Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

Annals of the Rheumatic Diseases

Volumn 71, Issue 3, 2012, Pages 455-462

  Hui, Wang ^a   Litherland, Gary J ^a   Elias, Martina S ^b   Kitson, Gareth I ^a   Cawston, Tim E ^a   Rowan, Andrew D ^a   Young, David A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COLLAGENASE; COLLAGENASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERSTITIAL COLLAGENASE; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOASSAY; IMMUNOBLOTTING; KNEE OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; SUPERNATANT; WHITE ADIPOSE TISSUE; ZYMOGRAPHY;

ADIPOSE TISSUE, WHITE; ANIMALS; CARTILAGE, ARTICULAR; CATTLE; CELLS, CULTURED; COLLAGEN; COLLAGENASES; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INFLAMMATION MEDIATORS; LEPTIN; MATRIX METALLOPROTEINASES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NASAL CARTILAGES; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TISSUE CULTURE TECHNIQUES;

EID: 84857239741     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2011-200372     Document Type: Article

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