U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells

Archives of Toxicology

Volumn 88, Issue 12, 2014, Pages 2243-2259

  Smutny, Tomas ^a   Bitman, Michal ^a   Urban, Michal ^a   Dubecka, Michaela ^a   Vrzal, Radim ^b   Dvorak, Zdeněk ^b   Pavek, Petr ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

CYP3A4; Cytochrome P450; ERK cascade; Gene regulation; Pregnane X receptor

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CYTOCHROME P450; CYTOCHROME P450 3A; DACTINOMYCIN; PREGNANE X RECEPTOR; RIFAMPICIN; 1,3 BUTADIENE DERIVATIVE; CYP3A PROTEIN, HUMAN; ENZYME INHIBITOR; ISOENZYME; LIGAND; MAP2K1 PROTEIN, HUMAN; MAP2K2 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; NITRILE; PROTEIN BINDING; RENILLA LUCIFERIN 2 MONOOXYGENASE; STEROID RECEPTOR;

ARTICLE; CELL DEDIFFERENTIATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DRUG METABOLISM; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CARCINOMA; PRIMARY CULTURE; RECEPTOR BINDING ASSAY; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; METABOLISM; PLASMID; PRIMARY CELL CULTURE; PROMOTER REGION; SIGNAL TRANSDUCTION;

BUTADIENES; CYTOCHROME P-450 CYP3A; ENZYME INHIBITORS; HEP G2 CELLS; HEPATOCYTES; HUMANS; ISOENZYMES; LIGANDS; LUCIFERASES, RENILLA; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; NITRILES; PLASMIDS; PRIMARY CELL CULTURE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RECEPTORS, STEROID; TRANSFECTION; UP-REGULATION;

EID: 84912525497     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1254-2     Document Type: Article

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