Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene

Biochemical Pharmacology

Volumn 79, Issue 2, 2010, Pages 277-287

  Pavek, Petr ^a   Pospechova, Katerina ^a   Svecova, Lucie ^a   Syrova, Zdenka ^b   Stejskalova, Lucie ^a   Blazkova, Jana ^b   Dvorak, Zdenek ^c   Blahos, Jaroslav ^b  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^c PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

CYP3A4; Cytochrome P450; Metabolism; Nuclear receptors; Pharmacokinetics; Transcriptional regulation

Indexed keywords

CYTOCHROME P450 3A4; HETERODIMER; LIGAND; NUCLEOTIDE DERIVATIVE; PREGNANE X RECEPTOR; RETINOID X RECEPTOR ALPHA; RIFAMPICIN; VITAMIN D RECEPTOR;

ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTESTINE CELL; LIVER CELL; PLASMID; PRIORITY JOURNAL; RECEPTOR BINDING; REPORTER GENE; TRANSCRIPTION REGULATION; VITAMIN D RESPONSIVE ELEMENT;

BASE SEQUENCE; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; CYTOCHROME P-450 CYP3A; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTESTINES; RECEPTORS, CALCITRIOL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

EID: 71749099966     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.08.017     Document Type: Article

References (39)

1. Li A.P., Kaminski D.L., and Rasmussen A. Substrates of human hepatic cytochrome P450 3A4. Toxicology 104 (1995) 1-8
2. Finta C., and Zaphiropoulos P.G. The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons. Gene 260 (2000) 13-23
3. Martinez-Jimenez C.P., Jover R., Donato M.T., Castell J.V., and Gomez-Lechon M.J. Transcriptional regulation and expression of CYP3A4 in hepatocytes. Curr Drug Metab 8 (2007) 185-194
4. Tegude H., Schnabel A., Zanger U.M., Klein K., Eichelbaum M., and Burk O. Molecular mechanism of basal CYP3A4 regulation by hepatocyte nuclear factor 4alpha: evidence for direct regulation in the intestine. Drug Metab Dispos 35 (2007) 946-954
5. Bertilsson G., Heidrich J., Svensson K., Asman M., Jendeberg L., Sydow-Backman M., et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A 95 (1998) 12208-12213
6. Goodwin B., Hodgson E., and Liddle C. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol 56 (1999) 1329-1339
7. Lehmann J.M., McKee D.D., Watson M.A., Willson T.M., Moore J.T., and Kliewer S.A. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 102 (1998) 1016-1023
8. Goodwin B., Hodgson E., D'Costa D.J., Robertson G.R., and Liddle C. Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Mol Pharmacol 62 (2002) 359-365
9. Xie W., Barwick J.L., Simon C.M., Pierce A.M., Safe S., Blumberg B., et al. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev 14 (2000) 3014-3023
10. Drocourt L., Ourlin J.C., Pascussi J.M., Maurel P., and Vilarem M.J. Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J Biol Chem 277 (2002) 25125-25132
11. Thummel K.E., Brimer C., Yasuda K., Thottassery J., Senn T., Lin Y., et al. Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3. Mol Pharmacol 60 (2001) 1399-1406
12. Pascussi J.M., Drocourt L., Gerbal-Chaloin S., Fabre J.M., Maurel P., and Vilarem M.J. Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor. Eur J Biochem 268 (2001) 6346-6358
13. Tirona R.G., Lee W., Leake B.F., Lan L.B., Cline C.B., Lamba V., et al. The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Nat Med 9 (2003) 220-224
14. Wolbold R., Klein K., Burk O., Nussler A.K., Neuhaus P., Eichelbaum M., et al. Sex is a major determinant of CYP3A4 expression in human liver. Hepatology 38 (2003) 978-988
15. Lin J.H. CYP induction-mediated drug interactions: in vitro assessment and clinical implications. Pharm Res 23 (2006) 1089-1116
16. Makishima M., Okamoto A.Y., Repa J.J., Tu H., Learned R.M., Luk A., et al. Identification of a nuclear receptor for bile acids. Science 284 (1999) 1362-1365
17. Pavek P., and Dvorak Z. Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues. Curr Drug Metab 9 (2008) 129-143
18. Barwick J.L., Quattrochi L.C., Mills A.S., Potenza C., Tukey R.H., and Guzelian P.S. Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol 50 (1996) 10-16
19. Blumberg B., Sabbagh Jr. W., Juguilon H., Bolado Jr. J., van Meter C.M., Ong E.S., et al. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 12 (1998) 3195-3205
20. Makishima M., Lu T.T., Xie W., Whitfield G.K., Domoto H., Evans R.M., et al. Vitamin D receptor as an intestinal bile acid sensor. Science 296 (2002) 1313-1316
21. Matsumura K., Saito T., Takahashi Y., Ozeki T., Kiyotani K., Fujieda M., et al. Identification of a novel polymorphic enhancer of the human CYP3A4 gene. Mol Pharmacol 65 (2004) 326-334
22. Liu F.J., Song X., Yang D., Deng R., and Yan B. The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha. Biochem J 409 (2008) 243-250
23. Toriyabe T., Nagata K., Takada T., Aratsu Y., Matsubara T., Yoshinari K., et al. Unveiling a new essential cis-element for the transactivation of the CYP3A4 gene by xenobiotics. Mol Pharmacol. (2008)
24. Burk O., Arnold K.A., Nussler A.K., Schaeffeler E., Efimova E., Avery B.A., et al. Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol 67 (2005) 1954-1965
25. Cerveny L., Svecova L., Anzenbacherova E., Vrzal R., Staud F., Dvorak Z., et al. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways. Drug Metab Dispos 35 (2007) 1032-1041
26. Cui M., Klopot A., Jiang Y., and Fleet J.C. The effect of differentiation on 1,25 dihydroxyvitamin D-mediated gene expression in the enterocyte-like cell line, Caco-2. J Cell Physiol 218 (2009) 113-121
27. Matsubara T., Yoshinari K., Aoyama K., Sugawara M., Sekiya Y., Nagata K., et al. Role of vitamin D receptor in the lithocholic acid-mediated CYP3A induction in vitro and in vivo. Drug Metab Dispos 36 (2008) 2058-2063
28. Thompson P.D., Jurutka P.W., Whitfield G.K., Myskowski S.M., Eichhorst K.R., Dominguez C.E., et al. Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements. Biochem Biophys Res Commun 299 (2002) 730-738
29. Svecova L., Vrzal R., Burysek L., Anzenbacherova E., Cerveny L., Grim J., et al. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug Metab Dispos 36 (2008) 339-348
30. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29 (2001) e45
31. Berger U., Wilson P., McClelland R.A., Colston K., Haussler M.R., Pike J.W., et al. Immunocytochemical detection of 1,25-dihydroxyvitamin D receptors in normal human tissues. J Clin Endocrinol Metab 67 (1988) 607-613
32. Xie W., Radominska-Pandya A., Shi Y., Simon C.M., Nelson M.C., Ong E.S., et al. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci U S A 98 (2001) 3375-3380
33. Staudinger J.L., Goodwin B., Jones S.A., Hawkins-Brown D., MacKenzie K.I., LaTour A., et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A 98 (2001) 3369-3374
34. Hofmann A.F. Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity. Drug Metab Rev 36 (2004) 703-722
35. Rosenfeld M.G., Lunyak V.V., and Glass C.K. Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev 20 (2006) 1405-1428
36. Quack M., and Carlberg C. Ligand-triggered stabilization of vitamin D receptor/retinoid X receptor heterodimer conformations on DR4-type response elements. J Mol Biol 296 (2000) 743-756
37. Jurutka P.W., Thompson P.D., Whitfield G.K., Eichhorst K.R., Hall N., Dominguez C.E., et al. Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4. J Cellular Biochem 94 (2005) 917-943
38. Adachi R., Shulman A.I., Yamamoto K., Shimomura I., Yamada S., Mangelsdorf D.J., et al. Structural determinants for vitamin D receptor response to endocrine and xenobiotic signals. Mol Endocrinol 18 (2004) 43-52
39. Choi M., Yamamoto K., Itoh T., Makishima M., Mangelsdorf D.J., Moras D., et al. Interaction between vitamin D receptor and vitamin D ligands: two-dimensional alanine scanning mutational analysis. Chem Biol 10 (2003) 261-270