Effects of sex steroid hormones and menopause on serum leptin concentrations

Gynecological Endocrinology

Volumn 16, Issue 6, 2002, Pages 479-491

  Di Carlo, C ^a   Tommaselli, G A ^a   Nappi, C ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Hormone Replacement Therapy; Leptin; Menopause; Sex Steroids

Indexed keywords

LEPTIN; SEX HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BODY COMPOSITION; BODY MASS; CONTROLLED STUDY; DIETARY INTAKE; DRUG EFFECT; HORMONAL REGULATION; HORMONE SUBSTITUTION; MALNUTRITION; MENOPAUSE; NONHUMAN; OVULATION; PRIORITY JOURNAL; RAT; REVIEW; SEXUAL BEHAVIOR; SUBSTITUTION THERAPY; TISSUE DISTRIBUTION;

EID: 0036969502     PISSN: 09513590     EISSN: None     Source Type: Journal    
DOI: 10.1080/gye.16.6.479.491     Document Type: Review

References (128)

1. Cameron JL, Nosbisch C. Suppression of pulsatile luteinizing hormone and testosterone secretion during short term food restriction in the adult male rhesus monkey (Macaca mulatta). Endocrinology 1991;128:1532-40
2. Cameron JL, Weltzin TE, McConaha C, et al. Slowing of pulsatile luteinizing hormone secretion in men after 48 hours of fasting. J Clin Endocrinol Metab 1991;73:35-41
3. Foster DL, Nagatani S. Physiological perspective of leptin as a regulator of reproduction: role in timing puberty. J Biol Reprod 1999;60:205-15
4. Foster DL, Olster DH. Effects of restricted nutrition on puberty in the lamb: pattern of tonic luteinizing hormone (LH) secretion and competency of the LH surge system. Endocrinology 1985;116:375-81
5. Kennedy GC, Mitra J. Body weight and food intake as initiating factors for puberty in the rat. J Physiol 1963;166:408-18
6. Schillo KK. Effects of dietary energy on control of luteinizing hormone secretion in cattle and sheep. J Anim Sci 1882;70:1271-82
7. Wade GN, Schneider JE, Li H-Y. Control of fertility by metabolic cues. Am J Physiol 1996;270:E1-E19
8. Gill CJ, Rissmann EF. Female sexual behaviour is inhibited by short- and long-term food restriction. Physiol Behav 1997;61:387-94
9. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32
10. Madej T, Boguski MS, Buyaub SM. Threadly analysis suggests that the obese gene product may be a helical cytokine. FEBS Letters 1995;373:13-18
11. Masuzaki H, Ogawa Y, Isse N, et al. Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 1995;44:855-8
12. Sinha M, Opentanova I, Ohannesian JP, et al. Evidence of free and bound leptin in human circulation: studies in lean and obese subjects and during short-term fasting. J Clin Invest 1996;98:1277-82
13. Campfield LA, Smith FJ, Burn P. The OB protein (leptin) pathway - a link between adipose tissue mass and central neural networks. Horm Metab Res 1996;28:619-32
14. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive leptin concentrations in normal-weight and obese women. N Engl J Med 1996;334:292-5
15. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurements of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med 1995;1:1155-61
16. Ma Z, Gingerich RL, Santiago JV, et al. Radioimmunoassay of leptin in human plasma. Clin Chem 1996;42:942-6
17. Di Carlo C, Tommaselli GA, Pisano G, et al. Serum leptin levels in postmenopausal women: effects of transdermal hormone replacement therapy. Menopause 2000;7:36-41
18. Ingalls AM, Dickie MD, Snell GD. Obese, new mutation in the mouse. J Hered 1950;41:317-18
19. Harris RB, Zhou J, Redman SM, et al. A leptin dose response study in obese (ob/ob) and lean (+/?) mice. Endocrinology 1998;139:8-19
20. Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene on body weight regulation in ob/ob mice. Science 1995;269:540-3
21. Campfield LA, Smith FJ, Guisez Y, et al. Recombinant mouse Ob protein: evidence for a peripheral signal linking adiposity and central neuronal networks. Science 1995;269:546-9
22. Halaas JL, Gajwala KS, Maffei M, et al. Weight-reducing effect of the plasma protein encoded by the obese gene. Science 1995;269:543-6
23. Barash IA, Cheung CC, Weigle DS, et al. Leptin is a metabolic signal to the reproductive system. Endocrinology 1996;137:144-7
24. Chehab FF, Lim ME, Lu R. Correction of sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet 1996;12:318-20
25. Mouzih K, Lu R, Chehab FF. Leptin treatment recues the sterility of genetically obese ob/ob males. Endocrinology 1997;138:1190-3
26. The writing group for the PEPI trial. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. J Am Med Assoc 1995;273:199-208
27. Gambacciani M, Ciaponi M, Cappagli B, et al. Body weight, body fat distribution, and hormonal replacement therapy in early postmenopausal women. J Clin Endocrinol Metab 1997;82:414-17
28. Gambacciani M, Ciaponi M, Cappagli B, et al. Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy. Maturitas 2001;39:125-32
29. Burger HG, Dudley EC, Hopper JL, et al. The endocrinology of the menopausal transition: a cross-sectional study of a population-based sample. J Clin Endocrinol Metab 1995;80:3537-45
30. Forbes GB, Reina JC. Adult lean body mass declines with age: longitudinal observations. Metabolism 1970;19:653-63
31. Swerdloff RS, Batt RA, Bray GA. Reproductive hormonal function in the genetically obese (ob/ob) mouse. Endocrinology 1994;98:1359-64
32. Yu WH, Walczewska A, Karanth S, et al. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 1997;94:1023-8
33. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;334:292-5
34. Farooqi IS, Jebb SA, Langmack G, et al. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999;341:879-84
35. Strobel A, Issad T, Camoin L, et al. A leptin mis-sense mutation associated with hypogonadism and morbid obesity. Nature Genet 1998;18:213-15
36. Clement K, Vaisse C, Lahlou N. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401
37. Edwardson JA, Hough LC. The pituitary-adrenal system of the genetically obese (ob/ob) mouse. J Endocrinol 1975;65:99-107
38. Cioffi JA, Shafer AW, Zupancic TJ, et al. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nature Med 1996;12:585-9
39. Karlsson C, Lindell K, Svensson E, et al. Expression of functional leptin receptors in the human ovary. J Clin Endocrinol Metab 1997;82:4144-8
40. Catzeflis C, Pierroz DD, Rohner-Jeanrenaud F, et al. Neuropeptide Y administered chronically into the lateral ventricle profoundly inhibits both the gonadotropic and somatotropic axis in the intact adult female rats. Endocrinology 1993;132:335-34
41. Pierroz DD, Catzeflis C, Aebi AC, et al. Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats. Endocrinology 1996;137:3-12
42. Raposinho PD, Pedrazzini T, Tommaselli GA, et al. The neuropeptide Y Y1 antagonist/Y4 agonist 1229U91 stimulates LH secretion through NPY Y4 receptors: assessment using NPY Y1-deficient mice. The Endocrine Society's 82nd Annual Meeting, June 21-24 2000, Toronto, Canada
43. Murakami T, Iida M, Shinam K. Dexamethasone regulates obese expression in isolated rat adipocytes. Biochem Biophys Res Commun 1995;214:5301-4
44. Sliker LJ, Sloop KW, Surface PL, et al. Regulation of ob m-RNA and protein by glucocorticoids and cAMP. J Biol Chem 1996;27:5301-4
45. Kristiensen K, Pedersen SB, Richelsen B. Regulation of leptin by steroid hormones in rat adipose tissue. Biochem Biophys Res Commun 1999;259:624-30
46. Shimizu H, Shimomura Y, Nakanishi Y, et al. Estrogen increases in vivo leptin production in rats and human subjects. J Endocrinol 1997;154:285-92
47. Machinal F, Dieudonne MN, Leneveu MC, et al. In vivo and in vitro ob gene expression and leptin secretion in rat adipocytes: evidence for a regional specific regulation by sex steroid hormones. Endocrinology 1999;140:1567-74
48. Casabiell X, Pineiro V, Peino R, et al. Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulates leptin release in women, but not in men. J Clin Endocrinol Metab 1998;83:2149-55
49. Pineiro V, Casabiell X, Lage M, et al. Dihydrotestosterone, stanozolol, androstenedione and dehydroepiandrosterone sulphate inhibit leptin secretion in female but not in male samples of omental adipose tissue in vitro: lack of effect of testosterone. J Endocrinol 1999;160:425-32
50. Montague C, Prins J, Sanders L, et al. Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes 1997;46:342-7
51. Lonnquist F, Arner P, Nordfors L, et al. Over-expression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Med 1995;1:950-3
52. Hamilton BS, Paglia D, Kwan AY, et al. Increased obese mRNA expression in omental fat cells from massively obese human. Nature Med 1995;1:953-6
53. Kumar V, Chambon P. The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell 1988;55:145-56
54. Savouret JF, Rauch M, Redeuilh G, et al. Interplay between estrogen, progestins, retinoic acid and AP-1 on a single regulatory site in the progesterone receptor gene. J Biol Chem 1994;269:28955-62
55. 3H]estradiol binding in rat adipose tissue. Endocrinology 1978;103:1695-701
56. Wabitsch M, Blum W, Vogel E, et al. Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest 1997;100:808-813
57. Yoneda N, Saito S, Kimura M, et al. The influence of ovariectomy on ob gene expression in rats. Horm Metab Res 1998;30:263-5
58. Watanobe H, Suda T. A detailed study on the role of sex steroid milieu in determining plasma leptin concentrations in adult male and female rats. Biochem Biophys Res Commun 1999;259:56-9
59. Wu-Peng S, Rosenbaum M, Nicolson M, et al. Effects of exogenous gonadal steroids on leptin homeostasis in rats. Obes Res 1999;7:586-92
60. Pelleymounter MA, Baker MB, McCaleb M. Does estradiol mediate leptin's effects on adiposity and body weight? Am J Physiol 1999;276:E955-E963
61. Pinilla L, Seoane M, Gonzalez L, et al. Regulation of serum leptin levels by gonadal function in rats. Eur J Endocrinol 1999;140:468-73
62. Chu SC, Chou YC, Liu JY, et al. Fluctuation of serum leptin level in rats after ovariectomy and the influence of estrogen supplement. Life Sci 1999;64:2299-306
63. Brann DW, De Sevilla L, Zamorano PL, et al. Regulation of leptin gene expression and secretion by steroid hormones. Steroids 1999;64:659-63
64. Richards RJ, Porter JR, Svec F. Serum leptin, lipids, free fatty acids, and fat pads in long-term dehydroepiandrosterone-treated Zucker rats. Proc Soc Exp Biol Med 2000;223:258-62
65. Wade GN, Gray JM, Bartness TJ. Gonadal influences on adiposity. Int J Obes 1985;9:83-92
66. Ambrosius W, Compton J, Bowsher R, et al. Relationship of race, age, and sex hormone differences to serum leptin concentrations in children and adolescents. Horm Res 1998;49:240-6
67. Paolisso G, Rizoo MR, Marone CM, et al. Plasma sex hormones are significantly associated with plasma leptin concentrations. Clin Endocrinol 1998;48:291-7
68. Licinio J, Negrao A, Mantzoros C, et al. Sex differences in circulating human leptin pulse amplitude: clinical implications. J Clin Endocrinol Metab 1998;83:4140-7
69. Hellstrom L, Wahrenberg H, Hruska K, et al. Mechanism behind gender differences in circulating leptin levels. J Intern Med 2000;247:457-62
70. Matsuda V, Yokoda I, Iida M, et al. Serum leptin concentration in cord blood: relationship to birth weight and gender. J Clin Endocrinol Metab 1997;82:1642-4
71. Ellis K, Nicolson M. Leptin levels and body fatness in children: effects of gender, ethnicity, and sexual development. Pediatr Res 1997;42:484-8
72. Arslanian S, Suprasongsin C, Kalhan S, et al. Plasma leptin in children: relationship to puberty, gender, body composition, insulin sensitivity, and energy expenditure. Metabolism 1998;47:309-12
73. Argente J, Barrios V, Chowen J, et al. Leptin levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimia nervosa. J Pediatr 1997;131:833-8
74. Kotani K, Tokunaga K, Fujioka S, et al. Sexual dimorphism of age-related whole body fat changes in the obese. Int J Obes 1994;18:207-12
75. Leenen R, Kooy KVD, Duerenberg P, et al. Visceral fat accumulation in obese subjects: relation to energy expenditure and response to weight loss. Am J Physiol 1992;263:E913-E919
76. Harmelen VV, Reynisdottir S, Erikkson P, et al. Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 1998;47:913-17
77. Nagy T, Bower G, Trowbridge C, et al. Effects of gender, ethnicity, body composition, and fat distribution on serum leptin levels in children. J Clin Endocrinol Metab 1997;82:2148-52
78. Hube F, Lietz U, Igel M, et al. Differences in leptin mRNA levels between omental and subcutaneous adipose tissue from obese humans. Horm Metab Res 1996;28:690-3
79. Roemmich J, Clark P, Berr S, et al. Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. Am J Physiol 1998;275:E543-E551
80. Mantzoros CS, Flier JS, Rogol AD. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab 1997;82:1066-70
81. Clayton P, Gill M, Hall C, et al. Serum leptin through childhood and adolescence. Clin Endocrinol 1997;46:733-7
82. Jockenhovel M, Bum W, Vogel E, et al. Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. J Clin Endocrinol Metab 1997;82:2510-13
83. Elbers J, Asscheman H, Seidell J, et al. Reversal of sex hormone difference in serum leptin levels upon cross-sex hormone administration in transsexual. J Clin Endocrinol Metab 1997;82:3267-70
84. Laughlin G, Morales A, Yen SSC. Serum leptin levels in women with polycystic ovary syndrome: the role of insulin resistance/hyperinsulinemia. J Clin Endocrinol Metab 1997;82:1692-6
85. Rouru J, Antilla L, Koskinen P, et al. Serum leptin concentrations in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1997;82:1697-1700
86. Mantzoros CS, Dunaif A, Flier JS. Leptin concentration in the polycystic ovary syndrome. J Clin Endocrinol Metab 1997;82:1687-91
87. Hardie L, Trayhurn P, Abramovich D, et al. Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol 1997;47:101-6
88. Riad-Gabriel M, Jinagouda SD, Sharma A, et al. Changes in plasma leptin during the menstrual cycle. Eur J Endocrinol 1998;139:528-31
89. Buffenstein R, Poppit SD, McDevitt RM, et al. Food intake and the menstrual cycle: a retrospective analysis, with implications for appetite research. Physiol Behav 1995;58:1067-77
90. Poehlman ET, Tchernof A. Traversing the menopause: changes in energy expenditure and body composition. Coron Artery Dis 1998;9:799-803
91. Gower BA, Nagy TR, Goran MI, et al. Fat distribution and plasma lipid-lipoprotein concentrations in pre- and post-menopausal women. Int J Obes Relat Metab Disord 1998;22:605-11
92. Tchernof A, Poehlman ET. Effects of the menopause transition on body fatness and body fat distribution. Obes Res 1998;6:246-54
93. Toth MJ, Tchernof A, Sites CK, et al. Menopause-related changes in body fat distribution. Ann N Y Acad Sci 2000;904:502-6
94. Corpas E, Harman SM, Blackman MR. Human growth hormone and human aging. Endocr Rev 1993;14:20-39
95. Iranmanesh A, Lizzaralde G, Veldhuis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab 1991;73:1081-8
96. Veldhuis JD, Iranmanesh A, Ho KKY, et al. Dual defects in pulsatile GH secretion and clearance subserve the hyposomatotropism of obesity in man. J Clin Endocrinol Metab 1991;72:51-9
97. Salomon F, Cuneo RC, Hesp R, et al. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adult with growth hormone deficiency. N Engl J Med 1989;321:1797-803
98. Moller N, Jorgensen JOL, Alberti KG, et al. Short-term effects of growth hormone on fuel oxidation and regional substrate metabolism in normal man. J Clin Endocrinol Metab 1990;70:1179-86
99. O'Sullivan AJ, Kelly JJ, Hoffman DM, et al. Body composition and energy expenditure in acromegalia. J Clin Endocrinol Metab 1994;78:381-6
100. Hoffman DM, O'Sullivan AJ, Freund J, et al. Adults with growth hormone deficiency have abnormal body composition but normal energy metabolism. J Clin Endocrinol Metab 1995;80:72-7
101. Goodman HM. In vitro actions of growth hormone on glucose metabolism in adipose tissue. Endocrinology 1965;76:216-25
102. Goodman HM, Kostyo JL. Altered profiles of biological activity of growth hormone fragments on adipocyte metabolism. Endocrinology 1981;108:553-8
103. Gavin J, Gorden P, Roth J, et al. Characteristics of the human lymphocyte insulin receptor. J Biol Chem 1973;248:2202-7
104. Pascual M, Larralde J, Martinez JA. Insulin-like growth factor I (IGF-I) affects plasma lipid profile and inhibits the lipolytic action of growth hormone (GH) in isolated adipocytes. Life Sci 1995;57:1213-18
105. Guo SS, Zeller C, Chumlea WC, et al. Aging body composition, and lifestyle: the Fels Longitudinal Study. Am J Clin Nutr 1999;70:405-11
106. Hassager C, Christiansen C. Estrogen/gestagen therapy changes soft tissue body composition in postmenopausal women. Metabolism 1989;38:662-5
107. Hanggi W, Lippuner K, Jaeger P, et al. Differential impact of conventional oral or transdermal hormone replacement therapy or tibolone on body composition in postmenopausal women. Clin Endocrinol 1998;48:691-9
108. Aloia JF, Vaswani A, Russo L, et al. The influence of menopause and hormonal replacement therapy on body composition. Am J Obstet Gynecol 1995;172:896-900
109. Castracane VD, Kraemer RR, Franken MA, et al. Serum leptin concentration in women: effect of age, obesity, and estrogen. Fertil Steril 1998;70:472-7
110. Moller N, O'Brien P, Nair KS. Disruption of the relationship between fat content and leptin levels with aging in humans. J Clin Endocrinol Metab 1998;83:931-4
111. Havel PJ, Kasim-Karakas S, Dubuc GR, et al. Gender differences in plasma leptin concentrations. Nat Med 1996;2:949-50
112. Rosenbaum M, Nicolson M, Hirsch J, et al. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 1996;81:3424-7
113. Haffner SM, Mykkanen L, Stern MP. Leptin concentrations in the San Antonio Heart Study: effect of menopausal status and postmenopausal hormone replacement therapy. Am J Epidemiol 1997;146:581-5
114. Kohrt WM, Landt M, Birge SJ Jr. Serum leptin levels are reduced in response to exercise training but not hormone replacement therapy, in older women. J Clin Endocrinol Metab 1996;81:3980-5
115. Nicklas BJ, Toth MJ, Goldberg AP, et al. Racial differences in plasma leptin concentration in obese postmenopausal women. J Clin Endocrinol Metab 1997;82:315-17
116. Hadji P, Hars O, Bock K, et al. The influence of menopause and body mass index on serum leptin concentrations. Eur J Endocrinol 2000;143:55-60
117. Lavoie HB, Taylor AE, Sharpless JL, et al. Effects of short hormone replacement on serum leptin levels in postmenopausal women. Clin Endocrinol 1999;51:415-42
118. Cento RM, Proto C, Spada RS, et al. Leptin levels in menopause: effect of estrogen replacement therapy. Horm Res 1999;52:269-73
119. Milewicz A, Bidzinska B, Mikulski E, et al. Influence of obesity and menopausal status on serum leptin, cholecystokinin, galanin and neuropeptide Y levels. Gynecol Endocrinol 2000;14:196-203
120. Kristiensen K, Pedersen SB, Vestergaard PV, et al. Hormone replacement therapy affects body composition and leptin differently in obese and non-obese postmenopausal women. J Endocrinol 1999;163:55-62
121. Riondino G, Isidori AM, Fabbri A, et al. Leptin changes in normal weight and obese women in pre- and post-menopausal conditions. J Endocrinol Invest 1999;22:(Suppl. to no. 10), 66-7
122. Gower BA, Nagy TR, Goran MI, et al. Leptin in postmenopausal women: influence of hormone therapy, insulin, and fat distribution. J Clin Endocrinol Metab 2000;85:1770-5
123. Salbach B, Nawroth PP, Kubler W, et al. Serum leptin and body weight in postmenopausal women under transdermal hormone replacement therapy. Eur J Med Res 2000;28:63-6
124. Baranowska B, Radzikowska M, Wasilewska-Dziubinska E, et al. Relationship among leptin, neuropeptide Y, and galanin in young women and in postmenopausal women. Menopause 2000;7:149-55
125. Laivuori H, Koistinen HA, Karonen S-L, et al. Comparison between 1 year oral transdermal oestradiol and sequential norethisterone acetate on circulating concentrations of leptin in postmenopausal women. Hum Reprod 2001;16:1632-5
126. Elbers JM, de Valk-de Roo GW, Popp-Snijders C, et al. Effects of administration of 17β-oestradiol on serum leptin levels in healthy postmenopausal women. Clin Endocrinol 1999;51:449-54
127. Sumner AE, Falkner B, Kushner H, et al. Relationship of leptin concentration to gender, menopause, age, diabetes, and fat mass in african americans. Obes Res 1998;6:128-33
128. Licinio J, Mantzoros C, Negrao AB, et al. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 1997;3:575-9