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Volumn 34, Issue 10, 2012, Pages 893-900

Whole chromosome aneuploidy: Big mutations drive adaptation by phenotypic leap

Author keywords

Adaptation; Aneuploidy; Population; Stress

Indexed keywords

ANEUPLOIDY; ANGIOGENESIS; ARTICLE; CANDIDA ALBICANS; CARCINOGENESIS; CELL PROLIFERATION; CHROMOSOMAL INSTABILITY; COPY NUMBER VARIATION; CRYPTOCOCCUS NEOFORMANS; DOWN SYNDROME; ENVIRONMENTAL STRESS; EVOLUTIONARY ADAPTATION; GENE DELETION; GENE MUTATION; GENETIC VARIABILITY; HUMAN; KARYOTYPE; LEISHMANIA; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PHENOTYPE; SACCHAROMYCES CEREVISIAE; STRESS; WELLBEING;

EID: 84866296846     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201200069     Document Type: Article
Times cited : (59)

References (74)
  • 1
  • 2
    • 0035462116 scopus 로고    scopus 로고
    • Evolutionary conservation between budding yeast and human kinetochores
    • Kitagawa K, Hieter P. 2001. Evolutionary conservation between budding yeast and human kinetochores. Nat Rev Mol Cell Biol 2: 678- 87.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 678-687
    • Kitagawa, K.1    Hieter, P.2
  • 3
    • 77951196642 scopus 로고    scopus 로고
    • Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal
    • Maresca TJ, Salmon ED. 2010. Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal. J Cell Sci 123: 825- 35.
    • (2010) J Cell Sci , vol.123 , pp. 825-835
    • Maresca, T.J.1    Salmon, E.D.2
  • 4
    • 0346155805 scopus 로고    scopus 로고
    • The spindle assembly and spindle position checkpoints
    • Lew DJ, Burke DJ. 2003. The spindle assembly and spindle position checkpoints. Annu Rev Genet 37: 251- 82.
    • (2003) Annu Rev Genet , vol.37 , pp. 251-282
    • Lew, D.J.1    Burke, D.J.2
  • 5
    • 77956858683 scopus 로고    scopus 로고
    • Genomic plasticity of the human fungal pathogen Candida albicans
    • Selmecki A, Forche A, Berman J. 2010. Genomic plasticity of the human fungal pathogen Candida albicans. Eukaryot Cell 9: 991- 1008.
    • (2010) Eukaryot Cell , vol.9 , pp. 991-1008
    • Selmecki, A.1    Forche, A.2    Berman, J.3
  • 6
    • 78649636162 scopus 로고    scopus 로고
    • Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer
    • Pavelka N, Rancati G, Li R. 2010. Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer. Curr Opin Cell Biol 22: 809- 15.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 809-815
    • Pavelka, N.1    Rancati, G.2    Li, R.3
  • 7
    • 84857192718 scopus 로고    scopus 로고
    • Causes and consequences of aneuploidy in cancer
    • Gordon DJ, Resio B, Pellman D. 2012. Causes and consequences of aneuploidy in cancer. Nat Rev Genet 13: 189- 203.
    • (2012) Nat Rev Genet , vol.13 , pp. 189-203
    • Gordon, D.J.1    Resio, B.2    Pellman, D.3
  • 8
    • 80054054260 scopus 로고    scopus 로고
    • The aneuploidy paradox: costs and benefits of an incorrect karyotype
    • Sheltzer JM, Amon A. 2011. The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends Genet 27: 446- 53.
    • (2011) Trends Genet , vol.27 , pp. 446-453
    • Sheltzer, J.M.1    Amon, A.2
  • 9
    • 13144260659 scopus 로고    scopus 로고
    • Down syndrome and genetics - a case of linked histories
    • Patterson D, Costa ACS. 2005. Down syndrome and genetics - a case of linked histories. Nat Rev Genet 6: 137- 47.
    • (2005) Nat Rev Genet , vol.6 , pp. 137-147
    • Patterson, D.1    Costa, A.C.S.2
  • 10
    • 67649522162 scopus 로고    scopus 로고
    • Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
    • Holland AJ, Cleveland DW. 2009. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol 10: 478- 87.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 478-487
    • Holland, A.J.1    Cleveland, D.W.2
  • 12
    • 77958004840 scopus 로고    scopus 로고
    • The ploidy conveyor of mature hepatocytes as a source of genetic variation
    • Duncan AW, Taylor MH, Hickey RD, Hanlon Newell AE, et al. 2010. The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature 467: 707- 10.
    • (2010) Nature , vol.467 , pp. 707-710
    • Duncan, A.W.1    Taylor, M.H.2    Hickey, R.D.3    Hanlon Newell, A.E.4
  • 14
    • 17444446946 scopus 로고    scopus 로고
    • Widespread aneuploidy revealed by DNA microarray expression profiling
    • Hughes TR, Roberts CJ, Dai H, Jones AR, et al. 2000. Widespread aneuploidy revealed by DNA microarray expression profiling. Nat Genet 25: 333- 7.
    • (2000) Nat Genet , vol.25 , pp. 333-337
    • Hughes, T.R.1    Roberts, C.J.2    Dai, H.3    Jones, A.R.4
  • 15
    • 55449107183 scopus 로고    scopus 로고
    • Variations in stress sensitivity and genomic expression in diverse S. cerevisiae isolates
    • Kvitek DJ, Will JL, Gasch AP. 2008. Variations in stress sensitivity and genomic expression in diverse S. cerevisiae isolates. PLoS Genet 4: e1000223.
    • (2008) PLoS Genet , vol.4
    • Kvitek, D.J.1    Will, J.L.2    Gasch, A.P.3
  • 16
    • 0031951769 scopus 로고    scopus 로고
    • Chromosomal polymorphism and adaptation to specific industrial environments of Saccharomyces strains
    • Codon AC, Benitez T, Korhola M. 1998. Chromosomal polymorphism and adaptation to specific industrial environments of Saccharomyces strains. Appl Microbiol Biotechnol 49: 154- 63.
    • (1998) Appl Microbiol Biotechnol , vol.49 , pp. 154-163
    • Codon, A.C.1    Benitez, T.2    Korhola, M.3
  • 17
    • 3042732668 scopus 로고    scopus 로고
    • Aneuploidy and copy number breakpoints in the genome of lager yeasts mapped by microarray hybridisation
    • Bond U, Neal C, Donnelly D, James T. 2004. Aneuploidy and copy number breakpoints in the genome of lager yeasts mapped by microarray hybridisation. Curr Genet 45: 360- 70.
    • (2004) Curr Genet , vol.45 , pp. 360-370
    • Bond, U.1    Neal, C.2    Donnelly, D.3    James, T.4
  • 18
    • 79952262678 scopus 로고    scopus 로고
    • Whole-genome comparison reveals novel genetic elements that characterize the genome of industrial strains of Saccharomyces cerevisiae
    • Borneman AR, Desany BA, Riches D, Affourtit JP, et al. 2011. Whole-genome comparison reveals novel genetic elements that characterize the genome of industrial strains of Saccharomyces cerevisiae. PLoS Genet 7: e1001287.
    • (2011) PLoS Genet , vol.7
    • Borneman, A.R.1    Desany, B.A.2    Riches, D.3    Affourtit, J.P.4
  • 19
    • 0347361696 scopus 로고    scopus 로고
    • Genome-wide amplifications caused by chromosomal rearrangements play a major role in the adaptive evolution of natural yeast
    • Infante JJ, Dombek KM, Rebordinos L, Cantoral JM, et al. 2003. Genome-wide amplifications caused by chromosomal rearrangements play a major role in the adaptive evolution of natural yeast. Genetics 165: 1745- 59.
    • (2003) Genetics , vol.165 , pp. 1745-1759
    • Infante, J.J.1    Dombek, K.M.2    Rebordinos, L.3    Cantoral, J.M.4
  • 20
    • 43549104936 scopus 로고    scopus 로고
    • Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans
    • Hu G, Liu I, Sham A, Stajich JE, et al. 2008. Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans. Genome Biol 9: R41.
    • (2008) Genome Biol , vol.9
    • Hu, G.1    Liu, I.2    Sham, A.3    Stajich, J.E.4
  • 21
    • 33746506280 scopus 로고    scopus 로고
    • Aneuploidy and isochromosome formation in drug-resistant Candida albicans
    • Selmecki A, Forche A, Berman J. 2006. Aneuploidy and isochromosome formation in drug-resistant Candida albicans. Science 313: 367- 70.
    • (2006) Science , vol.313 , pp. 367-370
    • Selmecki, A.1    Forche, A.2    Berman, J.3
  • 22
    • 77954047286 scopus 로고    scopus 로고
    • Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes
    • Sionov E, Lee H, Chang YC, Kwon-Chung KJ. 2010. Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes. PLoS Pathog 6: e1000848.
    • (2010) PLoS Pathog , vol.6
    • Sionov, E.1    Lee, H.2    Chang, Y.C.3    Kwon-Chung, K.J.4
  • 24
    • 83055181962 scopus 로고    scopus 로고
    • Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania
    • Rogers MB, Hilley JD, Dickens NJ, Wilkes J, et al. 2011. Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania. Genome Res 21: 2129- 42.
    • (2011) Genome Res , vol.21 , pp. 2129-2142
    • Rogers, M.B.1    Hilley, J.D.2    Dickens, N.J.3    Wilkes, J.4
  • 25
    • 64849083163 scopus 로고    scopus 로고
    • Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector
    • Akopyants NS, Kimblin N, Secundino N, Patrick R, et al. 2009. Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector. Science 324: 265- 8.
    • (2009) Science , vol.324 , pp. 265-268
    • Akopyants, N.S.1    Kimblin, N.2    Secundino, N.3    Patrick, R.4
  • 26
    • 66749169417 scopus 로고    scopus 로고
    • Chromosome instability is common in human cleavage-stage embryos
    • Vanneste E, Voet T, Le Caignec C, Ampe M, et al. 2009. Chromosome instability is common in human cleavage-stage embryos. Nat Med 15: 577- 83.
    • (2009) Nat Med , vol.15 , pp. 577-583
    • Vanneste, E.1    Voet, T.2    Le Caignec, C.3    Ampe, M.4
  • 29
    • 79959652880 scopus 로고    scopus 로고
    • Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy
    • Ozery-Flato M, Linhart C, Trakhtenbrot L, Izraeli S, et al. 2011. Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy. Genome Biol 12: R61.
    • (2011) Genome Biol , vol.12
    • Ozery-Flato, M.1    Linhart, C.2    Trakhtenbrot, L.3    Izraeli, S.4
  • 30
    • 37049012350 scopus 로고    scopus 로고
    • Aneuploidy and confined chromosomal mosaicism in the developing human brain
    • Yurov YB, Iourov IY, Vorsanova SG, Liehr T, et al. 2007. Aneuploidy and confined chromosomal mosaicism in the developing human brain. PLoS One 2: e558.
    • (2007) PLoS One , vol.2
    • Yurov, Y.B.1    Iourov, I.Y.2    Vorsanova, S.G.3    Liehr, T.4
  • 31
    • 20044379205 scopus 로고    scopus 로고
    • Constitutional aneuploidy in the normal human brain
    • Rehen SK, Yung YC, McCreight MP, Kaushal D, et al. 2005. Constitutional aneuploidy in the normal human brain. J Neurosci 25: 2176- 80.
    • (2005) J Neurosci , vol.25 , pp. 2176-2180
    • Rehen, S.K.1    Yung, Y.C.2    McCreight, M.P.3    Kaushal, D.4
  • 32
    • 79251575297 scopus 로고    scopus 로고
    • Phenotypic consequences of aneuploidy in Arabidopsis thaliana
    • Henry IM, Dilkes BP, Miller ES, Burkart-Waco D, et al. 2010. Phenotypic consequences of aneuploidy in Arabidopsis thaliana. Genetics 186: 1231- 45.
    • (2010) Genetics , vol.186 , pp. 1231-1245
    • Henry, I.M.1    Dilkes, B.P.2    Miller, E.S.3    Burkart-Waco, D.4
  • 33
    • 55449135552 scopus 로고    scopus 로고
    • Effects of aneuploidy on genome structure, expression, and interphase organization in Arabidopsis thaliana
    • Huettel B, Kreil DP, Matzke M, Matzke AJ. 2008. Effects of aneuploidy on genome structure, expression, and interphase organization in Arabidopsis thaliana. PLoS Genet 4: e1000226.
    • (2008) PLoS Genet , vol.4
    • Huettel, B.1    Kreil, D.P.2    Matzke, M.3    Matzke, A.J.4
  • 34
    • 78149423336 scopus 로고    scopus 로고
    • Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast
    • Pavelka N, Rancati G, Zhu J, Bradford WD, et al. 2010. Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature 468: 321- 5.
    • (2010) Nature , vol.468 , pp. 321-325
    • Pavelka, N.1    Rancati, G.2    Zhu, J.3    Bradford, W.D.4
  • 35
    • 41749113291 scopus 로고    scopus 로고
    • An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
    • Selmecki A, Gerami-Nejad M, Paulson C, Forche A, et al. 2008. An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1. Mol Microbiol 68: 624- 41.
    • (2008) Mol Microbiol , vol.68 , pp. 624-641
    • Selmecki, A.1    Gerami-Nejad, M.2    Paulson, C.3    Forche, A.4
  • 36
    • 34548131710 scopus 로고    scopus 로고
    • Effects of aneuploidy on cellular physiology and cell division in haploid yeast
    • Torres EM, Sokolsky T, Tucker CM, Chan LY, et al. 2007. Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science 317: 916- 24.
    • (2007) Science , vol.317 , pp. 916-924
    • Torres, E.M.1    Sokolsky, T.2    Tucker, C.M.3    Chan, L.Y.4
  • 37
    • 56349088536 scopus 로고    scopus 로고
    • Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor
    • Rancati G, Pavelka N, Fleharty B, Noll A, et al. 2008. Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor. Cell 135: 879- 93.
    • (2008) Cell , vol.135 , pp. 879-893
    • Rancati, G.1    Pavelka, N.2    Fleharty, B.3    Noll, A.4
  • 38
    • 34547433234 scopus 로고    scopus 로고
    • Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations
    • Gao C, Furge K, Koeman J, Dykema K, et al. 2007. Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations. Proc Natl Acad Sci USA 104: 8995- 9000.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8995-9000
    • Gao, C.1    Furge, K.2    Koeman, J.3    Dykema, K.4
  • 39
    • 55349112533 scopus 로고    scopus 로고
    • Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
    • Williams BR, Prabhu VR, Hunter KE, Glazier CM, et al. 2008. Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science 322: 703- 9.
    • (2008) Science , vol.322 , pp. 703-709
    • Williams, B.R.1    Prabhu, V.R.2    Hunter, K.E.3    Glazier, C.M.4
  • 40
    • 4944234694 scopus 로고    scopus 로고
    • Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells
    • Upender MB, Habermann JK, McShane LM, Korn EL, et al. 2004. Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells. Cancer Res 64: 6941- 9.
    • (2004) Cancer Res , vol.64 , pp. 6941-6949
    • Upender, M.B.1    Habermann, J.K.2    McShane, L.M.3    Korn, E.L.4
  • 41
  • 42
    • 84862777815 scopus 로고    scopus 로고
    • Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy
    • Chen G, Bradford WD, Seidel CW, Li R. 2012. Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy. Nature 482: 246- 50.
    • (2012) Nature , vol.482 , pp. 246-250
    • Chen, G.1    Bradford, W.D.2    Seidel, C.W.3    Li, R.4
  • 43
    • 0037326058 scopus 로고    scopus 로고
    • Direct evidence for a critical role of myosin II in budding yeast cytokinesis and the evolvability of new cytokinetic mechanisms in the absence of myosin II
    • Tolliday N, Pitcher M, Li R. 2003. Direct evidence for a critical role of myosin II in budding yeast cytokinesis and the evolvability of new cytokinetic mechanisms in the absence of myosin II. Mol Biol Cell 14: 798- 809.
    • (2003) Mol Biol Cell , vol.14 , pp. 798-809
    • Tolliday, N.1    Pitcher, M.2    Li, R.3
  • 44
    • 80051871652 scopus 로고    scopus 로고
    • Aneuploidy drives genomic instability in yeast
    • Sheltzer JM, Blank HM, Pfau SJ, Tange Y, et al. 2011. Aneuploidy drives genomic instability in yeast. Science 333: 1026- 30.
    • (2011) Science , vol.333 , pp. 1026-1030
    • Sheltzer, J.M.1    Blank, H.M.2    Pfau, S.J.3    Tange, Y.4
  • 45
    • 34447546660 scopus 로고    scopus 로고
    • The distribution of fitness effects of new mutations
    • Eyre-Walker A, Keightley PD. 2007. The distribution of fitness effects of new mutations. Nat Rev Genet 8: 610- 8.
    • (2007) Nat Rev Genet , vol.8 , pp. 610-618
    • Eyre-Walker, A.1    Keightley, P.D.2
  • 46
    • 78049443323 scopus 로고    scopus 로고
    • Proteomic changes resulting from gene copy number variations in cancer cells
    • Geiger T, Cox J, Mann M. 2010. Proteomic changes resulting from gene copy number variations in cancer cells. PLoS Genet 6: e1001090.
    • (2010) PLoS Genet , vol.6
    • Geiger, T.1    Cox, J.2    Mann, M.3
  • 47
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. 2000. The hallmarks of cancer. Cell 100: 57- 70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 48
    • 33645789057 scopus 로고    scopus 로고
    • Understanding the basis for Down syndrome phenotypes
    • Roper RJ, Reeves RH. 2006. Understanding the basis for Down syndrome phenotypes. PLoS Genet 2: e50.
    • (2006) PLoS Genet , vol.2
    • Roper, R.J.1    Reeves, R.H.2
  • 50
    • 67650376000 scopus 로고    scopus 로고
    • Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective
    • Heng HH, Bremer SW, Stevens JB. Ye KJ, et al. 2009. Genetic and epigenetic heterogeneity in cancer: a genome-centric perspective. J Cell Physiol 220: 538- 47.
    • (2009) J Cell Physiol , vol.220 , pp. 538-547
    • Heng, H.H.1    Bremer, S.W.2    Stevens, J.B.3    Ye, K.J.4
  • 51
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial
    • Grimwade D, Walker H, Oliver F, Wheatley K, et al. 1998. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1, 612 patients entered into the MRC AML 10 trial. Blood 92: 2322- 33.
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3    Wheatley, K.4
  • 52
    • 0037089420 scopus 로고    scopus 로고
    • Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia
    • Le Beau MM, Bitts S, Davis EM, Kogan SC. 2002. Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia. Blood 99: 2985- 91.
    • (2002) Blood , vol.99 , pp. 2985-2991
    • Le Beau, M.M.1    Bitts, S.2    Davis, E.M.3    Kogan, S.C.4
  • 53
    • 78649395022 scopus 로고    scopus 로고
    • Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia
    • Jones L, Wei G, Sevcikova S, Phan V, et al. 2010. Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia. J Exp Med 207: 2581- 94.
    • (2010) J Exp Med , vol.207 , pp. 2581-2594
    • Jones, L.1    Wei, G.2    Sevcikova, S.3    Phan, V.4
  • 54
    • 0342905433 scopus 로고    scopus 로고
    • Risks of leukaemia and solid tumours in individuals with Down's syndrome
    • Hasle H, Clemmensen IH, Mikkelsen M. 2000. Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet 355: 165- 9.
    • (2000) Lancet , vol.355 , pp. 165-169
    • Hasle, H.1    Clemmensen, I.H.2    Mikkelsen, M.3
  • 55
    • 0037160991 scopus 로고    scopus 로고
    • Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study
    • Yang Q, Rasmussen SA, Friedman JM. 2002. Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet 359: 1019- 25.
    • (2002) Lancet , vol.359 , pp. 1019-1025
    • Yang, Q.1    Rasmussen, S.A.2    Friedman, J.M.3
  • 56
    • 0032941980 scopus 로고    scopus 로고
    • Transient myeloproliferative disorder (transient leukemia) and hematologic manifestations of Down syndrome
    • vii.
    • Zipursky A, Brown EJ, Christensen H, Doyle J. 1999. Transient myeloproliferative disorder (transient leukemia) and hematologic manifestations of Down syndrome. Clin Lab Med 19: 157- 67 vii.
    • (1999) Clin Lab Med , vol.19 , pp. 157-167
    • Zipursky, A.1    Brown, E.J.2    Christensen, H.3    Doyle, J.4
  • 57
    • 38349119730 scopus 로고    scopus 로고
    • Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome
    • Kirsammer G, Jilani S, Liu H, Davis E, et al. 2008. Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood 111: 767- 75.
    • (2008) Blood , vol.111 , pp. 767-775
    • Kirsammer, G.1    Jilani, S.2    Liu, H.3    Davis, E.4
  • 58
    • 77952978963 scopus 로고    scopus 로고
    • Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome
    • Ng AP, Hyland CD, Metcalf D, Carmichael CL, et al. 2010. Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood 115: 3966- 9.
    • (2010) Blood , vol.115 , pp. 3966-3969
    • Ng, A.P.1    Hyland, C.D.2    Metcalf, D.3    Carmichael, C.L.4
  • 59
    • 79953766940 scopus 로고    scopus 로고
    • Tumour evolution inferred by single-cell sequencing
    • Navin N, Kendall J, Troge J, Andrews P, et al. 2011. Tumour evolution inferred by single-cell sequencing. Nature 472: 90- 4.
    • (2011) Nature , vol.472 , pp. 90-94
    • Navin, N.1    Kendall, J.2    Troge, J.3    Andrews, P.4
  • 60
    • 0001815526 scopus 로고
    • Simultaneous detection of changes in chromosome number, gene conversion and intergenic recombination during mitosis of Saccharomyces cerevisiae: spontaneous and ultraviolet light induced events
    • Esposito MS, Maleas DT, Bjornstad KA, Bruschi CV. 1982. Simultaneous detection of changes in chromosome number, gene conversion and intergenic recombination during mitosis of Saccharomyces cerevisiae: spontaneous and ultraviolet light induced events. Curr Genet 6: 5- 11.
    • (1982) Curr Genet , vol.6 , pp. 5-11
    • Esposito, M.S.1    Maleas, D.T.2    Bjornstad, K.A.3    Bruschi, C.V.4
  • 61
    • 40849138236 scopus 로고    scopus 로고
    • Estimating the per-base-pair mutation rate in the yeast Saccharomyces cerevisiae
    • Lang GI, Murray AW. 2008. Estimating the per-base-pair mutation rate in the yeast Saccharomyces cerevisiae. Genetics 178: 67- 82.
    • (2008) Genetics , vol.178 , pp. 67-82
    • Lang, G.I.1    Murray, A.W.2
  • 62
    • 48249133274 scopus 로고    scopus 로고
    • A genome-wide view of the spectrum of spontaneous mutations in yeast
    • Lynch M, Sung W, Morris K, Coffey N, et al. 2008. A genome-wide view of the spectrum of spontaneous mutations in yeast. Proc Natl Acad Sci USA 105: 9272- 7.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 9272-9277
    • Lynch, M.1    Sung, W.2    Morris, K.3    Coffey, N.4
  • 64
    • 10644258336 scopus 로고    scopus 로고
    • Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
    • Hanks S, Coleman K, Reid S, Plaja A, et al. 2004. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet 36: 1159- 61.
    • (2004) Nat Genet , vol.36 , pp. 1159-1161
    • Hanks, S.1    Coleman, K.2    Reid, S.3    Plaja, A.4
  • 65
    • 79957612407 scopus 로고    scopus 로고
    • Mutations in CEP57 cause mosaic variegated aneuploidy syndrome
    • Snape K, Hanks S, Ruark E, Barros-Núñez P, et al. 2011. Mutations in CEP57 cause mosaic variegated aneuploidy syndrome. Nat Genet 43: 527- 9.
    • (2011) Nat Genet , vol.43 , pp. 527-529
    • Snape, K.1    Hanks, S.2    Ruark, E.3    Barros-Núñez, P.4
  • 67
    • 0036744787 scopus 로고    scopus 로고
    • Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E
    • Putkey FR, Cramer T, Morphew MK, Silk AD, et al. 2002. Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell 3: 351- 65.
    • (2002) Dev Cell , vol.3 , pp. 351-365
    • Putkey, F.R.1    Cramer, T.2    Morphew, M.K.3    Silk, A.D.4
  • 68
    • 0037173049 scopus 로고    scopus 로고
    • Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore
    • Stemmann O, Neidig A, Köcher T, Wilm M, et al. 2002. Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore. Proc Natl Acad Sci USA 99: 8585- 90.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8585-8590
    • Stemmann, O.1    Neidig, A.2    Köcher, T.3    Wilm, M.4
  • 69
    • 3042842156 scopus 로고    scopus 로고
    • Sgt1p and Skp1p modulate the assembly and turnover of CBF3 complexes required for proper kinetochore function
    • Rodrigo-Brenni MC, Thomas S, Bouck DC, Kaplan KB. 2004. Sgt1p and Skp1p modulate the assembly and turnover of CBF3 complexes required for proper kinetochore function. Mol Biol Cell 15: 3366- 78.
    • (2004) Mol Biol Cell , vol.15 , pp. 3366-3378
    • Rodrigo-Brenni, M.C.1    Thomas, S.2    Bouck, D.C.3    Kaplan, K.B.4
  • 70
    • 80052563657 scopus 로고    scopus 로고
    • Stress alters rates and types of loss of heterozygosity in Candida albicans
    • pii:
    • Forche A, Abbey D, Pisithkul T, Weinzierl MA, et al. 2011. Stress alters rates and types of loss of heterozygosity in Candida albicans. MBio 2: pii: e00129-11.
    • (2011) MBio , vol.2
    • Forche, A.1    Abbey, D.2    Pisithkul, T.3    Weinzierl, M.A.4
  • 71
    • 25844519550 scopus 로고    scopus 로고
    • HSP90 and the chaperoning of cancer
    • Whitesell L, Lindquist SL. 2005. HSP90 and the chaperoning of cancer. Nat Rev Cancer 5: 761- 72.
    • (2005) Nat Rev Cancer , vol.5 , pp. 761-772
    • Whitesell, L.1    Lindquist, S.L.2
  • 72
    • 79951689086 scopus 로고    scopus 로고
    • Identification of aneuploidy-selective antiproliferation compounds
    • Tang YC, Williams BR, Siegel JJ, Amon A. 2011. Identification of aneuploidy-selective antiproliferation compounds. Cell 144: 499- 512.
    • (2011) Cell , vol.144 , pp. 499-512
    • Tang, Y.C.1    Williams, B.R.2    Siegel, J.J.3    Amon, A.4
  • 73
    • 77951198477 scopus 로고    scopus 로고
    • Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites
    • Davies AE, Kaplan KB. 2010. Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites. J Cell Biol 189: 261- 74.
    • (2010) J Cell Biol , vol.189 , pp. 261-274
    • Davies, A.E.1    Kaplan, K.B.2
  • 74
    • 33746045662 scopus 로고    scopus 로고
    • 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation
    • Niikura Y, Ohta S, Vandenbeldt KJ, Abdulle R, et al. 2006. 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. Oncogene 25: 4133- 46.
    • (2006) Oncogene , vol.25 , pp. 4133-4146
    • Niikura, Y.1    Ohta, S.2    Vandenbeldt, K.J.3    Abdulle, R.4


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