-
1
-
-
0032403230
-
The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD
-
Bailey P, Sartorelli V, Hamamori Y, and Muscat GE (1998) The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD. Nucleic Acids Res 26:5501-5510.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 5501-5510
-
-
Bailey, P.1
Sartorelli, V.2
Hamamori, Y.3
Muscat, G.E.4
-
2
-
-
13144260727
-
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
-
Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Backman M, Ohlsson R, Postlind H, Blomquist P, and Berkenstam A (1998) Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci USA 95:12208-12213.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 12208-12213
-
-
Bertilsson, G.1
Heidrich, J.2
Svensson, K.3
Asman, M.4
Jendeberg, L.5
Sydow-Backman, M.6
Ohlsson, R.7
Postlind, H.8
Blomquist, P.9
Berkenstam, A.10
-
3
-
-
0032532134
-
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
-
Blumberg B, Sabbagh W Jr, Juguilon H, Bolado J Jr, van Meter CM, Ong ES, and Evans RM (1998) SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 12:3195-3205.
-
(1998)
Genes Dev
, vol.12
, pp. 3195-3205
-
-
Blumberg, B.1
Sabbagh Jr., W.2
Juguilon, H.3
Bolado Jr., J.4
Van Meter, C.M.5
Ong, E.S.6
Evans, R.M.7
-
4
-
-
0029097233
-
A transcriptional co-repressor that interacts with nuclear hormone receptors
-
Chen JD and Evans RM (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature (Lond) 377:454-457.
-
(1995)
Nature (Lond)
, vol.377
, pp. 454-457
-
-
Chen, J.D.1
Evans, R.M.2
-
5
-
-
0029794881
-
SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers
-
Chen JD, Umesono K, and Evans RM (1996) SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers. Proc Natl Acad Sci USA 93:7567-7571.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7567-7571
-
-
Chen, J.D.1
Umesono, K.2
Evans, R.M.3
-
6
-
-
0141529776
-
Daxx silencing sensitizes cells to multiple apoptotic pathways
-
Chen LY and Chen JD (2003) Daxx silencing sensitizes cells to multiple apoptotic pathways. Mol Cell Biol 23:7108-7121.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7108-7121
-
-
Chen, L.Y.1
Chen, J.D.2
-
8
-
-
0029859318
-
Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: Physical association is dependent on the E region of the orphan receptors
-
Downes M, Burke LJ, Bailey PJ, and Muscat GE (1996) Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors. Nucleic Acids Res 24:4379-4386.
-
(1996)
Nucleic Acids Res
, vol.24
, pp. 4379-4386
-
-
Downes, M.1
Burke, L.J.2
Bailey, P.J.3
Muscat, G.E.4
-
9
-
-
0034641739
-
Identification of a nuclear domain with deacetylase activity
-
Downes M, Ordentlich P, Kao HY, Alvarez JG, and Evans RM (2000) Identification of a nuclear domain with deacetylase activity. Proc Natl Acad Sci USA 97:10330-10335.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10330-10335
-
-
Downes, M.1
Ordentlich, P.2
Kao, H.Y.3
Alvarez, J.G.4
Evans, R.M.5
-
10
-
-
0033681001
-
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors
-
Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, and Xu HE (2000) Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol Cell 5:545-555.
-
(2000)
Mol Cell
, vol.5
, pp. 545-555
-
-
Gampe Jr., R.T.1
Montana, V.G.2
Lambert, M.H.3
Miller, A.B.4
Bledsoe, R.K.5
Milburn, M.V.6
Kliewer, S.A.7
Willson, T.M.8
Xu, H.E.9
-
11
-
-
0037197970
-
Interactions that determine the assembly of a retinoid X receptor/corepressor complex
-
Ghosh JC, Yang X, Zhang A, Lambert MH, Li H, Xu HE, and Chen JD (2002) Interactions that determine the assembly of a retinoid X receptor/corepressor complex. Proc Natl Acad Sci USA 99:5842-5847.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 5842-5847
-
-
Ghosh, J.C.1
Yang, X.2
Zhang, A.3
Lambert, M.H.4
Li, H.5
Xu, H.E.6
Chen, J.D.7
-
12
-
-
0032702726
-
The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
-
Goodwin B, Hodgson E, and Liddle C (1999) The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol 56:1329-1339.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 1329-1339
-
-
Goodwin, B.1
Hodgson, E.2
Liddle, C.3
-
13
-
-
0032924934
-
Cytochrome P-450 3A4: Regulation and role in drug metabolism
-
Guengerich FP (1999) Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol 39:1-17.
-
(1999)
Annu Rev Pharmacol Toxicol
, vol.39
, pp. 1-17
-
-
Guengerich, F.P.1
-
14
-
-
0033838465
-
The SMRT corepressor is regulated by a MEK-1 kinase pathway: Inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export
-
Hong SH and Privalsky ML (2000) The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export. Mol Cell Biol 20:6612-6625.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 6612-6625
-
-
Hong, S.H.1
Privalsky, M.L.2
-
15
-
-
0029132202
-
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
-
Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK, et al. (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature (Lond) 377:397-404.
-
(1995)
Nature (Lond)
, vol.377
, pp. 397-404
-
-
Horlein, A.J.1
Naar, A.M.2
Heinzel, T.3
Torchia, J.4
Gloss, B.5
Kurokawa, R.6
Ryan, A.7
Kamei, Y.8
Soderstrom, M.9
Glass, C.K.10
-
16
-
-
0033523917
-
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
-
Hu X and Lazar MA (1999) The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. Nature (Lond) 402:93-96.
-
(1999)
Nature (Lond)
, vol.402
, pp. 93-96
-
-
Hu, X.1
Lazar, M.A.2
-
17
-
-
0038517917
-
Liver X receptors interact with corepressors to regulate gene expression
-
Hu X, Li S, Wu J, Xia C, and Lala DS (2003) Liver X receptors interact with corepressors to regulate gene expression. Mol Endocrinol 17:1019-1026.
-
(2003)
Mol Endocrinol
, vol.17
, pp. 1019-1026
-
-
Hu, X.1
Li, S.2
Wu, J.3
Xia, C.4
Lala, D.S.5
-
18
-
-
0042592941
-
The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor
-
Ishizuka T and Lazar MA (2003) The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor. Mol Cell Biol 23:5122-5131.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 5122-5131
-
-
Ishizuka, T.1
Lazar, M.A.2
-
19
-
-
17744375160
-
The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
-
Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, et al. (2000) The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol 14:27-39.
-
(2000)
Mol Endocrinol
, vol.14
, pp. 27-39
-
-
Jones, S.A.1
Moore, L.B.2
Shenk, J.L.3
Wisely, G.B.4
Hamilton, G.A.5
McKee, D.D.6
Tomkinson, N.C.7
LeCluyse, E.L.8
Lambert, M.H.9
Willson, T.M.10
-
20
-
-
0037169551
-
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor and constitutive androstane receptor
-
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, and Edwards PA (2002) Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor and constitutive androstane receptor. J Biol Chem 277:2908-2915.
-
(2002)
J Biol Chem
, vol.277
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
Jones, S.A.4
Anisfeld, A.M.5
Stoltz, C.M.6
Tontonoz, P.7
Kliewer, S.8
Willson, T.M.9
Edwards, P.A.10
-
21
-
-
0037333974
-
Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR
-
Kawana K, Ikuta T, Kobayashi Y, Gotoh O, Takeda K, and Kawajiri K (2003) Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. Mol Pharmacol 63:524-531.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 524-531
-
-
Kawana, K.1
Ikuta, T.2
Kobayashi, Y.3
Gotoh, O.4
Takeda, K.5
Kawajiri, K.6
-
22
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterstrom RH, et al. (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92:73-82.
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
-
23
-
-
0032169485
-
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
-
Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, and Kliewer SA (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Investig 102:1016-1023.
-
(1998)
J Clin Investig
, vol.102
, pp. 1016-1023
-
-
Lehmann, J.M.1
McKee, D.D.2
Watson, M.A.3
Willson, T.M.4
Moore, J.T.5
Kliewer, S.A.6
-
24
-
-
0030784510
-
Characterization of receptor interaction and transcriptional repression by the corepressor SMRT
-
Li H, Leo C, Schroen DJ, and Chen JD (1997) Characterization of receptor interaction and transcriptional repression by the corepressor SMRT. Mol Endocrinol 11:2025-2037.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 2025-2037
-
-
Li, H.1
Leo, C.2
Schroen, D.J.3
Chen, J.D.4
-
26
-
-
0033616676
-
SMRTe, a silencing mediator for retinoid and thyroid hormone receptors- extended isoform that is more related to the nuclear receptor corepressor
-
Park EJ, Schroen DJ, Yang M, Li H, Li L, and Chen JD (1999) SMRTe, a silencing mediator for retinoid and thyroid hormone receptors- extended isoform that is more related to the nuclear receptor corepressor. Proc Natl Acad Sci USA 96:3519-3524.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3519-3524
-
-
Park, E.J.1
Schroen, D.J.2
Yang, M.3
Li, H.4
Li, L.5
Chen, J.D.6
-
27
-
-
0036236065
-
Induction of CYP3A expression by dehydroepiandrosterone: Involvement of the pregnane X receptor
-
Ripp SL, Fitzpatrick JL, Peters JM, and Prough RA (2002) Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor. Drug Metab Dispos 30:570-575.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 570-575
-
-
Ripp, S.L.1
Fitzpatrick, J.L.2
Peters, J.M.3
Prough, R.A.4
-
28
-
-
0038745433
-
Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein α and hepatocyte nuclear factor-3γ
-
Rodriguez-Antona C, Bort R, Jover R, Tindberg N, Ingelman-Sundberg M, Gomez-Lechon MJ, and Castell JV (2003) Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein α and hepatocyte nuclear factor-3γ. Mol Pharmacol 63:1180-1189.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 1180-1189
-
-
Rodriguez-Antona, C.1
Bort, R.2
Jover, R.3
Tindberg, N.4
Ingelman-Sundberg, M.5
Gomez-Lechon, M.J.6
Castell, J.V.7
-
29
-
-
0037370498
-
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
-
Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Ihrig MM, McManus MT, Gertler FB, et al. (2003) A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 33:401-406.
-
(2003)
Nat Genet
, vol.33
, pp. 401-406
-
-
Rubinson, D.A.1
Dillon, C.P.2
Kwiatkowski, A.V.3
Sievers, C.4
Yang, L.5
Kopinja, J.6
Rooney, D.L.7
Ihrig, M.M.8
McManus, M.T.9
Gertler, F.B.10
-
30
-
-
0032437889
-
Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element
-
Schuetz EG, Brimer C, and Schuetz JD (1998) Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element. Mol Pharmacol 54:1113-1117.
-
(1998)
Mol Pharmacol
, vol.54
, pp. 1113-1117
-
-
Schuetz, E.G.1
Brimer, C.2
Schuetz, J.D.3
-
31
-
-
0032446607
-
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
-
Shiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, Agard DA, and Greene GL (1998) The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell 95:927-937.
-
(1998)
Cell
, vol.95
, pp. 927-937
-
-
Shiau, A.K.1
Barstad, D.2
Loria, P.M.3
Cheng, L.4
Kushner, P.J.5
Agard, D.A.6
Greene, G.L.7
-
32
-
-
0030946201
-
Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT)
-
Shibata H, Nawaz Z, Tsai SY, O'Malley BW, and Tsai MJ (1997) Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT). Mol Endocrinol 11:714-724.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 714-724
-
-
Shibata, H.1
Nawaz, Z.2
Tsai, S.Y.3
O'Malley, B.W.4
Tsai, M.J.5
-
33
-
-
8344219885
-
Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver
-
Squires EJ, Sueyoshi T, and Negishi M (2004) Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. J Biol Chem 279:49307-49314.
-
(2004)
J Biol Chem
, vol.279
, pp. 49307-49314
-
-
Squires, E.J.1
Sueyoshi, T.2
Negishi, M.3
-
34
-
-
0035853165
-
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
-
Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, et al. (2001) The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 98:3369-3374.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3369-3374
-
-
Staudinger, J.L.1
Goodwin, B.2
Jones, S.A.3
Hawkins-Brown, D.4
MacKenzie, K.I.5
LaTour, A.6
Liu, Y.7
Klaassen, C.D.8
Brown, K.K.9
Reinhard, J.10
-
35
-
-
13844315320
-
Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury
-
Stedman CA, Liddle C, Coulter SA, Sonoda J, Alvarez JG, Moore DD, Evans RM, and Downes M (2005) Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Proc Natl Acad Sci USA 102:2063-2068.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 2063-2068
-
-
Stedman, C.A.1
Liddle, C.2
Coulter, S.A.3
Sonoda, J.4
Alvarez, J.G.5
Moore, D.D.6
Evans, R.M.7
Downes, M.8
-
36
-
-
0035038919
-
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
-
Synold TW, Dussault I, and Forman BM (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 7:584-590.
-
(2001)
Nat Med
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
37
-
-
0037031809
-
Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics
-
Takeshita A, Taguchi M, Koibuchi N, and Ozawa Y (2002) Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics. J Biol Chem 277:32453-32458.
-
(2002)
J Biol Chem
, vol.277
, pp. 32453-32458
-
-
Takeshita, A.1
Taguchi, M.2
Koibuchi, N.3
Ozawa, Y.4
-
38
-
-
0035968274
-
SMRTE inhibits MEF2C transcriptional activation by targeting HDAC4 and 5 to nuclear domains
-
Wu X, Li H, Park EJ, and Chen JD (2001) SMRTE inhibits MEF2C transcriptional activation by targeting HDAC4 and 5 to nuclear domains. J Biol Chem 276:24177-24185.
-
(2001)
J Biol Chem
, vol.276
, pp. 24177-24185
-
-
Wu, X.1
Li, H.2
Park, E.J.3
Chen, J.D.4
-
39
-
-
0034721159
-
Humanized xenobiotic response in mice expressing nuclear receptor SXR
-
Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, Neuschwander-Tetri BA, Brunt EM, Guzelian PS, and Evans RM (2000a) Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature (Lond) 406:435-439.
-
(2000)
Nature (Lond)
, vol.406
, pp. 435-439
-
-
Xie, W.1
Barwick, J.L.2
Downes, M.3
Blumberg, B.4
Simon, C.M.5
Nelson, M.C.6
Neuschwander-Tetri, B.A.7
Brunt, E.M.8
Guzelian, P.S.9
Evans, R.M.10
-
40
-
-
0033638960
-
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
-
Xie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B, Guzelian PS, and Evans RM (2000b) Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev 14:3014-3023.
-
(2000)
Genes Dev
, vol.14
, pp. 3014-3023
-
-
Xie, W.1
Barwick, J.L.2
Simon, C.M.3
Pierce, A.M.4
Safe, S.5
Blumberg, B.6
Guzelian, P.S.7
Evans, R.M.8
-
41
-
-
0035076197
-
The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver
-
Zelko I, Sueyoshi T, Kawamoto T, Moore R, and Negishi M (2001) The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver. Mol Cell Biol 21:2838-2846.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2838-2846
-
-
Zelko, I.1
Sueyoshi, T.2
Kawamoto, T.3
Moore, R.4
Negishi, M.5
|