fruhbeck G (2006) Intracellular signalling pathways activated by leptin. Biochem J 393: 7-20
-
(2006)
Biochem J
, vol.393
, pp. 7-20
-
-
Fruhbeck, G.1
-
9
-
-
0037171447
-
Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2
-
Gualillo O et al. (2002) Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2. Mol Cell Endocrinol 190: 83-89
-
(2002)
Mol Cell Endocrinol
, vol.190
, pp. 83-89
-
-
Gualillo, O.1
-
10
-
-
0032741972
-
Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
-
Howard JK et al. (1999) Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 104: 1051-1059
-
(1999)
J Clin Invest
, vol.104
, pp. 1051-1059
-
-
Howard, J.K.1
-
11
-
-
14844363594
-
Leptin in immunology
-
Matarese G et al. (2005) Leptin in immunology. J Immunol 174: 3137-3142
-
(2005)
J Immunol
, vol.174
, pp. 3137-3142
-
-
Matarese, G.1
-
12
-
-
0035195887
-
Leptin regulation of the immune response and the immunodeficiency of malnutrition
-
Faggioni R et al. (2001) Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 15: 2565-2571
-
(2001)
FASEB J
, vol.15
, pp. 2565-2571
-
-
Faggioni, R.1
-
13
-
-
33847312289
-
A key role of leptin in the control of regulatory T cell proliferation
-
De Rosa et al. (2007) A key role of leptin in the control of regulatory T cell proliferation. Immunity 26: 241-255
-
(2007)
Immunity
, vol.26
, pp. 241-255
-
-
Rosa, D.1
-
14
-
-
33747786726
-
Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis
-
Otero M et al. (2006) Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis 65: 1198-1201
-
(2006)
Ann Rheum Dis
, vol.65
, pp. 1198-1201
-
-
Otero, M.1
-
15
-
-
34247639924
-
The contribution of adipose tissue and adipokines to inflammation in joint diseases
-
Toussirot E et al. (2007) The contribution of adipose tissue and adipokines to inflammation in joint diseases. Curr Med Chem 14 1095-1100
-
(2007)
Curr Med Chem
, vol.14
, pp. 1095-1100
-
-
Toussirot, E.1
-
16
-
-
0032880663
-
+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation
-
+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation. Clin Rheumatol 18 394-401
-
(1999)
Clin Rheumatol
, vol.18
, pp. 394-401
-
-
Fraser, D.A.1
-
17
-
-
33750812250
-
The role of leptin in innate and adaptive immune response
-
Bernotiene E et al. (2006). The role of leptin in innate and adaptive immune response. Arthritis Res Ther 8: 217-226
-
(2006)
Arthritis Res Ther
, vol.8
, pp. 217-226
-
-
Bernotiene, E.1
-
18
-
-
34547680567
-
Further evidence for leptin involvement in cartilage homeostases
-
Gualillo O (2007) Further evidence for leptin involvement in cartilage homeostases. Osteoarthritis Cartilage 15: 857-860
-
(2007)
Osteoarthritis Cartilage
, vol.15
, pp. 857-860
-
-
Gualillo, O.1
-
19
-
-
0037332229
-
Synergistic induction of nitric oxide synthase type II: In vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells
-
Otero M et al. (2003) Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells. Arthritis Rheum 48: 404-409
-
(2003)
Arthritis Rheum
, vol.48
, pp. 404-409
-
-
Otero, M.1
-
20
-
-
30344486078
-
Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: Synergistic effect of leptin with interleukin-1
-
Otero M et al. (2005) Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: Synergistic effect of leptin with interleukin-1. Arthritis Res Ther 7: R581-R591
-
(2005)
Arthritis Res Ther
, vol.7
-
-
Otero, M.1
-
21
-
-
34547676409
-
Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism
-
Simopoulou T et al. (2007) Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. Osteoarthritis Cartilage 15: 872-883
-
(2007)
Osteoarthritis Cartilage
, vol.15
, pp. 872-883
-
-
Simopoulou, T.1
-
22
-
-
36549024994
-
Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: Possible molecular target for osteoarthritis therapeutic intervention
-
doi:10.1136/ard.2007.069377
-
Iliopoulos D et al. (2007) Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: Possible molecular target for osteoarthritis therapeutic intervention. Ann Rheum Dis [doi:10.1136/ard.2007.069377]
-
(2007)
Ann Rheum Dis
-
-
Iliopoulos, D.1
-
23
-
-
33947663558
-
-
Adiponectin in health and disease
-
Oh DK et al. (2007) Adiponectin in health and disease. Diabetes Obes Metab 9: 282-289
-
(2007)
Diabetes Obes Metab
, vol.9
, pp. 282-289
-
-
Oh, D.K.1
-
24
-
-
18844432308
-
Adiponectin and adiponectin receptors
-
Kadowaki T et al. (2005) Adiponectin and adiponectin receptors. Endocr Rev 26: 439-451
-
(2005)
Endocr Rev
, vol.26
, pp. 439-451
-
-
Kadowaki, T.1
-
25
-
-
30544439060
-
Therapy Insight: Adipocytokines in metabolic syndrome and related cardiovascular disease
-
Matsuzawa Y (2006) Therapy Insight: Adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med 3: 35-42
-
(2006)
Nat Clin Pract Cardiovasc Med
, vol.3
, pp. 35-42
-
-
Matsuzawa, Y.1
-
26
-
-
0141816765
-
Adipocytokines in synovial fluid
-
Schaffler A et al. (2003) Adipocytokines in synovial fluid. JAMA 290: 1709-1710
-
(2003)
JAMA
, vol.290
, pp. 1709-1710
-
-
Schaffler, A.1
-
27
-
-
33746772745
-
Altered levels of adipocytokines in association with insulin resistance in patients with systemic lupus erythematosus
-
Sada KE et al. (2006) Altered levels of adipocytokines in association with insulin resistance in patients with systemic lupus erythematosus. J Rheumatol 33: 1545-1552
-
(2006)
J Rheumatol
, vol.33
, pp. 1545-1552
-
-
Sada, K.E.1
-
28
-
-
33646067791
-
The potential of adiponectin in driving arthritis
-
Ehling A et al. (2006) The potential of adiponectin in driving arthritis. J Immunol 176: 4468-4478
-
(2006)
J Immunol
, vol.176
, pp. 4468-4478
-
-
Ehling, A.1
-
29
-
-
36549073742
-
Adiponectin induces nitric oxide synthase type 2 and pro-inflammatory cytokines in chondrocytes
-
Lago R et al. (2007) Adiponectin induces nitric oxide synthase type 2 and pro-inflammatory cytokines in chondrocytes. Ann Rheum Dis 66(Suppl 11): 142
-
(2007)
Ann Rheum Dis
, vol.66
, Issue.SUPPL. 11
, pp. 142
-
-
Lago, R.1
-
30
-
-
0035905758
-
The hormone resistin links obesity to diabetes
-
Steppan CM et al. (2001) The hormone resistin links obesity to diabetes. Nature 409: 307-312
-
(2001)
Nature
, vol.409
, pp. 307-312
-
-
Steppan, C.M.1
-
31
-
-
4644285153
-
Resistin levels in patients with obstructive sleep apnoea syndrome-the link to subclinical inflammation?
-
Harsch IA et al. (2004) Resistin levels in patients with obstructive sleep apnoea syndrome-the link to subclinical inflammation? Med Sci Monit 10: CR510-CR515
-
(2004)
Med Sci Monit
, vol.10
-
-
Harsch, I.A.1
-
32
-
-
14044257211
-
Resistin is an inflammatory marker of atherosclerosis in humans
-
Reilly MP et al. (2005) Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 111: 932-939
-
(2005)
Circulation
, vol.111
, pp. 932-939
-
-
Reilly, M.P.1
-
33
-
-
15744399190
-
An inflammatory cascade leading to hyperresistinernia in humans
-
Lehrke M et al. (2004) An inflammatory cascade leading to hyperresistinernia in humans. PLoS Med 1: E45
-
(2004)
PLoS Med
, vol.1
-
-
Lehrke, M.1
-
34
-
-
17844392652
-
Resistin, an adipokine with potent proinflammatory properties
-
Bokarewa M et al. (2005) Resistin, an adipokine with potent proinflammatory properties. J Immunol 174: 5789-5795
-
(2005)
J Immunol
, vol.174
, pp. 5789-5795
-
-
Bokarewa, M.1
-
35
-
-
34147205638
-
Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum
-
Senolt L et al. (2007) Resistin in rheumatoid arthritis synovial tissue, synovial fluid and serum. Ann Rheum Dis 66: 458-463
-
(2007)
Ann Rheum Dis
, vol.66
, pp. 458-463
-
-
Senolt, L.1
-
36
-
-
19944433652
-
Visfatin: A protein secreted by visceral fat that mimics the effects of insulin
-
Fukuhara A et al. (2005) Visfatin: A protein secreted by visceral fat that mimics the effects of insulin. Science 307: 426-430
-
(2005)
Science
, vol.307
, pp. 426-430
-
-
Fukuhara, A.1
-
37
-
-
85047693796
-
Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis
-
Jia SH et al. (2004) Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest 113: 1318-1327
-
(2004)
J Clin Invest
, vol.113
, pp. 1318-1327
-
-
Jia, S.H.1
-
38
-
-
33846527541
-
Visfatin, an adipocytokine with proinflammatory and immunomodulating properties
-
Moschen AR et al. (2007) Visfatin, an adipocytokine with proinflammatory and immunomodulating properties. J Immunol 178 1748-1758
-
(2007)
J Immunol
, vol.178
, pp. 1748-1758
-
-
Moschen, A.R.1
-
39
-
-
0032552988
-
Isolation and characterization of a novel enclogenous pepticle ligand for the human APJ receptor
-
Tatemoto K et al. (1998) Isolation and characterization of a novel enclogenous pepticle ligand for the human APJ receptor. Biochem Biophys Res Commun 251: 471-476
-
(1998)
Biochem Biophys Res Commun
, vol.251
, pp. 471-476
-
-
Tatemoto, K.1
-
40
-
-
33845682441
-
TNFalpha up-regulates apelin expression in human and mouse adipose tissue
-
Daviaud D et al. (2006) TNFalpha up-regulates apelin expression in human and mouse adipose tissue. FASEB J 20: 1528-1530
-
(2006)
FASEB J
, vol.20
, pp. 1528-1530
-
-
Daviaud, D.1
-
41
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112: 1821-1830
-
(2003)
J Clin Invest
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
-
42
-
-
23044473651
-
Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity
-
Hicla K et al. (2005) Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA 102: 10610-10615
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 10610-10615
-
-
Hicla, K.1
-
43
-
-
0035896642
-
Hepcidin, a urinary antimicrobial pepticle synthesized in the liver
-
Park CH et al. (2001) Hepcidin, a urinary antimicrobial pepticle synthesized in the liver. J Biol Chem 276: 7806-7810
-
(2001)
J Biol Chem
, vol.276
, pp. 7806-7810
-
-
Park, C.H.1
-
44
-
-
33748265283
-
Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH
-
Bekri S et al. (2006) Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 131: 788-796
-
(2006)
Gastroenterology
, vol.131
, pp. 788-796
-
-
Bekri, S.1
-
45
-
-
33846392878
-
Hepcidin activation during inflammation: Make it STAT
-
Fleming RE (2007) Hepcidin activation during inflammation: Make it STAT. Gastroenterology 132: 447-449
-
(2007)
Gastroenterology
, vol.132
, pp. 447-449
-
-
Fleming, R.E.1
-
46
-
-
33846212344
-
STAT3 is required for IL-6-gpl 30-dependent activation of hepcidin in vivo
-
Pietrangelo A et al. (2007) STAT3 is required for IL-6-gpl 30-dependent activation of hepcidin in vivo. Gastroenterology 132: 294-300
-
(2007)
Gastroenterology
, vol.132
, pp. 294-300
-
-
Pietrangelo, A.1
-
47
-
-
33144479356
-
Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue
-
Schaffler A et al. (2005) Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue. Biochim Biophys Acta 1732: 96-102
-
(2005)
Biochim Biophys Acta
, vol.1732
, pp. 96-102
-
-
Schaffler, A.1
-
48
-
-
37849185741
-
Gene transcript changes in individual rainbow trout livers following an inflammatory stimulus
-
Gerwick L et al. (2007) Gene transcript changes in individual rainbow trout livers following an inflammatory stimulus. Fish Shellfish Immunol 22: 157-171
-
(2007)
Fish Shellfish Immunol
, vol.22
, pp. 157-171
-
-
Gerwick, L.1
-
49
-
-
34249674520
-
Omentin plasma levels and gene expression are decreased in obesity
-
de Souza Batista CM et al. (2007) Omentin plasma levels and gene expression are decreased in obesity. Diabetes 56: 1655-1661
-
(2007)
Diabetes
, vol.56
, pp. 1655-1661
-
-
de Souza Batista, C.M.1
-
50
-
-
23244457836
-
Dissecting asthma using focused transgenic modeling and functional genomics
-
Kuperman DA et al. (2005) Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol 116: 305-311
-
(2005)
J Allergy Clin Immunol
, vol.116
, pp. 305-311
-
-
Kuperman, D.A.1
-
51
-
-
33750453786
-
Convergence between bone and energy homeostases: Leptin regulation of bone mass
-
Karsenty G (2006) Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab 4: 341-348
-
(2006)
Cell Metab
, vol.4
, pp. 341-348
-
-
Karsenty, G.1
|