Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

Science

Volumn 322, Issue 5902, 2008, Pages 703-709

  Williams, Bret R ^a   Prabhu, Vineet R ^a   Hunter, Karen E ^a,b   Glazier, Christina M ^a   Whittaker, Charles A ^a   Housman, David E ^a   Amon, Angelika ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Gerstner Sloan Kettering Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER; CHROMOSOME; FITNESS; GENETIC ENGINEERING; HEALTH RISK; METABOLISM; RODENT;

ANEUPLOIDY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL IMMORTALIZATION; CELL LINE; CELL METABOLISM; CELL PROLIFERATION; CELL VOLUME; GENE EXPRESSION; MAMMAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRISOMY;

ANEUPLOIDY; ANIMALS; CELL AGING; CELL CYCLE; CELL LINE; CELL PROLIFERATION; CELL SIZE; CELL TRANSFORMATION, NEOPLASTIC; CULTURE MEDIA; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE DOSAGE; GENE EXPRESSION; GENOMIC INSTABILITY; GLUCOSE; GLUTAMINE; METABOLIC NETWORKS AND PATHWAYS; MICE; SERIAL PASSAGE; TRANSLOCATION, GENETIC; TRISOMY;

MAMMALIA;

EID: 55349112533     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1160058     Document Type: Article

References (41)

1. E. M. Torres et al., Science 317, 916 (2007).
2. O. Niwa, Y. Tange, A. Kurabayashi, Yeast 23, 937 (2006).
3. O. Niwa, M. Yanagida, Curr. Genet. 9, 463 (1985).
4. D. L. Lindsley et al., Genetics 71, 157 (1972).
5. B. McClintock, Genetics 14, 180 (1929).
6. K. Singh, D. S. Multani, G. S. Khush, Genetics 143, 517 (1996).
7. A. P. Dyban, V. S. Baranov, Cytogenetics of Mammalian Embryonic Development (Oxford Univ. Press, New York, 1987).
8. A. Gropp, H. Winking, E. W. Herbst, C. P. Claussen, J. Exp. Zool. 228, 253 (1983).
9. G. S. Pai, R. C. Lewandowski, D. S. Borgaonkar, Handbook of Chromosomal Syndromes (Wiley, New York, 2003).
10. A. Gropp, U. Kolbus, D. Giers, Cytogenet. Cell Genet. 14, 42 (1975).
11. Chromosome size and coding gene statistics were obtained from the National Center for Biotechnology Information m37 mouse assembly; see www.ensembl.org/Mus_musculus/index.html.
12. Materials and methods are available as supporting material on Science Online.
13. R. Mao, C. L. Zielke, H. R. Zielke, J. Pevsner, Genomics 81, 457 (2003).
14. M. Abercrombie, Exp. Cell Res. Suppl. 8, 188 (1961).
15. K. Nielsen, M. Marcus, A. Gropp, Hereditas 102, 77 (1985).
16. M. Rosner et al., J. Neural Transm. Suppl. 67, 51 (2003).
17. R. Moreno-Sanchez, S. Rodriguez-Enriquez, A. Marin-Hernandez, E. Saavedra, FEBS J. 274, 1393 (2007).
18. O. Warburg, K. Posener, E. Negelein, Biochem. Z. 152, 309 (1924).
19. T. Boveri, Verhandlungen der physikalisch-medizinischen Gesellschaft zu Würzburg Neu Folge 35, 67 (1902).
20. D. Satge et al., Am. J. Med. Genet. 78, 207 (1998).
21. H. Hasle, I. H. Clemmensen, M. Mikkelsen, Lancet 355, 165 (2000).
22. D. Satge, A. J. Sasco, B. Lacour, Int. J. Cancer 106, 297 (2003).
23. B. A. Weaver, A. D. Silk, C. Montagna, P. Verdier-Pinard, D. W. Cleveland, Cancer Cell 11, 25 (2007).
24. R. Sotillo et al., Cancer Cell 11, 9 (2007).
25. D. J. Baker et al., Nat. Genet. 36, 744 (2004).
26. T. E. Sussan, A. Yang, F. Li, M. C. Ostrowski, R. H. Reeves, Nature 451, 73 (2008).
27. G. J. Todaro, H. Green, J. Cell Biol. 17, 299 (1963).
28. D. J. Segal, E. E. McCoy, J. Cell. Physiol. 83, 85 (1974).
29. I. Tannock, R. P. Hill, The Basic Science of Oncology (Pergamon Press, New York, 1987).
30. P. S. Larson et al., J. Pathol. 209, 307 (2006).
31. L. Bomme et al., Cancer Genet. Cytogenet. 106, 66 (1998).
32. L. Bomme et al., Int. J. Cancer 92, 816 (2001).
33. I. M. Shih et al., Proc. Natl. Acad. Sci. U.S.A. 98, 2640 (2001).
34. T. Edlund, S. Normark, Nature 292, 269 (1981).
35. R. G. Ponder, N. C. Fonville, S. M. Rosenberg, Mol. Cell 19, 791 (2005).
36. A. Selmecki, A. Forche, J. Berman, Science 313, 367 (2006).
37. H. M. Sung, G. Yeamans, C. A. Ross, R. E. Yasbin, J. Bacteriol. 185, 2153 (2003).
38. V. T. Mihaylova et al., Mol. Cell. Biol. 23, 3265 (2003).
39. E. Farber, Biochem. Pharmacol. 39, 1837 (1990).
40. A. Haddow, Acta Unio Int. Contra Cancrum 3, 342 (1938).
41. We thank E. Vazile in the Koch Institute Microscopy and Imaging Facility for help with SKY analysis; M. Luo in the MIT BioMicro Center for help with microarray analysis; L. Chan for assistance with the double linear fit models for immortalization kinetics; A. Regev and M. Guttman for advice and assistance with statistical analysis; and M. Dunham, M. Hemann, J. Lees, F. Solomon, and members of the Amon lab for critical reading of this manuscript. This work was supported by the Howard Hughes Medical Institute, a David Koch Research Award, a grant from the Curt W. and Kathy Marble Cancer Research Fund, and a David Koch Graduate Fellowship (V.R.P.). All microarray data are provided in final processed form in table S1 and as raw data through the Gene Expression Omnibus (www.ncbi.nlm.nih.gov/geo) under accession number GSE12501.