HBxAPα/Rsf-1-mediated HBx-hBubR1 interactions regulate the mitotic spindle checkpoint and chromosome instability

Carcinogenesis

Volumn 34, Issue 7, 2013, Pages 1680-1688

  Chae, Sunyoung ^a,b   Ji, Jae Hoon ^a   Kwon, Soon Hwan ^a   Lee, Ho Soo ^a   Lim, Jung Mi ^c   Kang, Dongmin ^c   Lee, Chang Woo ^d   Cho, Hyeseong ^a  

^a Ajou University School of Medicine   (South Korea)

^b Ajou University   (South Korea)

^c Ewha Womans University   (South Korea)

^d Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BUB1 RELATED PROTEIN; CELL CYCLE PROTEIN 20; HEPATITIS B VIRUS X PROTEIN; HEPATITIS B VIRUS X PROTEIN ASSOCIATED PROTEIN ALPHA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CENTROMERE; CHROMATIN; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DELETION MUTANT; GENE INDUCTION; GENE SILENCING; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; M PHASE CELL CYCLE CHECKPOINT; MITOSIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REGULATORY MECHANISM;

CELL CYCLE PROTEINS; CHROMOSOMAL INSTABILITY; HEK293 CELLS; HELA CELLS; HUMANS; KINETOCHORES; LIVER NEOPLASMS; M PHASE CELL CYCLE CHECKPOINTS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; SEQUENCE DELETION; TRANS-ACTIVATORS; TRANSFECTION;

EID: 84880263801     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt105     Document Type: Article

References (48)

1. Lengauer, C. et al. (1997) Genetic instability in colorectal cancers. Nature, 386, 623-627.
2. Gollin, S.M. (2004) Chromosomal instability. Curr. Opin. Oncol., 16, 25-31.
3. Holland, A.J. et al. (2009) Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat. Rev. Mol. Cell Biol., 10, 478-487.
4. Kops, G.J. et al. (2005) On the road to cancer: aneuploidy and the mitotic checkpoint. Nat. Rev. Cancer, 5, 773-785.
5. Li, X. et al. (1995) Mitotic forces control a cell-cycle checkpoint. Nature, 373, 630-632.
6. Yu, H. (2002) Regulation of APC-Cdc20 by the spindle checkpoint. Curr. Opin. Cell Biol., 14, 706-714.
7. Sudakin, V. et al. (2001) Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J. Cell Biol., 154, 925-936.
8. Baker, D.J. et al. (2004) BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat. Genet., 36, 744-749.
9. Dobles, M. et al. (2000) Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell, 101, 635-645.
10. Iwanaga, Y. et al. (2007) Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increase the incidence of tumors in mice. Cancer Res., 67, 160-166.
11. Rao, C.V. et al. (2005) Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proc. Natl Acad. Sci. U. S. A., 102, 4365-4370.
12. Parkin, D.M. (2006) The global health burden of infection-associated cancers in the year 2002. Int. J. Cancer, 118, 3030-3044.
13. Llovet, J.M. et al. (2003) Hepatocellular carcinoma. Lancet, 362, 1907-1917.
14. Laurent-Puig, P. et al. (2001) Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology, 120, 1763-1773.
15. Marchio, A. et al. (2000) Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients. Oncogene, 19, 3733-3738.
16. Livezey, K.W. et al. (2002) Increased chromosomal alterations and micronuclei formation in human hepatoma HepG2 cells transfected with the hepatitis B virus HBX gene. Mutat. Res., 505, 63-74.
17. Murakami, S. (2001) Hepatitis B virus X protein: a multifunctional viral regulator. J. Gastroenterol., 36, 651-660.
18. Kim, C.M. et al. (1991) HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature, 351, 317-320.
19. Martin-Lluesma, S. et al. (2008) Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1. Hepatology, 48, 1467-1476.
20. Wu, B.K. et al. (2006) Blocking of G1/S transition and cell death in the regenerating liver of hepatitis B virus X protein transgenic mice. Biochem. Biophys. Res. Commun., 340, 916-928.
21. Hodgson, A.J. et al. (2008) Premature cell cycle entry induced by hepatitis B virus regulatory HBx protein during compensatory liver regeneration. Cancer Res., 68, 10341-10348.
22. Studach, L. et al. (2010) Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidy. J. Biol. Chem., 285, 30282-30293.
23. Rakotomalala, L. et al. (2008) Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy. J. Biol. Chem., 283, 28729-28740.
24. van Breugel, P.C. et al. (2012) Hepatitis B virus X protein stimulates gene expression selectively from extrachromosomal DNA templates. Hepatology, 56, 2116-2124.
25. Neuveut, C. et al. (2010) Mechanisms of HBV-related hepatocarcinogenesis. J. Hepatol., 52, 594-604.
26. Wang, X.W. et al. (2002) Molecular pathogenesis of human hepatocellular carcinoma. Toxicology, 181-182, 43-47.
27. Kim, S. et al. (2008) HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint. Oncogene, 27, 3457-3464.
28. Fujii, R. et al. (2006) HBXIP, cellular target of hepatitis B virus oncoprotein, is a regulator of centrosome dynamics and cytokinesis. Cancer Res., 66, 9099-9107.
29. Yun, C. et al. (2004) Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogenactivated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway. Mol. Cancer Res., 2, 159-169.
30. Shamay, M. et al. (2002) Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. J. Biol. Chem., 277, 9982-9988.
31. Shamay, M. et al. (2002) HBXAP, a novel PHD-finger protein, possesses transcription repression activity. Genomics, 79, 523-529.
32. LeRoy, G. et al. (1998) Requirement of RSF and FACT for transcription of chromatin templates in vitro. Science, 282, 1900-1904.
33. Loyola, A. et al. (2001) Reconstitution of recombinant chromatin establishes a requirement for histone-tail modifications during chromatin assembly and transcription. Genes Dev., 15, 2837-2851.
34. Loyola, A. et al. (2003) Functional analysis of the subunits of the chromatin assembly factor RSF. Mol. Cell. Biol., 23, 6759-6768.
35. Sheu, J.J. et al. (2008) The roles of human sucrose nonfermenting protein 2 homologue in the tumor-promoting functions of Rsf-1. Cancer Res., 68, 4050-4057.
36. Shih, Ie. M. et al. (2005) Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma. Proc. Natl Acad. Sci. U. S. A., 102, 14004-14009.
37. Fang, F.M. et al. (2011) Overexpression of a chromatin remodeling factor, RSF-1/HBXAP, correlates with aggressive oral squamous cell carcinoma. Am. J. Pathol., 178, 2407-2415.
38. Li, Q. et al. (2012) Rsf-1 is overexpressed in non-small cell lung cancers and regulates cyclinD1 expression and ERK activity. Biochem. Biophys. Res. Commun., 420, 6-10.
39. Perpelescu, M. et al. (2009) Active establishment of centromeric CENP-A chromatin by RSF complex. J. Cell Biol., 185, 397-407.
40. Yun, C. et al. (2000) Chemotherapeutic drug, adriamycin, restores the function of p53 protein in hepatitis B virus X (HBx) protein-expressing liver cells. Oncogene, 19, 5163-5172.
41. Meraldi, P. et al. (2004) Timing and checkpoints in the regulation of mitotic progression. Dev. Cell, 7, 45-60.
42. Tang, H. et al. (2005) The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication. J. Virol., 79, 5548-5556.
43. Liu, H. et al. (2009) Effect of a conserved peptide derived from Kunitz domain of hepatitis B virus x protein on the cell cycle and apoptosis of HepG2 cells via the proteasome pathway. Chin. Med. J. (Engl.), 122, 460-465.
44. Cleveland, D.W. et al. (2003) Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell, 112, 407-421.
45. Liu, S. et al. (2012) Rsf-1 overexpression correlates with poor prognosis and cell proliferation in colon cancer. Tumour Biol., 33, 1485-1491.
46. Tai, H.C. et al. (2012) Associations of Rsf-1 overexpression with poor therapeutic response and worse survival in patients with nasopharyngeal carcinoma. J. Clin. Pathol., 65, 248-253.
47. Sheu, J.J. et al. (2010) Rsf-1, a chromatin remodeling protein, induces DNA damage and promotes genomic instability. J. Biol. Chem., 285, 38260-38269.
48. Wen, Y. et al. (2008) Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle formation. J. Biol. Chem., 283, 2793-2803.