Dual roles of nuclear receptor liver X receptor a (LXRa) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator

Biochemical Pharmacology

Volumn 86, Issue 3, 2013, Pages 428-436

  Watanabe, Keisuke ^a   Sakurai, Kaori ^a   Tsuchiya, Yuri ^a   Yamazoe, Yasushi ^a   Yoshinari, Kouichi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Cholesterol homeostasis; Enzyme induction; Human hepatocyte; Nuclear receptor; Transcriptional crosstalk

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; CYTOCHROME P450 2B6; CYTOCHROME P450 3A4; LIVER X RECEPTOR ALPHA; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; RIFAMPICIN; CELL NUCLEUS RECEPTOR; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; DIMETHYL SULFOXIDE; LIVER X RECEPTOR; ORPHAN NUCLEAR RECEPTOR; PREGNANE X RECEPTOR; RETINOID X RECEPTOR;

ARTICLE; CELL STRAIN HEPG2; CHOLESTEROL METABOLISM; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; HOMEOSTASIS; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSACTIVATION; WESTERN BLOTTING; 24(S)-HYDROXYCHOLESTEROL; 24S-HC; 6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE-O-(3,4-DICHLOROBENZYL)OXIME; AGED; BIOSYNTHESIS; CAR; CELL CULTURE; CHOLESTEROL HOMEOSTASIS; CITCO; CONSTITUTIVE ACTIVE/ANDROSTANE RECEPTOR; DIRECT REPEAT SEPARATED BY 4 NUCLEOTIDES; DR-4; ELECTROPHORETIC MOBILITY SHIFT ASSAYS; ENZYME INDUCTION; ER-6; EVERTED REPEAT SEPARATED BY 6 NUCLEOTIDES; FEMALE; GENE EXPRESSION REGULATION; HUMAN HEPATOCYTE; LIVER X RECEPTOR Α; LXRΑ; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PXR; QRT-PCR; QUANTITATIVE REVERSE TRANSCRIPTION-PCR; RXR; SREBP-2; STEROL REGULATORY ELEMENT-BINDING PROTEIN-2; TRANSCRIPTIONAL CROSSTALK;

24(S)-HYDROXYCHOLESTEROL; 24S-HC; 6-(4-CHLOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE-O-(3,4-DICHLOROBENZYL)OXIME; CAR; CHOLESTEROL HOMEOSTASIS; CITCO; CONSTITUTIVE ACTIVE/ANDROSTANE RECEPTOR; DIMETHYL SULFOXIDE; DIRECT REPEAT SEPARATED BY 4 NUCLEOTIDES; DMSO; DR-4; ELECTROPHORETIC MOBILITY SHIFT ASSAYS; EMSA; ENZYME INDUCTION; ER-6; EVERTED REPEAT SEPARATED BY 6 NUCLEOTIDES; HUMAN HEPATOCYTE; LIVER X RECEPTOR Α; LXRΑ; NUCLEAR RECEPTOR; PREGNANE X RECEPTOR; PXR; QRT-PCR; QUANTITATIVE REVERSE TRANSCRIPTION-PCR; RETINOID X RECEPTOR; RXR; SREBP-2; STEROL REGULATORY ELEMENT-BINDING PROTEIN-2; TRANSCRIPTIONAL CROSSTALK;

AGED; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEP G2 CELLS; HEPATOCYTES; HUMANS; MIDDLE AGED; ORPHAN NUCLEAR RECEPTORS;

EID: 84884574859     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.05.016     Document Type: Article

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