Leptin deficiency in vivo enhances the ability of splenic dendritic cells to activate T cells

International Immunology

Volumn 26, Issue 11, 2014, Pages 627-636

  Ramirez, Oscar ^a   Garza, Kristine M ^a  

^a UNIVERSITY OF TEXAS AT EL PASO   (United States)

Author keywords

CD4+ T cells; Cytokines; Helper T cells; T cell activation

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2; LEPTIN; LEPTIN RECEPTOR; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIGEN PRESENTATION; ARTICLE; BACTERIAL LOAD; CELLULAR IMMUNITY; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; DENDRITIC CELL; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; HYBRIDOMA; IN VIVO STUDY; INFLAMMATION; LEPTIN DEFICIENCY; MIXED LYMPHOCYTE REACTION; MOUSE; MYCOBACTERIUM AVIUM; NONHUMAN; PHAGOCYTOSIS; PHENOTYPE; PROTEIN EXPRESSION; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; WILD TYPE; ANIMAL; C57BL MOUSE; CELL COUNT; CHEMISTRY; CYTOLOGY; DEFICIENCY; GENE EXPRESSION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; MIXED LYMPHOCYTE CULTURE; SPLEEN; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; CELL COUNT; DENDRITIC CELLS; FEMALE; GENE EXPRESSION; LEPTIN; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYCOBACTERIUM AVIUM; PHENOTYPE; RECEPTORS, LEPTIN; SPLEEN; T-LYMPHOCYTES;

EID: 84911372986     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxu067     Document Type: Article

References (39)

1. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. and Friedman, J. M. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425.
2. Banks, W. A. 2004. The many lives of leptin. Peptides 25:331.
3. Arora, S. and Anubhuti. 2006. Role of neuropeptides in appetite regulation and obesity-a review. Neuropeptides 40:375.
4. Tartaglia, L. A., Dembski, M., Weng, X. et al. 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263.
5. Tartaglia, L. A. 1997. The leptin receptor. J. Biol. Chem. 272:6093.
6. Hegyi, K., Fülöp, K., Kovács, K., Tóth, S. and Falus, A. 2004. Leptin-induced signal transduction pathways. Cell Biol. Int. 28:159.
7. Halaas, J. L. and Friedman, J. M. 1997. Leptin and its receptor. J. Endocrinol. 155:215.
8. Zabeau, L., Lavens, D., Peelman, F., Eyckerman, S., Vandekerckhove, J. and Tavernier, J. 2003. The ins and outs of leptin receptor activation. FEBS Lett. 546:45.
9. Fei, H., Okano, H. J., Li, C. et al. 1997. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl Acad. Sci. USA 94:7001.
10. Papathanassoglou, E., El-Haschimi, K., Li, X. C., Matarese, G., Strom, T. and Mantzoros, C. 2006. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J. Immunol. 176:7745.
11. Mattioli, B., Straface, E., Quaranta, M. G., Giordani, L. and Viora, M. 2005. Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. J. Immunol. 174:6820.
12. Lee, F. Y., Li, Y., Yang, E. K. et al. 1999. Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. Am. J. Physiol.-Cell Physiol. 276:C386.
13. Loffreda, S., Yang, S. Q., Lin, H. Z. et al. 1998. Leptin regulates proinflammatory immune responses. FASEB J. 12:57.
14. Sánchez-Margalet, V., Martín-Romero, C., Santos-Alvarez, J., Goberna, R., Najib, S. and Gonzalez-Yanes, C. 2003. Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin. Exp. Immunol. 133:11.
15. Zarkesh-Esfahani, H., Pockley, A. G., Wu, Z., Hellewell, P. G., Weetman, A. P. and Ross, R. J. 2004. Leptin indirectly activates human neutrophils via induction of TNF-alpha. J. Immunol. 172:1809.
16. Lord, G. M., Matarese, G., Howard, J. K., Baker, R. J., Bloom, S. R. and Lechler, R. I. 1998. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394:897.
17. Martín-Romero, C., Santos-Alvarez, J., Goberna, R. and Sánchez- Margalet, V. 2000. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell. Immunol. 199:15.
18. Farooqi, I. S., Matarese, G., Lord, G. M. et al. 2002. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/ metabolic dysfunction of human congenital leptin deficiency. J. Clin. Invest. 110:1093.
19. Mancuso, P., Gottschalk, A., Phare, S. M., Peters-Golden, M., Lukacs, N. W. and Huffnagle, G. B. 2002. Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J. Immunol. 168:4018.
20. Ikejima, S., Sasaki, S., Sashinami, H. et al. 2005. Impairment of host resistance to Listeria monocytogenes infection in liver of db/ db and ob/ob mice. Diabetes 54:182.
21. Wieland, C. W., Florquin, S., Chan, E. D. et al. 2005. Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice. Int. Immunol. 17:1399.
22. Matarese, G., Di Giacomo, A., Sanna, V. et al. 2001. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J. Immunol. 166:5909.
23. Busso, N., So, A., Chobaz-Péclat, V. et al. 2002. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J. Immunol. 168:875.
24. Matarese, G., Sanna, V., Di Giacomo, A. et al. 2001. Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males. Eur. J. Immunol. 31:1324.
25. Matarese, G., Sanna, V., Lechler, R. I. et al. 2002. Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes 51:1356.
26. Mellman, I. and Steinman, R. M. 2001. Dendritic cells: specialized and regulated antigen processing machines. Cell 106:255.
27. Mellman, I., Turley, S. J. and Steinman, R. M. 1998. Antigen processing for amateurs and professionals. Trends Cell Biol. 8:231.
28. Lanzavecchia, A. and Sallusto, F. 2001. Regulation of T cell immunity by dendritic cells. Cell 106:263.
29. Mattioli, B., Straface, E., Matarrese, P. et al. 2008. Leptin as an immunological adjuvant: enhanced migratory and CD8+ T cell stimulatory capacity of human dendritic cells exposed to leptin. FASEB J. 22:2012.
30. Lam, Q. L., Liu, S., Cao, X. and Lu, L. 2006. Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur. J. Immunol. 36:3118.
31. Macia, L., Delacre, M., Abboud, G. et al. 2006. Impairment of dendritic cell functionality and steady-state number in obese mice. J. Immunol. 177:5997.
32. Zhao, Y., Sun, R., You, L., Gao, C. and Tian, Z. 2003. Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem. Biophys. Res. Commun. 300:247.
33. De Rosa, V., Procaccini, C., Calì, G. et al. 2007. A key role of leptin in the control of regulatory T cell proliferation. Immunity 26:241.
34. Asselin-Paturel, C., Brizard, G., Pin, J.-J., Brière, F. and Trinchieri, G. 2003. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J. Immunol. 171:6466.
35. Siegmund, B., Lehr, H. A. and Fantuzzi, G. 2002. Leptin: a pivotal mediator of intestinal inflammation in mice. Gastroenterology 122:2011.
36. Siegmund, B., Lear-Kaul, K. C., Faggioni, R. and Fantuzzi, G. Leptin deficiency, not obesity, protects mice from Con A-induced hepatitis. Eur. J. Immunol. 32:552.
37. Iliev, I. D., Mileti, E., Matteoli, G., Chieppa, M., and Rescigno, M. Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal Immunol. 2:340.
38. Besin, G., Gaudreau, S., Ménard, M., Guindi, C., Dupuis, G. and Amrani, A. 2008. Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes. Diabetes 57:2107.
39. Matarese, G., La Cava, A., Sanna, V. et al. 2002. Balancing susceptibility to infection and autoimmunity: a role for leptin? Trends Immunol. 23:182.