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Volumn 334, Issue 2, 2015, Pages 350-358

DNA damage checkpoint recovery and cancer development

Author keywords

Carcinogenesis; Cell cycle checkpoints; DNA damage; Neoplasms; Oncogenes

Indexed keywords

GROWTH FACTOR; PHOSPHATASE; TUMOR PROTEIN;

EID: 84929513000     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2015.03.011     Document Type: Review
Times cited : (67)

References (82)
  • 1
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: safeguarding genome integrity
    • Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 2003, 3:155-168.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 2
    • 33847737716 scopus 로고    scopus 로고
    • DNA damage checkpoint: from initiation to recovery or adaptation
    • Bartek J., Lukas J. DNA damage checkpoint: from initiation to recovery or adaptation. Curr. Opin. Cell. Biol. 2007, 19:238-245.
    • (2007) Curr. Opin. Cell. Biol. , vol.19 , pp. 238-245
    • Bartek, J.1    Lukas, J.2
  • 3
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck J., Coates J., Jackson S.P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005, 434:605-611.
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 4
    • 21644456228 scopus 로고    scopus 로고
    • Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors
    • Collins I., Garrett M.D. Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. Curr. Opin. Pharmacol. 2005, 5:366-373.
    • (2005) Curr. Opin. Pharmacol. , vol.5 , pp. 366-373
    • Collins, I.1    Garrett, M.D.2
  • 7
    • 33846128155 scopus 로고    scopus 로고
    • The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
    • Mallette F.A., Gaumont-Leclerc M.F., Ferbeyre G. The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev. 2007, 21:43-48.
    • (2007) Genes Dev. , vol.21 , pp. 43-48
    • Mallette, F.A.1    Gaumont-Leclerc, M.F.2    Ferbeyre, G.3
  • 11
    • 77952505653 scopus 로고    scopus 로고
    • Sequential loss of cell cycle checkpoint control contributes to malignant transformation of murine embryonic fibroblasts induced by 20-methylcholanthrene
    • Mukherjee S.1, Manna S., Pal D., Mukherjee P., Panda C.K. Sequential loss of cell cycle checkpoint control contributes to malignant transformation of murine embryonic fibroblasts induced by 20-methylcholanthrene. J. Cell. Physiol. 2010, 224:49-58.
    • (2010) J. Cell. Physiol. , vol.224 , pp. 49-58
    • Mukherjee, S.1.1    Manna, S.2    Pal, D.3    Mukherjee, P.4    Panda, C.K.5
  • 12
    • 84904262422 scopus 로고    scopus 로고
    • Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress
    • Wallace M.D., Southard T.L., Schimenti K.J., Schimenti J.C. Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress. Oncogene 2014, 33:3688-3695.
    • (2014) Oncogene , vol.33 , pp. 3688-3695
    • Wallace, M.D.1    Southard, T.L.2    Schimenti, K.J.3    Schimenti, J.C.4
  • 14
    • 77958498222 scopus 로고    scopus 로고
    • The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    • Smith J., Tho L.M., Xu N., Gillespie D.A. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv. Cancer Res. 2010, 108:73-112.
    • (2010) Adv. Cancer Res. , vol.108 , pp. 73-112
    • Smith, J.1    Tho, L.M.2    Xu, N.3    Gillespie, D.A.4
  • 15
    • 84858332163 scopus 로고    scopus 로고
    • Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis
    • Tho L.M., Libertini S., Rampling R., Sansom O., Gillespie D.A. Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis. Oncogene 2012, 31:1366-1375.
    • (2012) Oncogene , vol.31 , pp. 1366-1375
    • Tho, L.M.1    Libertini, S.2    Rampling, R.3    Sansom, O.4    Gillespie, D.A.5
  • 16
    • 84865433349 scopus 로고    scopus 로고
    • DNA damage checkpoints in stem cells, ageing and cancer
    • Sperka T., Wang J., Rudolph K.L. DNA damage checkpoints in stem cells, ageing and cancer. Nat. Rev. Mol. Cell Biol. 2012, 13:579-590.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 579-590
    • Sperka, T.1    Wang, J.2    Rudolph, K.L.3
  • 18
    • 33751293168 scopus 로고    scopus 로고
    • Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis
    • Tort F., Bartkova J., Sehested M., Orntoft T., Lukas J., Bartek J. Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis. Cancer Res. 2006, 66:10258-10263.
    • (2006) Cancer Res. , vol.66 , pp. 10258-10263
    • Tort, F.1    Bartkova, J.2    Sehested, M.3    Orntoft, T.4    Lukas, J.5    Bartek, J.6
  • 19
    • 36949005417 scopus 로고    scopus 로고
    • DNA damage signalling guards against activated oncogenes and tumour progression
    • Bartek J., Bartkova J., Lukas J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 2007, 26:7773-7779.
    • (2007) Oncogene , vol.26 , pp. 7773-7779
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3
  • 20
    • 82755186408 scopus 로고    scopus 로고
    • Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence
    • Larsson L.G. Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence. Semin. Cancer Biol. 2011, 21:367-376.
    • (2011) Semin. Cancer Biol. , vol.21 , pp. 367-376
    • Larsson, L.G.1
  • 21
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • Halazonetis T.D., Gorgoulis V.G., Bartek J. An oncogene-induced DNA damage model for cancer development. Science 2008, 319:1352-1355.
    • (2008) Science , vol.319 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 24
    • 2542459341 scopus 로고    scopus 로고
    • Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the polo-like kinase
    • Yoo H.Y., Kumagai A., Shevchenko A., Shevchenko A., Dunphy W.G. Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the polo-like kinase. Cell 2004, 117:575-588.
    • (2004) Cell , vol.117 , pp. 575-588
    • Yoo, H.Y.1    Kumagai, A.2    Shevchenko, A.3    Shevchenko, A.4    Dunphy, W.G.5
  • 25
    • 79955681281 scopus 로고    scopus 로고
    • Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer
    • Medema R.H., Macurek L. Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer. F1000 Biol. Rep. 2011, 3:10.
    • (2011) F1000 Biol. Rep. , vol.3 , pp. 10
    • Medema, R.H.1    Macurek, L.2
  • 26
    • 68249119893 scopus 로고    scopus 로고
    • DNA damage checkpoint inactivation: adaptation and recovery
    • Clémenson C., Marsolier-Kergoat M.C. DNA damage checkpoint inactivation: adaptation and recovery. DNA Repair 2009, 8:1101-1109.
    • (2009) DNA Repair , vol.8 , pp. 1101-1109
    • Clémenson, C.1    Marsolier-Kergoat, M.C.2
  • 27
    • 28444483130 scopus 로고    scopus 로고
    • Gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair
    • Chowdhury D., Keogh M.C., Ishii H., Peterson C.L., Buratowski S., Lieberman J. gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol. Cell 2005, 20:801-809.
    • (2005) Mol. Cell , vol.20 , pp. 801-809
    • Chowdhury, D.1    Keogh, M.C.2    Ishii, H.3    Peterson, C.L.4    Buratowski, S.5    Lieberman, J.6
  • 28
    • 77955170847 scopus 로고    scopus 로고
    • Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response
    • Yan Y., Cao P.T., Greer P.M., Nagengast E.S., Kolb R.H., Mumby M.C., Cowan K.H. Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response. Oncogene 2010, 29:4317-4329.
    • (2010) Oncogene , vol.29 , pp. 4317-4329
    • Yan, Y.1    Cao, P.T.2    Greer, P.M.3    Nagengast, E.S.4    Kolb, R.H.5    Mumby, M.C.6    Cowan, K.H.7
  • 29
    • 1842483852 scopus 로고    scopus 로고
    • Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway
    • Bulavin D.V., Phillips C., Nannenga B., Timofeev O., Donehower L.A., Anderson C.W., Appella E., Fornace A.J. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat. Genet. 2004, 36:343-350.
    • (2004) Nat. Genet. , vol.36 , pp. 343-350
    • Bulavin, D.V.1    Phillips, C.2    Nannenga, B.3    Timofeev, O.4    Donehower, L.A.5    Anderson, C.W.6    Appella, E.7    Fornace, A.J.8
  • 30
    • 27744481299 scopus 로고    scopus 로고
    • Chemical inhibition of Wip1phosphatase contributes to suppression of tumorigenesis
    • Belova G.I., Demidov O.N., Fornace A.J., Bulavin D.V. Chemical inhibition of Wip1phosphatase contributes to suppression of tumorigenesis. Cancer Biol. Ther. 2005, 4:1154-1158.
    • (2005) Cancer Biol. Ther. , vol.4 , pp. 1154-1158
    • Belova, G.I.1    Demidov, O.N.2    Fornace, A.J.3    Bulavin, D.V.4
  • 33
    • 77951064789 scopus 로고    scopus 로고
    • Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition
    • Macůrek L., Lindqvist A., Voets O., Kool J., Vos H.R., Medema R.H. Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition. Oncogene 2010, 29:2281-2291.
    • (2010) Oncogene , vol.29 , pp. 2281-2291
    • Macůrek, L.1    Lindqvist, A.2    Voets, O.3    Kool, J.4    Vos, H.R.5    Medema, R.H.6
  • 34
    • 14644438485 scopus 로고    scopus 로고
    • Checkpoint adaptation and recovery: back with Polo after the break
    • van Vugt M.A., Medema R.H. Checkpoint adaptation and recovery: back with Polo after the break. Cell Cycle 2004, 3:1383-1386.
    • (2004) Cell Cycle , vol.3 , pp. 1383-1386
    • van Vugt, M.A.1    Medema, R.H.2
  • 35
    • 4444321565 scopus 로고    scopus 로고
    • Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells
    • van Vugt M.A., Bras A., Medema R.H. Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol. Cell 2004, 15:799-811.
    • (2004) Mol. Cell , vol.15 , pp. 799-811
    • van Vugt, M.A.1    Bras, A.2    Medema, R.H.3
  • 36
    • 84885179495 scopus 로고    scopus 로고
    • The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery
    • Chow J.P., Poon R.Y. The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery. Oncogene 2013, 32:4778-4788.
    • (2013) Oncogene , vol.32 , pp. 4778-4788
    • Chow, J.P.1    Poon, R.Y.2
  • 37
    • 0043032435 scopus 로고    scopus 로고
    • Human claspin is required for replication checkpoint control
    • Chini C.C., Chen J. Human claspin is required for replication checkpoint control. J. Biol. Chem. 2003, 278:30057-30062.
    • (2003) J. Biol. Chem. , vol.278 , pp. 30057-30062
    • Chini, C.C.1    Chen, J.2
  • 38
    • 34447651363 scopus 로고    scopus 로고
    • Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome
    • Semple J.I., Smits V.A., Fernaud J.R., Mamely I., Freire R. Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome. Cell Death Differ. 2007, 14:1433-1442.
    • (2007) Cell Death Differ. , vol.14 , pp. 1433-1442
    • Semple, J.I.1    Smits, V.A.2    Fernaud, J.R.3    Mamely, I.4    Freire, R.5
  • 39
    • 33746429958 scopus 로고    scopus 로고
    • Destruction of Claspin by SCF-betaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
    • Mailand N., Bekker-Jensen S., Bartek J., Lukas J. Destruction of Claspin by SCF-betaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol. Cell 2006, 23:307-318.
    • (2006) Mol. Cell , vol.23 , pp. 307-318
    • Mailand, N.1    Bekker-Jensen, S.2    Bartek, J.3    Lukas, J.4
  • 41
    • 33645316142 scopus 로고    scopus 로고
    • Targeting polo-like kinase 1 for cancer therapy
    • Strebhardt K., Ullrich A. Targeting polo-like kinase 1 for cancer therapy. Nat. Rev. Cancer 2006, 6:321-330.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 321-330
    • Strebhardt, K.1    Ullrich, A.2
  • 42
    • 84873412441 scopus 로고    scopus 로고
    • The Greatwall kinase: a new pathway in the control of the cell cycle
    • Lorca T., Castro A. The Greatwall kinase: a new pathway in the control of the cell cycle. Oncogene 2013, 32:537-543.
    • (2013) Oncogene , vol.32 , pp. 537-543
    • Lorca, T.1    Castro, A.2
  • 43
    • 1242330004 scopus 로고    scopus 로고
    • Greatwall kinase: a nuclear protein required for proper chromosome condensation and mitotic progression in Drosophila
    • Yu J., Fleming S.L., Williams B., Williams E.V., Li Z., Somma P., Rieder C.L., Goldberg M.L. Greatwall kinase: a nuclear protein required for proper chromosome condensation and mitotic progression in Drosophila. J. Cell Biol. 2004, 164:487-492.
    • (2004) J. Cell Biol. , vol.164 , pp. 487-492
    • Yu, J.1    Fleming, S.L.2    Williams, B.3    Williams, E.V.4    Li, Z.5    Somma, P.6    Rieder, C.L.7    Goldberg, M.L.8
  • 45
    • 80051700434 scopus 로고    scopus 로고
    • Greatwall and polo-like kinase 1 coordinate to promote checkpoint recovery
    • Peng A., Wang L., Fisher L.A. Greatwall and polo-like kinase 1 coordinate to promote checkpoint recovery. J. Biol. Chem. 2011, 286:28996-29004.
    • (2011) J. Biol. Chem. , vol.286 , pp. 28996-29004
    • Peng, A.1    Wang, L.2    Fisher, L.A.3
  • 46
    • 84864248776 scopus 로고    scopus 로고
    • The overlooked greatwall: a new perspective on mitotic control
    • Glover D.M. The overlooked greatwall: a new perspective on mitotic control. Open Biol. 2012, 2:120023.
    • (2012) Open Biol. , vol.2 , pp. 120023
    • Glover, D.M.1
  • 47
    • 34147216135 scopus 로고    scopus 로고
    • Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B
    • Geng L., Zhang X., Zheng S., Legerski R.J. Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B. Mol. Cell Biol. 2007, 27:2625-2635.
    • (2007) Mol. Cell Biol. , vol.27 , pp. 2625-2635
    • Geng, L.1    Zhang, X.2    Zheng, S.3    Legerski, R.J.4
  • 48
    • 67650531167 scopus 로고    scopus 로고
    • Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E
    • Wang H., Zhang X., Geng L., Teng L., Legerski R.J. Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E. J. Biol. Chem. 2009, 284:18236-18243.
    • (2009) J. Biol. Chem. , vol.284 , pp. 18236-18243
    • Wang, H.1    Zhang, X.2    Geng, L.3    Teng, L.4    Legerski, R.J.5
  • 49
    • 84880408763 scopus 로고    scopus 로고
    • FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy
    • Wierstra I. FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy. Adv. Cancer Res. 2013, 119:191-419.
    • (2013) Adv. Cancer Res. , vol.119 , pp. 191-419
    • Wierstra, I.1
  • 53
    • 37549029237 scopus 로고    scopus 로고
    • Turning off the G2 DNA damage checkpoint
    • Calonge T.M., O'Connell M.J. Turning off the G2 DNA damage checkpoint. DNA Repair 2008, 7:136-140.
    • (2008) DNA Repair , vol.7 , pp. 136-140
    • Calonge, T.M.1    O'Connell, M.J.2
  • 54
    • 84886935092 scopus 로고    scopus 로고
    • Deacetylase Rpd3 facilitates checkpoint adaptation by preventing Rad53 overactivation
    • Tao R., Xue H., Zhang J., Liu J., Deng H., Chen Y.G. Deacetylase Rpd3 facilitates checkpoint adaptation by preventing Rad53 overactivation. Mol. Cell. Biol. 2013, 33:4212-4224.
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 4212-4224
    • Tao, R.1    Xue, H.2    Zhang, J.3    Liu, J.4    Deng, H.5    Chen, Y.G.6
  • 56
    • 84878893650 scopus 로고    scopus 로고
    • High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients
    • Magnussen G.I., Hellesylt E., Nesland J.M., Trope C.G., Flørenes V.A., Holm R. High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients. BMC Cancer 2013, 13:288.
    • (2013) BMC Cancer , vol.13 , pp. 288
    • Magnussen, G.I.1    Hellesylt, E.2    Nesland, J.M.3    Trope, C.G.4    Flørenes, V.A.5    Holm, R.6
  • 57
    • 84862185038 scopus 로고    scopus 로고
    • High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy
    • Magnussen G.I., Holm R., Emilsen E., Rosnes A.K., Slipicevic A., Flørenes V.A. High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy. PloS One 2012, 7:e38254.
    • (2012) PloS One , vol.7 , pp. e38254
    • Magnussen, G.I.1    Holm, R.2    Emilsen, E.3    Rosnes, A.K.4    Slipicevic, A.5    Flørenes, V.A.6
  • 58
    • 0033564832 scopus 로고    scopus 로고
    • Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck
    • Knecht R., Elez R., Oechler M., Solbach C., von Ilberg C., Strebhardt K. Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck. Cancer Res. 1999, 59:2794-2797.
    • (1999) Cancer Res. , vol.59 , pp. 2794-2797
    • Knecht, R.1    Elez, R.2    Oechler, M.3    Solbach, C.4    von Ilberg, C.5    Strebhardt, K.6
  • 62
    • 4444354564 scopus 로고    scopus 로고
    • Von Hoff DD.Identification of human polo-like kinase 1 as a potential therapeutic target in pancreatic cancer
    • Gray P.J., Bearss D.J., Han H., Nagle R., Tsao M.S., Dean N. Von Hoff DD.Identification of human polo-like kinase 1 as a potential therapeutic target in pancreatic cancer. Mol. Cancer Ther. 2004, 3:641-646.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 641-646
    • Gray, P.J.1    Bearss, D.J.2    Han, H.3    Nagle, R.4    Tsao, M.S.5    Dean, N.6
  • 65
    • 60949096831 scopus 로고    scopus 로고
    • The balance of Polo-like kinase 1 in tumorigenesis
    • Lu L.Y., Yu X. The balance of Polo-like kinase 1 in tumorigenesis. Cell Div. 2009, 4:4.
    • (2009) Cell Div. , vol.4 , pp. 4
    • Lu, L.Y.1    Yu, X.2
  • 67
    • 77952310725 scopus 로고    scopus 로고
    • Polo-like kinase1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass
    • Chun G., Bae D., Nickens K., O'Brien T.J., Patierno S.R., Ceryak S. Polo-like kinase1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass. Carcinogenesis 2010, 31:785-793.
    • (2010) Carcinogenesis , vol.31 , pp. 785-793
    • Chun, G.1    Bae, D.2    Nickens, K.3    O'Brien, T.J.4    Patierno, S.R.5    Ceryak, S.6
  • 69
    • 70149098944 scopus 로고    scopus 로고
    • Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin
    • Spardy N., Covella K., Cha E., Hoskins E.E., Wells S.I., Duensing A., Duensing S. Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin. Cancer Res. 2009, 69:7022-7029.
    • (2009) Cancer Res. , vol.69 , pp. 7022-7029
    • Spardy, N.1    Covella, K.2    Cha, E.3    Hoskins, E.E.4    Wells, S.I.5    Duensing, A.6    Duensing, S.7
  • 70
    • 43049128122 scopus 로고    scopus 로고
    • The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways
    • Lu X., Nguyen T.A., Moon S.H., Darlington Y., Sommer M., Donehower L.A. The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways. Cancer Metastasis Rev. 2008, 27:123-135.
    • (2008) Cancer Metastasis Rev. , vol.27 , pp. 123-135
    • Lu, X.1    Nguyen, T.A.2    Moon, S.H.3    Darlington, Y.4    Sommer, M.5    Donehower, L.A.6
  • 71
    • 24944485819 scopus 로고    scopus 로고
    • Cancer-associated PP2A A alpha subunits induce functional haploinsufficiency and tumorigenicity
    • Chen W., Arroyo J.D., Timmons J.C., Possemato R., Hahn W.C. Cancer-associated PP2A A alpha subunits induce functional haploinsufficiency and tumorigenicity. Cancer Res. 2005, 65:8183-8192.
    • (2005) Cancer Res. , vol.65 , pp. 8183-8192
    • Chen, W.1    Arroyo, J.D.2    Timmons, J.C.3    Possemato, R.4    Hahn, W.C.5
  • 74
    • 84880420467 scopus 로고    scopus 로고
    • Expression and significance of the Wip1 proto-oncogene in colorectal cancer
    • Li Z.T., Zhang L., Gao X.Z., Jiang X.H., Sun L.Q. Expression and significance of the Wip1 proto-oncogene in colorectal cancer. Asian Pac. J. Cancer Prev. 2013, 14:1975-1979.
    • (2013) Asian Pac. J. Cancer Prev. , vol.14 , pp. 1975-1979
    • Li, Z.T.1    Zhang, L.2    Gao, X.Z.3    Jiang, X.H.4    Sun, L.Q.5
  • 77
    • 0029587261 scopus 로고
    • Protein serine/threonine phosphatases as binding proteins for okadaic acid
    • Nagao M., Shima H., Nakayasu M., Sugimura T. Protein serine/threonine phosphatases as binding proteins for okadaic acid. Mutat. Res. 1995, 333:173-179.
    • (1995) Mutat. Res. , vol.333 , pp. 173-179
    • Nagao, M.1    Shima, H.2    Nakayasu, M.3    Sugimura, T.4
  • 78
    • 84878431342 scopus 로고    scopus 로고
    • Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer
    • Seshacharyulu P., Pandey P., Datta K., Batra S.K. Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer. Cancer Lett. 2013, 335:9-18.
    • (2013) Cancer Lett. , vol.335 , pp. 9-18
    • Seshacharyulu, P.1    Pandey, P.2    Datta, K.3    Batra, S.K.4
  • 79
    • 0034708257 scopus 로고    scopus 로고
    • Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms
    • Calin G.A., di Iasio M.G., Caprini E., Vorechovsky I., Natali P.G., Sozzi G., Croce C.M., Barbanti-Brodano G., Russo G., Negrini M. Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms. Oncogene 2000, 19:1191-1195.
    • (2000) Oncogene , vol.19 , pp. 1191-1195
    • Calin, G.A.1    di Iasio, M.G.2    Caprini, E.3    Vorechovsky, I.4    Natali, P.G.5    Sozzi, G.6    Croce, C.M.7    Barbanti-Brodano, G.8    Russo, G.9    Negrini, M.10
  • 80
    • 74549145041 scopus 로고    scopus 로고
    • A new target for proteasome inhibitors: FoxM1
    • Gartel A.L. A new target for proteasome inhibitors: FoxM1. Expert Opin. Investig. Drugs 2010, 19:235-242.
    • (2010) Expert Opin. Investig. Drugs , vol.19 , pp. 235-242
    • Gartel, A.L.1
  • 82
    • 84880079013 scopus 로고    scopus 로고
    • Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment
    • Zhou Z., Jing C., Zhang L., Takeo F., Kim H., Huang Y., Liu Z., Wan Y. Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment. J. Biol. Chem. 2013, 288:18134-18145.
    • (2013) J. Biol. Chem. , vol.288 , pp. 18134-18145
    • Zhou, Z.1    Jing, C.2    Zhang, L.3    Takeo, F.4    Kim, H.5    Huang, Y.6    Liu, Z.7    Wan, Y.8


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