Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes

Life Sciences

Volumn 140, Issue , 2015, Pages 75-78

  Scotece, Morena ^a,b   Mobasheri, Ali ^b,c,d  

^a HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^b UNIVERSITY OF SURREY   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Adipokine; Cartilage; Chondrocyte; Inflammation; Leptin; Obesity; Osteoarthritis (OA)

Indexed keywords

ADIPOCYTOKINE; LEPTIN; LEPTIN RECEPTOR;

ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL FUNCTION; HUMAN; OBESITY; OSTEOARTHRITIS; PATHOGENESIS; PREVALENCE; REVIEW; WHITE ADIPOSE TISSUE; PATHOPHYSIOLOGY; PHYSIOLOGY;

CARTILAGE, ARTICULAR; CHONDROCYTES; HUMANS; LEPTIN; OSTEOARTHRITIS;

EID: 84944513747     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.05.025     Document Type: Review

References (52)

1. C.F. Dillon, E.K. Rasch, Q. Gu, and R. Hirsch Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991-94 J. Rheumatol. 33 11 2006 2271 2279
2. A. Mobasheri, C. Matta, R. Zakany, and G. Musumeci Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis Maturitas 80 3 2015 237 244
3. A.I. Maroudas Balance between swelling pressure and collagen tension in normal and degenerate cartilage Nature 260 5554 1976 808 809
4. R.A. Bank, M. Soudry, A. Maroudas, J. Mizrahi, and J.M. TeKoppele The increased swelling and instantaneous deformation of osteoarthritic cartilage is highly correlated with collagen degradation Arthritis Rheum. 43 2210 2000 2202 2210
5. H. Jahr, C. Matta, and A. Mobasheri Physicochemical and biomechanical in cell-based articular cartilage repair Curr. Rheumatol. Rep. 2015 10.1007/S11926-014-0493-9
6. A.D. Woolf, and B. Pfleger Burden of major musculoskeletal conditions Bull. World Health Organ. 81 9 2003 646 656
7. L.S. Lohmander, and E.M. Roos Clinical update: treating osteoarthritis Lancet 370 9605 2007 2082 2084
8. E. Yusuf, R.G. Nelissen, A. Ioan-Facsinay, V. Stojanovic-Susulic, J. DeGroot, G. van Osch, S. Middeldorp, T.W. Huizinga, and M. Kloppenburg Association between weight or body mass index and hand osteoarthritis: a systematic review Ann. Rheum. Dis. 69 4 2010 761 765
9. P. Pottie, N. Presle, B. Terlain, P. Netter, D. Mainard, and F. Berenbaum Obesity and osteoarthritis: more complex than predicted! Ann. Rheum. Dis. 65 11 2006 1403 1405
10. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 6505 1994 425 432
11. Green ED, Maffei M, Braden VV, Proenca R, DeSilva U, Zhang Y, Chua SC, Jr., Leibel RL, Weissenbach J, Friedman JM. The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res. 1995;5 (1):5-12.
12. R.S. Ahima, and J.S. Flier Adipose tissue as an endocrine organ Trends Endocrinol. Metab. 11 8 2000 327 332
13. H. Dumond, N. Presle, B. Terlain, D. Mainard, D. Loeuille, P. Netter, and P. Pottie Evidence for a key role of leptin in osteoarthritis Arthritis Rheum. 48 11 2003 3118 3129
14. M. Morroni, R. De Matteis, C. Palumbo, M. Ferretti, I. Villa, A. Rubinacci, S. Cinti, and G. Marotti In vivo leptin expression in cartilage and bone cells of growing rats and adult humans J. Anat. 205 4 2004 291 296
15. N. Presle, P. Pottie, H. Dumond, C. Guillaume, F. Lapicque, S. Pallu, D. Mainard, P. Netter, and B. Terlain Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of Joint Tissues to Their Articular Production Osteoarthr. Cartil. 14 7 2006 690 695
16. T. Simopoulou, K.N. Malizos, D. Iliopoulos, N. Stefanou, L. Papatheodorou, M. Ioannou, and A. Tsezou Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism Osteoarthr. Cartil. 15 8 2007 872 883
17. D. Iliopoulos, K.N. Malizos, and A. Tsezou Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention Ann. Rheum. Dis. 66 12 2007 1616 1621
18. K. Jarvinen, K. Vuolteenaho, R. Nieminen, T. Moilanen, R.G. Knowles, and E. Moilanen Selective iNOS inhibitor 1400 W enhances anti-catabolic IL-10 and reduces destructive MMP-10 in OA cartilage. Survey of the effects of 1400 W on inflammatory mediators produced by OA cartilage as detected by protein antibody array Clin. Exp. Rheumatol. 26 2 2008 275 282
19. M.A. Cowley, J.L. Smart, M. Rubinstein, M.G. Cerdan, S. Diano, T.L. Horvath, R.D. Cone, and M.J. Low Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus Nature 411 6836 2001 480 484
20. M.K. Sinha, J. Sturis, J. Ohannesian, S. Magosin, T. Stephens, M.L. Heiman, K.S. Polonsky, and J.F. Caro Ultradian oscillations of leptin secretion in humans Biochem. Biophys. Res. Commun. 228 3 1996 733 738
21. N. Ghilardi, and R.C. Skoda The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line Mol. Endocrinol. 11 4 1997 393 399
22. G. Bahrenberg, I. Behrmann, A. Barthel, P. Hekerman, P.C. Heinrich, H.G. Joost, and W. Becker Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers Mol. Endocrinol. 16 4 2002 859 872
23. D.W. White, K.K. Kuropatwinski, R. Devos, H. Baumann, and L.A. Tartaglia Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization J. Biol. Chem. 272 7 1997 4065 4071
24. R. Devos, Y. Guisez, J. Van der Heyden, D.W. White, M. Kalai, M. Fountoulakis, and G. Plaetinck Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding J. Biol. Chem. 272 29 1997 18304 18310
25. A.S. Banks, S.M. Davis, S.H. Bates, and M.G. Myers Jr. Activation of downstream signals by the long form of the leptin receptor J. Biol. Chem. 275 19 2000 14563 14572
26. C. Bjorbaek, S. Uotani, B. da Silva, and J.S. Flier Divergent signaling capacities of the long and short isoforms of the leptin receptor J. Biol. Chem. 272 51 1997 32686 32695
27. O. Gualillo, S. Eiras, D.W. White, C. Dieguez, and F.F. Casanueva Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2 Mol. Cell. Endocrinol. 190 1-2 2002 83 89
28. K.D. Niswender, G.J. Morton, W.H. Stearns, C.J. Rhodes, M.G. Myers Jr., and M.W. Schwartz Intracellular signalling. Key enzyme in leptin-induced anorexia Nature 413 6858 2001 794 795
29. K. Vuolteenaho, A. Koskinen, M. Kukkonen, R. Nieminen, U. Paivarinta, T. Moilanen, and E. Moilanen Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage-mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production Mediat. Inflamm. 2009 2009 345838
30. Y. Akasaka, M. Tsunoda, T. Ogata, T. Ide, and K. Murakami Direct evidence for leptin-induced lipid oxidation independent of long-form leptin receptor Biochim. Biophys. Acta 1801 10 2010 1115 1122
31. B.F. Belgardt, A. Husch, E. Rother, M.B. Ernst, F.T. Wunderlich, B. Hampel, T. Klockener, D. Alessi, P. Kloppenburg, and J.C. Bruning PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response Cell Metab. 7 4 2008 291 301
32. A. Oswal, and G. Yeo Leptin and the control of body weight: a review of its diverse central targets, signaling mechanisms, and role in the pathogenesis of obesity Obesity (Silver Spring) 18 2 2010 221 229
33. A. Koskinen, K. Vuolteenaho, R. Nieminen, T. Moilanen, and E. Moilanen Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients Clin. Exp. Rheumatol. 29 1 2011 57 64
34. O. Gualillo, S. Eiras, F. Lago, C. Dieguez, and F.F. Casanueva Elevated serum leptin concentrations induced by experimental acute inflammation Life Sci. 67 20 2000 2433 2441
35. M. Rosenbaum, M. Nicolson, J. Hirsch, S.B. Heymsfield, D. Gallagher, F. Chu, and R.L. Leibel Effects of gender, body composition, and menopause on plasma concentrations of leptin J. Clin. Endocrinol. Metab. 81 9 1996 3424 3427
36. C.A. Karvonen-Gutierrez, S.D. Harlow, P. Mancuso, J. Jacobson, C.F. Mendes de Leon, and B. Nan Association of leptin levels with radiographic knee osteoarthritis among a cohort of midlife women Arthritis Care Res. 65 6 2013 936 944 (Hoboken)
37. J.H. Ku, C.K. Lee, B.S. Joo, B.M. An, S.H. Choi, T.H. Wang, and H.L. Cho Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis Clin. Rheumatol. 28 12 2009 1431 1435
38. A. Lubbeke, A. Finckh, G.J. Puskas, D. Suva, A. Ladermann, S. Bas, D. Fritschy, C. Gabay, and P. Hoffmeyer Do synovial leptin levels correlate with pain in end stage arthritis? Int. Orthop. 37 10 2013 2071 2079
39. T.M. Griffin, J.L. Huebner, V.B. Kraus, and F. Guilak Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis Arthritis Rheum. 60 10 2009 2935 2944
40. M. Massengale, B. Lu, J.J. Pan, J.N. Katz, and D.H. Solomon Adipokine hormones and hand osteoarthritis: radiographic severity and pain PLoS One 7 10 2012 e47860
41. P.A. Berry, S.W. Jones, F.M. Cicuttini, A.E. Wluka, and R.A. Maciewicz Temporal relationship between serum adipokines, biomarkers of bone and cartilage turnover, and cartilage volume loss in a population with clinical knee osteoarthritis Arthritis Rheum. 63 3 2011 700 707
42. J.P. Bao, W.P. Chen, J. Feng, P.F. Hu, Z.L. Shi, and L.D. Wu Leptin plays a catabolic role on articular cartilage Mol. Biol. Rep. 37 7 2010 3265 3272
43. Y. Figenschau, G. Knutsen, S. Shahazeydi, O. Johansen, and B. Sveinbjornsson Human articular chondrocytes express functional leptin receptors Biochem. Biophys. Res. Commun. 287 1 2001 190 197
44. M. Otero, J.J. Gomez Reino, and O. Gualillo Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells Arthritis Rheum. 48 2 2003 404 409
45. M. Otero, R. Lago, F. Lago, J.J. Reino, and O. Gualillo Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1 Arthritis Res. Ther. 7 3 2005 R581 R591
46. - 9 genes expression by mitogen-activated protein kinases and NF-kB signaling pathways in human chondrocytes Cell Biol. Int. 39 1 2015 104 112
47. R. Gomez, M. Scotece, J. Conde, J.J. Gomez-Reino, F. Lago, and O. Gualillo Adiponectin and leptin increase IL-8 production in human chondrocytes Ann. Rheum. Dis. 70 11 2011 2052 2054
48. J. Conde, M. Scotece, V. Lopez, R. Gomez, F. Lago, J. Pino, J.J. Gomez-Reino, and O. Gualillo Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes PLoS One 7 12 2012 e52533
49. S.J. Wang, X.F. Li, L.S. Jiang, and L.Y. Dai Leptin regulates estrogen receptor gene expression in ATDC5 cells through the extracellular signal regulated kinase signaling pathway J. Cell. Biochem. 113 4 2012 1323 1332
50. J. Liang, J. Feng, W.K. Wu, J. Xiao, Z. Wu, D. Han, Y. Zhu, and G. Qiu Leptin-mediated cytoskeletal remodeling in chondrocytes occurs via the RhoA/ROCK pathway J. Orthop. Res. 29 3 2011 369 374
51. M. Ben-Eliezer, M. Phillip, and G. Gat-Yablonski Leptin regulates chondrogenic differentiation in ATDC5 cell-line through JAK/STAT and MAPK pathways Endocrine 32 2 2007 235 244
52. Y. Kishida, M. Hirao, N. Tamai, A. Nampei, T. Fujimoto, T. Nakase, N. Shimizu, H. Yoshikawa, and A. Myoui Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification Bone 37 5 2005 607 621