메뉴 건너뛰기




Volumn 12, Issue , 2012, Pages

Alterations of leptin in the course of inflammation and severe sepsis

Author keywords

Adipocytes; Drotrecogin alpha (activated); Leptin; mRNA; Sepsis; Supernatants

Indexed keywords

DROTRECOGIN; LEPTIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84866171025     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-12-217     Document Type: Article
Times cited : (47)

References (46)
  • 1
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: Inflammation and the pleiotropic role of white adipose tissue
    • 10.1079/BJN20041213, 15469638
    • Trayhurn P, Wood IS. Adipokines: Inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004, 92:347-355. 10.1079/BJN20041213, 15469638.
    • (2004) Br J Nutr , vol.92 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 2
    • 34249983235 scopus 로고    scopus 로고
    • The emerging role of adipokines as mediators of inflammation and immune responses
    • 10.1016/j.cytogfr.2007.04.007, 17507280
    • Lago F, Dieguez C, Gomez-Reino J, Gualillo O. The emerging role of adipokines as mediators of inflammation and immune responses. Cytokine Growth Factor Rev. 2007, 18:313-325. 10.1016/j.cytogfr.2007.04.007, 17507280.
    • (2007) Cytokine Growth Factor Rev. , vol.18 , pp. 313-325
    • Lago, F.1    Dieguez, C.2    Gomez-Reino, J.3    Gualillo, O.4
  • 3
    • 18144408371 scopus 로고    scopus 로고
    • Adipose tissue, adipokines, and inflammation
    • quiz 920, 10.1016/j.jaci.2005.02.023, 15867843
    • Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 2005, 115:911-919. quiz 920, 10.1016/j.jaci.2005.02.023, 15867843.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 911-919
    • Fantuzzi, G.1
  • 5
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The accp/sccm consensus conference committee. American college of chest physicians/society of critical care medicine
    • 10.1378/chest.101.6.1644, 1303622
    • Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The accp/sccm consensus conference committee. American college of chest physicians/society of critical care medicine. Chest 1992, 101:1644-1655. 10.1378/chest.101.6.1644, 1303622.
    • (1992) Chest , vol.101 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3    Dellinger, R.P.4    Fein, A.M.5    Knaus, W.A.6    Schein, R.M.7    Sibbald, W.J.8
  • 7
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the united states: Analysis of incidence, outcome, and associated costs of care
    • 10.1097/00003246-200107000-00002, 11445675
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the united states: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29:1303-1310. 10.1097/00003246-200107000-00002, 11445675.
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 9
    • 13444283302 scopus 로고    scopus 로고
    • Dynamic evolution of coagulopathy in the first day of severe sepsis: Relationship with mortality and organ failure
    • 10.1097/01.CCM.0000153520.31562.48, 15699837
    • Dhainaut JF, Shorr AF, Macias WL, Kollef MJ, Levi M, Reinhart K, Nelson DR. Dynamic evolution of coagulopathy in the first day of severe sepsis: Relationship with mortality and organ failure. Crit Care Med 2005, 33:341-348. 10.1097/01.CCM.0000153520.31562.48, 15699837.
    • (2005) Crit Care Med , vol.33 , pp. 341-348
    • Dhainaut, J.F.1    Shorr, A.F.2    Macias, W.L.3    Kollef, M.J.4    Levi, M.5    Reinhart, K.6    Nelson, D.R.7
  • 11
    • 77949443146 scopus 로고    scopus 로고
    • The diagnostic value of serum leptin monitoring and its correlation with tumor necrosis factor-alpha in critically ill patients: A prospective observational study
    • 10.1186/cc8911, 2887140, 20230641
    • Yousef AA, Amr YM, Suliman GA. The diagnostic value of serum leptin monitoring and its correlation with tumor necrosis factor-alpha in critically ill patients: A prospective observational study. Crit Care 2010, 14:R33. 10.1186/cc8911, 2887140, 20230641.
    • (2010) Crit Care , vol.14
    • Yousef, A.A.1    Amr, Y.M.2    Suliman, G.A.3
  • 12
    • 77956489969 scopus 로고    scopus 로고
    • Sepsis induced changes of adipokines and cytokines - septic patients compared to morbidly obese patients
    • 10.1186/1471-2482-10-26, 2944119, 20825686
    • Hillenbrand A, Knippschild U, Weiss M, Schrezenmeier H, Henne-Bruns D, Huber-Lang M, Wolf AM. Sepsis induced changes of adipokines and cytokines - septic patients compared to morbidly obese patients. BMC Surg 2010, 10:26. 10.1186/1471-2482-10-26, 2944119, 20825686.
    • (2010) BMC Surg , vol.10 , pp. 26
    • Hillenbrand, A.1    Knippschild, U.2    Weiss, M.3    Schrezenmeier, H.4    Henne-Bruns, D.5    Huber-Lang, M.6    Wolf, A.M.7
  • 13
    • 68349094024 scopus 로고    scopus 로고
    • Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin
    • 10.1186/cc7956, 2750156, 19589139
    • Langouche L, Vander Perre S, Frystyk J, Flyvbjerg A, Hansen TK, Van den Berghe G. Adiponectin, retinol-binding protein 4, and leptin in protracted critical illness of pulmonary origin. Crit Care 2009, 13:R112. 10.1186/cc7956, 2750156, 19589139.
    • (2009) Crit Care , vol.13
    • Langouche, L.1    Vander Perre, S.2    Frystyk, J.3    Flyvbjerg, A.4    Hansen, T.K.5    Van den Berghe, G.6
  • 14
    • 0025861039 scopus 로고
    • Inflammation and coagulation: Linked processes potentially regulated through a common pathway mediated by protein c
    • Esmon CT, Taylor FB, Snow TR. Inflammation and coagulation: Linked processes potentially regulated through a common pathway mediated by protein c. Thromb Haemost 1991, 66:160-165.
    • (1991) Thromb Haemost , vol.66 , pp. 160-165
    • Esmon, C.T.1    Taylor, F.B.2    Snow, T.R.3
  • 15
    • 0036250817 scopus 로고    scopus 로고
    • Recombinant human activated protein c attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kappab
    • 10.1097/00003246-200205001-00019, 12004250
    • Joyce DE, Grinnell BW. Recombinant human activated protein c attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kappab. Crit Care Med 2002, 30:S288-293. 10.1097/00003246-200205001-00019, 12004250.
    • (2002) Crit Care Med , vol.30
    • Joyce, D.E.1    Grinnell, B.W.2
  • 16
    • 0037352279 scopus 로고    scopus 로고
    • Activated protein c blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
    • 10.1038/nm826, 12563316
    • Cheng T, Liu D, Griffin JH, Fernandez JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein c blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003, 9:338-342. 10.1038/nm826, 12563316.
    • (2003) Nat Med. , vol.9 , pp. 338-342
    • Cheng, T.1    Liu, D.2    Griffin, J.H.3    Fernandez, J.A.4    Castellino, F.5    Rosen, E.D.6    Fukudome, K.7    Zlokovic, B.V.8
  • 17
    • 33748951738 scopus 로고    scopus 로고
    • [mechanisms of action of recombinant human activated protein c]
    • Brueckmann M, Huhle G, Max M. [mechanisms of action of recombinant human activated protein c]. Anaesthesist 2006, 55(Suppl 1):5-15.
    • (2006) Anaesthesist , vol.55 , Issue.SUPPL. 1 , pp. 5-15
    • Brueckmann, M.1    Huhle, G.2    Max, M.3
  • 18
    • 2342511466 scopus 로고    scopus 로고
    • Activated protein c inhibits the release of macrophage inflammatory protein-1-alpha from thp-1 cells and from human monocytes
    • 10.1016/j.cyto.2004.01.004, 15135804
    • Brueckmann M, Hoffmann U, De Rossi L, Weiler HM, Liebe V, Lang S, Kaden JJ, Borggrefe M, Haase KK, Huhle G. Activated protein c inhibits the release of macrophage inflammatory protein-1-alpha from thp-1 cells and from human monocytes. Cytokine 2004, 26:106-113. 10.1016/j.cyto.2004.01.004, 15135804.
    • (2004) Cytokine , vol.26 , pp. 106-113
    • Brueckmann, M.1    Hoffmann, U.2    De Rossi, L.3    Weiler, H.M.4    Liebe, V.5    Lang, S.6    Kaden, J.J.7    Borggrefe, M.8    Haase, K.K.9    Huhle, G.10
  • 19
    • 12144259892 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) inhibits nf-kappa b activation and mip-1-alpha release from isolated mononuclear cells of patients with severe sepsis
    • 10.1007/s00011-004-1291-z, 15597147
    • Brueckmann M, Hoffmann U, Dvortsak E, Lang S, Kaden JJ, Borggrefe M, Haase KK. Drotrecogin alfa (activated) inhibits nf-kappa b activation and mip-1-alpha release from isolated mononuclear cells of patients with severe sepsis. Inflamm Res 2004, 53:528-533. 10.1007/s00011-004-1291-z, 15597147.
    • (2004) Inflamm Res , vol.53 , pp. 528-533
    • Brueckmann, M.1    Hoffmann, U.2    Dvortsak, E.3    Lang, S.4    Kaden, J.J.5    Borggrefe, M.6    Haase, K.K.7
  • 20
    • 20144389016 scopus 로고    scopus 로고
    • Recombinant human activated protein c upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein c receptor and activation of protease-activated receptor-1
    • Brueckmann M, Horn S, Lang S, Fukudome K, Schulze Nahrup A, Hoffmann U, Kaden JJ, Borggrefe M, Haase KK, Huhle G. Recombinant human activated protein c upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein c receptor and activation of protease-activated receptor-1. Thromb Haemost 2005, 93:743-750.
    • (2005) Thromb Haemost , vol.93 , pp. 743-750
    • Brueckmann, M.1    Horn, S.2    Lang, S.3    Fukudome, K.4    Schulze Nahrup, A.5    Hoffmann, U.6    Kaden, J.J.7    Borggrefe, M.8    Haase, K.K.9    Huhle, G.10
  • 22
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative rt-pcr data by geometric averaging of multiple internal control genes
    • 126239, 12184808
    • Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. Accurate normalization of real-time quantitative rt-pcr data by geometric averaging of multiple internal control genes. Genome Biol 2002, 3:RESEARCH0034. 126239, 12184808.
    • (2002) Genome Biol , vol.3
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6    Speleman, F.7
  • 23
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time pcr data by the comparative c(t) method
    • 10.1038/nprot.2008.73, 18546601
    • Schmittgen TD, Livak KJ. Analyzing real-time pcr data by the comparative c(t) method. Nat Protoc 2008, 3:1101-1108. 10.1038/nprot.2008.73, 18546601.
    • (2008) Nat Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 24
    • 27844522342 scopus 로고    scopus 로고
    • Comparative Ct method. ABI Prism 7700 Sequence Detection System. User Bulletin no. 2
    • Livak KJ. Comparative Ct method. ABI Prism 7700 Sequence Detection System. User Bulletin no. 2. PE Applied Biosystems. 1997,
    • (1997) PE Applied Biosystems.
    • Livak, K.J.1
  • 25
    • 0003529520 scopus 로고    scopus 로고
    • Cold Spring Harbor Laboratory Press, New York, Dieffenbach CW, Dveksler GS, 2
    • PCR primer, a laboratory manual 2003, Cold Spring Harbor Laboratory Press, New York, Dieffenbach CW, Dveksler GS, 2.
    • (2003) PCR primer, a laboratory manual
  • 26
    • 0022256529 scopus 로고
    • Apache ii: A severity of disease classification system
    • 10.1097/00003246-198510000-00009, 3928249
    • Knaus WA, Draper EA, Wagner DP, Zimmerman JE. Apache ii: A severity of disease classification system. Crit Care Med 1985, 13:818-829. 10.1097/00003246-198510000-00009, 3928249.
    • (1985) Crit Care Med , vol.13 , pp. 818-829
    • Knaus, W.A.1    Draper, E.A.2    Wagner, D.P.3    Zimmerman, J.E.4
  • 27
    • 33746298889 scopus 로고    scopus 로고
    • Recombinant human activated protein c
    • 10.1016/j.ijantimicag.2006.05.021, 16837170
    • Hughes M. Recombinant human activated protein c. Int J Antimicrob Agents 2006, 28:90-94. 10.1016/j.ijantimicag.2006.05.021, 16837170.
    • (2006) Int J Antimicrob Agents , vol.28 , pp. 90-94
    • Hughes, M.1
  • 29
    • 84873089343 scopus 로고    scopus 로고
    • R&D Systems Inc, Minneapolis, USA, internet-address: , Quantikine®
    • Quantikine® human leptin Immunoassay 2009, R&D Systems Inc, Minneapolis, USA, internet-address: http://www.rndsystems.com/pdf/dlp00.pdf, Quantikine®.
    • (2009) human leptin Immunoassay
  • 30
    • 0034455170 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha inhibits leptin production in subcutaneous and omental adipocytes from morbidly obese humans
    • 10.1210/jc.85.2.530, 10690850
    • Fawcett RL, Waechter AS, Williams LB, Zhang P, Louie R, Jones R, Inman M, Huse J, Considine RV. Tumor necrosis factor-alpha inhibits leptin production in subcutaneous and omental adipocytes from morbidly obese humans. J Clin Endocrinol Metab 2000, 85:530-535. 10.1210/jc.85.2.530, 10690850.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 530-535
    • Fawcett, R.L.1    Waechter, A.S.2    Williams, L.B.3    Zhang, P.4    Louie, R.5    Jones, R.6    Inman, M.7    Huse, J.8    Considine, R.V.9
  • 31
    • 0031576548 scopus 로고    scopus 로고
    • Transforming growth factor-beta enhances and pro-inflammatory cytokines inhibit ob gene expression in 3 t3-l1 adipocytes
    • 10.1006/bbrc.1997.7663, 9388486
    • Granowitz EV. Transforming growth factor-beta enhances and pro-inflammatory cytokines inhibit ob gene expression in 3 t3-l1 adipocytes. Biochem Biophys Res Commun 1997, 240:382-385. 10.1006/bbrc.1997.7663, 9388486.
    • (1997) Biochem Biophys Res Commun , vol.240 , pp. 382-385
    • Granowitz, E.V.1
  • 32
    • 0033765235 scopus 로고    scopus 로고
    • Regulation by cytokines of leptin expression in human bone marrow adipocytes
    • 10.1055/s-2007-978658, 11069201
    • Laharrague P, Truel N, Fontanilles AM, Corberand JX, Penicaud L, Casteilla L. Regulation by cytokines of leptin expression in human bone marrow adipocytes. Horm Metab Res 2000, 32:381-385. 10.1055/s-2007-978658, 11069201.
    • (2000) Horm Metab Res , vol.32 , pp. 381-385
    • Laharrague, P.1    Truel, N.2    Fontanilles, A.M.3    Corberand, J.X.4    Penicaud, L.5    Casteilla, L.6
  • 34
    • 0032706353 scopus 로고    scopus 로고
    • Depot-specific release of leptin from subcutaneous and omental adipocytes in suspension culture: Effect of tumor necrosis factor-alpha and transforming growth factor-beta1
    • 10.1530/eje.0.1410436, 10526261
    • Gottschling-Zeller H, Birgel M, Scriba D, Blum WF, Hauner H. Depot-specific release of leptin from subcutaneous and omental adipocytes in suspension culture: Effect of tumor necrosis factor-alpha and transforming growth factor-beta1. Eur J Endocrinol 1999, 141:436-442. 10.1530/eje.0.1410436, 10526261.
    • (1999) Eur J Endocrinol , vol.141 , pp. 436-442
    • Gottschling-Zeller, H.1    Birgel, M.2    Scriba, D.3    Blum, W.F.4    Hauner, H.5
  • 35
    • 0035946468 scopus 로고    scopus 로고
    • Chemokines control fat accumulation and leptin secretion by cultured human adipocytes
    • 10.1016/S0303-7207(01)00394-X, 11325518
    • Gerhardt CC, Romero IA, Cancello R, Camoin L, Strosberg AD. Chemokines control fat accumulation and leptin secretion by cultured human adipocytes. Mol Cell Endocrinol 2001, 175:81-92. 10.1016/S0303-7207(01)00394-X, 11325518.
    • (2001) Mol Cell Endocrinol , vol.175 , pp. 81-92
    • Gerhardt, C.C.1    Romero, I.A.2    Cancello, R.3    Camoin, L.4    Strosberg, A.D.5
  • 37
    • 0032866142 scopus 로고    scopus 로고
    • Relationship of plasma leptin to plasma cytokines and human survivalin sepsis and septic shock
    • 10.1086/314963, 10438392
    • Arnalich F, Lopez J, Codoceo R, Jim nez M, Madero R, Montiel C. Relationship of plasma leptin to plasma cytokines and human survivalin sepsis and septic shock. J Infect Dis 1999, 180:908-911. 10.1086/314963, 10438392.
    • (1999) J Infect Dis , vol.180 , pp. 908-911
    • Arnalich, F.1    Lopez, J.2    Codoceo, R.3    Jim nez, M.4    Madero, R.5    Montiel, C.6
  • 38
    • 0031769566 scopus 로고    scopus 로고
    • Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm, in cortisol and leptin secretion
    • 10.1210/jc.83.1.280, 9435456
    • Bornstein SR, Licinio J, Tauchnitz R, Engelmann L, Negrao AB, Gold P, Chrousos GP. Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm, in cortisol and leptin secretion. J Clin Endocrinol Metab 1998, 83:280-283. 10.1210/jc.83.1.280, 9435456.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 280-283
    • Bornstein, S.R.1    Licinio, J.2    Tauchnitz, R.3    Engelmann, L.4    Negrao, A.B.5    Gold, P.6    Chrousos, G.P.7
  • 39
    • 0035691881 scopus 로고    scopus 로고
    • Serum leptin levels in septic men correlate well with c-reactive protein (crp) and tnf-alpha but not with bmi
    • Maruna P, Gurlich R, Frasko R, Haluzik M. Serum leptin levels in septic men correlate well with c-reactive protein (crp) and tnf-alpha but not with bmi. Physiol Res 2001, 50:589-594.
    • (2001) Physiol Res , vol.50 , pp. 589-594
    • Maruna, P.1    Gurlich, R.2    Frasko, R.3    Haluzik, M.4
  • 40
    • 0035746523 scopus 로고    scopus 로고
    • Humoral markers of severity and prognosis of critical illness
    • 10.1053/beem.2001.0169, 11800523
    • Nylen ES, Alarifi AA. Humoral markers of severity and prognosis of critical illness. Best Pract Res Clin Endocrinol Metab. 2001, 15:553-573. 10.1053/beem.2001.0169, 11800523.
    • (2001) Best Pract Res Clin Endocrinol Metab. , vol.15 , pp. 553-573
    • Nylen, E.S.1    Alarifi, A.A.2
  • 41
    • 0032438674 scopus 로고    scopus 로고
    • Leptin and interleukin-6 in sepsis
    • 10.1055/s-2007-978967, 9930630
    • Torpy DJ, Bornstein SR, Chrousos GP. Leptin and interleukin-6 in sepsis. Horm Metab Res 1998, 30:726-729. 10.1055/s-2007-978967, 9930630.
    • (1998) Horm Metab Res , vol.30 , pp. 726-729
    • Torpy, D.J.1    Bornstein, S.R.2    Chrousos, G.P.3
  • 43
    • 56849098695 scopus 로고    scopus 로고
    • Levels of oxidized low-density lipoproteins are increased in patients with severe sepsis
    • 10.1016/j.jcrc.2008.09.002, 19056019
    • Behnes M, Brueckmann M, Liebe V, Liebetrau C, Lang S, Putensen C, Borggrefe M, Hoffmann U. Levels of oxidized low-density lipoproteins are increased in patients with severe sepsis. J Crit Care. 2008, 23:537-541. 10.1016/j.jcrc.2008.09.002, 19056019.
    • (2008) J Crit Care. , vol.23 , pp. 537-541
    • Behnes, M.1    Brueckmann, M.2    Liebe, V.3    Liebetrau, C.4    Lang, S.5    Putensen, C.6    Borggrefe, M.7    Hoffmann, U.8
  • 44
    • 47349131517 scopus 로고    scopus 로고
    • Time-course of neopterin levels in patients suffering from severe sepsis treated with and without drotrecogin-alpha (activated)
    • 10.1080/00365540701808978, 18584538
    • Behnes M, Brueckmann M, Wiessner M, Kettenmann E, Liebetrau C, Lang S, Putensen C, Borggrefe M, Hoffmann U. Time-course of neopterin levels in patients suffering from severe sepsis treated with and without drotrecogin-alpha (activated). Scand J Infect Dis 2008, 40:503-508. 10.1080/00365540701808978, 18584538.
    • (2008) Scand J Infect Dis , vol.40 , pp. 503-508
    • Behnes, M.1    Brueckmann, M.2    Wiessner, M.3    Kettenmann, E.4    Liebetrau, C.5    Lang, S.6    Putensen, C.7    Borggrefe, M.8    Hoffmann, U.9
  • 45
    • 84865494981 scopus 로고    scopus 로고
    • Alterations of adiponectin in the course of inflammation and severe sepsis
    • 10.1097/SHK.0b013e318261e0dc, 22744305
    • Behnes M, Brueckmann M, Lang S, Putensen C, Saur J, Borggrefe M, Hoffmann U. Alterations of adiponectin in the course of inflammation and severe sepsis. Shock 2012, 38:243-248. 10.1097/SHK.0b013e318261e0dc, 22744305.
    • (2012) Shock , vol.38 , pp. 243-248
    • Behnes, M.1    Brueckmann, M.2    Lang, S.3    Putensen, C.4    Saur, J.5    Borggrefe, M.6    Hoffmann, U.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.