Synergistic induction of nitric oxide synthase type II: In vitro effect of leptin and interferon-γ in human chondrocytes and ATDC5 chondrogenic cells

Arthritis and Rheumatism

Volumn 48, Issue 2, 2003, Pages 404-409

  Otero, Miguel ^a   Gomez Reino, Juan Jesús ^b   Gualillo, Oreste ^a  

^a Instituto de Salud Carlos III   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGUANIDINE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; JANUS KINASE; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL STRAIN; COLORIMETRY; CONTROLLED STUDY; CULTURE MEDIUM; DOSE RESPONSE; EMBRYO CELL; ENZYME ACTIVATION; ENZYME INDUCTION; HUMAN; HUMAN TISSUE; INFLAMMATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARTILAGE, ARTICULAR; CELL LINE; CHONDROCYTES; DRUG SYNERGISM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERFERON TYPE II; JANUS KINASE 2; LEPTIN; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS;

EID: 0037332229     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.10811     Document Type: Article

References (17)

1. Goldring MB. The role of the chondrocyte in osteoarthritis. Arthritis Rheum 2000;43:1916-26.
2. Kim SJ, Ju JW, Oh CD, Yoon YM, Song WK, Kim JH, et al. ERK-1/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status. J Biol Chem 2002;277:1332-9.
3. Sasaki K, Hattori T, Fujisawa T, Takahashi K, Inoue H, Takigawa M. Nitric oxide mediates interleukin-1 induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes. J Biochem (Tokyo) 1998;123:431-9.
4. 2 production in explants of human osteoarthritic knee menisci. Arthritis Rheum 2001;44:2078-83.
5. Lord GM, Matarese G, Howard JK, Lechler RI. The bioenergetics of the immune system. Science 2001;292:855-6.
6. Steppan CM, Crawford DT, Chidsey-Frink KL, Ke H, Swick AG. Leptin is a potent stimulator of bone growth in ob/ob mice. Regul Pept 2000;92:73-8.
7. Gualillo O, Eiras S, Lago F, Dieguez C, Casanueva FF. Elevated serum leptin concentrations induced by experimental acute inflammation. Life Sci 2000;67:2433-41.
8. Bjorbaek C, Uotani S, da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997;272:32686-95.
9. Figenschau Y, Knutseh G, Shahazeydi S, Johansen O, Sveinbjornsson B. Human articular chondrocytes express functional leptin receptors. Biochem Biophys Res Commun 2001;287:190-7.
10. Thomas DP, Sunters A, Gentry A, Grigoriadis AE. Inhibition of chondrocyte differentiation in vitro by constitutive and inducible overexpression of the c-fos proto-oncogene. J Cell Sci 2000;113:439-50.
11. Palmer RM, Hickery MS, Charles IG, Moncada S, Bayliss MT. Induction of nitric oxide synthase in human chondrocytes. Biochem Biophys Res Commun 1993;193:398-405.
12. Stadler J, Stefanovic-Racic M, Billiar TR, Curran RD, McIntyre LA, Georgescu HI, et al. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol 1991;147:3915-20.
13. Vuolteenaho K, Moilanen T, Al-Saffar N, Knowles RG, Moilanen E. Regulation of the nitric oxide production resulting from the glucocorticoid-insensitive expression of iNOS in human osteoarthritic cartilage. Osteoarthritis Cartilage 2001;9:597-605.
14. Moos V, Fickert S, Muller B, Weber U, Sieper J. Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage. J Rheumatol 1999;26:870-9.
15. Busso N, So A, Chobaz-Peclat V, Morard C, Martinez-Soria E, Talabot-Ayer D, et al. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol 2002;168:875-82.
16. Faggioni R, Fantuzzi G, Fuller J, Dinarello CA, Feingold KR, Grunfeld C. IL-1β mediates leptin induction during inflammation. Am J Physiol 1998;274:R204-8.
17. De Bari C, Dell'Accio F, Tylzanowski P, Luyten FP. Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum 2001;44:1928-42.