Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-faslpr mice

Journal of Immunology

Volumn 192, Issue 3, 2014, Pages 979-984

  Fujita, Yoshimasa ^a   Fujii, Takao ^b   Mimori, Tsuneyo ^b   Sato, Tomomi ^a   Nakamura, Takuji ^a   Iwao, Haruka ^a   Nakajima, Akio ^a   Miki, Miyuki ^a   Tomoyuki, T ^a   Kawanami, Takafumi ^a   Tanaka, Masao ^a   Masaki, Yasufumi ^a   Fukushima, Toshihiro ^a   Okazaki, Toshiro ^a   Umehara, Hisanori ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; DOUBLE STRANDED DNA ANTIBODY; FAS ANTIGEN; IMMUNOGLOBULIN G; LEPTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; FLOW CYTOMETRY; IMMUNOGLOBULIN BLOOD LEVEL; IN VITRO STUDY; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN URINE LEVEL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; SPLENOMEGALY; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIBODIES, ANTINUCLEAR; AUTOANTIGENS; CELLS, CULTURED; CROSSES, GENETIC; DNA; FEMALE; IMMUNOGLOBULIN G; KIDNEY; LEPTIN; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE COUNT; MALE; MICE, INBRED C57BL; MICE, INBRED MRL LPR; MICE, OBESE; RHEUMATOID FACTOR; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; SPLEEN; SPLENOMEGALY; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84893362864     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1301685     Document Type: Article

References (41)

1. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.
2. Satoh, N., Y. Ogawa, G. Katsuura, T. Tsuji, H. Masuzaki, J. Hiraoka, T. Okazaki, M. Tamaki, M. Hayase, Y. Yoshimasa, et al. 1997. Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: evidence for loss of its satiety effect in VMH-lesioned rats. Endocrinology 138: 947-954.
3. Stephens, T. W., M. Basinski, P. K. Bristow, J. M. Bue-Valleskey, S. G. Burgett, L. Craft, J. Hale, J. Hoffmann, H. M. Hsiung, A. Kriauciunas, et al. 1995. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377: 530-532.
4. Chandra, R. K. 1997. Nutrition and the immune system: an introduction. Am. J. Clin. Nutr. 66: 460S-463S.
5. Shimomura, I., T. Funahashi, M. Takahashi, K. Maeda, K. Kotani, T. Nakamura, S. Yamashita, M. Miura, Y. Fukuda, K. Takemura, et al. 1996. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat. Med. 2: 800-803.
6. Hoggard, N., J. G. Mercer, D. V. Rayner, K. Moar, P. Trayhurn, and L. M. Williams. 1997. Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization. Biochem. Biophys. Res. Commun. 232: 383-387.
7. Sivitz, W. I., S. A. Walsh, D. A. Morgan, M. J. Thomas, and W. G. Haynes. 1997. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 138: 3395-3401.
8. Bai, Y., S. Zhang, K. S. Kim, J. K. Lee, and K. H. Kim. 1996. Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J. Biol. Chem. 271: 13939-13942.
9. Yamashita, T., T. Murakami, S. Otani, M. Kuwajima, and K. Shima. 1998. Leptin receptor signal transduction: OBRa and OBRb of fa type. Biochem. Biophys. Res. Commun. 246: 752-759.
10. Cioffi, J. A., A. W. Shafer, T. J. Zupancic, J. Smith-Gbur, A. Mikhail, D. Platika, and H. R. Snodgrass. 1996. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat. Med. 2: 585-589.
11. Bennett, B. D., G. P. Solar, J. Q. Yuan, J. Mathias, G. R. Thomas, and W. Matthews. 1996. A role for leptin and its cognate receptor in hematopoiesis. Curr. Biol. 6: 1170-1180.
12. Lord, G. M., G. Matarese, J. K. Howard, R. J. Baker, S. R. Bloom, and R. I. Lechler. 1998. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394: 897-901.
13. Konopleva, M., A. Mikhail, Z. Estrov, S. Zhao, D. Harris, G. Sanchez-Williams, S. M. Kornblau, J. Dong, K. O. Kliche, S. Jiang, et al. 1999. Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-Apoptotic activities. Blood 93: 1668-1676.
14. Tsuchiya, T., H. Shimizu, T. Horie, and M. Mori. 1999. Expression of leptin receptor in lung: leptin as a growth factor. Eur. J. Pharmacol. 365: 273-279.
15. Coleman, D. L. 1978. Obese and diabetes: two mutant genes causing diabetesobesity syndromes in mice. Diabetologia 14: 141-148.
16. Ogawa, Y., H. Masuzaki, K. Hosoda, M. Aizawa-Abe, J. Suga, M. Suda, K. Ebihara, H. Iwai, N. Matsuoka, N. Satoh, et al. 1999. Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. Diabetes 48: 1822-1829.
17. Chandra, R. K. 1980. Cell-mediated immunity in genetically obese C57BL/6J ob/ob) mice. Am. J. Clin. Nutr. 33: 13-16.
18. Mandel, M. A., and A. A. Mahmoud. 1978. Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J. Immunol. 120: 1375-1377.
19. Fujita, Y., M. Murakami, Y. Ogawa, H. Masuzaki, M. Tanaka, S. Ozaki, K. Nakao, and T. Mimori. 2002. Leptin inhibits stress-induced apoptosis of T lymphocytes. Clin. Exp. Immunol. 128: 21-26.
20. Fujii, T., M. Okada, T. Mimori, and J. Craft. 2002. The transmembrane form of TNF-Alpha drives autoantibody production in the absence of CD154: studies using MRL/Mp-Fas(lpr) mice. Clin. Exp. Immunol. 130: 224-232.
21. Fujii, T., M. Okada, Y. Fujita, T. Sato, M. Tanaka, T. Usui, H. Umehara, and T. Mimori. 2009. Vaccination with autoreactive CD4(+)Th1 clones in lupusprone MRL/Mp-Fas(lpr/lpr) mice. J. Autoimmun. 33: 125-134.
22. Ma, J., J. Xu, M. P. Madaio, Q. Peng, J. Zhang, I. S. Grewal, R. A. Flavell, and J. Craft. 1996. Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses. J. Immunol. 157: 417-426.
23. Namae, M., Y. Mori, K. Yasuda, T. Kadowaki, Y. Kanazawa, and K. Komeda. 1998. New method for genotyping the mouse Lep(ob) mutation, using a polymerase chain reaction assay. Lab. Anim. Sci. 48: 103-104.
24. Murakami, M., T. Tsubata, M. Okamoto, A. Shimizu, S. Kumagai, H. Imura, and T. Honjo. 1992. Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice. Nature 357: 77-80.
25. Suganami, T., M. Mukoyama, A. Sugawara, K. Mori, T. Nagae, M. Kasahara, K. Yahata, H. Makino, Y. Fujinaga, Y. Ogawa, et al. 2001. Overexpression of brain natriuretic peptide in mice ameliorates immune-mediated renal injury. J. Am. Soc. Nephrol. 12: 2652-2663.
26. Zarkesh-Esfahani, H., G. Pockley, R. A. Metcalfe, M. Bidlingmaier, Z. Wu, A. Ajami, A. P. Weetman, C. J. Strasburger, and R. J. Ross. 2001. High-dose leptin activates human leukocytes via receptor expression on monocytes. J. Immunol. 167: 4593-4599.
27. Seaman, W. E., D. Wofsy, J. S. Greenspan, and J. A. Ledbetter. 1983. Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease. J. Immunol. 130: 1713-1718.
28. Garcia-Gonzalez, A., L. Gonzalez-Lopez, I. C. Valera-Gonzalez, E. G. Cardona-Munoz, M. Salazar-Paramo, M. González-Ortiz, E. Martínez-Abundis, and J. I. Gamez-Nava. 2002. Serum leptin levels in women with systemic lupus erythematosus. Rheumatol. Int. 22: 138-141.
29. Anders, H. J., M. Rihl, A. Heufelder, O. Loch, and M. Schattenkirchner. 1999. Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis. Metabolism 48: 745-748.
30. Evereklioglu, C., H. S. Inaloz, N. Kirtak, S. Doganay, M. Bulbul, E. Ozerol, H. Er, and E. Ozbek. 2002. Serum leptin concentration is increased in patients with Behçet's syndrome and is correlated with disease activity. Br. J. Dermatol. 147: 331-336.
31. Crispín, J. C., M. Oukka, G. Bayliss, R. A. Cohen, C. A. Van Beek, I. E. Stillman, V. C. Kyttaris, Y. T. Juang, and G. C. Tsokos. 2008. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J. Immunol. 181: 8761-8766.
32. Zhang, Z., V. C. Kyttaris, and G. C. Tsokos. 2009. The role of IL-23/IL-17 axis in lupus nephritis. J. Immunol. 183: 3160-3169.
33. Tian, Z., R. Sun, H. Wei, and B. Gao. 2002. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem. Biophys. Res. Commun. 298: 297-302.
34. Liu, Y., Y. Yu, G. Matarese, and A. La Cava. 2012. Cutting edge: fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus. J. Immunol. 188: 2070-2073.
35. Taleb, S., O. Herbin, H. Ait-Oufella, W. Verreth, P. Gourdy, V. Barateau, R. Merval, B. Esposito, K. Clément, P. Holvoet, et al. 2007. Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 27: 2691-2698.
36. De Rosa, V., C. Procaccini, G. Cali, G. Pirozzi, S. Fontana, S. Zappacosta, A. La Cava, and G. Matarese. 2007. A key role of leptin in the control of regulatory T cell proliferation. Immunity 26: 241-255.
37. Wang, S., S. E. Baidoo, Y. Liu, C. Zhu, J. Tian, J. Ma, J. Tong, J. Chen, X. Tang, H. Xu, and L. Lu. 2013. T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimotos thyroiditis. Clin. Exp. Immunol. 171: 63-68.
38. Deng, J., Y. Liu, M. Yang, S. Wang, M. Zhang, X. Wang, K. H. Ko, Z. Hua, L. Sun, X. Cao, and L. Lu. 2012. Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response. Arthritis Rheum. 64: 3564-3573.
39. Chen, X. Q., Y. C. Yu, H. H. Deng, J. Z. Sun, Z. Dai, Y. W. Wu, and M. Yang. 2010. Plasma IL-17A is increased in new-onset SLE patients and associated with disease activity. J. Clin. Immunol. 30: 221-225.
40. Wong, C. K., L. C. Lit, L. S. Tam, E. K. Li, P. T. Wong, and C. W. Lam. 2008. Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin. Immunol. 127: 385-393.
41. Shah, K., W. W. Lee, S. H. Lee, S. H. Kim, S. W. Kang, J. Craft, and I. Kang. 2010. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Res. Ther. 12: R53.