Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 36, 2011, Pages 14944-14949

  Toller, Isabella M ^a   Neelsen, Kai J ^a   Steger, Martin ^a   Hartung, Mara L ^a   Hottiger, Michael O ^a   Stucki, Manuel ^a   Kalali, Behnam ^b   Gerhard, Markus ^b   Sartori, Alessandro A ^a   Lopes, Massimo ^a   Müller, Anne ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Chromosome breaks; DNA damage signaling; Gastric tumorigenesis; Genomic instability

Indexed keywords

ADHESIN; ATR PROTEIN; CAGA PROTEIN; CELL NUCLEUS DNA; DOUBLE STRANDED DNA; HISTONE H2AX; MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; CARCINOGENICITY; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; EPITHELIUM CELL; GENETIC STABILITY; HELICOBACTER PYLORI; HOST CELL; HUMAN; HUMAN CELL; MAMMAL CELL; MESENCHYME CELL; METAPHASE CHROMOSOME; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL ADHESION; BACTERIAL PROTEINS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME ABERRATIONS; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; EPITHELIAL CELLS; GENOMIC ISLANDS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HISTONES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; STOMACH NEOPLASMS; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA; BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI; MAMMALIA; MURINAE;

EID: 80052607184     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1100959108     Document Type: Article

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