Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation

Oncogene

Volumn 32, Issue 26, 2013, Pages 3139-3146

  Ly, P ^a   Kim, S B ^a   Kaisani, A A ^a   Marian, G ^a   Wright, W E ^a   Shay, J W ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

AICAR; aneuploidy; EGFR; chromosomal instability; trisomy

Indexed keywords

5 AMINOIMIDAZOLE 4 CARBOXAMIDE 1 BETA DEXTRO RIBOFURANOSIDE; ANTINEOPLASTIC AGENT; CYTOSTATIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEASOME; UNCLASSIFIED DRUG;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL METABOLISM; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; DIPLOIDY; DOSE RESPONSE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRISOMY 7; TUMOR XENOGRAFT; UBIQUITINATION;

AMINOIMIDAZOLE CARBOXAMIDE; ANEUPLOIDY; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COLON; COLORECTAL NEOPLASMS; EPITHELIAL CELLS; HUMANS; HYPOGLYCEMIC AGENTS; INTESTINAL MUCOSA; LEUPEPTINS; MICE; NEOPLASM TRANSPLANTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTOR, EPIDERMAL GROWTH FACTOR; RIBONUCLEOTIDES; TRANSPLANTATION, HETEROLOGOUS; TRISOMY; UBIQUITINATION;

MURINAE;

EID: 84879692122     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.339     Document Type: Article

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