Preferential physical and functional interaction of pregnane X receptor with the SMRTα isoform

Molecular Pharmacology

Volumn 75, Issue 2, 2009, Pages 363-373

  Li, Chia Wei ^b   Dinh, Gia Khanh ^a   Don Chen, J ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA CYANOPREGNENOLONE; CLOTRIMAZOLE; HISTONE DEACETYLASE; ISOPROTEIN; PREGNANE X RECEPTOR; RIFAMPICIN; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BREAST; CELL STRAIN COS7; CELL STRAIN HEK293; CELL STRAIN HEPG2; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY; LIVER; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROSTATE; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BINDING; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION;

ANIMALS; DNA-BINDING PROTEINS; GENE SILENCING; HUMANS; MICE; PROTEIN ISOFORMS; RABBITS; RECEPTORS, STEROID; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 59449108239     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.047845     Document Type: Article

References (40)

1. Blumberg B, Sabbagh W Jr, Juguilon H, Bolado J Jr, van Meter CM, Ong ES, and Evans RM (1998) SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 12:3195-3205.
2. Chen JD and Evans RM (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377:454-457.
3. Falkner KC, Pinaire JA, Xiao GH, Geoghegan TE, and Prough RA (2001) Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: involvement of both the glucocorticoid and pregnane X receptors. Mol Pharmacol 60:611-619.
4. Gao YD, Olson SH, Balkovec JM, Zhu Y, Royo I, Yabut J, Evers R, Tan EY, Tang W, Hartley DP, et al. (2007) Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach. Xenobiotica 37:124-138.
5. Geick A, Eichelbaum M, and Burk O (2001) Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 276:14581-14587.
6. Ghosh JC, Yang X, Zhang A, Lambert MH, Li H, Xu HE, and Chen JD (2002) Interactions that determine the assembly of a retinoid X receptor/corepressor
7. complex. Proc Natl Acad Sci USA 99:5842-5847.
8. Goodson ML, Jonas BA, and Privalsky ML (2005) Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. J Biol Chem 280:7493-7503.
9. Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, and Shiekhattar R (2000) A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes Dev 14:1048-1057.
10. Harmsen S, Meijerman I, Beijnen JH, and Schellens JH (2007) The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology. Cancer Treat Rev 33:369-380.
11. Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, and Glass CK (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377:397-404.
12. Hu X and Lazar MA (1999) The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. Nature 402:93-96.
13. Johnson DR, Li CW, Chen LY, Ghosh JC, and Chen JD (2006) Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Mol Pharmacol 69:99-108.
14. Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, and Edwards PA (2002) Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem 277:2908-2915.
15. Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterström RH, et al. (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92:73-82.
16. Kodama S, Koike C, Negishi M, and Yamamoto Y (2004) Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes. Mol Cell Biol 24:7931-7940.
17. Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, and Kliewer SA (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 102:1016-1023.
18. Leo C and Chen JD (2000) The SRC family of nuclear receptor coactivators. Gene 245:1-11.
19. Li H, Leo C, Zhu J, Wu X, O'Neil J, Park EJ, and Chen JD (2000) Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. Mol Cell Biol 20:1784-1796.
20. Liu H, Shaw CK, Reineke EL, Liu Y, and Kao HY (2004) Retinoid X receptor α(RXRa) helix 12 plays an inhibitory role in the recruitment of the p160 coactivators by unliganded RXRα/retinoic acid receptor α heterodimers. J Biol Chem 279:45208-45218.
21. Moore JT, Moore LB, Maglich JM, and Kliewer SA (2003) Functional and structural comparison of PXR and CAR. Biochim Biophys Acta 1619:235-238.
22. Muangmoonchai R, Smirlis D, Wong SC, Edwards M, Phillips IR, and Shephard EA (2001) Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1. Biochem J 355: 71-78.
23. Nagy L, Kao HY, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, and Evans RM (1997) Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 89:373-380.
24. Ordentlich P, Downes M, Xie W, Genin A, Spinner NB, and Evans RM (1999) Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc Natl Acad Sci USA 96:2639-2644.
25. Park EJ, Schroen DJ, Yang M, Li H, Li L, and Chen JD (1999) SMRTe, a silencing mediator for retinoid and thyroid hormone receptors- extended isoform that is more related to the nuclear receptor corepressor. Proc Natl Acad Sci U S A 96: 3519-3524.
26. Polo JM, Dell'Oso T, Ranuncolo SM, Cerchietti L, Beck D, Da Silva GF, Prive GG, Licht JD, and Melnick A (2004) Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat Med 10: 1329-1335.
27. Privalsky ML (2001) Regulation of SMRT and N-CoR corepressor function. Curr Top Microbiol Immunol 254:117-136.
28. Privalsky ML (2004) The role ofcorepressors in transcriptional regulation by nuclear hormone receptors. Annu Rev Physiol 66:315-360.
29. Synold TW, Dussault I, and Forman BM (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 7:584-590.
30. Tagami T, Kopp P, Johnson W, Arseven OK, and Jameson JL (1998) The thyroid hormone receptor variant alpha2 is a weak antagonist because it is deficient in interactions with nuclear receptor corepressors. Endocrinology 139:2535-2544.
31. Toell A, Kröncke KD, Kleinert H, and Carlberg C (2002) Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands. J Cell Biochem 85:72-82.
32. Ung CY, Li H, Yap CW, and Chen YZ (2007) In silico prediction of pregnane X receptor activators by machine learning approaches. Mol Pharmacol 71:158-168.
33. Urquhart BL, Tirona RG, and Kim RB (2007) Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs. J Clin Pharmacol 47:566 -578.
34. Wang CY, Li CW, Chen JD, and Welsh WJ (2006) Structural model reveals key interactions in the assembly of the pregnane X receptor/corepressor complex. Mol Pharmacol 69:1513-1517.
35. Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, and Redinbo MR (2001) The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science 292:2329 -2333.
36. Westin S, Rosenfeld MG, and Glass CK (2000) Nuclear receptor coactivators. Adv Pharmacol 47:89-112.
37. Wipf P, Gong H, Janjic JM, Li S, Day BW, and Xie W (2007) New opportunities for pregnane X receptor (PXR) targeting in drug development. lessons from enantio-and species-specific PXR ligands identified from a discovery library of amino acid analogues. Mini Rev Med Chem 7:617-625.
38. Wu X, Li H, and Chen JD (2001) The human homologue ofthe yeast DNArepair and TFIIH regulator MMS19 is an AF-1-specific coactivator ofestrogen receptor. JBiol Chem 276:23962-23968.
39. Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, Cobb JE, McKee DD, Galardi CM, Plunket KD, Nolte RT, et al. (2002) Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature 415:813-817.
40. Zhang A, Yeung PL, Li CW, Tsai SC, Dinh GK, Wu X, Li H, and Chen JD (2004) Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators. J Biol Chem 279:33799 -33805.