Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways

Diabetes

Volumn 50, Issue 5, 2001, Pages 955-961

  O'Rourke, Lisa ^a   Yeaman, Steven J ^b   Shepherd, Peter R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ESTER; CHOLESTEROL ESTERASE; CYCLIC AMP; HORMONE SENSITIVE LIPASE; INSULIN; JANUS KINASE; LEPTIN; LEPTIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL METABOLISM; CONTROLLED STUDY; HORMONAL REGULATION; HORMONE ACTION; MACROPHAGE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0035039275     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.5.955     Document Type: Article

References (58)

1. Type 2 diabetes: When insulin secretion fails to compensate for insulin resistance
2. Serum immunoreactive leptin levels in normal weight and obese humans
3. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight reduced subjects
4. Role of free fatty acids in the pathogenesis of insulin resistance and diabetes
5. Hyperglycemia and cardiovascular disease in type-2 diabetes
6. A definition of initial, fatty streak and intermediate lesions of atherosclerosis
7. Atherosclerosis: An inflammatory disease
8. Targeted disruption of hormone sensitive lipase results in male sterility and adipocytes hypertrophy, but not in obesity
9. Hormone sensitive lipase overexpression increases cholesteryl ester hydrolysis in macrophages
10. Impaired mobilisation of cholesterol from stored cholesteryl esters in human (THP1) macrophages
11. Genetic differences of lipid metabolism in macrophages from C57BL/6J and C3H/HeN mice
12. Inhibition of cholesteryl ester accumulation by 17 β estradiol in macrophages through activation of neutral cholesterol esterase
13. Down-regulation of hormone-sensitive lipase in sterol laden J774.2 macrophages
14. Cholesterol-mediated changes of neutral cholesterol esterase activity in macrophages
15. The multifunctional role of hormone-sensitive lipase in lipid metabolism
16. Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes
17. Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein
18. Lipotransin: A novel docking protein for hormone-sensitive lipase
19. Novel forms of lipolysis induced by leptin
20. Direct effects of leptin on brown and white adipose tissue
21. In vitro effect of leptin on mouse adipocytes: Evidence for a possible autocrine/paracrine role of leptin
22. Activation of downstream signals by the long form of the leptin receptor
23. Compartment specific regulation of phosphoinositide 3-kinase by PDGF and insulin in 3T3-L1 adipocytes
24. Hormone-sensitive lipase in differentiated 3T3-L1 cells and its activation by cyclic AMP-dependent protein kinase
25. cAMP stimulates cholesteryl ester clearance to high density lipoproteins in J774 macrophages
26. Induction of cellular cholesterol efflux to lipid-free apolipoprotein A-I by cAMP
27. Species-specific alternative splicing generates a catalytically inactive form of human hormone-sensitive lipase
28. Triglyceride, diglyceride, monoglyceride, and cholesterol ester hydrolases in chicken adipose tissue activated by adenosine 3′:5′-monophosphate-dependent protein kinase
29. Phosphorylation and activation of hormone-sensitive lipase in isolated macrophages
30. Neutral cholesterol esterase activity in macrophages and its enhancement by cAMP-dependent protein kinase
31. The role of SOCS3 in Leptin signaling and leptin resistance
32. Selective interaction between leptin and insulin signaling pathways in a hepatic cell line
33. Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes
34. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
35. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes
36. Obesity is a medical problem
37. Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk
38. Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for a PI 3-kinase mediated effect
39. Leptin inhibits insulin secretion by activation of phosphodiesterase 3b
40. Lack of effect of leptin on glucose transport, lipoprotein lipase and insulin action in adipose and muscle cells
41. Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes
42. Leptin impairs the metabolic actions of insulin in isolated rat adipocytes
43. The full-length leptin receptor has signalling capabilities of interleukin 6-type cytokine receptors
44. The leptin receptor
45. Leptin can induce proliferation, differentiation and functional activation of hematopoietic cells
46. A role for leptin and its cognate receptor in hematopoiesis
47. Human leptin enhances activation and proliferation of human circulating T lymphocytes
48. Human leptin stimulates proliferation and activation of human circulating monocytes
49. Leptin modulates T-cell immune response and reverses starvation-induced immunosuppression
50. Regulation of fatty acid homeostasis in cells: Novel role of leptin
51. cAMP-dependent protein kinase and lipolysis in rat adipocytes: Multiple modes of insulin regulation of lipolysis and regulation of insulin responses by adenyl cyclase regulators
52. Insulin-induced phosphorylation and activation of phosphodiesterase 3b in rat adipocytes: Possible role for protein kinase B but not MAP kinase or p70 S6 kinase
53. Mechanism involved in the regulation of free fatty acid release from isolated human fat cells by acylation-stimulating protein and insulin
54. In vitro differentiation of human monocytes to macrophages: Changes in PDE profile and its relationship to suppression of tumour necrosis factor α release by PDE inhibitors
55. IL3 and IL4 activate PDE3 and PDE4 by two different methods in FDCP2 myeloid cells
56. IRS-1 is essential for insulin stimulated and IL4 stimulated mitogenisisin hematopoietic cells
57. The protein phosphatases responsible for dephosphorylation of hormone-sensitive lipase in isolated rat adipocytes
58. Leptin directly stimulates catecholamine secretion and synthesis in cultured porcine adrenal chromaffin cells