메뉴 건너뛰기




Volumn 10, Issue 1, 2013, Pages

Increased activation and cytokine secretion in B cells stimulated with leptin in aged humans

Author keywords

B cells; IL 10; IL 6; TNF

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 6; LEPTIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84872534007     PISSN: None     EISSN: 17424933     Source Type: Journal    
DOI: 10.1186/1742-4933-10-3     Document Type: Article
Times cited : (34)

References (43)
  • 1
    • 2442618838 scopus 로고    scopus 로고
    • The weight of leptin in autoimmunity
    • 10.1038/nri1350, 15122202
    • Cava A, Matarese G. The weight of leptin in autoimmunity. Nat Rev Immunol 2004, 4:371-379. 10.1038/nri1350, 15122202.
    • (2004) Nat Rev Immunol , vol.4 , pp. 371-379
    • Cava, A.1    Matarese, G.2
  • 2
    • 0031965266 scopus 로고    scopus 로고
    • Leptin regulates proinflammatory immune responses
    • Loffreda S, Rai R, Yang SQ, et al. Leptin regulates proinflammatory immune responses. FASEB J 1998, 12:57-65.
    • (1998) FASEB J , vol.12 , pp. 57-65
    • Loffreda, S.1    Rai, R.2    Yang, S.Q.3
  • 3
    • 0033602850 scopus 로고    scopus 로고
    • Human leptin stimulates proliferation and activation of human circulating monocytes
    • 10.1006/cimm.1999.1490, 10357875
    • Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol 1999, 194:6-11. 10.1006/cimm.1999.1490, 10357875.
    • (1999) Cell Immunol , vol.194 , pp. 6-11
    • Santos-Alvarez, J.1    Goberna, R.2    Sanchez-Margalet, V.3
  • 4
    • 0034628016 scopus 로고    scopus 로고
    • Human leptin enhances activation and proliferation of human circulating T lymphocytes
    • 10.1006/cimm.1999.1594, 10675271
    • Martin-Romero C, Santos-Alvarez J, Governa R, Sanchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 2000, 199:15-24. 10.1006/cimm.1999.1594, 10675271.
    • (2000) Cell Immunol , vol.199 , pp. 15-24
    • Martin-Romero, C.1    Santos-Alvarez, J.2    Governa, R.3    Sanchez-Margalet, V.4
  • 6
    • 2342623445 scopus 로고    scopus 로고
    • Inflammatory mediators in the elderly
    • 10.1016/j.exger.2004.01.009, 15130663
    • Krabbe KS, Pedersen M, Bruunsggaard H. Inflammatory mediators in the elderly. Exp Gerontol 2004, 39:687-699. 10.1016/j.exger.2004.01.009, 15130663.
    • (2004) Exp Gerontol , vol.39 , pp. 687-699
    • Krabbe, K.S.1    Pedersen, M.2    Bruunsggaard, H.3
  • 7
    • 33745384267 scopus 로고    scopus 로고
    • Molecular mechanisms of aging-associated inflammation
    • 10.1016/j.canlet.2005.04.009, 15978720
    • Sarkar D, Fisher PB. Molecular mechanisms of aging-associated inflammation. Cancer Lett 2006, 236(1):13-23. 10.1016/j.canlet.2005.04.009, 15978720.
    • (2006) Cancer Lett , vol.236 , Issue.1 , pp. 13-23
    • Sarkar, D.1    Fisher, P.B.2
  • 8
    • 0037397789 scopus 로고    scopus 로고
    • Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes
    • 10.1016/S0047-6374(03)00027-7, 12714258
    • Pedersen M, Bruunsgaard H, Weis N, Hendel HW, Andreassen BU, Eldrup E, Dela F, Pedersen BK. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mech Ageing Dev 2003, 124:495-502. 10.1016/S0047-6374(03)00027-7, 12714258.
    • (2003) Mech Ageing Dev , vol.124 , pp. 495-502
    • Pedersen, M.1    Bruunsgaard, H.2    Weis, N.3    Hendel, H.W.4    Andreassen, B.U.5    Eldrup, E.6    Dela, F.7    Pedersen, B.K.8
  • 9
    • 0034051068 scopus 로고    scopus 로고
    • Age-associated increased interleukin-6 gene expression, late life disease, and frailty
    • 10.1146/annurev.med.51.1.245, 10774463
    • Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late life disease, and frailty. Ann Rev Med 2000, 51:245-270. 10.1146/annurev.med.51.1.245, 10774463.
    • (2000) Ann Rev Med , vol.51 , pp. 245-270
    • Ershler, W.B.1    Keller, E.T.2
  • 10
    • 0035047271 scopus 로고    scopus 로고
    • Aging and proinflammatory cytokines
    • 10.1097/00062752-200105000-00001, 11303144
    • Bruunsgaard H, Pedersen M, Pedersen BK. Aging and proinflammatory cytokines. Curr Opin Hematol 2001, 8:131-136. 10.1097/00062752-200105000-00001, 11303144.
    • (2001) Curr Opin Hematol , vol.8 , pp. 131-136
    • Bruunsgaard, H.1    Pedersen, M.2    Pedersen, B.K.3
  • 12
    • 70349537505 scopus 로고    scopus 로고
    • Gender-based differences in leptinemia in healthy aging, non-obese individuals associate with increased marker of oxidative stress
    • 2596325, 19079674
    • Agrawal A, Lourenço EV, Gupta S, La Cava A. Gender-based differences in leptinemia in healthy aging, non-obese individuals associate with increased marker of oxidative stress. Int J Clin Exp Med. 2008, 1(4):305-309. 2596325, 19079674.
    • (2008) Int J Clin Exp Med. , vol.1 , Issue.4 , pp. 305-309
    • Agrawal, A.1    Lourenço, E.V.2    Gupta, S.3    La Cava, A.4
  • 13
    • 0035092710 scopus 로고    scopus 로고
    • Serum leptin levels in the elderly: relationship with gender and nutritional status
    • Smirnoff P, Almiral-Seliger D, Schwartz B. Serum leptin levels in the elderly: relationship with gender and nutritional status. J Nutr Health Aging 2001, 5:29-32.
    • (2001) J Nutr Health Aging , vol.5 , pp. 29-32
    • Smirnoff, P.1    Almiral-Seliger, D.2    Schwartz, B.3
  • 15
    • 9444249827 scopus 로고    scopus 로고
    • Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women
    • 10.1016/j.cccn.2004.09.003, 15563886
    • Zhong N, Wu XP, Xu ZR, Wang AH, Luo XH, Cao XZ, Xie H, Shan PF, Liao EY. Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. Clin Chim Acta 2005, 351:161-168. 10.1016/j.cccn.2004.09.003, 15563886.
    • (2005) Clin Chim Acta , vol.351 , pp. 161-168
    • Zhong, N.1    Wu, X.P.2    Xu, Z.R.3    Wang, A.H.4    Luo, X.H.5    Cao, X.Z.6    Xie, H.7    Shan, P.F.8    Liao, E.Y.9
  • 17
    • 13844301899 scopus 로고    scopus 로고
    • Innate immunity in aging: impact on macrophage function
    • 10.1111/j.1474-9728.2004.00102.x, 15268749
    • Plowden J, Renshaw-Hoelscher M, Engleman C, Katz J, Sambhara S. Innate immunity in aging: impact on macrophage function. Aging Cell 2004, 3:161-167. 10.1111/j.1474-9728.2004.00102.x, 15268749.
    • (2004) Aging Cell , vol.3 , pp. 161-167
    • Plowden, J.1    Renshaw-Hoelscher, M.2    Engleman, C.3    Katz, J.4    Sambhara, S.5
  • 18
    • 0036977172 scopus 로고    scopus 로고
    • Effect of aging on macrophage function
    • 10.1016/S0531-5565(02)00125-0, 12559402
    • Lloberas J, Celada A. Effect of aging on macrophage function. Exp Gerontol 2002, 37:1325-1331. 10.1016/S0531-5565(02)00125-0, 12559402.
    • (2002) Exp Gerontol , vol.37 , pp. 1325-1331
    • Lloberas, J.1    Celada, A.2
  • 19
    • 16844363815 scopus 로고    scopus 로고
    • The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function
    • Chelvarajan RL, Collins SM, Van Willigen JM, Bondada S. The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function. J Leukoc Biol 2005, 77:503-512.
    • (2005) J Leukoc Biol , vol.77 , pp. 503-512
    • Chelvarajan, R.L.1    Collins, S.M.2    Van Willigen, J.M.3    Bondada, S.4
  • 20
    • 78651275576 scopus 로고    scopus 로고
    • Impaired functions of peripheral blood monocyte subpopulations in aged humans
    • 10.1007/s10875-010-9448-8, 2970801, 20703784
    • Nyugen J, Agrawal S, Gollapudi S, Gupta S. Impaired functions of peripheral blood monocyte subpopulations in aged humans. J Clin Immunol 2010, 30:806-813. 10.1007/s10875-010-9448-8, 2970801, 20703784.
    • (2010) J Clin Immunol , vol.30 , pp. 806-813
    • Nyugen, J.1    Agrawal, S.2    Gollapudi, S.3    Gupta, S.4
  • 21
    • 0030741166 scopus 로고    scopus 로고
    • Production of cytokines by human B cells in health and disease
    • 10.1016/S0167-5699(97)01080-3, 9238838
    • Pistoia V. Production of cytokines by human B cells in health and disease. Immunol Today 1997, 18:343-350. 10.1016/S0167-5699(97)01080-3, 9238838.
    • (1997) Immunol Today , vol.18 , pp. 343-350
    • Pistoia, V.1
  • 22
    • 2942737209 scopus 로고    scopus 로고
    • Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium bur are required for development of follicles in the Peyer's patches
    • Tumanov AV, Kuprash DV, Mach JA, Nedospasov SA, Chervonsky AV. Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium bur are required for development of follicles in the Peyer's patches. J Immunol 2004, 173:86-91.
    • (2004) J Immunol , vol.173 , pp. 86-91
    • Tumanov, A.V.1    Kuprash, D.V.2    Mach, J.A.3    Nedospasov, S.A.4    Chervonsky, A.V.5
  • 24
    • 79953892799 scopus 로고    scopus 로고
    • LR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors
    • Epub 2010 Sep 7. Erratum in: J Clin Immunol. 2011, 10.1007/s10875-010-9456-8, 3064903, 20821041
    • Agrawal S, Gupta S. LR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors. J Clin Immunol 2011, 31:89-98. Epub 2010 Sep 7. Erratum in: J Clin Immunol. 2011, 10.1007/s10875-010-9456-8, 3064903, 20821041.
    • (2011) J Clin Immunol , vol.31 , pp. 89-98
    • Agrawal, S.1    Gupta, S.2
  • 25
    • 79961167339 scopus 로고    scopus 로고
    • Leptin activates human B cells to secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway
    • 10.1007/s10875-010-9507-1, 3132280, 21243519
    • Agrawal S, Gollapudi S, Su H, Gupta S. Leptin activates human B cells to secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway. J Clin Immunol 2011, 31:472-478. 10.1007/s10875-010-9507-1, 3132280, 21243519.
    • (2011) J Clin Immunol , vol.31 , pp. 472-478
    • Agrawal, S.1    Gollapudi, S.2    Su, H.3    Gupta, S.4
  • 26
    • 34249775503 scopus 로고    scopus 로고
    • Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway
    • Agrawal A, Agrawal S, Cao JN, Su H, Osann K, Gupta S. Altered innate immune functioning of dendritic cells in elderly humans: a role of phosphoinositide 3-kinase-signaling pathway. J Immunol 2007, 178:6912-6922.
    • (2007) J Immunol , vol.178 , pp. 6912-6922
    • Agrawal, A.1    Agrawal, S.2    Cao, J.N.3    Su, H.4    Osann, K.5    Gupta, S.6
  • 27
    • 0036697779 scopus 로고    scopus 로고
    • Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines
    • Lord GM, Matarese G, Howard JK, Bloom SR, Lechler RL. Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines. J Leuco Biol 2002, 72:330-338.
    • (2002) J Leuco Biol , vol.72 , pp. 330-338
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3    Bloom, S.R.4    Lechler, R.L.5
  • 28
    • 0033782028 scopus 로고    scopus 로고
    • Leptin in the regulation of immunity, inflammation and hematopoiesis
    • Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation and hematopoiesis. J Leukoc Biol 2000, 68:437-446.
    • (2000) J Leukoc Biol , vol.68 , pp. 437-446
    • Fantuzzi, G.1    Faggioni, R.2
  • 29
    • 65449170377 scopus 로고    scopus 로고
    • Leptin signaling: a key pathway in immune responses
    • 10.2174/157436209787048711, 2747760, 19774101
    • Procaccini C, Lourenco EV, Matarese G, Cava A. Leptin signaling: a key pathway in immune responses. Curr Signal Transduct Ther 2009, 4:22-30. 10.2174/157436209787048711, 2747760, 19774101.
    • (2009) Curr Signal Transduct Ther , vol.4 , pp. 22-30
    • Procaccini, C.1    Lourenco, E.V.2    Matarese, G.3    Cava, A.4
  • 30
    • 21844468939 scopus 로고    scopus 로고
    • Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kuffer cells
    • 10.1016/j.lfs.2005.04.004, 15979653
    • Shen J, Sakaida I, Uchida K, Terai S, Okita K. Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kuffer cells. Life Sci 2005, 77:1502-1515. 10.1016/j.lfs.2005.04.004, 15979653.
    • (2005) Life Sci , vol.77 , pp. 1502-1515
    • Shen, J.1    Sakaida, I.2    Uchida, K.3    Terai, S.4    Okita, K.5
  • 31
    • 30044434035 scopus 로고    scopus 로고
    • Intracellular signaling pathways activated by leptin
    • 1383660, 16336196
    • Fruhbeck G. Intracellular signaling pathways activated by leptin. Biochem J 2006, 393:7-20. 1383660, 16336196.
    • (2006) Biochem J , vol.393 , pp. 7-20
    • Fruhbeck, G.1
  • 32
    • 0030913257 scopus 로고    scopus 로고
    • IL-12 directly stimulates expression of IL-10 by CD5+ B cells and IL-6 by both CD5+ and CD5- B cells; possible involvement in age-associated cytokine dysregulation
    • 10.1093/intimm/9.5.745, 9184920
    • Spencer NF, Daynes RA. IL-12 directly stimulates expression of IL-10 by CD5+ B cells and IL-6 by both CD5+ and CD5- B cells; possible involvement in age-associated cytokine dysregulation. Int Immunol 1997, 9:745-754. 10.1093/intimm/9.5.745, 9184920.
    • (1997) Int Immunol , vol.9 , pp. 745-754
    • Spencer, N.F.1    Daynes, R.A.2
  • 33
    • 33847312289 scopus 로고    scopus 로고
    • A key role of leptin in the control of regulatory T cells proliferation
    • 10.1016/j.immuni.2007.01.011, 17307705
    • Rosa V, Orocaccini C, Cai G, Pirozzi G, Fontana S, Zappacosta S, Cava A, Matarese G. A key role of leptin in the control of regulatory T cells proliferation. Immunity 2007, 26:241-255. 10.1016/j.immuni.2007.01.011, 17307705.
    • (2007) Immunity , vol.26 , pp. 241-255
    • Rosa, V.1    Orocaccini, C.2    Cai, G.3    Pirozzi, G.4    Fontana, S.5    Zappacosta, S.6    Cava, A.7    Matarese, G.8
  • 34
    • 74649083783 scopus 로고    scopus 로고
    • CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients
    • 10.1016/j.immuni.2009.11.009, 20079667
    • Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 2010, 32:129-140. 10.1016/j.immuni.2009.11.009, 20079667.
    • (2010) Immunity , vol.32 , pp. 129-140
    • Blair, P.A.1    Noreña, L.Y.2    Flores-Borja, F.3    Rawlings, D.J.4    Isenberg, D.A.5    Ehrenstein, M.R.6    Mauri, C.7
  • 35
    • 0033009367 scopus 로고    scopus 로고
    • Possible role of IL-10 in autoantibody production and in the fate of human cord blood CD5+ B cells
    • 10.1046/j.1365-3083.1999.00545.x, 10354374
    • Villasenor-Bustamante A, Alvarado-De La Berrera C, Richaud-Patin Y, Martinez-Ayala H, Llorente L. Possible role of IL-10 in autoantibody production and in the fate of human cord blood CD5+ B cells. Scand J Immunol 1999, 49:629-632. 10.1046/j.1365-3083.1999.00545.x, 10354374.
    • (1999) Scand J Immunol , vol.49 , pp. 629-632
    • Villasenor-Bustamante, A.1    Alvarado-De La Berrera, C.2    Richaud-Patin, Y.3    Martinez-Ayala, H.4    Llorente, L.5
  • 36
    • 0030913257 scopus 로고    scopus 로고
    • IL-12 directly stimulates expression of IL-10 by CD5+ B cells and IL-6 by both CD5+ and CD5- B cells; possible involvement in age-associated cytokine dysregulation
    • Spencer NF, Daynes RA. IL-12 directly stimulates expression of IL-10 by CD5+ B cells and IL-6 by both CD5+ and CD5- B cells; possible involvement in age-associated cytokine dysregulation. Internat Immunol 1997, 9:745-754.
    • (1997) Internat Immunol , vol.9 , pp. 745-754
    • Spencer, N.F.1    Daynes, R.A.2
  • 37
  • 38
    • 17444374245 scopus 로고    scopus 로고
    • Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs
    • 10.1016/j.immuni.2005.02.008, 15845451
    • Sun CM, Deriaud E, Leclerc C, Lo-Man R. Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs. Immunity 2005, 22:467-477. 10.1016/j.immuni.2005.02.008, 15845451.
    • (2005) Immunity , vol.22 , pp. 467-477
    • Sun, C.M.1    Deriaud, E.2    Leclerc, C.3    Lo-Man, R.4
  • 39
    • 0141922966 scopus 로고    scopus 로고
    • Role of IL-10 in the distribution of B cell subsets in the mouse B-1 cell population
    • Pers JO, Jamin C, Youinous P, Charreire J. Role of IL-10 in the distribution of B cell subsets in the mouse B-1 cell population. Eur Cytokine Netw 2003, 14:178-185.
    • (2003) Eur Cytokine Netw , vol.14 , pp. 178-185
    • Pers, J.O.1    Jamin, C.2    Youinous, P.3    Charreire, J.4
  • 41
    • 62849109985 scopus 로고    scopus 로고
    • Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells
    • 10.1111/j.1349-7006.2008.01053.x, 19154413
    • Gao J, Tian J, Lv Y, Shi F, Kong F, Shi H, Zhao L. Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. Cancer Sci 2009, 100:389-395. 10.1111/j.1349-7006.2008.01053.x, 19154413.
    • (2009) Cancer Sci , vol.100 , pp. 389-395
    • Gao, J.1    Tian, J.2    Lv, Y.3    Shi, F.4    Kong, F.5    Shi, H.6    Zhao, L.7
  • 42
    • 34047250349 scopus 로고    scopus 로고
    • Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
    • 10.1158/0008-5472.CAN-06-3075, 2925446, 17363567
    • Saxena NK, Sharma D, Ding X, Lin S, Marra F, Merlin D, Anania FA. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res 2007, 67:2497-2507. 10.1158/0008-5472.CAN-06-3075, 2925446, 17363567.
    • (2007) Cancer Res , vol.67 , pp. 2497-2507
    • Saxena, N.K.1    Sharma, D.2    Ding, X.3    Lin, S.4    Marra, F.5    Merlin, D.6    Anania, F.A.7
  • 43
    • 0035838266 scopus 로고    scopus 로고
    • Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway
    • 10.1006/cimm.2001.1815, 11585385
    • Sanchez-Margallet V, Martin-Romero C. Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell Immunol 2001, 211:30-36. 10.1006/cimm.2001.1815, 11585385.
    • (2001) Cell Immunol , vol.211 , pp. 30-36
    • Sanchez-Margallet, V.1    Martin-Romero, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.