Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 8, 2014, Pages 3020-3025

  Lissa, Delphine ^a,b,c   Senovilla, Laura ^a,b,d   Rello Varona, Santiago ^a,b,c   Vitale, Ilio ^e   Michaud, Mickaël ^a,b,c   Pietrocola, Federico ^a,b,c   Boilève, Alice ^a,b,c   Obrist, Florine ^a,b,c   Bordenave, Chloé ^a,b,c   Garcia, Pauline ^a,b,c   Michels, Judith ^a,b,c   Jemaà, Mohamed ^a,b,c   Kepp, Oliver ^a,b,f   Castedo, Maria ^a,b,f   Kroemer, Guido ^a,b,f,g  

^a INSERM   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d University Paris XI   (France)

^e REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^f UNIVERSITÉ PARIS DESCARTES   (France)

^g HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; PROTEIN P53; RESVERATROL;

ANIMAL TISSUE; ARTICLE; CARCINOMA CELL; CELL CYCLE PROGRESSION; CHEMOPROPHYLAXIS; COLON CARCINOMA; CONTROLLED STUDY; EPITHELIUM CELL; FLUOROMETRY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POLYPLOIDY; PRIORITY JOURNAL; TETRAPLOIDY; VIDEO MICROSCOPY;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; ASPIRIN; CELL DEATH; CELL LINE, TUMOR; EPITHELIAL CELLS; FLOW CYTOMETRY; IMAGE PROCESSING, COMPUTER-ASSISTED; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MICE, INBRED C57BL; MICROSCOPY, VIDEO; STILBENES; TETRAPLOIDY;

EID: 84896845618     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1318440111     Document Type: Article

References (46)

1. Ganem NJ, Pellman D (2007) Limiting the proliferation of polyploid cells. Cell 131(3):437- 440.
2. Gordon DJ, Resio B, Pellman D (2012) Causes and consequences of aneuploidy in cancer. Nat Rev Genet 13(3):189-203.
3. Storchova Z, Kuffer C (2008) The consequences of tetraploidy and aneuploidy. J Cell Sci 121(Pt 23):3859-3866.
4. Vitale I, et al. (2011) Illicit survival of cancer cells during polyploidization and depolyploidization. Cell Death Differ 18(9):1403-1413.
5. Vitale I, Galluzzi L, Castedo M, Kroemer G (2011) Mitotic catastrophe: A mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol 12(6):385-392.
6. Senovilla L, et al. (2012) An immunosurveillance mechanism controls cancer cell ploidy. Science 337(6102):1678-1684.
7. Davoli T, de Lange T (2011) The causes and consequences of polyploidy in normal development and cancer. Annu Rev Cell Dev Biol 27:585-610.
8. Andreassen PR, Lohez OD, Lacroix FB, Margolis RL (2001) Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. Mol Biol Cell 12(5): 1315-1328. (Pubitemid 33044413)
9. Castedo M, et al. (2006) Apoptosis regulation in tetraploid cancer cells. EMBO J 25(11):2584-2595. (Pubitemid 44012240)
10. Vitale I, et al. (2010) Multipolar mitosis of tetraploid cells: Inhibition by p53 and dependency on Mos. EMBO J 29(7):1272-1284.
11. Boilève A, et al. (2013) Immunosurveillance against tetraploidization-induced colon tumorigenesis. Cell Cycle 12(3):473-479.
12. Fujiwara T, et al. (2005) Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437(7061):1043-1047. (Pubitemid 41486987)
13. Senovilla L, et al. (2009) p53 represses the polyploidization of primary mammary epithelial cells by activating apoptosis. Cell Cycle 8(9):1380-1385.
14. Caldwell CM, Green RA, Kaplan KB (2007) APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. J Cell Biol 178(7):1109-1120. (Pubitemid 47480220)
15. Dikovskaya D, et al. (2007) Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol 176(2):183-195. (Pubitemid 46143259)
16. Weaver BA, Silk AD, Cleveland DW (2006) Cell biology: Nondisjunction, aneuploidy and tetraploidy. Nature 442(7104):E9-E10, discussion E10.
17. Ganem NJ, Godinho SA, Pellman D (2009) A mechanism linking extra centrosomes to chromosomal instability. Nature 460(7252):278-282.
18. Silk AD, et al. (2013) Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors. Proc Natl Acad Sci USA 110(44):E4134-E4141.
19. Vitale I, et al. (2007) Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway. PLoS ONE 2(12):e1337.
20. Marxer M, et al. (2012) Tetraploidization increases sensitivity to Aurora B kinase inhibition. Cell Cycle 11(13):2567-2577.
21. Kwon M, et al. (2008) Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev 22(16):2189-2203.
22. Rello-Varona S, et al. (2009) Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5. Cell Cycle 8(7):1030-1035.
23. Piotrowska H, Kucinska M, Murias M (2012) Biological activity of piceatannol: Leaving the shadow of resveratrol. Mutat Res 750(1):60-82.
24. Potter GA, et al. (2002) The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. Br J Cancer 86(5):774-778. (Pubitemid 34250822)
25. Moreira AC, Silva AM, Santos MS, Sardão VA (2013) Resveratrol affects differently rat liver and brain mitochondrial bioenergetics and oxidative stress in vitro: investigation of the role of gender. Food Chem Toxicol 53:18-26.
26. Zini R, Morin C, Bertelli A, Bertelli AA, Tillement JP (1999) Effects of resveratrol on the rat brain respiratory chain. Drugs Exp Clin Res 25(2-3):87-97. (Pubitemid 29257599)
27. Galluzzi L, et al. (2012) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 19(1):107-120.
28. Park SJ, et al. (2012) Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148(3):421-433.
29. Dyke HJ, Montana JG (2002) Update on the therapeutic potential of PDE4 inhibitors. Expert Opin Investig Drugs 11(1):1-13. (Pubitemid 34048615)
30. Morselli E, et al. (2010) Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 1:e10.
31. Din FV, et al. (2012) Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology 142(7), 1504, e3.
32. Hawley SA, et al. (2012) The ancient drug salicylate directly activates AMP-activated protein kinase. Science 336(6083):918-922.
33. Bunz F, et al. (1999) Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 104(3):263-269.
34. Su LK, et al. (1992) Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256(5057):668-670.
35. Mahmoud NN, et al. (1998) Aspirin prevents tumors in a murine model of familial adenomatous polyposis. Surgery 124(2):225-231. (Pubitemid 28372920)
36. Sale S, et al. (2005) Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4′- tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells. Int J Cancer 115(2):194- 201.
37. Sansom OJ, Stark LA, Dunlop MG, Clarke AR (2001) Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice. Cancer Res 61(19):7060-7064. (Pubitemid 32946497)
38. Schneider Y, et al. (2001) Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis. Nutr Cancer 39(1):102-107. (Pubitemid 32880955)
39. Chung JH, Manganiello V, Dyck JR (2012) Resveratrol as a calorie restriction mimetic: Therapeutic implications. Trends Cell Biol 22(10):546-554.
40. Patel KR, et al. (2011) Clinical trials of resveratrol. Ann N Y Acad Sci 1215:161-169.
41. Rothwell PM, et al. (2011) Effect of daily aspirin on long-term risk of death due to cancer: Analysis of individual patient data from randomised trials. Lancet 377(9759):31- 41.
42. Athar M, Back JH, Kopelovich L, Bickers DR, Kim AL (2009) Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. Arch Biochem Biophys 486(2):95-102.
43. Baur JA, Sinclair DA (2006) Therapeutic potential of resveratrol: The in vivo evidence. Nat Rev Drug Discov 5(6):493-506. (Pubitemid 44136961)
44. Chan AT, Ogino S, Fuchs CS (2007) Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med 356(21):2131-2142. (Pubitemid 47010839)
45. Liao X, et al. (2012) Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med 367(17):1596-1606.
46. Nielsen SF, Nordestgaard BG, Bojesen SE (2012) Statin use and reduced cancer-related mortality. N Engl J Med 367(19):1792-1802.