메뉴 건너뛰기




Volumn 513, Issue 7517, 2014, Pages 202-209

Comprehensive molecular characterization of gastric adenocarcinoma

(255)  Bass, Adam J a   Thorsson, Vesteinn b   Shmulevich, Ilya b   Reynolds, Sheila M b   Miller, Michael b   Bernard, Brady b   Hinoue, Toshinori c   Laird, Peter W c   Curtis, Christina d   Shen, Hui c   Weisenberger, Daniel J c   Schultz, Nikolaus e   Shen, Ronglai e   Weinhold, Nils e   Kelsen, David P e   Bowlby, Reanne f   Chu, Andy f   Kasaian, Katayoon f   Mungall, Andrew J f   Robertson, A Gordon f   more..


Author keywords

[No Author keywords available]

Indexed keywords

DNA; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; JANUS KINASE 2; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; PROTEIN TYROSINE KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEOME;

EID: 84907270779     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13480     Document Type: Article
Times cited : (4846)

References (41)
  • 1
    • 84892961071 scopus 로고    scopus 로고
    • GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide
    • accessed on January 15, 2014
    • Ferlay, J. et al. GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide. IARC CancerBase 11, http://globocan.iarc.fr, accessed on January 15, 2014 (2013).
    • (2013) IARC CancerBase , vol.11
    • Ferlay, J.1
  • 2
    • 12644292106 scopus 로고
    • The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma
    • Laurén, P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol., Microbiol. Scand. 64, 31-49 (1965).
    • (1965) Acta Pathol., Microbiol. Scand. , vol.64 , pp. 31-49
    • Laurén, P.1
  • 3
    • 77955179596 scopus 로고    scopus 로고
    • International Agency for Research on Cancer
    • th edn (International Agency for Research on Cancer, 2010).
    • (2010) th Edn
  • 4
    • 0035856021 scopus 로고    scopus 로고
    • Helicobacter pylori infection and the development of gastric cancer
    • Uemura, N. et al. Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 345, 784-789 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , pp. 784-789
    • Uemura, N.1
  • 5
    • 67650073366 scopus 로고    scopus 로고
    • Recent patterns in gastric cancer: A global overview
    • Bertuccio, P. et al. Recent patterns in gastric cancer: a global overview. International J. Cancer 125, 666-673 (2009).
    • (2009) International J. Cancer , vol.125 , pp. 666-673
    • Bertuccio, P.1
  • 6
    • 0033029710 scopus 로고    scopus 로고
    • Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer
    • Richards, F. M. et al. Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. Hum.Mol. Genet. 8, 607-610 (1999).
    • (1999) Hum.Mol. Genet. , vol.8 , pp. 607-610
    • Richards, F.M.1
  • 7
    • 0029825370 scopus 로고    scopus 로고
    • Analysis for microsatellite instability and mutations of the DNA mismatch repair gene hMLH1 in familial gastric cancer
    • Keller, G. et al. Analysis for microsatellite instability and mutations of the DNA mismatch repair gene hMLH1 in familial gastric cancer. International J Cancer 68, 571-576 (1996).
    • (1996) International J Cancer , vol.68 , pp. 571-576
    • Keller, G.1
  • 8
    • 0033229890 scopus 로고    scopus 로고
    • Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
    • Toyota, M. et al. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res. 59, 5438-5442 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 5438-5442
    • Toyota, M.1
  • 9
    • 80051486834 scopus 로고    scopus 로고
    • Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy
    • Tan, I. B. et al. Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. Gastroenterology 141, 476-485 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 476-485
    • Tan, I.B.1
  • 10
    • 84883185766 scopus 로고    scopus 로고
    • Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil
    • Lei, Z. et al. Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil. Gastroenterology 145, 554-565 (2013).
    • (2013) Gastroenterology , vol.145 , pp. 554-565
    • Lei, Z.1
  • 11
    • 0038576352 scopus 로고    scopus 로고
    • Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer
    • Boussioutas, A. et al. Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer. Cancer Res. 63, 2569-2577 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 2569-2577
    • Boussioutas, A.1
  • 12
    • 82255183148 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
    • Wang, K. et al. Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nature Genet. 43, 1219-1223 (2011).
    • (2011) Nature Genet. , vol.43 , pp. 1219-1223
    • Wang, K.1
  • 13
    • 70449331456 scopus 로고    scopus 로고
    • Integrative clustering ofmultiple genomicdata types using a joint latent variablemodel with application to breast and lung cancer subtype analysis
    • Shen, R., Olshen, A. B.&Ladanyi, M. Integrative clustering ofmultiple genomicdata types using a joint latent variablemodel with application to breast and lung cancer subtype analysis. Bioinformatics 25, 2906-2912 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 2906-2912
    • Shen, R.1    Olshen, A.B.2    Ladanyi, M.3
  • 14
    • 69249098986 scopus 로고    scopus 로고
    • Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location
    • Murphy, G., Pfeiffer, R., Camargo, M. C. & Rabkin, C. S. Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location. Gastroenterology 137, 824-833 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 824-833
    • Murphy, G.1    Pfeiffer, R.2    Camargo, M.C.3    Rabkin, C.S.4
  • 15
    • 82655181474 scopus 로고    scopus 로고
    • Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes
    • Matsusaka, K. et al. Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes. Cancer Res. 71, 7187-7197 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 7187-7197
    • Matsusaka, K.1
  • 16
    • 79952563183 scopus 로고    scopus 로고
    • EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1
    • Geddert, H., Zur Hausen, A., Gabbert, H. E. & Sarbia, M. EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1. Anal. Cell. Pathol. 33, 143-149 (2010).
    • (2010) Anal. Cell. Pathol. , vol.33 , pp. 143-149
    • Geddert, H.1    Zur Hausen, A.2    Gabbert, H.E.3    Sarbia, M.4
  • 17
    • 84862502170 scopus 로고    scopus 로고
    • High-throughput mutation profiling identifies frequent somatic mutations in advanced gastric adenocarcinoma
    • Lee, J. et al. High-throughput mutation profiling identifies frequent somatic mutations in advanced gastric adenocarcinoma. PLoS ONE 7, e38892 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e38892
    • Lee, J.1
  • 18
    • 84873885753 scopus 로고    scopus 로고
    • Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer
    • Sukawa, Y. et al. Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer. World J. Gastroenterology 18, 6577-6586 (2012).
    • (2012) World J. Gastroenterology , vol.18 , pp. 6577-6586
    • Sukawa, Y.1
  • 19
    • 84878510017 scopus 로고    scopus 로고
    • Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity: Implications for possible immune adjuvant therapy
    • Strong, M. J. et al. Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity: implications for possible immune adjuvant therapy. PLoS Pathog. 9, e1003341 (2013).
    • (2013) PLoS Pathog. , vol.9 , pp. e1003341
    • Strong, M.J.1
  • 20
    • 84870950067 scopus 로고    scopus 로고
    • The Cancer Genome Atlas Network Comprehensive molecular characterization of human colon and rectal cancer
    • The Cancer Genome Atlas Network Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012).
    • (2012) Nature , vol.487 , pp. 330-337
  • 21
    • 84877254190 scopus 로고    scopus 로고
    • Integrated genomic characterization of endometrial carcinoma
    • Cancer Genome Atlas Research Network. Integrated genomic characterization of endometrial carcinoma. Nature 497, 67-73 (2013).
    • (2013) Nature , vol.497 , pp. 67-73
    • Cancer Genome Atlas Research Network1
  • 22
    • 84880507665 scopus 로고    scopus 로고
    • Mutational heterogeneity in cancer and the search for new cancer-associated genes
    • Lawrence, M. S. et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499, 214-218 (2013).
    • (2013) Nature , vol.499 , pp. 214-218
    • Lawrence, M.S.1
  • 23
    • 84866535863 scopus 로고    scopus 로고
    • Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes
    • Bernal, M., Ruiz-Cabello, F., Concha, A., Paschen, A. & Garrido, F. Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes. Cancer Immunol. Immunother. 61, 1359-1371 (2012).
    • (2012) Cancer Immunol. Immunother. , vol.61 , pp. 1359-1371
    • Bernal, M.1    Ruiz-Cabello, F.2    Concha, A.3    Paschen, A.4    Garrido, F.5
  • 24
    • 84865994665 scopus 로고    scopus 로고
    • Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
    • Greulich, H. et al. Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc. Natl Acad. Sci. USA 109, 14476-14481 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 14476-14481
    • Greulich, H.1
  • 25
    • 83055161507 scopus 로고    scopus 로고
    • Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype
    • Grossmann, V. et al. Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood 118, 6153-6163 (2011).
    • (2011) Blood , vol.118 , pp. 6153-6163
    • Grossmann, V.1
  • 26
    • 84864492215 scopus 로고    scopus 로고
    • Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
    • Pugh, T. J. et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 488, 106-110 (2012).
    • (2012) Nature , vol.488 , pp. 106-110
    • Pugh, T.J.1
  • 27
    • 84878593111 scopus 로고    scopus 로고
    • Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
    • Dulak, A. M. et al. Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nature Genet. 45, 478-486 (2013).
    • (2013) Nature Genet. , vol.45 , pp. 478-486
    • Dulak, A.M.1
  • 28
    • 0344305784 scopus 로고    scopus 로고
    • Cell migration: Integrating signals from front to back
    • Ridley, A. J. et al. Cell migration: integrating signals from front to back. Science 302, 1704-1709 (2003).
    • (2003) Science , vol.302 , pp. 1704-1709
    • Ridley, A.J.1
  • 29
    • 84888437392 scopus 로고    scopus 로고
    • Physiological roles of Rho and Rho effectors in mammals
    • Thumkeo, D., Watanabe, S. & Narumiya, S. Physiological roles of Rho and Rho effectors in mammals. Eur. J. Cell Biol. 92, 303-315 (2013).
    • (2013) Eur. J. Cell Biol. , vol.92 , pp. 303-315
    • Thumkeo, D.1    Watanabe, S.2    Narumiya, S.3
  • 30
    • 0035168740 scopus 로고    scopus 로고
    • Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation
    • Aznar, S. et al. Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation. Mol. Biol. Cell 12, 3282-3294 (2001).
    • (2001) Mol. Biol. Cell , vol.12 , pp. 3282-3294
    • Aznar, S.1
  • 31
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer-new molecular targets come of age
    • Yu, H. & Jove, R. The STATs of cancer-new molecular targets come of age. Nature Rev. Cancer 4, 97-105 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 32
    • 84895829862 scopus 로고    scopus 로고
    • Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas
    • Palomero, T. et al. Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nature Genet. 46, 166-170 (2014).
    • (2014) Nature Genet. , vol.46 , pp. 166-170
    • Palomero, T.1
  • 33
    • 84895809383 scopus 로고    scopus 로고
    • Somatic RHOA mutation in angioimmunoblastic T cell lymphoma
    • Sakata-Yanagimoto, M. et al. Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nature Genet. 46, 171-175 (2014).
    • (2014) Nature Genet. , vol.46 , pp. 171-175
    • Sakata-Yanagimoto, M.1
  • 34
    • 81755172054 scopus 로고    scopus 로고
    • The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading
    • Doherty, G. J. et al. The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading. Mol. Biol. Cell 22, 4380-4389 (2011).
    • (2011) Mol. Biol. Cell , vol.22 , pp. 4380-4389
    • Doherty, G.J.1
  • 35
    • 0030052368 scopus 로고    scopus 로고
    • Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
    • Joneson, T., White, M. A., Wigler, M. H. & Bar-Sagi, D. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science 271, 810-812 (1996).
    • (1996) Science , vol.271 , pp. 810-812
    • Joneson, T.1    White, M.A.2    Wigler, M.H.3    Bar-Sagi, D.4
  • 36
    • 79957638275 scopus 로고    scopus 로고
    • Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals
    • Türeci, O. et al. Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals. Gene 481, 83-92 (2011).
    • (2011) Gene , vol.481 , pp. 83-92
    • Türeci, O.1
  • 37
    • 84879866976 scopus 로고    scopus 로고
    • PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies
    • Chen, B. J. et al. PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies. Clinical Cancer Res 19, 3462-3473 (2013).
    • (2013) Clinical Cancer Res , vol.19 , pp. 3462-3473
    • Chen, B.J.1
  • 38
    • 84858206832 scopus 로고    scopus 로고
    • Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: Implications for targeted therapy
    • Green, M. R. et al. Constitutive AP-1 activity and EBV infection induce PD-L1 in Hodgkin lymphomas and posttransplant lymphoproliferative disorders: implications for targeted therapy. Clinical Cancer Res 18, 1611-1618 (2012).
    • (2012) Clinical Cancer Res , vol.18 , pp. 1611-1618
    • Green, M.R.1
  • 39
    • 84870950067 scopus 로고    scopus 로고
    • The Cancer Genome Atlas Network Comprehensive molecular characterization of human colon and rectal cancer
    • The Cancer Genome Atlas Network Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012).
    • (2012) Nature , vol.487 , pp. 330-337
  • 40
    • 84892852372 scopus 로고    scopus 로고
    • Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): An international, randomised, multicentre, placebo-controlled, phase 3 trial
    • Fuchs, C. S. et al. Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet 383, 31-39 (2014).
    • (2014) Lancet , vol.383 , pp. 31-39
    • Fuchs, C.S.1
  • 41
    • 58149186477 scopus 로고    scopus 로고
    • PID: The pathway interaction database
    • Schaefer, C. F. et al. PID: the pathway interaction database. Nucleic Acids Res. 37, D674-D679 (2009).
    • (2009) Nucleic Acids Res. , vol.37 , pp. D674-D679
    • Schaefer, C.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.