P16INK4a reporter mice reveal age-promoting effects of environmental toxicants

Journal of Clinical Investigation

Volumn 124, Issue 1, 2014, Pages 169-173

  Sorrentino, Jessica A ^a,b   Krishnamurthy, Janakiraman ^b   Tilley, Stephen ^b   Alb Jr , James G ^b   Burd, Christin E ^c   Sharpless, Norman E ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC; CIGARETTE SMOKE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GERONTOGEN; LUCIFERASE; TOXIC SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL AGING; CONTROLLED STUDY; GENETIC TRANSCRIPTION; IN VIVO STUDY; LIPID DIET; MOUSE; NONHUMAN; PRIORITY JOURNAL; ULTRAVIOLET RADIATION;

EID: 84892904754     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI70960     Document Type: Article

References (35)

1. Long GG, Morton D, Peters T, Short B, Skydsgaard M. Alternative mouse models for carcinogenicity assessment: industry use and issues with pathology interpretation. Toxicol Pathol. 2010;38(1):43-50.
2. Goldsworthy TL, et al. Transgenic animals in toxicology. Fundam Appl Toxicol. 1994;22(1):8-19.
3. Jacobson-Kram D, Sistare FD, Jacobs AC. Use of transgenic mice in carcinogenicity hazard assessment. Toxicol Pathol. 2004;32(suppl 1):49-52.
4. Martin GM. Interactions of aging and environmental agents: the gerontological perspective. Prog Clin Biol Res. 1987;228:25-80.
5. Nielsen GP, Stemmer-Rachamimov AO, Shaw J, Roy JE, Koh J, Louis DN. Immunohistochemical survey of p16INK4A expression in normal human adult and infant tissues. Lab Invest. 1999; 79(9):1137-1143.
6. Zindy F, Quelle DE, Roussel MF, Sherr CJ. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene. 1997;15(2):203-211.
7. Krishnamurthy J, et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest. 2004;114(9):1299-1307.
8. Liu Y, et al. Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging. Aging Cell. 2009;8(4):439-448.
9. Molofsky AV, et al. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 2006;443(7110):448-452.
10. Janzen V, et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 2006;443(7110):421-426.
11. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev. 2008;22(22):3115-3120.
12. Liu Y, et al. Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes. Blood. 2011; 117(12):3257-3267.
13. Krishnamurthy J, et al. p16INK4a induces an agedependent decline in islet regenerative potential. Nature. 2006;443(7110):453-457.
14. Jeck WR, Siebold AP, Sharpless NE. Review: a metaanalysis of GWAS and age-Associated diseases. Aging Cell. 2012;11(5):727-731.
15. Berent-Maoz B, Montecino-Rodriguez E, Signer RA, Dorshkind K. Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood. 2012;119(24):5715-5721.
16. Baker DJ, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-Associated disorders. Nature. 2011;479(7372):232-236.
17. Chen H, et al. PDGF signalling controls age-dependent proliferation in pancreatic beta-cells. Nature. 2011;478(7369):349-355.
18. Burd CE, et al. Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model. Cell. 2013;152(1-2):340-351.
19. Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z, Sharpless NE. Expression of linear and novel circular forms of an INK4/ARF-Associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet. 2010;6(12):e1001233.
20. Visel A, et al. Targeted deletion of the 9p21 noncoding coronary artery disease risk interval in mice. Nature. 2010;464(7287):409-412.
21. Wang CY, et al. Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Sci Signal. 2009;2(62):ra11.
22. Shi Q, et al. Endothelial senescence after high-cholesterol, high-fat diet challenge in baboons. Am J Physiol Heart Circ Physiol. 2007;292(6):H2913- H2920.
23. Kapaj S, Peterson H, Liber K, Bhattacharya P. Human health effects from chronic arsenic poisoning- A review. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2006;41(10):2399-2428.
24. Yamauchi H, Aminaka Y, Yoshida K, Sun G, Pi J, Waalkes MP. Evaluation of DNA damage in patients with arsenic poisoning: urinary 8-hydroxydeoxyguanine. Toxicol Appl Pharmacol. 2004; 198(3):291-296.
25. Hartwig A, Groblinghoff UD, Beyersmann D, Natarajan AT, Filon R, Mullenders LH. Interaction of arsenic(III) with nucleotide excision repair in UVirradiated human fibroblasts. Carcinogenesis. 1997; 18(2):399-405.
26. Andrew AS, Karagas MR, Hamilton JW. Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water. Int J Cancer. 2003;104(3):263-268.
27. Paul DS, Harmon AW, Devesa V, Thomas DJ, Styblo M. Molecular mechanisms of the diabetogenic effects of arsenic: inhibition of insulin signaling by arsenite and methylarsonous acid. Environ Health Perspect. 2007;115(5):734-742.
28. DeMarini DM. Genotoxicity of tobacco smoke and tobacco smoke condensate: a review. Mutat Res. 2004; 567(2-3):447-474.
29. Pfeifer GP, Denissenko MF, Olivier M, Tretyakova N, Hecht SS, Hainaut P. Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-Associated cancers. Oncogene. 2002; 21(48):7435-7451.
30. Bernhard D, Moser C, Backovic A, Wick G. Cigarette smoke - An aging accelerator? Exp Gerontol. 2007; 42(3):160-165.
31. Ito K, Barnes PJ. COPD as a disease of accelerated lung aging. Chest. 2009;135(1):173-180.
32. Nelson JA, et al. Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy. Aging Cell. 2012;11(5):916-918.
33. Kligman LH. Photoaging. Manifestations, prevention, and treatment. Clin Geriatr Med. 1989; 5(1):235-251.
34. Scharffetter-Kochanek K, et al. Photoaging of the skin from phenotype to mechanisms. Exp Gerontol. 2000;35(3):307-316.
35. Sone H, Kagawa Y. Pancreatic ® cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice. Diabetologia. 2005;48(1):58-67.