메뉴 건너뛰기




Volumn 56, Issue 3, 2017, Pages 791-803

Emerging links among Chromosome Instability (CIN), cancer, and aging

Author keywords

aging; BubR1 (Bub1 related 1); cancer; Chromosome Instability (CIN); immune system; mice; senescence; Sgo1 (Shugoshin1); transcriptome

Indexed keywords

TRANSCRIPTOME;

EID: 84992176811     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22539     Document Type: Article
Times cited : (21)

References (152)
  • 1
    • 74049135504 scopus 로고    scopus 로고
    • Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris
    • Boveri T. Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J Cell Sci 2008; 121:1–84.
    • (2008) J Cell Sci , vol.121 , pp. 1-84
    • Boveri, T.1
  • 2
    • 67649522162 scopus 로고    scopus 로고
    • Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis
    • Holland AJ, Cleveland DW. Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol 2009; 10:478–487.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 478-487
    • Holland, A.J.1    Cleveland, D.W.2
  • 3
    • 84948434186 scopus 로고    scopus 로고
    • Revisiting tumour aneuploidy- the place of ploidy assessment in the molecular era
    • Danielsen HE, Pradhan M, Novelli M. Revisiting tumour aneuploidy- the place of ploidy assessment in the molecular era. Nat Rev Clin Oncol 2016; 13:291–304.
    • (2016) Nat Rev Clin Oncol , vol.13 , pp. 291-304
    • Danielsen, H.E.1    Pradhan, M.2    Novelli, M.3
  • 5
    • 84944883776 scopus 로고    scopus 로고
    • Microsatellite instability in colorectal cancer: Clinicopathological significance
    • Setaffy L, Langner C. Microsatellite instability in colorectal cancer: Clinicopathological significance. Pol J Pathol 2015; 66:203–218.
    • (2015) Pol J Pathol , vol.66 , pp. 203-218
    • Setaffy, L.1    Langner, C.2
  • 6
    • 84940004205 scopus 로고    scopus 로고
    • Microsatellite instability: An update
    • Yamamoto H, Imai K. Microsatellite instability: An update. Arch Toxicol 2015; 89:899–921.
    • (2015) Arch Toxicol , vol.89 , pp. 899-921
    • Yamamoto, H.1    Imai, K.2
  • 7
    • 84918813931 scopus 로고    scopus 로고
    • Causes and consequences of microsatellite instability in gastric carcinogenesis
    • Velho S, Fernandes MS, Leite M, Figueiredo C, Seruca R. Causes and consequences of microsatellite instability in gastric carcinogenesis. World J Gastroenterol 2014; 20:16433–16442.
    • (2014) World J Gastroenterol , vol.20 , pp. 16433-16442
    • Velho, S.1    Fernandes, M.S.2    Leite, M.3    Figueiredo, C.4    Seruca, R.5
  • 8
    • 84874362586 scopus 로고    scopus 로고
    • Replication stress links structural and numerical cancer chromosomal instability
    • Burrell RA, McClelland SE, Endesfelder D, et al. Replication stress links structural and numerical cancer chromosomal instability. Nature 2013; 494:492–496.
    • (2013) Nature , vol.494 , pp. 492-496
    • Burrell, R.A.1    McClelland, S.E.2    Endesfelder, D.3
  • 9
    • 84953348769 scopus 로고    scopus 로고
    • Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer
    • Liu C, Srihari S, Lal S, et al. Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer. Mol Oncol 2016; 10:179–193.
    • (2016) Mol Oncol , vol.10 , pp. 179-193
    • Liu, C.1    Srihari, S.2    Lal, S.3
  • 10
    • 85047698408 scopus 로고    scopus 로고
    • Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization
    • Dunican DS, McWilliam P, Tighe O, Parle-McDermott A, Croke DT. Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization. Oncogene 2002; 21:3253–3257.
    • (2002) Oncogene , vol.21 , pp. 3253-3257
    • Dunican, D.S.1    McWilliam, P.2    Tighe, O.3    Parle-McDermott, A.4    Croke, D.T.5
  • 11
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood LD, Parsons DW, Jones S, et al. The genomic landscapes of human breast and colorectal cancers. Science 2007; 318:1108–1113.
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3
  • 12
    • 84891103023 scopus 로고    scopus 로고
    • Genomic instability and colon carcinogenesis: From the perspective of genes
    • Rao CV, Yamada HY. Genomic instability and colon carcinogenesis: From the perspective of genes. Front Oncol 2013; 3:130.
    • (2013) Front Oncol , vol.3 , pp. 130
    • Rao, C.V.1    Yamada, H.Y.2
  • 13
    • 33745603755 scopus 로고    scopus 로고
    • Patterns of genomic instability in gastric cancer: Clinical implications and perspectives
    • Ottini L, Falchetti M, Lupi R, et al. Patterns of genomic instability in gastric cancer: Clinical implications and perspectives. Ann Oncol 2006; 17:vii97–vi102.
    • (2006) Ann Oncol , vol.17 , pp. vii97-vi102
    • Ottini, L.1    Falchetti, M.2    Lupi, R.3
  • 14
    • 84907270779 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of gastric adenocarcinoma
    • Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 2014; 513:202–209.
    • (2014) Nature , vol.513 , pp. 202-209
  • 15
    • 84937793347 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability
    • Toda K, Nagasaka T, Umeda Y, et al. Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability. Clin Epigenetics 2015; 7:73.
    • (2015) Clin Epigenetics , vol.7 , pp. 73
    • Toda, K.1    Nagasaka, T.2    Umeda, Y.3
  • 16
    • 80052607184 scopus 로고    scopus 로고
    • Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells
    • Toller IM, Neelsen KJ, Steger M, et al. Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells. Proc Natl Acad Sci USA 2011; 108:14944–14949.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14944-14949
    • Toller, I.M.1    Neelsen, K.J.2    Steger, M.3
  • 17
    • 84927755764 scopus 로고    scopus 로고
    • Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection
    • Kidane D, Murphy DL, Sweasy JB. Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection. Oncogenesis 2014; 3:e28.
    • (2014) Oncogenesis , vol.3
    • Kidane, D.1    Murphy, D.L.2    Sweasy, J.B.3
  • 18
    • 84880263801 scopus 로고    scopus 로고
    • HBxAPα/Rsf-1-mediated HBx-hBubR1 interactions regulate the mitotic spindle checkpoint and chromosome instability
    • Chae S, Ji JH, Kwon SH, et al. HBxAPα/Rsf-1-mediated HBx-hBubR1 interactions regulate the mitotic spindle checkpoint and chromosome instability. Carcinogenesis 2013; 34:1680–1688.
    • (2013) Carcinogenesis , vol.34 , pp. 1680-1688
    • Chae, S.1    Ji, J.H.2    Kwon, S.H.3
  • 19
    • 44449120297 scopus 로고    scopus 로고
    • HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint
    • Kim S, Park SY, Yong H, et al. HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint. Oncogene 2008; 27:3457–3464.
    • (2008) Oncogene , vol.27 , pp. 3457-3464
    • Kim, S.1    Park, S.Y.2    Yong, H.3
  • 20
    • 33646192070 scopus 로고    scopus 로고
    • Overexpression of hepatitis C virus NS5A protein induces chromosome instability via mitotic cell cycle dysregulation
    • Baek KH, Park HY, Kang CM, et al. Overexpression of hepatitis C virus NS5A protein induces chromosome instability via mitotic cell cycle dysregulation. J Mol Biol 2006; 359:22–34.
    • (2006) J Mol Biol , vol.359 , pp. 22-34
    • Baek, K.H.1    Park, H.Y.2    Kang, C.M.3
  • 21
    • 3543150890 scopus 로고    scopus 로고
    • Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway
    • Yun C, Cho H, Kim SJ, et al. Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway. Mol Cancer Res 2004; 2:159–169.
    • (2004) Mol Cancer Res , vol.2 , pp. 159-169
    • Yun, C.1    Cho, H.2    Kim, S.J.3
  • 22
    • 75149140916 scopus 로고    scopus 로고
    • Mitotic chromosomal instability and cancer: Mouse modelling of the human disease
    • Schvartzman JM, Sotillo R, Benezra R. Mitotic chromosomal instability and cancer: Mouse modelling of the human disease. Nat Rev Cancer 2010; 10:102–115.
    • (2010) Nat Rev Cancer , vol.10 , pp. 102-115
    • Schvartzman, J.M.1    Sotillo, R.2    Benezra, R.3
  • 23
    • 9144253124 scopus 로고    scopus 로고
    • Slippage of mitotic arrest and enhanced tumor development in mice with BubR1haploinsufficiency
    • Dai W, Wang Q, Liu T, et al. Slippage of mitotic arrest and enhanced tumor development in mice with BubR1haploinsufficiency. Cancer Res 2004; 64:440–445.
    • (2004) Cancer Res , vol.64 , pp. 440-445
    • Dai, W.1    Wang, Q.2    Liu, T.3
  • 24
    • 84927612281 scopus 로고    scopus 로고
    • Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice
    • Yamada HY, Zhang Y, Reddy A, et al. Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice. Carcinogenesis 2015; 36:429–440.
    • (2015) Carcinogenesis , vol.36 , pp. 429-440
    • Yamada, H.Y.1    Zhang, Y.2    Reddy, A.3
  • 25
    • 80053364894 scopus 로고    scopus 로고
    • Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations
    • Janssen A, van der Burg M, Szuhai K, Kops GJ, Medema RH. Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science 2011; 333:1895–1898.
    • (2011) Science , vol.333 , pp. 1895-1898
    • Janssen, A.1    van der Burg, M.2    Szuhai, K.3    Kops, G.J.4    Medema, R.H.5
  • 26
    • 80052153162 scopus 로고    scopus 로고
    • Centrosome clustering and chromosomal (in)stability: A matter of life and death
    • Krämer A, Maier B, Bartek J. Centrosome clustering and chromosomal (in)stability: A matter of life and death. Mol Oncol 2011; 5:324–335.
    • (2011) Mol Oncol , vol.5 , pp. 324-335
    • Krämer, A.1    Maier, B.2    Bartek, J.3
  • 27
    • 84856424908 scopus 로고    scopus 로고
    • DNA breaks and chromosome pulverization from errors in mitosis
    • Crasta K, Ganem NJ, Dagher R, et al. DNA breaks and chromosome pulverization from errors in mitosis. Nature 2012; 482:53–58.
    • (2012) Nature , vol.482 , pp. 53-58
    • Crasta, K.1    Ganem, N.J.2    Dagher, R.3
  • 28
    • 84930941966 scopus 로고    scopus 로고
    • Chromothripsis from DNA damage in micronuclei
    • Zhang CZ, Spektor A, Cornils H, et al. Chromothripsis from DNA damage in micronuclei. Nature 2015; 522:179–184.
    • (2015) Nature , vol.522 , pp. 179-184
    • Zhang, C.Z.1    Spektor, A.2    Cornils, H.3
  • 29
    • 27144518175 scopus 로고    scopus 로고
    • Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines
    • Shi Q, King RW. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature 2005; 437:1038–1042.
    • (2005) Nature , vol.437 , pp. 1038-1042
    • Shi, Q.1    King, R.W.2
  • 30
    • 4644281946 scopus 로고    scopus 로고
    • Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy
    • Vogel C, Kienitz A, Hofmann I, Müller R, Bastians H. Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy. Oncogene 2004; 23:6845–6853.
    • (2004) Oncogene , vol.23 , pp. 6845-6853
    • Vogel, C.1    Kienitz, A.2    Hofmann, I.3    Müller, R.4    Bastians, H.5
  • 31
    • 84857504660 scopus 로고    scopus 로고
    • Cellular senescence and tumor suppressor gene p16
    • Rayess H, Wang MB, Srivatsan ES. Cellular senescence and tumor suppressor gene p16. Int J Cancer 2012; 130:1715–1725.
    • (2012) Int J Cancer , vol.130 , pp. 1715-1725
    • Rayess, H.1    Wang, M.B.2    Srivatsan, E.S.3
  • 32
    • 84908570573 scopus 로고    scopus 로고
    • Cellular senescence and aging: The role of B-MYB
    • Mowla SN, Lam EW, Jat PS. Cellular senescence and aging: The role of B-MYB. Aging Cell 2014; 13:773–779.
    • (2014) Aging Cell , vol.13 , pp. 773-779
    • Mowla, S.N.1    Lam, E.W.2    Jat, P.S.3
  • 33
    • 84929513000 scopus 로고    scopus 로고
    • DNA damage checkpoint recovery and cancer development
    • Wang H, Zhang X, Teng L, Legerski RJ. DNA damage checkpoint recovery and cancer development. Exp Cell Res 2015; 334:350–358.
    • (2015) Exp Cell Res , vol.334 , pp. 350-358
    • Wang, H.1    Zhang, X.2    Teng, L.3    Legerski, R.J.4
  • 34
    • 84924677799 scopus 로고    scopus 로고
    • The same, only different—DNA damage checkpoints and their reversal throughout the cell cycle
    • Shaltiel IA, Krenning L, Bruinsma W, Medema RH. The same, only different—DNA damage checkpoints and their reversal throughout the cell cycle. J Cell Sci 2015; 128:607–620.
    • (2015) J Cell Sci , vol.128 , pp. 607-620
    • Shaltiel, I.A.1    Krenning, L.2    Bruinsma, W.3    Medema, R.H.4
  • 35
    • 84946186771 scopus 로고    scopus 로고
    • A multi-targeted approach to suppress tumor-promoting inflammation
    • Samadi AK, Bilsland A, Georgakilas AG, et al. A multi-targeted approach to suppress tumor-promoting inflammation. Semin Cancer Biol 2015; 35:S151–184.
    • (2015) Semin Cancer Biol , vol.35 , pp. S151-184
    • Samadi, A.K.1    Bilsland, A.2    Georgakilas, A.G.3
  • 38
    • 84900969225 scopus 로고    scopus 로고
    • Ink4a/Arf expression is a biomarker of aging
    • Krishnamurthy J, Torrice C, Ramsey MR, et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004; 114:1299–1307.
    • (2004) J Clin Invest , vol.114 , pp. 1299-1307
    • Krishnamurthy, J.1    Torrice, C.2    Ramsey, M.R.3
  • 39
    • 67651180787 scopus 로고    scopus 로고
    • Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging
    • Liu Y, Sanoff HK, Cho H, et al. Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging. Aging Cell 2009; 8:439–448.
    • (2009) Aging Cell , vol.8 , pp. 439-448
    • Liu, Y.1    Sanoff, H.K.2    Cho, H.3
  • 40
    • 0030612349 scopus 로고    scopus 로고
    • Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging
    • Zindy F, Quelle DE, Roussel MF, Sherr CJ. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene 1997; 15:203–211.
    • (1997) Oncogene , vol.15 , pp. 203-211
    • Zindy, F.1    Quelle, D.E.2    Roussel, M.F.3    Sherr, C.J.4
  • 42
    • 84871963013 scopus 로고    scopus 로고
    • p21WAF1 and tumourigenesis: 20 years after
    • Warfel NA, El-Deiry WS. p21WAF1 and tumourigenesis: 20 years after. Curr Opin Oncol 2013; 25:52–58.
    • (2013) Curr Opin Oncol , vol.25 , pp. 52-58
    • Warfel, N.A.1    El-Deiry, W.S.2
  • 43
    • 84864572894 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor p21(Waf1): Contemporary view on its role in senescence and oncogenesis
    • Romanov VS, Pospelov VA, Pospelova TV. Cyclin-dependent kinase inhibitor p21(Waf1): Contemporary view on its role in senescence and oncogenesis. Biochemistry (Mosc) 2012; 77:575–584.
    • (2012) Biochemistry (Mosc) , vol.77 , pp. 575-584
    • Romanov, V.S.1    Pospelov, V.A.2    Pospelova, T.V.3
  • 44
    • 73649145175 scopus 로고    scopus 로고
    • The function of p27 KIP1 during tumor development
    • Lee J, Kim SS. The function of p27 KIP1 during tumor development. Exp Mol Med 2009; 41:765–771.
    • (2009) Exp Mol Med , vol.41 , pp. 765-771
    • Lee, J.1    Kim, S.S.2
  • 45
    • 33747587608 scopus 로고    scopus 로고
    • Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all
    • Gil J, Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all. Nat Rev Mol Cell Biol 2006; 7:667–677.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 667-677
    • Gil, J.1    Peters, G.2
  • 46
    • 84904702784 scopus 로고    scopus 로고
    • Cellular senescence: From physiology to pathology
    • Muñoz-Espín D, Serrano M. Cellular senescence: From physiology to pathology. Nat Rev Mol Cell Biol 2014; 15:482–496.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 482-496
    • Muñoz-Espín, D.1    Serrano, M.2
  • 47
    • 84961201728 scopus 로고    scopus 로고
    • NKG2D ligands mediate immunosurveillance of senescent cells
    • Sagiv A, Burton DG, Moshayev Z, et al. NKG2D ligands mediate immunosurveillance of senescent cells. Aging (Albany NY) 2016; 8:328–344.
    • (2016) Aging (Albany NY) , vol.8 , pp. 328-344
    • Sagiv, A.1    Burton, D.G.2    Moshayev, Z.3
  • 48
    • 84925944989 scopus 로고    scopus 로고
    • Cellular senescence: From growth arrest to immunogenic conversion
    • Burton DG, Faragher RG. Cellular senescence: From growth arrest to immunogenic conversion. Age (Dordr) 2015; 37:27.
    • (2015) Age (Dordr) , vol.37 , pp. 27
    • Burton, D.G.1    Faragher, R.G.2
  • 49
    • 84904861169 scopus 로고    scopus 로고
    • Immune surveillance of unhealthy cells by natural killer cells
    • Iannello A, Raulet DH. Immune surveillance of unhealthy cells by natural killer cells. Cold Spring Harb Symp Quant Biol 2013; 78:249–257.
    • (2013) Cold Spring Harb Symp Quant Biol , vol.78 , pp. 249-257
    • Iannello, A.1    Raulet, D.H.2
  • 51
    • 84923247523 scopus 로고    scopus 로고
    • Consensus guidelines for the detection of immunogenic cell death
    • Kepp O, Senovilla L, Vitale I, et al. Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology 2014; 3:955691.
    • (2014) Oncoimmunology , vol.3 , pp. 955691
    • Kepp, O.1    Senovilla, L.2    Vitale, I.3
  • 52
    • 84964317484 scopus 로고    scopus 로고
    • Calreticulin expression in human non-small cell lung cancers correlates with increased accumulation of antitumor immune cells and favorable prognosis
    • Fucikova J, Becht E, Iribarren K, et al. Calreticulin expression in human non-small cell lung cancers correlates with increased accumulation of antitumor immune cells and favorable prognosis. Cancer Res 2016; 76:1746–1756.
    • (2016) Cancer Res , vol.76 , pp. 1746-1756
    • Fucikova, J.1    Becht, E.2    Iribarren, K.3
  • 53
    • 55349112533 scopus 로고    scopus 로고
    • Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
    • Williams BR, Prabhu VR, Hunter KE, et al. Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science 2008; 322:703–709.
    • (2008) Science , vol.322 , pp. 703-709
    • Williams, B.R.1    Prabhu, V.R.2    Hunter, K.E.3
  • 54
    • 79951689086 scopus 로고    scopus 로고
    • Identification of aneuploidy-selective antiproliferation compounds
    • Tang YC, Williams BR, Siegel JJ, Amon A. Identification of aneuploidy-selective antiproliferation compounds. Cell 2011; 144:499–512.
    • (2011) Cell , vol.144 , pp. 499-512
    • Tang, Y.C.1    Williams, B.R.2    Siegel, J.J.3    Amon, A.4
  • 55
    • 84943560653 scopus 로고    scopus 로고
    • Aneuploidy-induced cellular stresses limit autophagic degradation
    • Santaguida S, Vasile E, White E, Amon A. Aneuploidy-induced cellular stresses limit autophagic degradation. Genes Dev 2015; 29:2010–2021.
    • (2015) Genes Dev , vol.29 , pp. 2010-2021
    • Santaguida, S.1    Vasile, E.2    White, E.3    Amon, A.4
  • 56
    • 84861591789 scopus 로고    scopus 로고
    • Detectable clonal mosaicism from birth to old age and its relationship to cancer
    • Laurie CC, Laurie CA, Rice K, et al. Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet 2012; 44:642–650.
    • (2012) Nat Genet , vol.44 , pp. 642-650
    • Laurie, C.C.1    Laurie, C.A.2    Rice, K.3
  • 57
    • 84931030132 scopus 로고    scopus 로고
    • Common genetic and epigenetic syndromes
    • Adams DJ, Clark DA. Common genetic and epigenetic syndromes. Pediatr Clin North Am 2015; 62:411–426.
    • (2015) Pediatr Clin North Am , vol.62 , pp. 411-426
    • Adams, D.J.1    Clark, D.A.2
  • 60
    • 84896715917 scopus 로고    scopus 로고
    • Unstable genomes elevate transcriptome dynamics
    • Stevens JB, Liu G, Abdallah BY, et al. Unstable genomes elevate transcriptome dynamics. Int J Cancer 2014; 134:2074–2087.
    • (2014) Int J Cancer , vol.134 , pp. 2074-2087
    • Stevens, J.B.1    Liu, G.2    Abdallah, B.Y.3
  • 62
    • 84887145591 scopus 로고    scopus 로고
    • A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis
    • Sheltzer JM. A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis. Cancer Res 2013; 73:6401–6412.
    • (2013) Cancer Res , vol.73 , pp. 6401-6412
    • Sheltzer, J.M.1
  • 63
    • 78149423336 scopus 로고    scopus 로고
    • Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast
    • Pavelka N, Rancati G, Zhu J, et al. Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature 2010; 468:321–325.
    • (2010) Nature , vol.468 , pp. 321-325
    • Pavelka, N.1    Rancati, G.2    Zhu, J.3
  • 65
    • 84867525305 scopus 로고    scopus 로고
    • A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect
    • Shaukat Z, Wong HW, Nicolson S, Saint RB, Gregory SL. A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect. PLoS ONE 2012; 7:e7447.
    • (2012) PLoS ONE , vol.7
    • Shaukat, Z.1    Wong, H.W.2    Nicolson, S.3    Saint, R.B.4    Gregory, S.L.5
  • 66
    • 84896806608 scopus 로고    scopus 로고
    • JNK signaling is needed to tolerate chromosomal instability
    • Wong HW, Shaukat Z, Wang J, Saint R, Gregory SL. JNK signaling is needed to tolerate chromosomal instability. Cell Cycle 2014; 13:622–631.
    • (2014) Cell Cycle , vol.13 , pp. 622-631
    • Wong, H.W.1    Shaukat, Z.2    Wang, J.3    Saint, R.4    Gregory, S.L.5
  • 67
    • 84938556302 scopus 로고    scopus 로고
    • Chromosomal instability causes sensitivity to metabolic stress
    • Shaukat Z, Liu D, Choo A, et al. Chromosomal instability causes sensitivity to metabolic stress. Oncogene 2015; 34:4044–4055.
    • (2015) Oncogene , vol.34 , pp. 4044-4055
    • Shaukat, Z.1    Liu, D.2    Choo, A.3
  • 68
    • 77953770988 scopus 로고    scopus 로고
    • Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy
    • Suijkerbuijk SJ, van Osch MH, Bos FL, Hanks S, Rahman N, Kops GJ. Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy. Cancer Res 2010; 70:4891–4900.
    • (2010) Cancer Res , vol.70 , pp. 4891-4900
    • Suijkerbuijk, S.J.1    van Osch, M.H.2    Bos, F.L.3    Hanks, S.4    Rahman, N.5    Kops, G.J.6
  • 69
    • 32444444090 scopus 로고    scopus 로고
    • Monoallelic BUB1 B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome
    • Matsuura S, Matsumoto Y, Morishima K, et al. Monoallelic BUB1 B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome. Am J Med Genet A 2006; 140:358–367.
    • (2006) Am J Med Genet A , vol.140 , pp. 358-367
    • Matsuura, S.1    Matsumoto, Y.2    Morishima, K.3
  • 70
    • 84893396021 scopus 로고    scopus 로고
    • TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome
    • Ochiai H, Miyamoto T, Kanai A, et al. TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome. Proc Natl Acad Sci USA 2014; 111:1461–1466.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 1461-1466
    • Ochiai, H.1    Miyamoto, T.2    Kanai, A.3
  • 71
    • 84906066935 scopus 로고    scopus 로고
    • Mosaic variegated aneuploidy in mouse BubR1 deficient embryos and pregnancy loss in human
    • Schmid M, Steinlein C, Tian Q, et al. Mosaic variegated aneuploidy in mouse BubR1 deficient embryos and pregnancy loss in human. Chromosome Res 2014; 22:375–392.
    • (2014) Chromosome Res , vol.22 , pp. 375-392
    • Schmid, M.1    Steinlein, C.2    Tian, Q.3
  • 73
    • 18044394368 scopus 로고    scopus 로고
    • Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells
    • McGuinness BE, Hirota T, Kudo NR, Peters JM, Nasmyth K. Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. PLoS Biol 2005; 3:e86.
    • (2005) PLoS Biol , vol.3
    • McGuinness, B.E.1    Hirota, T.2    Kudo, N.R.3    Peters, J.M.4    Nasmyth, K.5
  • 74
    • 79960997890 scopus 로고    scopus 로고
    • Cleavage of cohesin rings coordinates the separation of centrioles and chromatids
    • Schöckel L, Möckel M, Mayer B, Boos D, Stemmann O. Cleavage of cohesin rings coordinates the separation of centrioles and chromatids. Nat Cell Biol 2011; 13:966–972.
    • (2011) Nat Cell Biol , vol.13 , pp. 966-972
    • Schöckel, L.1    Möckel, M.2    Mayer, B.3    Boos, D.4    Stemmann, O.5
  • 75
    • 84908684632 scopus 로고    scopus 로고
    • Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm
    • Chetaille P, Preuss C, Burkhard S, et al. Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Nat Genet 2014; 46:1245–1249.
    • (2014) Nat Genet , vol.46 , pp. 1245-1249
    • Chetaille, P.1    Preuss, C.2    Burkhard, S.3
  • 76
    • 84876343455 scopus 로고    scopus 로고
    • Aneuploidy in health, disease, and aging
    • Ricke RM, van Deursen JM. Aneuploidy in health, disease, and aging. J Cell Biol 2013; 201:11–21.
    • (2013) J Cell Biol , vol.201 , pp. 11-21
    • Ricke, R.M.1    van Deursen, J.M.2
  • 77
    • 84955705942 scopus 로고    scopus 로고
    • CINcere modelling: What have mouse models for chromosome instability taught us
    • Simon JE, Bakker B, Foijer F. CINcere modelling: What have mouse models for chromosome instability taught us? Recent Results Cancer Res 2015; 200:39–60.
    • (2015) Recent Results Cancer Res , vol.200 , pp. 39-60
    • Simon, J.E.1    Bakker, B.2    Foijer, F.3
  • 78
    • 70249109233 scopus 로고    scopus 로고
    • Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: A perspective from genetic studies in mice
    • Rao CV, Yamada HY, Yao Y, Dai W. Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: A perspective from genetic studies in mice. Carcinogenesis 2009; 30:1469–1474.
    • (2009) Carcinogenesis , vol.30 , pp. 1469-1474
    • Rao, C.V.1    Yamada, H.Y.2    Yao, Y.3    Dai, W.4
  • 80
    • 49849083943 scopus 로고    scopus 로고
    • Whole chromosome instability and cancer: A complex relationship
    • Ricke RM, van Ree JH, van Deursen JM. Whole chromosome instability and cancer: A complex relationship. Trends Genet 2008; 24:457–466.
    • (2008) Trends Genet , vol.24 , pp. 457-466
    • Ricke, R.M.1    van Ree, J.H.2    van Deursen, J.M.3
  • 81
    • 0032478547 scopus 로고    scopus 로고
    • Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint proteinM AD1
    • Jin DY, Spencer F, Jeang KT. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint proteinM AD1. Cell 1998; 93:81–91.
    • (1998) Cell , vol.93 , pp. 81-91
    • Jin, D.Y.1    Spencer, F.2    Jeang, K.T.3
  • 82
    • 33646092999 scopus 로고    scopus 로고
    • Structural activation of Mad2 in the mitotic spindle checkpoint: The two-state Mad2 model versus the Mad2 template model
    • Yu H. Structural activation of Mad2 in the mitotic spindle checkpoint: The two-state Mad2 model versus the Mad2 template model. J Cell Biol 2006; 173:153–157.
    • (2006) J Cell Biol , vol.173 , pp. 153-157
    • Yu, H.1
  • 83
    • 84941029899 scopus 로고    scopus 로고
    • Structure of an intermediate conformer of the spindle checkpoint protein Mad2
    • Hara M, Özkan E, Sun H, Yu H, Luo X. Structure of an intermediate conformer of the spindle checkpoint protein Mad2. Proc Natl Acad Sci USA 2015; 112:11252–11257.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 11252-11257
    • Hara, M.1    Özkan, E.2    Sun, H.3    Yu, H.4    Luo, X.5
  • 84
    • 33846428426 scopus 로고    scopus 로고
    • Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice
    • Iwanaga Y, Chi YH, Miyazato A, et al. Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice. Cancer Res 2007; 67:160–166.
    • (2007) Cancer Res , vol.67 , pp. 160-166
    • Iwanaga, Y.1    Chi, Y.H.2    Miyazato, A.3
  • 85
    • 60549094835 scopus 로고    scopus 로고
    • Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice
    • Chi YH, Ward JM, Cheng LI, Yasunaga J, Jeang KT. Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice. Int J Cancer 2009; 124:1483–1489.
    • (2009) Int J Cancer , vol.124 , pp. 1483-1489
    • Chi, Y.H.1    Ward, J.M.2    Cheng, L.I.3    Yasunaga, J.4    Jeang, K.T.5
  • 86
    • 84865156842 scopus 로고    scopus 로고
    • Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons
    • Ryan SD, Britigan EM, Zasadil LM, et al. Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons. Proc Natl Acad Sci USA 2012; 109:E2205–2214.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. E2205-2214
    • Ryan, S.D.1    Britigan, E.M.2    Zasadil, L.M.3
  • 87
    • 0035905811 scopus 로고    scopus 로고
    • MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
    • Michel LS, Liberal V, Chatterjee A, et al. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 2001; 409:355–359.
    • (2001) Nature , vol.409 , pp. 355-359
    • Michel, L.S.1    Liberal, V.2    Chatterjee, A.3
  • 88
    • 84874260902 scopus 로고    scopus 로고
    • Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells
    • Foijer F, DiTommaso T, Donati G, et al. Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells. Proc Natl Acad Sci USA 2013; 110:2928–2933.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 2928-2933
    • Foijer, F.1    DiTommaso, T.2    Donati, G.3
  • 89
    • 77949773695 scopus 로고    scopus 로고
    • Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
    • Sotillo R, Schvartzman JM, Socci ND, Benezra R. Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 2010; 464:436–440.
    • (2010) Nature , vol.464 , pp. 436-440
    • Sotillo, R.1    Schvartzman, J.M.2    Socci, N.D.3    Benezra, R.4
  • 90
    • 84925009217 scopus 로고    scopus 로고
    • Polyploidy can drive rapid adaptation in yeast
    • Selmecki AM, Maruvka YE, Richmond PA, et al. Polyploidy can drive rapid adaptation in yeast. Nature 2015; 519:349–352.
    • (2015) Nature , vol.519 , pp. 349-352
    • Selmecki, A.M.1    Maruvka, Y.E.2    Richmond, P.A.3
  • 91
    • 84866296846 scopus 로고    scopus 로고
    • Whole chromosome aneuploidy: Big mutations drive adaptation by phenotypic leap
    • Chen G, Rubinstein B, Li R. Whole chromosome aneuploidy: Big mutations drive adaptation by phenotypic leap. Bioessays 2012; 34:893–900.
    • (2012) Bioessays , vol.34 , pp. 893-900
    • Chen, G.1    Rubinstein, B.2    Li, R.3
  • 92
    • 84864007881 scopus 로고    scopus 로고
    • Chromosomal instability (CIN) phenotype, CIN high or CIN low, predicts survival for colorectalcancer
    • Watanabe T, Kobunai T, Yamamoto Y, et al. Chromosomal instability (CIN) phenotype, CIN high or CIN low, predicts survival for colorectalcancer. J Clin Oncol 2012; 30:2256–2264.
    • (2012) J Clin Oncol , vol.30 , pp. 2256-2264
    • Watanabe, T.1    Kobunai, T.2    Yamamoto, Y.3
  • 93
    • 84930209361 scopus 로고    scopus 로고
    • Chromosomal instability as a prognostic marker in cervical cancer
    • How C, Bruce J, So J, et al. Chromosomal instability as a prognostic marker in cervical cancer. BMC Cancer 2015; 15:361.
    • (2015) BMC Cancer , vol.15 , pp. 361
    • How, C.1    Bruce, J.2    So, J.3
  • 94
    • 0037500859 scopus 로고    scopus 로고
    • Chromosomal instability detected by fluorescence in situ hybridization in surgical specimens of non-small cell lung cancer is associated with poor survival
    • Nakamura H, Saji H, Idiris A, et al. Chromosomal instability detected by fluorescence in situ hybridization in surgical specimens of non-small cell lung cancer is associated with poor survival. Clin Cancer Res 2003; 9:2294–2299.
    • (2003) Clin Cancer Res , vol.9 , pp. 2294-2299
    • Nakamura, H.1    Saji, H.2    Idiris, A.3
  • 95
    • 80052558778 scopus 로고    scopus 로고
    • Overexpression of MAD2 predicts clinical outcome in primary lung cancer patients
    • Kato T, Daigo Y, Aragaki M, et al. Overexpression of MAD2 predicts clinical outcome in primary lung cancer patients. Lung Cancer 2011; 74:124–131.
    • (2011) Lung Cancer , vol.74 , pp. 124-131
    • Kato, T.1    Daigo, Y.2    Aragaki, M.3
  • 98
    • 84963642647 scopus 로고    scopus 로고
    • Epidermal development, growth control, and homeostasis in the face of centrosome amplification
    • Kulukian A, Holland AJ, Vitre B, Naik S, Cleveland DW, Fuchs E. Epidermal development, growth control, and homeostasis in the face of centrosome amplification. Proc Natl Acad Sci USA 2015; 112:E6311–6320.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. E6311-6320
    • Kulukian, A.1    Holland, A.J.2    Vitre, B.3    Naik, S.4    Cleveland, D.W.5    Fuchs, E.6
  • 99
    • 84963670630 scopus 로고    scopus 로고
    • Chronic centrosome amplification without tumorigenesis
    • Vitre B, Holland AJ, Kulukian A, et al. Chronic centrosome amplification without tumorigenesis. Proc Natl Acad Sci USA 2015; 112:E6321–6330.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. E6321-6330
    • Vitre, B.1    Holland, A.J.2    Kulukian, A.3
  • 100
    • 84952638225 scopus 로고    scopus 로고
    • Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis
    • Serçin Ö, Larsimont JC, Karambelas AE, et al. Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis. Nat Cell Biol 2016; 18:100–110.
    • (2016) Nat Cell Biol , vol.18 , pp. 100-110
    • Serçin, Ö.1    Larsimont, J.C.2    Karambelas, A.E.3
  • 101
    • 10744222603 scopus 로고    scopus 로고
    • BUBR1 deficiency results in abnormal megakaryopoiesis
    • Wang Q, Liu T, Fang Y, et al. BUBR1 deficiency results in abnormal megakaryopoiesis. Blood 2004; 103:1278–1285.
    • (2004) Blood , vol.103 , pp. 1278-1285
    • Wang, Q.1    Liu, T.2    Fang, Y.3
  • 102
    • 9144253124 scopus 로고    scopus 로고
    • Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency
    • Dai W, Wang Q, Liu T, et al. Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res 2004; 64:440–445.
    • (2004) Cancer Res , vol.64 , pp. 440-445
    • Dai, W.1    Wang, Q.2    Liu, T.3
  • 103
    • 15444370589 scopus 로고    scopus 로고
    • Colonic tumorigenesis in BubR1+/? ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability
    • Rao CV, Yang YM, Swamy MV, et al. Colonic tumorigenesis in BubR1+/? ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proc Natl Acad Sci USA 2005; 102:4365–4370.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4365-4370
    • Rao, C.V.1    Yang, Y.M.2    Swamy, M.V.3
  • 104
    • 84863073742 scopus 로고    scopus 로고
    • BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation
    • Choi E, Park PG, Lee HO, et al. BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation. Dev Cell 2012; 22:295–308.
    • (2012) Dev Cell , vol.22 , pp. 295-308
    • Choi, E.1    Park, P.G.2    Lee, H.O.3
  • 105
    • 67651161889 scopus 로고    scopus 로고
    • BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis
    • Choi E, Choe H, Min J, Choi JY, Kim J, Lee H. BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis. EMBO J 2009; 28:2077–2089.
    • (2009) EMBO J , vol.28 , pp. 2077-2089
    • Choi, E.1    Choe, H.2    Min, J.3    Choi, J.Y.4    Kim, J.5    Lee, H.6
  • 106
    • 84880803876 scopus 로고    scopus 로고
    • Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation
    • Park I, Lee HO, Choi E, et al. Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation. J Cell Biol 2013; 202:295–309.
    • (2013) J Cell Biol , vol.202 , pp. 295-309
    • Park, I.1    Lee, H.O.2    Choi, E.3
  • 107
    • 3042761646 scopus 로고    scopus 로고
    • BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
    • Baker DJ, Jeganathan KB, Cameron JD, et al. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet 2004; 36:744–749.
    • (2004) Nat Genet , vol.36 , pp. 744-749
    • Baker, D.J.1    Jeganathan, K.B.2    Cameron, J.D.3
  • 108
    • 84871717211 scopus 로고    scopus 로고
    • Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
    • Baker DJ, Dawlaty MM, Wijshake T, et al. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol 2013; 15:96–102.
    • (2013) Nat Cell Biol , vol.15 , pp. 96-102
    • Baker, D.J.1    Dawlaty, M.M.2    Wijshake, T.3
  • 109
    • 80855138775 scopus 로고    scopus 로고
    • Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
    • Baker DJ, Wijshake T, Tchkonia T, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011; 479:232–236.
    • (2011) Nature , vol.479 , pp. 232-236
    • Baker, D.J.1    Wijshake, T.2    Tchkonia, T.3
  • 110
    • 84958093401 scopus 로고    scopus 로고
    • Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
    • Baker DJ, Childs BG, Durik M, et al. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature 2016; 530:184–189.
    • (2016) Nature , vol.530 , pp. 184-189
    • Baker, D.J.1    Childs, B.G.2    Durik, M.3
  • 111
    • 84930541259 scopus 로고    scopus 로고
    • BubR1 kinase: Protection against aneuploidy and premature aging
    • Kapanidou M, Lee S, Bolanos-Garcia VM. BubR1 kinase: Protection against aneuploidy and premature aging. Trends Mol Med 2015; 21:364–372.
    • (2015) Trends Mol Med , vol.21 , pp. 364-372
    • Kapanidou, M.1    Lee, S.2    Bolanos-Garcia, V.M.3
  • 112
    • 84903744004 scopus 로고    scopus 로고
    • SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
    • North BJ, Rosenberg MA, Jeganathan KB, et al. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J 2014; 33:1438–1453.
    • (2014) EMBO J , vol.33 , pp. 1438-1453
    • North, B.J.1    Rosenberg, M.A.2    Jeganathan, K.B.3
  • 113
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: Biological insights and disease relevance
    • Haigis MC, Sinclair DA. Mammalian sirtuins: Biological insights and disease relevance. Annu Rev Pathol 2010; 5:253–295.
    • (2010) Annu Rev Pathol , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 115
    • 84923385382 scopus 로고    scopus 로고
    • Spartan deficiency causes genomic instability and progeroid phenotypes
    • Maskey RS, Kim MS, Baker DJ, et al. Spartan deficiency causes genomic instability and progeroid phenotypes. Nat Commun 2014; 5:5744.
    • (2014) Nat Commun , vol.5 , pp. 5744
    • Maskey, R.S.1    Kim, M.S.2    Baker, D.J.3
  • 116
    • 84908674649 scopus 로고    scopus 로고
    • Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features
    • Lessel D, Vaz B, Halder S, et al. Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. Nat Genet 2014; 46:1239–1244.
    • (2014) Nat Genet , vol.46 , pp. 1239-1244
    • Lessel, D.1    Vaz, B.2    Halder, S.3
  • 117
    • 84924872816 scopus 로고    scopus 로고
    • Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model
    • Rao CV, Sanghera S, Zhang Y, et al. Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model. Mol Carcinog 2016; 55:600–610.
    • (2016) Mol Carcinog , vol.55 , pp. 600-610
    • Rao, C.V.1    Sanghera, S.2    Zhang, Y.3
  • 118
    • 84863172276 scopus 로고    scopus 로고
    • Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis
    • Yamada HY, Yao Y, Wang X, et al. Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis. Cell Cycle 2012; 11:479–488.
    • (2012) Cell Cycle , vol.11 , pp. 479-488
    • Yamada, H.Y.1    Yao, Y.2    Wang, X.3
  • 119
    • 84926523961 scopus 로고    scopus 로고
    • Senescence-associated inflammatory responses: Aging and cancer perspectives
    • Lasry A, Ben-Neriah Y. Senescence-associated inflammatory responses: Aging and cancer perspectives. Trends Immunol 2015; 36:217–228.
    • (2015) Trends Immunol , vol.36 , pp. 217-228
    • Lasry, A.1    Ben-Neriah, Y.2
  • 120
    • 84914818823 scopus 로고    scopus 로고
    • Senescent cells: SASPected drivers of age-related pathologies
    • Ovadya Y, Krizhanovsky V. Senescent cells: SASPected drivers of age-related pathologies. Biogerontology 2014; 15:627–642.
    • (2014) Biogerontology , vol.15 , pp. 627-642
    • Ovadya, Y.1    Krizhanovsky, V.2
  • 121
    • 84892731189 scopus 로고    scopus 로고
    • Cellular senescence and its effector programs
    • Salama R, Sadaie M, Hoare M, Narita M. Cellular senescence and its effector programs. Genes Dev 2014; 28:99–114.
    • (2014) Genes Dev , vol.28 , pp. 99-114
    • Salama, R.1    Sadaie, M.2    Hoare, M.3    Narita, M.4
  • 122
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: The dark side of tumor suppression
    • Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: The dark side of tumor suppression. Annu Rev Pathol 2010; 5:99–118.
    • (2010) Annu Rev Pathol , vol.5 , pp. 99-118
    • Coppé, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 123
    • 84966397603 scopus 로고    scopus 로고
    • JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
    • Xu M, Tchkonia T, Ding H, et al. JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age. Proc Natl Acad Sci USA 2015; 112:E6301–6310.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. E6301-6310
    • Xu, M.1    Tchkonia, T.2    Ding, H.3
  • 124
    • 84944584456 scopus 로고    scopus 로고
    • Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2
    • Alimbetov D, Davis T, Brook AJ, et al. Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2. Biogerontology 2016; 17:305–315.
    • (2016) Biogerontology , vol.17 , pp. 305-315
    • Alimbetov, D.1    Davis, T.2    Brook, A.J.3
  • 125
    • 84864010194 scopus 로고    scopus 로고
    • Glucocorticoids suppress selected components of the senescence-associated secretory phenotype
    • Laberge RM, Zhou L, Sarantos MR, et al. Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell 2012; 11:569–578.
    • (2012) Aging Cell , vol.11 , pp. 569-578
    • Laberge, R.M.1    Zhou, L.2    Sarantos, M.R.3
  • 126
    • 84877822086 scopus 로고    scopus 로고
    • Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-êB activation
    • Moiseeva O, Deschênes-Simard X, St-Germain E, et al. Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-êB activation. Aging Cell 2013; 12:489–498.
    • (2013) Aging Cell , vol.12 , pp. 489-498
    • Moiseeva, O.1    Deschênes-Simard, X.2    St-Germain, E.3
  • 127
    • 84938751873 scopus 로고    scopus 로고
    • MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
    • Laberge RM, Sun Y, Orjalo AV, et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol 2015; 17:1049–1061.
    • (2015) Nat Cell Biol , vol.17 , pp. 1049-1061
    • Laberge, R.M.1    Sun, Y.2    Orjalo, A.V.3
  • 128
    • 84940587703 scopus 로고    scopus 로고
    • MTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
    • Herranz N, Gallage S, Mellone M, et al. MTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype. Nat Cell Biol 2015; 17:1205–1217.
    • (2015) Nat Cell Biol , vol.17 , pp. 1205-1217
    • Herranz, N.1    Gallage, S.2    Mellone, M.3
  • 129
    • 84929340201 scopus 로고    scopus 로고
    • Health effects of long-Term rapamycin treatment: The impact on mouse health of enteric rapamycin treatment from four months of age throughout life
    • Fischer KE, Gelfond JA, Soto VY, et al. Health effects of long-Term rapamycin treatment: The impact on mouse health of enteric rapamycin treatment from four months of age throughout life. PLoS ONE 2015; 10:e0126644.
    • (2015) PLoS ONE , vol.10
    • Fischer, K.E.1    Gelfond, J.A.2    Soto, V.Y.3
  • 130
    • 84896834460 scopus 로고    scopus 로고
    • Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome
    • Fok WC, Chen Y, Bokov A, et al. Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS ONE 2014; 9:e83988.
    • (2014) PLoS ONE , vol.9
    • Fok, W.C.1    Chen, Y.2    Bokov, A.3
  • 131
    • 84881247539 scopus 로고    scopus 로고
    • Rapamycin extends murine lifespan but has limited effects on aging
    • Neff F, Flores-Dominguez D, Ryan DP, et al. Rapamycin extends murine lifespan but has limited effects on aging. J Clin Invest 2013; 123:3272–3291.
    • (2013) J Clin Invest , vol.123 , pp. 3272-3291
    • Neff, F.1    Flores-Dominguez, D.2    Ryan, D.P.3
  • 132
    • 84901231782 scopus 로고    scopus 로고
    • Emerging roles of the p38 MAPK and PI3 K/AKT/mTOR pathways in oncogene-induced senescence
    • Xu Y, Li N, Xiang R, Sun P. Emerging roles of the p38 MAPK and PI3 K/AKT/mTOR pathways in oncogene-induced senescence. Trends Biochem Sci 2014; 39:268–276.
    • (2014) Trends Biochem Sci , vol.39 , pp. 268-276
    • Xu, Y.1    Li, N.2    Xiang, R.3    Sun, P.4
  • 133
  • 134
    • 84965032167 scopus 로고    scopus 로고
    • Cancer immunotherapy: The beginning of the end of cancer
    • Farkona S, Diamandis EP, Blasutig IM. Cancer immunotherapy: The beginning of the end of cancer? BMC Med 2016; 14:73.
    • (2016) BMC Med , vol.14 , pp. 73
    • Farkona, S.1    Diamandis, E.P.2    Blasutig, I.M.3
  • 135
    • 84961219372 scopus 로고    scopus 로고
    • The future of cancer treatment: Immunomodulation, CARs and combination immunotherapy
    • Khalil DN, Smith EL, Brentjens RJ, Wolchok JD. The future of cancer treatment: Immunomodulation, CARs and combination immunotherapy. Nat Rev Clin Oncol 2016; 13:273–290.
    • (2016) Nat Rev Clin Oncol , vol.13 , pp. 273-290
    • Khalil, D.N.1    Smith, E.L.2    Brentjens, R.J.3    Wolchok, J.D.4
  • 136
    • 84960422665 scopus 로고    scopus 로고
    • Coussens LM the basis of oncoimmunology
    • Palucka AK. Coussens LM the basis of oncoimmunology. Cell 2016; 164:1233–1247.
    • (2016) Cell , vol.164 , pp. 1233-1247
    • Palucka, A.K.1
  • 137
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon J, Costes A, Sanchez-Cabo F, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 2006; 313:1960–1964.
    • (2006) Science , vol.313 , pp. 1960-1964
    • Galon, J.1    Costes, A.2    Sanchez-Cabo, F.3
  • 138
    • 84885724091 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in humancancer
    • Bindea G, Mlecnik B, Tosolini M, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in humancancer. Immunity 2013; 39:782–795.
    • (2013) Immunity , vol.39 , pp. 782-795
    • Bindea, G.1    Mlecnik, B.2    Tosolini, M.3
  • 139
    • 84959363559 scopus 로고    scopus 로고
    • Immune checkpoint therapy for non-small-cell lung cancer: An update
    • Xia B, Herbst RS. Immune checkpoint therapy for non-small-cell lung cancer: An update. Immunotherapy 2016; 8:279–298.
    • (2016) Immunotherapy , vol.8 , pp. 279-298
    • Xia, B.1    Herbst, R.S.2
  • 142
    • 84876134219 scopus 로고    scopus 로고
    • Granule exocytosis mediates immune surveillance of senescent cells
    • Sagiv A, Biran A, Yon M, Simon J, Lowe SW, Krizhanovsky V. Granule exocytosis mediates immune surveillance of senescent cells. Oncogene 2013; 32:1971–1977.
    • (2013) Oncogene , vol.32 , pp. 1971-1977
    • Sagiv, A.1    Biran, A.2    Yon, M.3    Simon, J.4    Lowe, S.W.5    Krizhanovsky, V.6
  • 143
    • 0037373258 scopus 로고    scopus 로고
    • G1 tetraploidy checkpoint and the suppression of tumorigenesis
    • Margolis RL, Lohez OD, Andreassen PR. G1 tetraploidy checkpoint and the suppression of tumorigenesis. J Cell Biochem 2003; 88:673–683.
    • (2003) J Cell Biochem , vol.88 , pp. 673-683
    • Margolis, R.L.1    Lohez, O.D.2    Andreassen, P.R.3
  • 144
    • 84908128003 scopus 로고    scopus 로고
    • Failure of cell cleavage induces senescence in tetraploid primary cells
    • Panopoulos A, Pacios-Bras C, Choi J, et al. Failure of cell cleavage induces senescence in tetraploid primary cells. Mol Biol Cell 2014; 25:3105–3118.
    • (2014) Mol Biol Cell , vol.25 , pp. 3105-3118
    • Panopoulos, A.1    Pacios-Bras, C.2    Choi, J.3
  • 145
    • 84942853636 scopus 로고    scopus 로고
    • The inner centromere-shugoshin network prevents chromosomal instability
    • Tanno Y, Susumu H, Kawamura M, Sugimura H, Honda T, Watanabe Y. The inner centromere-shugoshin network prevents chromosomal instability. Science 2015; 349:1237–1240.
    • (2015) Science , vol.349 , pp. 1237-1240
    • Tanno, Y.1    Susumu, H.2    Kawamura, M.3    Sugimura, H.4    Honda, T.5    Watanabe, Y.6
  • 146
    • 84923052515 scopus 로고    scopus 로고
    • Sgo1 is a potential therapeutic target for hepatocellular carcinoma
    • Wang LH, Yen CJ, Li TN, Elowe S, Wang WC, Wang LH. Sgo1 is a potential therapeutic target for hepatocellular carcinoma. Oncotarget 2015; 6:2023–2033.
    • (2015) Oncotarget , vol.6 , pp. 2023-2033
    • Wang, L.H.1    Yen, C.J.2    Li, T.N.3    Elowe, S.4    Wang, W.C.5    Wang, L.H.6
  • 147
    • 84886501194 scopus 로고    scopus 로고
    • SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers
    • Matsuura S, Kahyo T, Shinmura K, et al. SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers. Sci Rep 2013; 3:3012.
    • (2013) Sci Rep , vol.3 , pp. 3012
    • Matsuura, S.1    Kahyo, T.2    Shinmura, K.3
  • 148
    • 58849147078 scopus 로고    scopus 로고
    • Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer
    • Iwaizumi M, Shinmura K, Mori H, et al. Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer. Gut 2009; 58:249–260.
    • (2009) Gut , vol.58 , pp. 249-260
    • Iwaizumi, M.1    Shinmura, K.2    Mori, H.3
  • 149
    • 84958212218 scopus 로고    scopus 로고
    • Systemic chromosome instability resulted in colonic transcriptomic changes in metabolic, proliferation, and stem cell regulators in Sgo1−/+ mice
    • Rao CV, Sanghera S, Zhang Y, et al. Systemic chromosome instability resulted in colonic transcriptomic changes in metabolic, proliferation, and stem cell regulators in Sgo1−/+ mice. Cancer Res 2016; 76:630–642.
    • (2016) Cancer Res , vol.76 , pp. 630-642
    • Rao, C.V.1    Sanghera, S.2    Zhang, Y.3
  • 150
    • 85043644085 scopus 로고    scopus 로고
    • Systemic chromosome instability in Shugoshin -1 mice resulted in compromised glutathione pathway, activation of Wnt signaling, and defects in immune system in the lung
    • Yamada HY, Kumar G, Zhang Y, et al. Systemic chromosome instability in Shugoshin -1 mice resulted in compromised glutathione pathway, activation of Wnt signaling, and defects in immune system in the lung. Oncogenesis 2016; 5:e256.
    • (2016) Oncogenesis , vol.5
    • Yamada, H.Y.1    Kumar, G.2    Zhang, Y.3
  • 151
    • 84879692122 scopus 로고    scopus 로고
    • Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation
    • Ly P, Kim SB, Kaisani AA, Marian G, Wright WE, Shay JW. Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation. Oncogene 2013; 32:3139–3146.
    • (2013) Oncogene , vol.32 , pp. 3139-3146
    • Ly, P.1    Kim, S.B.2    Kaisani, A.A.3    Marian, G.4    Wright, W.E.5    Shay, J.W.6
  • 152
    • 84896845618 scopus 로고    scopus 로고
    • Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention
    • Lissa D, Senovilla L, Rello-Varona S, et al. Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention. Proc Natl Acad Sci USA 2014; 111:3020–3025.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 3020-3025
    • Lissa, D.1    Senovilla, L.2    Rello-Varona, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.