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Volumn 10, Issue 5, 2015, Pages

Health effects of long-term rapamycin treatment: The impact on mouse health of enteric rapamycin treatment from four months of age throughout life

Author keywords

[No Author keywords available]

Indexed keywords

RAPAMYCIN;

EID: 84929340201     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0126644     Document Type: Article
Times cited : (64)

References (46)
  • 1
    • 84883785478 scopus 로고    scopus 로고
    • Late-life rapamycin treatment reverses age-related heart dysfunction
    • PMID: 23734717
    • Flynn JM, O'Leary MN, Zambataro CA, Academia EC, Presley MP, Garrett BJ, et al. Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell. 2013; 12(5):851-62. doi: 10.1111/acel. 12109 PMID: 23734717.
    • (2013) Aging Cell. , vol.12 , Issue.5 , pp. 851-862
    • Flynn, J.M.1    O'Leary, M.N.2    Zambataro, C.A.3    Academia, E.C.4    Presley, M.P.5    Garrett, B.J.6
  • 2
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • PMID: 19587680
    • Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009; 460(7253):392-5. doi: 10.1038/ nature08221 PMID: 19587680
    • (2009) Nature. , vol.460 , Issue.7253 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 3
    • 79951794971 scopus 로고    scopus 로고
    • Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
    • Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de CR, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. JGerontolA BiolSciMedSci. 2011; 66 (2):191-201. doi: glq178 [pii];doi: 10.1093/gerona/glq178
    • (2011) JGerontolA BiolSciMedSci. , vol.66 , Issue.2 , pp. 191-201
    • Miller, R.A.1    Harrison, D.E.2    Astle, C.M.3    Baur, J.A.4    Boyd, A.R.5    De, C.R.6
  • 4
    • 83755165458 scopus 로고    scopus 로고
    • Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
    • PMID: 22107964
    • Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, et al. Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle. 2011; 10(24):4230-6. doi: 18486 [pii];doi: 10.4161/cc.10.24.18486 PMID: 22107964
    • (2011) Cell Cycle. , vol.10 , Issue.24 , pp. 4230-4236
    • Anisimov, V.N.1    Zabezhinski, M.A.2    Popovich, I.G.3    Piskunova, T.S.4    Semenchenko, A.V.5    Tyndyk, M.L.6
  • 5
    • 75549090275 scopus 로고    scopus 로고
    • MTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    • Chen C, Liu Y, Liu Y, Zheng P. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. SciSignal. 2009; 2(98):ra75.
    • (2009) SciSignal. , vol.2 , Issue.98 , pp. ra75
    • Chen, C.1    Liu, Y.2    Liu, Y.3    Zheng, P.4
  • 6
    • 35648995939 scopus 로고    scopus 로고
    • MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae
    • PMID: 17914901
    • Medvedik O, Lamming DW, Kim KD, Sinclair DA. MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol. 2007; 5(10):e261. doi: 06-PLBI-RA-0346 [pii];doi: 10.1371/journal.pbio.0050261 PMID: 17914901
    • (2007) PLoS Biol. , vol.5 , Issue.10 , pp. e261
    • Medvedik, O.1    Lamming, D.W.2    Kim, K.D.3    Sinclair, D.A.4
  • 7
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • PMID: 16418483
    • Powers RW III, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 2006; 20(2):174-84. PMID: 16418483
    • (2006) Genes Dev. , vol.20 , Issue.2 , pp. 174-184
    • Powers, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 8
    • 77955747346 scopus 로고    scopus 로고
    • With TOR, less is more: A key role for the conserved nutrient-sensing TOR pathway in aging
    • PMID: 20519118
    • Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, et al. With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab. 2010; 11(6):453-65. doi: S1550-4131(10)00153-1 [pii];doi: 10.1016/j.cmet.2010.05.001 PMID: 20519118
    • (2010) Cell Metab. , vol.11 , Issue.6 , pp. 453-465
    • Kapahi, P.1    Chen, D.2    Rogers, A.N.3    Katewa, S.D.4    Li, P.W.5    Thomas, E.L.6
  • 9
    • 27744511769 scopus 로고    scopus 로고
    • Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
    • PMID: 16293764
    • Kaeberlein M, Powers RW III, Steffen KK, Westman EA, Hu D, Dang N, et al. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science. 2005; 310(5751):1193-6. PMID: 16293764
    • (2005) Science. , vol.310 , Issue.5751 , pp. 1193-1196
    • Kaeberlein, M.1    Powers, R.W.2    Steffen, K.K.3    Westman, E.A.4    Hu, D.5    Dang, N.6
  • 10
    • 79954632599 scopus 로고    scopus 로고
    • Role of TOR signaling in aging and related biological processes in Drosophila melanogaster
    • Epub 2010/12/07, PMID: 21130151; PubMed Central PMCID: PMCPmc3058120
    • Katewa SD, Kapahi P. Role of TOR signaling in aging and related biological processes in Drosophila melanogaster. Experimental gerontology. 2011; 46(5):382-90. Epub 2010/12/07. doi: 10.1016/j.exger. 2010.11.036 PMID: 21130151; PubMed Central PMCID: PMCPmc3058120.
    • (2011) Experimental Gerontology. , vol.46 , Issue.5 , pp. 382-390
    • Katewa, S.D.1    Kapahi, P.2
  • 12
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • PMID: 16469695
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell. 2006; 124(3):471-84. doi: S0092-8674(06)00108-5 [pii];doi: 10.1016/j.cell.2006.01.016 PMID: 16469695
    • (2006) Cell. , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 13
    • 77951227122 scopus 로고    scopus 로고
    • Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: Effects on cognitive impairments
    • PMID: 20178983
    • Caccamo A, Majumder S, Richardson A, Strong R, Oddo S. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. JBiolChem. 2010; 285(17):13107-20. doi: M110.100420 [pii];doi: 10.1074/jbc.M110.100420 PMID: 20178983
    • (2010) JBiolChem. , vol.285 , Issue.17 , pp. 13107-13120
    • Caccamo, A.1    Majumder, S.2    Richardson, A.3    Strong, R.4    Oddo, S.5
  • 14
    • 77956305343 scopus 로고    scopus 로고
    • Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
    • PMID: 20376313
    • Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, et al. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoSOne. 2010; 5(4):e9979. doi: 10.1371/journal.pone.0009979 PMID: 20376313
    • (2010) PLoSOne. , vol.5 , Issue.4 , pp. e9979
    • Spilman, P.1    Podlutskaya, N.2    Hart, M.J.3    Debnath, J.4    Gorostiza, O.5    Bredesen, D.6
  • 16
    • 84872564714 scopus 로고    scopus 로고
    • Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice
    • Epub 2012/11/06. PMID: 23123616; PubMed Central PMCID: PMCPmc3517941
    • Komarova EA, Antoch MP, Novototskaya LR, Chernova OB, Paszkiewicz G, Leontieva OV, et al. Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice. Aging. 2012; 4 (10):709-14. Epub 2012/11/06. PMID: 23123616; PubMed Central PMCID: PMCPmc3517941.
    • (2012) Aging. , vol.4 , Issue.10 , pp. 709-714
    • Komarova, E.A.1    Antoch, M.P.2    Novototskaya, L.R.3    Chernova, O.B.4    Paszkiewicz, G.5    Leontieva, O.V.6
  • 17
    • 84874987821 scopus 로고    scopus 로고
    • Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors
    • PMID: 23454836; PubMed Central PMCID: PMC3616197
    • Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, et al. Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors. Aging. 2013; 5(2):100-10. PMID: 23454836; PubMed Central PMCID: PMC3616197.
    • (2013) Aging. , vol.5 , Issue.2 , pp. 100-110
    • Livi, C.B.1    Hardman, R.L.2    Christy, B.A.3    Dodds, S.G.4    Jones, D.5    Williams, C.6
  • 18
    • 26044448312 scopus 로고    scopus 로고
    • Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein e knockout mice: Inhibitory effect on monocyte chemotaxis
    • PMID: 16160601
    • Pakala R, Stabile E, Jang GJ, Clavijo L, Waksman R. Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein E knockout mice: inhibitory effect on monocyte chemotaxis. J CardiovascPharmacol. 2005; 46(4):481-6. PMID: 16160601
    • (2005) J CardiovascPharmacol. , vol.46 , Issue.4 , pp. 481-486
    • Pakala, R.1    Stabile, E.2    Jang, G.J.3    Clavijo, L.4    Waksman, R.5
  • 19
    • 84858342119 scopus 로고    scopus 로고
    • Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1beta and enhancing NMDA signaling
    • Majumder S, Caccamo A, Medina DX, Benavides AD, Javors MA, Kraig E, et al. Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1beta and enhancing NMDA signaling. Aging Cell. 2011. doi: 10.1111/j.1474-9726.2011.00791.x
    • Aging Cell. , vol.2011
    • Majumder, S.1    Caccamo, A.2    Medina, D.X.3    Benavides, A.D.4    Javors, M.A.5    Kraig, E.6
  • 20
    • 84865525400 scopus 로고    scopus 로고
    • Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
    • Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, et al. Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience. 2012; 223C:102-13. doi: S0306-4522(12)00672-0 [pii];doi: 10.1016/j.neuroscience.2012.06.054
    • (2012) Neuroscience. , vol.223 , pp. 102-113
    • Halloran, J.1    Hussong, S.A.2    Burbank, R.3    Podlutskaya, N.4    Fischer, K.E.5    Sloane, L.B.6
  • 21
    • 84881247539 scopus 로고    scopus 로고
    • Rapamycin extends murine lifespan but has limited effects on aging
    • Epub 2013/07/19, PMID: 23863708; PubMed Central PMCID: PMCPmc3726163
    • Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schroder S, Adler T, et al. Rapamycin extends murine lifespan but has limited effects on aging. The Journal of clinical investigation. 2013; 123(8):3272-91. Epub 2013/07/19. doi: 10.1172/jci67674 PMID: 23863708; PubMed Central PMCID: PMCPmc3726163.
    • (2013) The Journal of Clinical Investigation. , vol.123 , Issue.8 , pp. 3272-3291
    • Neff, F.1    Flores-Dominguez, D.2    Ryan, D.P.3    Horsch, M.4    Schroder, S.5    Adler, T.6
  • 22
    • 84875331396 scopus 로고    scopus 로고
    • Duration of rapamycin treatment has differential effects on metabolism in mice
    • PMID: 23473038; PubMed Central PMCID: PMC3658445
    • Fang Y, Westbrook R, Hill C, Boparai RK, Arum O, Spong A, et al. Duration of rapamycin treatment has differential effects on metabolism in mice. Cell Metab. 2013; 17(3):456-62. doi: 10.1016/j.cmet.2013. 02.008 PMID: 23473038; PubMed Central PMCID: PMC3658445.
    • (2013) Cell Metab. , vol.17 , Issue.3 , pp. 456-462
    • Fang, Y.1    Westbrook, R.2    Hill, C.3    Boparai, R.K.4    Arum, O.5    Spong, A.6
  • 23
    • 84857926653 scopus 로고    scopus 로고
    • Rapamycin slows aging in mice
    • Epub 2012/02/24, PMID: 22356747
    • Spong A, Bartke A. Rapamycin slows aging in mice. Cell Cycle. 2012; 11(5):845. Epub 2012/02/24. doi: 10.4161/cc.11.5.19607 PMID: 22356747.
    • (2012) Cell Cycle. , vol.11 , Issue.5 , pp. 845
    • Spong, A.1    Bartke, A.2
  • 24
    • 84859117806 scopus 로고    scopus 로고
    • Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
    • PMID: 22461615
    • Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012; 335 (6076):1638-43. doi: 335/6076/1638 [pii];doi: 10.1126/science.1215135 PMID: 22461615
    • (2012) Science. , vol.335 , Issue.6076 , pp. 1638-1643
    • Lamming, D.W.1    Ye, L.2    Katajisto, P.3    Goncalves, M.D.4    Saitoh, M.5    Stevens, D.M.6
  • 25
    • 84880507764 scopus 로고    scopus 로고
    • Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive
    • PMID: 23648089; PubMed Central PMCID: PMC3727050
    • Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE. Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. Aging Cell. 2013; 12(4):712-8. doi: 10.1111/acel.12097 PMID: 23648089; PubMed Central PMCID: PMC3727050.
    • (2013) Aging Cell. , vol.12 , Issue.4 , pp. 712-718
    • Lamming, D.W.1    Ye, L.2    Astle, C.M.3    Baur, J.A.4    Sabatini, D.M.5    Harrison, D.E.6
  • 26
    • 0347626159 scopus 로고    scopus 로고
    • Current immunosuppressive agents: Efficacy, side effects, and utilization
    • PMID: 14710781
    • Smith JM, Nemeth TL, McDonald RA. Current immunosuppressive agents: efficacy, side effects, and utilization. PediatrClinNorth Am. 2003; 50(6):1283-300. PMID: 14710781
    • (2003) PediatrClinNorth Am. , vol.50 , Issue.6 , pp. 1283-1300
    • Smith, J.M.1    Nemeth, T.L.2    McDonald, R.A.3
  • 27
    • 84899440403 scopus 로고    scopus 로고
    • Effect of different immunosuppressive drugs on immune cells from young and old healthy persons
    • Epub 2014/01/18, PMID: 24434865
    • Welzl K, Kern G, Mayer G, Weinberger B, Saemann MD, Sturm G, et al. Effect of different immunosuppressive drugs on immune cells from young and old healthy persons. Gerontology. 2014; 60(3):229-38. Epub 2014/01/18. doi: 10.1159/000356020 PMID: 24434865.
    • (2014) Gerontology. , vol.60 , Issue.3 , pp. 229-238
    • Welzl, K.1    Kern, G.2    Mayer, G.3    Weinberger, B.4    Saemann, M.D.5    Sturm, G.6
  • 28
    • 84868302065 scopus 로고    scopus 로고
    • Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence
    • PMID: 22981852
    • Hinojosa CA, Mgbemena V, Van RS, Austad SN, Miller RA, Bose S, et al. Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. ExpGerontol. 2012; 47(12):958-65. doi: S0531-5565(12)00250-1 [pii];doi: 10.1016/j.exger.2012.08. 013 PMID: 22981852
    • (2012) ExpGerontol. , vol.47 , Issue.12 , pp. 958-965
    • Hinojosa, C.A.1    Mgbemena, V.2    Van Rs Austad, S.N.3    Miller, R.A.4    Bose, S.5
  • 30
    • 79955486262 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids
    • PMID: 21430254
    • Dickinson JM, Fry CS, Drummond MJ, Gundermann DM, Walker DK, Glynn EL, et al. Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids. JNutr. 2011; 141(5):856-62. doi: jn.111.139485 [pii];doi: 10.3945/ jn.111.139485 PMID: 21430254
    • (2011) JNutr. , vol.141 , Issue.5 , pp. 856-862
    • Dickinson, J.M.1    Fry, C.S.2    Drummond, M.J.3    Gundermann, D.M.4    Walker, D.K.5    Glynn, E.L.6
  • 31
  • 32
    • 79952763934 scopus 로고    scopus 로고
    • Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex i (mTORC1) blocks long-term synaptic plasticity and memory storage
    • PMID: 21307309
    • Stoica L, Zhu PJ, Huang W, Zhou H, Kozma SC, Costa-Mattioli M. Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage. ProcNatlAcadSciUSA. 2011; 108(9):3791-6. doi: 1014715108 [pii];doi: 10.1073/pnas. 1014715108 PMID: 21307309
    • (2011) ProcNatlAcadSciUSA. , vol.108 , Issue.9 , pp. 3791-3796
    • Stoica, L.1    Zhu, P.J.2    Huang, W.3    Zhou, H.4    Kozma, S.C.5    Costa-Mattioli, M.6
  • 33
    • 33845606405 scopus 로고    scopus 로고
    • Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons
    • PMID: 17167087
    • Parsons RG, Gafford GM, Helmstetter FJ. Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons. JNeurosci. 2006; 26(50):12977-83. doi: 26/50/12977 [pii];doi: 10.1523/JNEUROSCI.4209-06.2006 PMID: 17167087
    • (2006) JNeurosci. , vol.26 , Issue.50 , pp. 12977-12983
    • Parsons, R.G.1    Gafford, G.M.2    Helmstetter, F.J.3
  • 34
    • 33747890068 scopus 로고    scopus 로고
    • Tacrolimus and sirolimus cause insulin resistance in normal sprague dawley rats
    • PMID: 16926589
    • Larsen JL, Bennett RG, Burkman T, Ramirez AL, Yamamoto S, Gulizia J, et al. Tacrolimus and sirolimus cause insulin resistance in normal sprague dawley rats. Transplantation. 2006; 82(4):466-70. doi: 10.1097/01.tp.0000229384.22217.15;00007890-200608270-00005 [pii]. PMID: 16926589
    • (2006) Transplantation. , vol.82 , Issue.4 , pp. 466-470
    • Larsen, J.L.1    Bennett, R.G.2    Burkman, T.3    Ramirez, A.L.4    Yamamoto, S.5    Gulizia, J.6
  • 35
    • 84896834460 scopus 로고    scopus 로고
    • Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome
    • Epub 2014/01/11, PMID: 24409289; PubMed Central PMCID: PMCPmc3883653
    • Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, et al. Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PLoS One. 2014; 9(1):e83988. Epub 2014/01/11. doi: 10.1371/journal.pone.0083988 PMID: 24409289; PubMed Central PMCID: PMCPmc3883653.
    • (2014) PLoS One. , vol.9 , Issue.1 , pp. e83988
    • Fok, W.C.1    Chen, Y.2    Bokov, A.3    Zhang, Y.4    Salmon, A.B.5    Diaz, V.6
  • 36
    • 31344478502 scopus 로고    scopus 로고
    • Housing density does not influence the longevity effect of calorie restriction
    • PMID: 16424282
    • Ikeno Y, Hubbard GB, Lee S, Richardson A, Strong R, Diaz V, et al. Housing density does not influence the longevity effect of calorie restriction. JGerontolA BiolSciMedSci. 2005; 60(12):1510-7. PMID: 16424282
    • (2005) JGerontolA BiolSciMedSci. , vol.60 , Issue.12 , pp. 1510-1517
    • Ikeno, Y.1    Hubbard, G.B.2    Lee, S.3    Richardson, A.4    Strong, R.5    Diaz, V.6
  • 38
    • 78651468722 scopus 로고    scopus 로고
    • Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    • Epub 2010/11/26, PMID: 21094524; PubMed Central PMCID: PMCPmc3018849
    • Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, et al. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell. 2010; 143 (5):802-12. Epub 2010/11/26. doi: 10.1016/j.cell.2010.10.002 PMID: 21094524; PubMed Central PMCID: PMCPmc3018849.
    • (2010) Cell. , vol.143 , Issue.5 , pp. 802-812
    • Someya, S.1    Yu, W.2    Hallows, W.C.3    Xu, J.4    Vann, J.M.5    Leeuwenburgh, C.6
  • 40
    • 73349109524 scopus 로고    scopus 로고
    • Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis
    • Epub 2009/11/11, PMID: 19901338; PubMed Central PMCID: PMCPmc2780799
    • Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, et al. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc Natl Acad Sci U S A. 2009; 106 (46):19432-7. Epub 2009/11/11. doi: 10.1073/pnas.0908786106 PMID: 19901338; PubMed Central PMCID: PMCPmc2780799.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , Issue.46 , pp. 19432-19437
    • Someya, S.1    Xu, J.2    Kondo, K.3    Ding, D.4    Salvi, R.J.5    Yamasoba, T.6
  • 41
    • 33947728561 scopus 로고    scopus 로고
    • Novel method for high-throughput phenotyping of sleep in mice
    • PMID: 16985007
    • Pack AI, Galante RJ, Maislin G, Cater J, Metaxas D, Lu S, et al. Novel method for high-throughput phenotyping of sleep in mice. Physiol Genomics. 2007; 28(2):232-8. doi: 00139.2006 [pii];doi: 10.1152/ physiolgenomics.00139.2006 PMID: 16985007
    • (2007) Physiol Genomics. , vol.28 , Issue.2 , pp. 232-238
    • Pack, A.I.1    Galante, R.J.2    Maislin, G.3    Cater, J.4    Metaxas, D.5    Lu, S.6
  • 42
    • 0029805021 scopus 로고    scopus 로고
    • Step length reductions in advanced age: The role of ankle and hip kinetics
    • PMID: 8914503
    • Judge JO, Davis RB III, Ounpuu S. Step length reductions in advanced age: the role of ankle and hip kinetics. JGerontolA BiolSciMedSci. 1996; 51(6):M303-M12. PMID: 8914503
    • (1996) JGerontolA BiolSciMedSci. , vol.51 , Issue.6 , pp. M303-M12
    • Judge, J.O.1    Davis, R.B.2    Ounpuu, S.3
  • 43
    • 0041466271 scopus 로고    scopus 로고
    • Differences among eight inbred strains of mice in motor ability and motor learning on a rotorod
    • PMID: 12953787
    • McFadyen MP, Kusek G, Bolivar VJ, Flaherty L. Differences among eight inbred strains of mice in motor ability and motor learning on a rotorod. Genes Brain Behav. 2003; 2(4):214-9. PMID: 12953787
    • (2003) Genes Brain Behav. , vol.2 , Issue.4 , pp. 214-219
    • McFadyen, M.P.1    Kusek, G.2    Bolivar, V.J.3    Flaherty, L.4
  • 44
    • 84966281067 scopus 로고    scopus 로고
    • How many ways can mouse behavioral experiments go wrong? Confounding variables in mouse models of neurodegenerative diseases and how to control them
    • Brockman HJ. Burlington, VT: Academic Press
    • Schellinck HMC DP, Brown RE. How many ways can mouse behavioral experiments go wrong? Confounding variables in mouse models of neurodegenerative diseases and how to control them. In: Brockman HJ, editor. Advances in the Study of Behavior. Burlington, VT: Academic Press; 2010. p. 255- 366.
    • (2010) Advances in the Study of Behavior , pp. 255-366
    • Schellinck, H.M.C.D.P.1    Brown, R.E.2
  • 45
    • 84901403995 scopus 로고    scopus 로고
    • Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
    • Epub 2013/12/18, PMID: 24341993; PubMed Central PMCID: PMCPmc4032600
    • Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, et al. Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell. 2014; 13(3):468-77. Epub 2013/12/18. doi: 10.1111/acel.12194 PMID: 24341993; PubMed Central PMCID: PMCPmc4032600.
    • (2014) Aging Cell. , vol.13 , Issue.3 , pp. 468-477
    • Miller, R.A.1    Harrison, D.E.2    Astle, C.M.3    Fernandez, E.4    Flurkey, K.5    Han, M.6
  • 46
    • 84887076737 scopus 로고    scopus 로고
    • ScientiFig: A tool to build publication-ready scientific figures
    • PMID: 24173380
    • Aigouy B, Mirouse V. ScientiFig: a tool to build publication-ready scientific figures. Nature methods. 2013; 10(11):1048. doi: 10.1038/nmeth.2692 PMID: 24173380.
    • (2013) Nature Methods. , vol.10 , Issue.11 , pp. 1048
    • Aigouy, B.1    Mirouse, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.