메뉴 건너뛰기




Volumn 58, Issue 4, 2006, Pages 742-759

International union of pharmacology. LXII. The NR1H and NR1I receptors: Constitutive androstane receptor, pregnene X receptor, farnesoid X receptor α, farnesoid X receptor β, liver X receptor α, liver X receptor β, and vitamin D receptor

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; ANDROGEN RECEPTOR; ANDROSTANE DERIVATIVE; ANDROSTANE RECEPTOR; ANTILIPEMIC AGENT; CELL NUCLEUS RECEPTOR; CLOTRIMAZOLE; FARNESOID X RECEPTOR; FARNESOID X RECEPTOR ALPHA; FARNESOID X RECEPTOR BETA; HYPERFORIN; LIGAND; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MECLOZINE; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PREGNENE X RECEPTOR; RIFAMPICIN; SR 12813; STEROID RECEPTOR; VITAMIN D RECEPTOR;

EID: 33751516329     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.58.4.6     Document Type: Review
Times cited : (175)

References (80)
  • 1
    • 0033303655 scopus 로고    scopus 로고
    • Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses
    • Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, Baron R, and Demay MB (1999) Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 140:4982-4987.
    • (1999) Endocrinology , vol.140 , pp. 4982-4987
    • Amling, M.1    Priemel, M.2    Holzmann, T.3    Chapin, K.4    Rueger, J.M.5    Baron, R.6    Demay, M.B.7
  • 4
    • 3042693908 scopus 로고    scopus 로고
    • Structural investigation of the ligand binding domain of the zebrafish VDR in complexes with 1α,25(OH)2D3 and Gemini: Purification, crystallization and preliminary X-ray diffraction analysis
    • Ciesielski F, Rochel N, Mitschler A, Kouzmenko A, and Moras D (2004) Structural investigation of the ligand binding domain of the zebrafish VDR in complexes with 1α,25(OH)2D3 and Gemini: purification, crystallization and preliminary X-ray diffraction analysis. J Steroid Biochem Mol Biol 89-90:55-59.
    • (2004) J Steroid Biochem Mol Biol , vol.89-90 , pp. 55-59
    • Ciesielski, F.1    Rochel, N.2    Mitschler, A.3    Kouzmenko, A.4    Moras, D.5
  • 6
    • 0003295132 scopus 로고    scopus 로고
    • Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump
    • Cui J, Huang L, Zhao A, Lew JL, Yu J, Sahoo S, Meinke PT, Royo I, Pelaez F, and Wright SD (2003) Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump. J Biol Chem 278:10214-10220.
    • (2003) J Biol Chem , vol.278 , pp. 10214-10220
    • Cui, J.1    Huang, L.2    Zhao, A.3    Lew, J.L.4    Yu, J.5    Sahoo, S.6    Meinke, P.T.7    Royo, I.8    Pelaez, F.9    Wright, S.D.10
  • 7
    • 0022507477 scopus 로고
    • The metabolism and functions of vitamin D
    • DeLuca HF (1986) The metabolism and functions of vitamin D. Adv Exp Med Biol 196:361-375.
    • (1986) Adv Exp Med Biol , vol.196 , pp. 361-375
    • DeLuca, H.F.1
  • 8
    • 0035204814 scopus 로고    scopus 로고
    • Vitamin D: Its role and uses in immunology
    • DeLuca HF and Cantorna MT (2001) Vitamin D: its role and uses in immunology. FASEB J 15:2579-2585.
    • (2001) FASEB J , vol.15 , pp. 2579-2585
    • DeLuca, H.F.1    Cantorna, M.T.2
  • 14
    • 0345304733 scopus 로고    scopus 로고
    • Crystal structure of the human liver X receptor β ligand-binding domain in complex with a synthetic agonist
    • Hoerer S, Schmid A, Heckel A, Budzinski RM, and Nar H (2003) Crystal structure of the human liver X receptor β ligand-binding domain in complex with a synthetic agonist. J Mol Biol 334:853-861.
    • (2003) J Mol Biol , vol.334 , pp. 853-861
    • Hoerer, S.1    Schmid, A.2    Heckel, A.3    Budzinski, R.M.4    Nar, H.5
  • 16
    • 5044237671 scopus 로고    scopus 로고
    • Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR
    • Huang W, Zhang J, Wei P, Schrader WT, and Moore DD (2004) Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol Endocrinol 18:2402-2408.
    • (2004) Mol Endocrinol , vol.18 , pp. 2402-2408
    • Huang, W.1    Zhang, J.2    Wei, P.3    Schrader, W.T.4    Moore, D.D.5
  • 22
  • 27
    • 1642498313 scopus 로고    scopus 로고
    • Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): One variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region
    • Koyano S, Kurose K, Saito Y, Ozawa S, Hasegawa R, Komamura K, Ueno K, Kamakura S, Kitakaze M, Nakajima T, et al. (2004) Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region. Drug Metab Dispos 32:149-154.
    • (2004) Drug Metab Dispos , vol.32 , pp. 149-154
    • Koyano, S.1    Kurose, K.2    Saito, Y.3    Ozawa, S.4    Hasegawa, R.5    Komamura, K.6    Ueno, K.7    Kamakura, S.8    Kitakaze, M.9    Nakajima, T.10
  • 30
    • 23144435169 scopus 로고    scopus 로고
    • Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics
    • Lamba J, Lamba V, and Schuetz E (2005) Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics. Curr Drug Metab 6:369-383.
    • (2005) Curr Drug Metab , vol.6 , pp. 369-383
    • Lamba, J.1    Lamba, V.2    Schuetz, E.3
  • 32
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, and Kliewer SA (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Investig 102:1016-1023.
    • (1998) J Clin Investig , vol.102 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3    Willson, T.M.4    Moore, J.T.5    Kliewer, S.A.6
  • 34
    • 0030610422 scopus 로고    scopus 로고
    • Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia
    • Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R, and Demay MB (1997) Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci USA 94:9831-9835.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9831-9835
    • Li, Y.C.1    Pirro, A.E.2    Amling, M.3    Delling, G.4    Baron, R.5    Bronson, R.6    Demay, M.B.7
  • 36
    • 0035851188 scopus 로고    scopus 로고
    • Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism
    • Lu TT, Repa JJ, and Mangelsdorf DJ (2001) Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J Biol Chem 276:37735-37738.
    • (2001) J Biol Chem , vol.276 , pp. 37735-37738
    • Lu, T.T.1    Repa, J.J.2    Mangelsdorf, D.J.3
  • 37
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • Ma K, Saha PK, Chan L, and Moore DD (2006) Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Investig 116:1102-1109.
    • (2006) J Clin Investig , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 45
    • 11144318237 scopus 로고    scopus 로고
    • Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
    • Moschetta A, Bookout AL, and Manglesdorf DJ (2004) Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat Med 10:1352-1358.
    • (2004) Nat Med , vol.10 , pp. 1352-1358
    • Moschetta, A.1    Bookout, A.L.2    Manglesdorf, D.J.3
  • 46
    • 23744437421 scopus 로고    scopus 로고
    • Noncalcemic actions of vitamin D receptor ligands
    • Nagpal S, Na S, and Rathnachalam R (2005) Noncalcemic actions of vitamin D receptor ligands. Endocr Rev 26:662-687.
    • (2005) Endocr Rev , vol.26 , pp. 662-687
    • Nagpal, S.1    Na, S.2    Rathnachalam, R.3
  • 49
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
    • Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, and Mangelsdorf DJ (1998) Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα. Cell 93:693-704.
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.M.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 50
    • 23144447140 scopus 로고    scopus 로고
    • CAR, the continuously advancing receptor, in drug metabolism and disease
    • Qatanani M and Moore DD (2005) CAR, the continuously advancing receptor, in drug metabolism and disease. Curr Drug Metab 6:329-339.
    • (2005) Curr Drug Metab , vol.6 , pp. 329-339
    • Qatanani, M.1    Moore, D.D.2
  • 51
    • 0033963897 scopus 로고    scopus 로고
    • The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand
    • Rochel N, Wurtz JM, Mitschler A, Klaholz B, and Moras D (2000) The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol Cell 5:173-179.
    • (2000) Mol Cell , vol.5 , pp. 173-179
    • Rochel, N.1    Wurtz, J.M.2    Mitschler, A.3    Klaholz, B.4    Moras, D.5
  • 54
    • 23444431623 scopus 로고    scopus 로고
    • Retinoid X receptor heterodimers in the metabolic syndrome
    • Shulman AI and Mangelsdorf DJ (2005) Retinoid X receptor heterodimers in the metabolic syndrome. N Engl J Med 353:604-615.
    • (2005) N Engl J Med , vol.353 , pp. 604-615
    • Shulman, A.I.1    Mangelsdorf, D.J.2
  • 55
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, and Gonzalez FJ (2000) Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102:731-744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 57
    • 10944250224 scopus 로고    scopus 로고
    • The nuclear xenobiotic receptor CAR; structural determinants of constitutive activation and Heterodimerization
    • Suino K, Peng L, Reynolds R, Li Y, Cha JY, Repa JJ, Kliewer SA, and Xu HE (2004) The nuclear xenobiotic receptor CAR; structural determinants of constitutive activation and Heterodimerization. Mol Cell 16:893-905.
    • (2004) Mol Cell , vol.16 , pp. 893-905
    • Suino, K.1    Peng, L.2    Reynolds, R.3    Li, Y.4    Cha, J.Y.5    Repa, J.J.6    Kliewer, S.A.7    Xu, H.E.8
  • 59
    • 3042726385 scopus 로고    scopus 로고
    • CAR, driving into the future
    • Swales K and Negishi M (2004) CAR, driving into the future. Mol Endocrinol 18:1589-1598.
    • (2004) Mol Endocrinol , vol.18 , pp. 1589-1598
    • Swales, K.1    Negishi, M.2
  • 61
    • 0037503924 scopus 로고    scopus 로고
    • Liver X receptor signaling pathways in cardiovascular disease
    • Tontonoz P and Mangelsdorf DJ (2003) Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol 17:985-993.
    • (2003) Mol Endocrinol , vol.17 , pp. 985-993
    • Tontonoz, P.1    Mangelsdorf, D.J.2
  • 64
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang H, Chen J, Hollister K, Sowers LC, and Forman BM (1999) Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 3:543-553.
    • (1999) Mol Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 65
    • 0043168030 scopus 로고    scopus 로고
    • Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor
    • Watkins RE, Davis-Searles PR, Lambert MH, and Redinbo MR (2003a) Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. J Mol Biol 331:815-828.
    • (2003) J Mol Biol , vol.331 , pp. 815-828
    • Watkins, R.E.1    Davis-Searles, P.R.2    Lambert, M.H.3    Redinbo, M.R.4
  • 68
    • 0034687397 scopus 로고    scopus 로고
    • The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
    • Wei P, Zhang J, Egan-Hafley M, Liang S, and Moore DD (2000) The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature (Lond) 407:920-923.
    • (2000) Nature (Lond) , vol.407 , pp. 920-923
    • Wei, P.1    Zhang, J.2    Egan-Hafley, M.3    Liang, S.4    Moore, D.D.5
  • 71
    • 0035992181 scopus 로고    scopus 로고
    • Minireview: Genomics versus orphan nuclear receptors - A half-time report
    • Willson TM and Moore JT (2002) Minireview: genomics versus orphan nuclear receptors - a half-time report. Mol Endocrinol 16:1135-1144.
    • (2002) Mol Endocrinol , vol.16 , pp. 1135-1144
    • Willson, T.M.1    Moore, J.T.2
  • 76
    • 0037364216 scopus 로고    scopus 로고
    • Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor
    • Zeitz U, Weber K, Soegiarto DW, Wolf E, Balling R, and Erben RG (2003) Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J 17:509-511.
    • (2003) FASEB J , vol.17 , pp. 509-511
    • Zeitz, U.1    Weber, K.2    Soegiarto, D.W.3    Wolf, E.4    Balling, R.5    Erben, R.G.6
  • 77
    • 0037064177 scopus 로고    scopus 로고
    • Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR
    • Zhang J, Huang W, Chua SS, Wei P, and Moore DD (2002) Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science (Wash DC) 298:422-424.
    • (2002) Science (Wash DC) , vol.298 , pp. 422-424
    • Zhang, J.1    Huang, W.2    Chua, S.S.3    Wei, P.4    Moore, D.D.5
  • 78
    • 10344224570 scopus 로고    scopus 로고
    • The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity
    • Zhang J, Huang W, Qatanani M, Evans RM, and Moore DD (2004) The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem 279:49517-49522.
    • (2004) J Biol Chem , vol.279 , pp. 49517-49522
    • Zhang, J.1    Huang, W.2    Qatanani, M.3    Evans, R.M.4    Moore, D.D.5
  • 79
    • 0037414757 scopus 로고    scopus 로고
    • Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
    • Zhang Y, Kast-Woelbern HR, and Edwards PA (2003) Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. J Biol Chem 278:104-110.
    • (2003) J Biol Chem , vol.278 , pp. 104-110
    • Zhang, Y.1    Kast-Woelbern, H.R.2    Edwards, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.