Pregnane X receptor (PXR)-mediated gene repression and cross-talk of PXR with other nuclear receptors via coactivator interactions

Frontiers in Pharmacology

Volumn 7, Issue NOV, 2016, Pages

  Pavek, Petr ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Cross talk; Gene regulation; Metabolism; Nuclear receptor; PXR

Indexed keywords

CELL NUCLEUS RECEPTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOCHROME P450 3A4; FARNESOID X RECEPTOR; GLUCOSE 6 PHOSPHATASE; GLUCOSE TRANSPORTER 2; GLUTATHIONE TRANSFERASE; HEAT SHOCK PROTEIN 90; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HISTONE DEACETYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; LIVER X RECEPTOR; ORGANIC CATION TRANSPORTER 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOENOLPYRUVATE CARBOXYLASE; PREGNANE X RECEPTOR; PROTEIN KINASE B; RETINOID X RECEPTOR ALPHA; SOMATOMEDIN BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSCRIPTION FACTOR FKHR; TUMOR NECROSIS FACTOR; UNINDEXED DRUG;

ARTICLE; BILE ACID METABOLISM; CHOLESTEROL METABOLISM; ENZYME ACTIVATION; EXPRESSED SEQUENCE TAG; GENE CONTROL; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; LIGAND BINDING; MOLECULAR INTERACTION; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

EID: 85003856199     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2016.00456     Document Type: Article

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