메뉴 건너뛰기




Volumn 27, Issue 7, 2016, Pages 689-711

Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases

Author keywords

Alzheimer's disease; DPP IV inhibitors; glucagon like peptide 1; glucose dependent insulinotropic polypeptide; incretin; insulin resistance; Parkinson's disease; type 2 diabetes mellitus

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; INCRETIN; ANTIDIABETIC AGENT; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; PEPTIDE; VENOM;

EID: 84991355119     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/revneuro-2016-0018     Document Type: Article
Times cited : (27)

References (266)
  • 1
    • 69549138878 scopus 로고    scopus 로고
    • Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
    • Abbas, T., Faivre, E., and Holscher, C. (2009). Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: interaction between type 2 diabetes and Alzheimer's disease. Behav. Brain Res. 205, 265-271.
    • (2009) Behav. Brain Res. , vol.205 , pp. 265-271
    • Abbas, T.1    Faivre, E.2    Holscher, C.3
  • 2
    • 18144381593 scopus 로고    scopus 로고
    • The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
    • Abbott, C.R., Monteiro, M., Small, C.J., Sajedi, A., Smith, K.L., Parkinson, J.R., Ghatei, M.A., and Bloom, S.R. (2005). The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res. 1044, 127-131.
    • (2005) Brain Res. , vol.1044 , pp. 127-131
    • Abbott, C.R.1    Monteiro, M.2    Small, C.J.3    Sajedi, A.4    Smith, K.L.5    Parkinson, J.R.6    Ghatei, M.A.7    Bloom, S.R.8
  • 3
    • 84928009282 scopus 로고    scopus 로고
    • Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: Role of RAGE-NFκB and Nrf2-antioxidant signaling pathways
    • Abdelsalam, R.M. and Safar, M.M. (2015). Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways. J. Neurochem. 133, 700-707.
    • (2015) J. Neurochem. , vol.133 , pp. 700-707
    • Abdelsalam, R.M.1    Safar, M.M.2
  • 4
    • 84961216425 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic and clinical evaluation of saxagliptin in type 2 diabetes
    • Anderson, R., Hayes, J., and Stephens, J.W. (2016). Pharmacokinetic, pharmacodynamic and clinical evaluation of saxagliptin in type 2 diabetes. Expert Opin. Drug Metab. Toxicol. 12, 467-473.
    • (2016) Expert Opin. Drug Metab. Toxicol. , vol.12 , pp. 467-473
    • Anderson, R.1    Hayes, J.2    Stephens, J.W.3
  • 5
    • 77951151612 scopus 로고    scopus 로고
    • Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    • Arakawa, M., Mita, T., Azuma, K., Ebato, C., Goto, H., Nomiyama, T., Fujitani, Y., Hirose, T., Kawamori, R., and Watada, H. (2010). Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes 59, 1030-1037.
    • (2010) Diabetes , vol.59 , pp. 1030-1037
    • Arakawa, M.1    Mita, T.2    Azuma, K.3    Ebato, C.4    Goto, H.5    Nomiyama, T.6    Fujitani, Y.7    Hirose, T.8    Kawamori, R.9    Watada, H.10
  • 7
    • 84957388554 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: Mechanisms of action
    • Athauda, D. and Foltynie, T. (2016). The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action. Drug Discov. Today. DOI: 10.1016/j. drudis.2016.01.013.
    • (2016) Drug Discov. Today.
    • Athauda, D.1    Foltynie, T.2
  • 9
    • 84864855869 scopus 로고    scopus 로고
    • Parkinson's disease, insulin resistance and novel agents of neuroprotection
    • Aviles-Olmos, I., Limousin, P., Lees, A., and Foltynie, T. (2013b). Parkinson's disease, insulin resistance and novel agents of neuroprotection. Brain 136, 374-384.
    • (2013) Brain , vol.136 , pp. 374-384
    • Aviles-Olmos, I.1    Limousin, P.2    Lees, A.3    Foltynie, T.4
  • 11
    • 36549030256 scopus 로고    scopus 로고
    • Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington's disease: Clinical consequences and therapeutic implications
    • Aziz, N.A., Swaab, D.F., Pijl, H., and Roos, R.A. (2007). Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington's disease: clinical consequences and therapeutic implications. Rev. Neurosci. 18, 223-251.
    • (2007) Rev. Neurosci. , vol.18 , pp. 223-251
    • Aziz, N.A.1    Swaab, D.F.2    Pijl, H.3    Roos, R.A.4
  • 13
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio, L.L. and Drucker, D.J. (2007). Biology of incretins: GLP-1 and GIP. Gastroenterology 132, 2131-2157.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 14
    • 4143116741 scopus 로고    scopus 로고
    • Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure
    • Baggio, L.L., Huang, Q., Brown, T.J., and Drucker, D.J. (2004). Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology 127, 546-558.
    • (2004) Gastroenterology , vol.127 , pp. 546-558
    • Baggio, L.L.1    Huang, Q.2    Brown, T.J.3    Drucker, D.J.4
  • 16
    • 84918549130 scopus 로고    scopus 로고
    • Linagliptin for the treatment of type 2 diabetes mellitus: A drug safety evaluation
    • Barnett, A.H. (2015). Linagliptin for the treatment of type 2 diabetes mellitus: a drug safety evaluation. Expert Opin. Drug Safety 14, 149-159.
    • (2015) Expert Opin. Drug Safety , vol.14 , pp. 149-159
    • Barnett, A.H.1
  • 17
    • 0020377971 scopus 로고
    • Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Characterization of the peptide
    • Bataille, D., Tatemoto, K., Gespach, C., Jornvall, H., Rosselin, G., and Mutt, V. (1982). Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Characterization of the peptide. FEBS Lett. 146, 79-86.
    • (1982) FEBS Lett. , vol.146 , pp. 79-86
    • Bataille, D.1    Tatemoto, K.2    Gespach, C.3    Jornvall, H.4    Rosselin, G.5    Mutt, V.6
  • 18
    • 38849196303 scopus 로고    scopus 로고
    • Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease
    • Bertilsson, G., Patrone, C., Zachrisson, O., Andersson, A., Dannaeus, K., Heidrich, J., Kortesmaa, J., Mercer, A., Nielsen, E., Ronnholm, H., et al. (2008). Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease. J. Neurosci. Res. 86, 326-338.
    • (2008) J. Neurosci. Res. , vol.86 , pp. 326-338
    • Bertilsson, G.1    Patrone, C.2    Zachrisson, O.3    Andersson, A.4    Dannaeus, K.5    Heidrich, J.6    Kortesmaa, J.7    Mercer, A.8    Nielsen, E.9    Ronnholm, H.10
  • 19
    • 84877632331 scopus 로고    scopus 로고
    • A novel GIPoxyntomodulin hybrid peptide acting through GIP, glucagon and GLP-1 receptors exhibits weight reducing and anti-diabetic properties
    • Bhat, V.K., Kerr, B.D., Flatt, P.R., and Gault, V.A. (2013a). A novel GIPoxyntomodulin hybrid peptide acting through GIP, glucagon and GLP-1 receptors exhibits weight reducing and anti-diabetic properties. Biochem. Pharmacol. 85, 1655-1662.
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 1655-1662
    • Bhat, V.K.1    Kerr, B.D.2    Flatt, P.R.3    Gault, V.A.4
  • 20
    • 84877763087 scopus 로고    scopus 로고
    • A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice
    • Bhat, V.K., Kerr, B.D., Vasu, S., Flatt, P.R., and Gault, V.A. (2013b). A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice. Diabetologia 56, 1417-1424.
    • (2013) Diabetologia , vol.56 , pp. 1417-1424
    • Bhat, V.K.1    Kerr, B.D.2    Vasu, S.3    Flatt, P.R.4    Gault, V.A.5
  • 24
    • 84907274301 scopus 로고    scopus 로고
    • Recent advances in the molecular genetics of type 2 diabetes mellitus
    • Brunetti, A., Chiefari, E., and Foti, D. (2014). Recent advances in the molecular genetics of type 2 diabetes mellitus. World J. Diabetes 5, 128-140.
    • (2014) World J. Diabetes , vol.5 , pp. 128-140
    • Brunetti, A.1    Chiefari, E.2    Foti, D.3
  • 25
    • 66049137664 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): Cellular localization, lesion-affected expression, and impaired regenerative axonal growth
    • Buhren, B.A., Gasis, M., Thorens, B., Muller, H.W., and Bosse, F. (2009). Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): cellular localization, lesion-affected expression, and impaired regenerative axonal growth. J. Neurosci. Res. 87, 1858-1870.
    • (2009) J. Neurosci. Res. , vol.87 , pp. 1858-1870
    • Buhren, B.A.1    Gasis, M.2    Thorens, B.3    Muller, H.W.4    Bosse, F.5
  • 26
    • 84856468940 scopus 로고    scopus 로고
    • Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders
    • Cai, H., Cong, W.N., Ji, S., Rothman, S., Maudsley, S., and Martin, B. (2012). Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders. Curr. Alzheimer Res. 9, 5-17.
    • (2012) Curr. Alzheimer Res. , vol.9 , pp. 5-17
    • Cai, H.1    Cong, W.N.2    Ji, S.3    Rothman, S.4    Maudsley, S.5    Martin, B.6
  • 27
    • 84878808238 scopus 로고    scopus 로고
    • Pharmacology, physiology, and mechanisms of incretin hormone action
    • Campbell, J.E. and Drucker, D.J. (2013). Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab. 17, 819-837.
    • (2013) Cell Metab. , vol.17 , pp. 819-837
    • Campbell, J.E.1    Drucker, D.J.2
  • 28
    • 84959239661 scopus 로고    scopus 로고
    • A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson's disease by reducing chronic inflammation in the brain
    • Cao, L., Li, D., Feng, P., Li, L., Xue, G.F., Li, G., and Holscher, C. (2016). A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson's disease by reducing chronic inflammation in the brain. Neuro Report 27, 384-391.
    • (2016) Neuro Report , vol.27 , pp. 384-391
    • Cao, L.1    Li, D.2    Feng, P.3    Li, L.4    Xue, G.F.5    Li, G.6    Holscher, C.7
  • 32
    • 84867577041 scopus 로고    scopus 로고
    • Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4
    • Chen, S., Liu, A.R., An, F.M., Yao, W.B., and Gao, X.D. (2012). Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4. Age (Dordr.) 34, 1211-1224.
    • (2012) Age (Dordr.) , vol.34 , pp. 1211-1224
    • Chen, S.1    Liu, A.R.2    An, F.M.3    Yao, W.B.4    Gao, X.D.5
  • 33
    • 84941558262 scopus 로고    scopus 로고
    • Clinical pharmacology of dipeptidyl peptidase 4 inhibitors indicated for the treatment of type 2 diabetes mellitus
    • Chen, X.W., He, Z.X., Zhou, Z.W., Yang, T., Zhang, X., Yang, Y.X., Duan, W., and Zhou, S.F. (2015a). Clinical pharmacology of dipeptidyl peptidase 4 inhibitors indicated for the treatment of type 2 diabetes mellitus. Clin. Exp. Pharmacol. Physiol. 42, 999-1024.
    • (2015) Clin. Exp. Pharmacol. Physiol. , vol.42 , pp. 999-1024
    • Chen, X.W.1    He, Z.X.2    Zhou, Z.W.3    Yang, T.4    Zhang, X.5    Yang, Y.X.6    Duan, W.7    Zhou, S.F.8
  • 34
    • 84947574098 scopus 로고    scopus 로고
    • Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease
    • Chen, Y., Zhang, Y., Li, L., and Holscher, C. (2015b). Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease. Eur. J. Pharmacol. 768, 21-27.
    • (2015) Eur. J. Pharmacol. , vol.768 , pp. 21-27
    • Chen, Y.1    Zhang, Y.2    Li, L.3    Holscher, C.4
  • 35
    • 84973428782 scopus 로고    scopus 로고
    • Targeting insulin signaling for the treatment of Alzheimer's disease
    • Chen, Y., Zhang, J., Zhang, B., and Gong, C.X. (2016). Targeting insulin signaling for the treatment of Alzheimer's disease. Curr. Top. Med. Chem. 16, 485-492.
    • (2016) Curr. Top. Med. Chem. , vol.16 , pp. 485-492
    • Chen, Y.1    Zhang, J.2    Zhang, B.3    Gong, C.X.4
  • 36
    • 66649106652 scopus 로고    scopus 로고
    • Exogenous glucosedependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes
    • Chia, C.W., Carlson, O.D., Kim, W., Shin, Y.K., Charles, C.P., Kim, H.S., Melvin, D.L., and Egan, J.M. (2009). Exogenous glucosedependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes. Diabetes 58, 1342-1349.
    • (2009) Diabetes , vol.58 , pp. 1342-1349
    • Chia, C.W.1    Carlson, O.D.2    Kim, W.3    Shin, Y.K.4    Charles, C.P.5    Kim, H.S.6    Melvin, D.L.7    Egan, J.M.8
  • 37
    • 84864479943 scopus 로고    scopus 로고
    • Targeting the glucagon receptor family for diabetes and obesity therapy
    • Cho, Y.M., Merchant, C.E., and Kieffer, T.J. (2012). Targeting the glucagon receptor family for diabetes and obesity therapy. Pharmacol. Ther. 135, 247-278.
    • (2012) Pharmacol. Ther. , vol.135 , pp. 247-278
    • Cho, Y.M.1    Merchant, C.E.2    Kieffer, T.J.3
  • 38
    • 84904982045 scopus 로고    scopus 로고
    • Di-peptidyl peptidase-4 inhibitor sitagliptin protects vascular function in metabolic syndrome: Possible role of epigenetic regulation
    • Cicek, F.A., Tokcaer-Keskin, Z., Ozcinar, E., Bozkus, Y., Akcali, K.C., and Turan, B. (2014). Di-peptidyl peptidase-4 inhibitor sitagliptin protects vascular function in metabolic syndrome: possible role of epigenetic regulation. Mol. Biol. Rep. 41, 4853-4863.
    • (2014) Mol. Biol. Rep. , vol.41 , pp. 4853-4863
    • Cicek, F.A.1    Tokcaer-Keskin, Z.2    Ozcinar, E.3    Bozkus, Y.4    Akcali, K.C.5    Turan, B.6
  • 39
    • 84909645342 scopus 로고    scopus 로고
    • Early detection of Alzheimer's disease using PiB and FDG PET
    • Cohen, A.D. and Klunk, W.E. (2014). Early detection of Alzheimer's disease using PiB and FDG PET. Neurobiol. Dis. 72 Pt A, 117-122.
    • (2014) Neurobiol. Dis. , vol.72 , pp. 117-122
    • Cohen, A.D.1    Klunk, W.E.2
  • 40
    • 84942198303 scopus 로고    scopus 로고
    • Distribution and characterisation of glucagonlike peptide-1 receptor expressing cells in the mouse brain
    • Cork, S.C., Richards, J.E., Holt, M.K., Gribble, F.M., Reimann, F., and Trapp, S. (2015). Distribution and characterisation of glucagonlike peptide-1 receptor expressing cells in the mouse brain. Mol. Metab. 4, 718-731.
    • (2015) Mol. Metab. , vol.4 , pp. 718-731
    • Cork, S.C.1    Richards, J.E.2    Holt, M.K.3    Gribble, F.M.4    Reimann, F.5    Trapp, S.6
  • 44
    • 84905493033 scopus 로고    scopus 로고
    • Exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice and promotes microglial M2 polarization
    • Darsalia, V., Hua, S., Larsson, M., Mallard, C., Nathanson, D., Nystrom, T., Sjoholm, A., Johansson, M.E., and Patrone, C. (2014). Exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice and promotes microglial M2 polarization. PLoS One 9, e103114.
    • (2014) PLoS One , vol.9 , pp. e103114
    • Darsalia, V.1    Hua, S.2    Larsson, M.3    Mallard, C.4    Nathanson, D.5    Nystrom, T.6    Sjoholm, A.7    Johansson, M.E.8    Patrone, C.9
  • 45
    • 84960910536 scopus 로고    scopus 로고
    • Gliptin-mediated neuroprotection against stroke requires chronic pretreatment and is independent of glucagon-like peptide-1 receptor
    • Darsalia, V., Larsson, M., Lietzau, G., Nathanson, D., Nystrom, T., Klein, T., and Patrone, C. (2016). Gliptin-mediated neuroprotection against stroke requires chronic pretreatment and is independent of glucagon-like peptide-1 receptor. Diabetes Obes. Metab. 18, 537-541.
    • (2016) Diabetes Obes. Metab. , vol.18 , pp. 537-541
    • Darsalia, V.1    Larsson, M.2    Lietzau, G.3    Nathanson, D.4    Nystrom, T.5    Klein, T.6    Patrone, C.7
  • 46
    • 0033766716 scopus 로고    scopus 로고
    • Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide
    • Deacon, C.F., Nauck, M.A., Meier, J., Hucking, K., and Holst, J.J. (2000). Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide. J. Clin. Endocrinol. Metab. 85, 3575-3581.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 3575-3581
    • Deacon, C.F.1    Nauck, M.A.2    Meier, J.3    Hucking, K.4    Holst, J.J.5
  • 47
    • 0035403058 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs
    • Deacon, C.F., Danielsen, P., Klarskov, L., Olesen, M., and Holst, J.J. (2001). Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs. Diabetes 50, 1588-1597.
    • (2001) Diabetes , vol.50 , pp. 1588-1597
    • Deacon, C.F.1    Danielsen, P.2    Klarskov, L.3    Olesen, M.4    Holst, J.J.5
  • 49
    • 78649707525 scopus 로고    scopus 로고
    • Discovery and characterization of taspoglutide, a novel analogue of human glucagon-like peptide-1, engineered for sustained therapeutic activity in type 2 diabetes
    • Dong, J.Z., Shen, Y., Zhang, J., Tsomaia, N., Mierke, D.F., and Taylor, J.E. (2011). Discovery and characterization of taspoglutide, a novel analogue of human glucagon-like peptide-1, engineered for sustained therapeutic activity in type 2 diabetes. Diabetes Obes. Metab. 13, 19-25.
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 19-25
    • Dong, J.Z.1    Shen, Y.2    Zhang, J.3    Tsomaia, N.4    Mierke, D.F.5    Taylor, J.E.6
  • 50
    • 33847617011 scopus 로고    scopus 로고
    • Mechanisms of action of glucagonlike peptide 1 in the pancreas
    • Doyle, M.E. and Egan, J.M. (2007). Mechanisms of action of glucagonlike peptide 1 in the pancreas. Pharmacol. Ther. 113, 546-593.
    • (2007) Pharmacol. Ther. , vol.113 , pp. 546-593
    • Doyle, M.E.1    Egan, J.M.2
  • 51
    • 67849084815 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation
    • Dozier, K.C., Cureton, E.L., Kwan, R.O., Curran, B., Sadjadi, J., and Victorino, G.P. (2009). Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation. Peptides 30, 1735-1741.
    • (2009) Peptides , vol.30 , pp. 1735-1741
    • Dozier, K.C.1    Cureton, E.L.2    Kwan, R.O.3    Curran, B.4    Sadjadi, J.5    Victorino, G.P.6
  • 52
    • 84869234340 scopus 로고    scopus 로고
    • 2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease
    • 2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease. Neuroscience 228, 294-300.
    • (2013) Neuroscience , vol.228 , pp. 294-300
    • Duffy, A.M.1    Holscher, C.2
  • 53
    • 0015791989 scopus 로고
    • Stimulation of insulin secretion by gastric inhibitory polypeptide in man
    • Dupre, J., Ross, S.A., Watson, D., and Brown, J.C. (1973). Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J. Clin. Endocrinol. Metab. 37, 826-828.
    • (1973) J. Clin. Endocrinol. Metab. , vol.37 , pp. 826-828
    • Dupre, J.1    Ross, S.A.2    Watson, D.3    Brown, J.C.4
  • 54
    • 84862010340 scopus 로고    scopus 로고
    • A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis
    • Dupuis, L., Dengler, R., Heneka, M.T., Meyer, T., Zierz, S., Kassubek, J., Fischer, W., Steiner, F., Lindauer, E., Otto, M., et al. (2012). A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis. PLoS One 7, e37885.
    • (2012) PLoS One , vol.7 , pp. e37885
    • Dupuis, L.1    Dengler, R.2    Heneka, M.T.3    Meyer, T.4    Zierz, S.5    Kassubek, J.6    Fischer, W.7    Steiner, F.8    Lindauer, E.9    Otto, M.10
  • 57
    • 84877115450 scopus 로고    scopus 로고
    • 2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer's disease mouse model
    • 2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer's disease mouse model. J. Alzheimers Dis. 35, 267-283.
    • (2013) J. Alzheimers Dis. , vol.35 , pp. 267-283
    • Faivre, E.1    Holscher, C.2
  • 58
    • 84876282371 scopus 로고    scopus 로고
    • 2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model
    • 2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model. Alzheimers Res. Ther. 5, 20-28.
    • (2013) Alzheimers Res. Ther. , vol.5 , pp. 20-28
    • Faivre, E.1    Holscher, C.2
  • 59
    • 84855544372 scopus 로고    scopus 로고
    • Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice
    • Faivre, E., Hamilton, A., and Holscher, C. (2012). Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice. Eur. J. Pharmacol. 674, 294-306.
    • (2012) Eur. J. Pharmacol. , vol.674 , pp. 294-306
    • Faivre, E.1    Hamilton, A.2    Holscher, C.3
  • 60
    • 67849124134 scopus 로고    scopus 로고
    • The effect of exenatide re-exposure on safety and efficacy
    • Faludi, P., Brodows, R., Burger, J., Ivanyi, T., and Braun, D.K. (2009). The effect of exenatide re-exposure on safety and efficacy. Peptides 30, 1771-1774.
    • (2009) Peptides , vol.30 , pp. 1771-1774
    • Faludi, P.1    Brodows, R.2    Burger, J.3    Ivanyi, T.4    Braun, D.K.5
  • 61
    • 0021927818 scopus 로고
    • Diabetes mellitus in Huntington disease
    • Farrer, L.A. (1985). Diabetes mellitus in Huntington disease. Clin. Genet. 27, 62-67.
    • (1985) Clin. Genet. , vol.27 , pp. 62-67
    • Farrer, L.A.1
  • 62
    • 84916244792 scopus 로고    scopus 로고
    • Ida-1, the Caenorhabditis elegans orthologue of mammalian diabetes autoantigen IA-2, potentially acts as a common modulator between Parkinson's disease and diabetes: Role of Daf-2/Daf-16 insulin like signalling pathway
    • Fatima, S., Haque, R., Jadiya, P., Shamsuzzama, Kumar, L., and Nazir, A. (2014). Ida-1, the Caenorhabditis elegans orthologue of mammalian diabetes autoantigen IA-2, potentially acts as a common modulator between Parkinson's disease and diabetes: role of Daf-2/Daf-16 insulin like signalling pathway. PLoS One 9, e113986.
    • (2014) PLoS One , vol.9 , pp. e113986
    • Fatima, S.1    Haque, R.2    Jadiya, P.3    Shamsuzzama, K.L.4    Nazir, A.5
  • 63
    • 79952817545 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus
    • Figueiredo, C.P., Antunes, V.L., Moreira, E.L., de Mello, N., Medeiros, R., Di Giunta, G., Lobao-Soares, B., Linhares, M., Lin, K., Mazzuco, T.L., et al. (2011). Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus. Peptides 32, 781-789.
    • (2011) Peptides , vol.32 , pp. 781-789
    • Figueiredo, C.P.1    Antunes, V.L.2    Moreira, E.L.3    De Mello, N.4    Medeiros, R.5    Di Giunta, G.6    Lobao-Soares, B.7    Linhares, M.8    Lin, K.9    Mazzuco, T.L.10
  • 67
    • 83455210130 scopus 로고    scopus 로고
    • Linagliptin, a dipeptidyl peptidase- 4 inhibitor with a unique pharmacological profile, and efficacy in a broad range of patients with type 2 diabetes
    • Forst, T. and Pfutzner, A. (2012). Linagliptin, a dipeptidyl peptidase- 4 inhibitor with a unique pharmacological profile, and efficacy in a broad range of patients with type 2 diabetes. Expert Opin. Pharmacother. 13, 101-110.
    • (2012) Expert Opin. Pharmacother. , vol.13 , pp. 101-110
    • Forst, T.1    Pfutzner, A.2
  • 69
    • 84872280267 scopus 로고    scopus 로고
    • Emerging DPP-4 inhibitors: Focus on linagliptin for type 2 diabetes
    • Gallwitz, B. (2013). Emerging DPP-4 inhibitors: focus on linagliptin for type 2 diabetes. Diabetes Metab. Syndr. Obes. Targets Ther. 6, 1-9.
    • (2013) Diabetes Metab. Syndr. Obes. Targets Ther. , vol.6 , pp. 1-9
    • Gallwitz, B.1
  • 70
    • 84860520259 scopus 로고    scopus 로고
    • GSK3: A key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease
    • Gao, C., Holscher, C., Liu, Y., and Li, L. (2012). GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease. Rev. Neurosci. 23, 1-11.
    • (2012) Rev. Neurosci. , vol.23 , pp. 1-11
    • Gao, C.1    Holscher, C.2    Liu, Y.3    Li, L.4
  • 71
    • 84898542999 scopus 로고    scopus 로고
    • Geniposide ameliorates learning memory deficits, reduces phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced Alzheimer rat model
    • Gao, C., Liu, Y., Jiang, Y., Ding, J., and Li, L. (2014). Geniposide ameliorates learning memory deficits, reduces phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced Alzheimer rat model. Brain Pathol. 24, 261-269.
    • (2014) Brain Pathol. , vol.24 , pp. 261-269
    • Gao, C.1    Liu, Y.2    Jiang, Y.3    Ding, J.4    Li, L.5
  • 72
    • 84883796648 scopus 로고    scopus 로고
    • Clinical review of sitagliptin: A DPP-4 inhibitor
    • Garg, K., Tripathi, C.D., and Kumar, S. (2013). Clinical review of sitagliptin: a DPP-4 inhibitor. J. Assoc. Physicians India 61, 645-649.
    • (2013) J. Assoc. Physicians India , vol.61 , pp. 645-649
    • Garg, K.1    Tripathi, C.D.2    Kumar, S.3
  • 73
    • 44149122563 scopus 로고    scopus 로고
    • GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by β-amyloid
    • Gault, V.A. and Holscher, C. (2008a). GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by β-amyloid. Eur. J. Pharmacol. 587, 112-117.
    • (2008) Eur. J. Pharmacol. , vol.587 , pp. 112-117
    • Gault, V.A.1    Holscher, C.2
  • 74
    • 42249106405 scopus 로고    scopus 로고
    • Protease-resistant glucosedependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by β-amyloid
    • Gault, V.A. and Holscher, C. (2008b). Protease-resistant glucosedependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by β-amyloid. J. Neurophysiol. 99, 1590-1595.
    • (2008) J. Neurophysiol. , vol.99 , pp. 1590-1595
    • Gault, V.A.1    Holscher, C.2
  • 75
    • 0036844953 scopus 로고    scopus 로고
    • 1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes
    • 1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes. Biochem. J. 367, 913-920.
    • (2002) Biochem. J. , vol.367 , pp. 913-920
    • Gault, V.A.1    Flatt, P.R.2    Bailey, C.J.3    Harriott, P.4    Greer, B.5    Mooney, M.H.6    O'Harte, F.P.7
  • 77
    • 0038818982 scopus 로고    scopus 로고
    • 2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo
    • 2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo. Metab. Clin. Exp. 52, 679-687.
    • (2003) Metab. Clin. Exp. , vol.52 , pp. 679-687
    • Gault, V.A.1    O'Harte, F.P.2    Harriott, P.3    Flatt, P.R.4
  • 79
    • 44249085588 scopus 로고    scopus 로고
    • C-terminal mini-PEGylation of glucose-dependent insulinotropic polypeptide exhibits metabolic stability and improved glucose homeostasis in dietary-induced diabetes
    • Gault, V.A., Kerr, B.D., Irwin, N., and Flatt, P.R. (2008). C-terminal mini-PEGylation of glucose-dependent insulinotropic polypeptide exhibits metabolic stability and improved glucose homeostasis in dietary-induced diabetes. Biochem. Pharmacol. 75, 2325-2333.
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 2325-2333
    • Gault, V.A.1    Kerr, B.D.2    Irwin, N.3    Flatt, P.R.4
  • 80
    • 79955583163 scopus 로고    scopus 로고
    • Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with type 2 diabetes and obesity
    • Gault, V.A., Kerr, B.D., Harriott, P., and Flatt, P.R. (2011). Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with type 2 diabetes and obesity. Clin. Sci. (Lond.) 121, 107-117.
    • (2011) Clin. Sci. (Lond.) , vol.121 , pp. 107-117
    • Gault, V.A.1    Kerr, B.D.2    Harriott, P.3    Flatt, P.R.4
  • 81
    • 84890275882 scopus 로고    scopus 로고
    • A novel glucagon-like peptide-1 (GLP-1)/glucagon hybrid peptide with tripleacting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mice
    • Gault, V.A., Bhat, V.K., Irwin, N., and Flatt, P.R. (2013). A novel glucagon-like peptide-1 (GLP-1)/glucagon hybrid peptide with tripleacting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mice. J. Biol. Chem. 288, 35581-35591.
    • (2013) J. Biol. Chem. , vol.288 , pp. 35581-35591
    • Gault, V.A.1    Bhat, V.K.2    Irwin, N.3    Flatt, P.R.4
  • 82
    • 84924732903 scopus 로고    scopus 로고
    • Sitagliptin, a DPP-4 inhibitor, improves recognition memory, oxidative stress, hippocampal neurogenesis and up-regulates key genes involved in cognitive decline
    • Gault, V.A., Lennox, R., and Flatt, P.R. (2015). Sitagliptin, a DPP-4 inhibitor, improves recognition memory, oxidative stress, hippocampal neurogenesis and up-regulates key genes involved in cognitive decline. Diabetes Obes. Metab. 7, 403-414.
    • (2015) Diabetes Obes. Metab. , vol.7 , pp. 403-414
    • Gault, V.A.1    Lennox, R.2    Flatt, P.R.3
  • 83
    • 84974559551 scopus 로고    scopus 로고
    • Alzheimer's disease, six-month treatment with GLP-1 analogue prevents decline of brain glucose metabolism: Randomized, placebo-controlled, double-blind clinical trial
    • Gejl, M., Gjedde, A., Egefjord, L., Moller, A., Hansen, S.B., Vang, K., Rodell, A.B., Braendgaard, H., Gottrup, H., Schacht, A., et al. (2016). Alzheimer's disease, six-month treatment with GLP-1 analogue prevents decline of brain glucose metabolism: randomized, placebo-controlled, double-blind clinical trial. Front. Aging Neurosci. DOI: 10.3389/fnagi.2016.00108.
    • (2016) Front. Aging Neurosci.
    • Gejl, M.1    Gjedde, A.2    Egefjord, L.3    Moller, A.4    Hansen, S.B.5    Vang, K.6    Rodell, A.B.7    Braendgaard, H.8    Gottrup, H.9    Schacht, A.10
  • 85
    • 82755176046 scopus 로고    scopus 로고
    • Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
    • Gengler, S., McClean, P.L., McCurtin, R., Gault, V.A., and Holscher, C. (2012). Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol. Aging 33, 265-276.
    • (2012) Neurobiol. Aging , vol.33 , pp. 265-276
    • Gengler, S.1    McClean, P.L.2    McCurtin, R.3    Gault, V.A.4    Holscher, C.5
  • 86
    • 23844434969 scopus 로고    scopus 로고
    • A comparison of the cellular and biological properties of DPP-IVresistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide
    • Green, B.D., Gault, V.A., O'Harte, F.P., and Flatt, P.R. (2005). A comparison of the cellular and biological properties of DPP-IVresistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Diabetes Obes. Metab. 7, 595-604.
    • (2005) Diabetes Obes. Metab. , vol.7 , pp. 595-604
    • Green, B.D.1    Gault, V.A.2    O'Harte, F.P.3    Flatt, P.R.4
  • 87
    • 77953177935 scopus 로고    scopus 로고
    • Physiologic and pharmacologic modulation of glucosedependent insulinotropic polypeptide (GIP) receptor expression in β-cells by peroxisome proliferator-activated receptor (PPAR)-g signaling: Possible mechanism for the GIP resistance in type 2 diabetes
    • Gupta, D., Peshavaria, M., Monga, N., Jetton, T.L., and Leahy, J.L. (2010). Physiologic and pharmacologic modulation of glucosedependent insulinotropic polypeptide (GIP) receptor expression in β-cells by peroxisome proliferator-activated receptor (PPAR)-g signaling: possible mechanism for the GIP resistance in type 2 diabetes. Diabetes 59, 1445-1450.
    • (2010) Diabetes , vol.59 , pp. 1445-1450
    • Gupta, D.1    Peshavaria, M.2    Monga, N.3    Jetton, T.L.4    Leahy, J.L.5
  • 88
    • 69549128161 scopus 로고    scopus 로고
    • Receptors for the insulin-like peptide GLP-1 are expressed on neurons in the CNS
    • Hamilton, A. and Holscher, C. (2009). Receptors for the insulin-like peptide GLP-1 are expressed on neurons in the CNS. Neuro Report 20, 1161-1166.
    • (2009) Neuro Report , vol.20 , pp. 1161-1166
    • Hamilton, A.1    Holscher, C.2
  • 89
    • 79751479118 scopus 로고    scopus 로고
    • Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain
    • Hamilton, A., Patterson, S., Porter, D., Gault, V.A., and Holscher, C. (2011). Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. J. Neurosci. Res. 89, 481-489.
    • (2011) J. Neurosci. Res. , vol.89 , pp. 481-489
    • Hamilton, A.1    Patterson, S.2    Porter, D.3    Gault, V.A.4    Holscher, C.5
  • 90
    • 84869090452 scopus 로고    scopus 로고
    • Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats
    • Han, W.N., Holscher, C., Yuan, L., Yang, W., Wang, X.H., Wu, M.N., and Qi, J.S. (2013). Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats. Neurobiol. Aging 34, 576-588.
    • (2013) Neurobiol. Aging , vol.34 , pp. 576-588
    • Han, W.N.1    Holscher, C.2    Yuan, L.3    Yang, W.4    Wang, X.H.5    Wu, M.N.6    Qi, J.S.7
  • 91
    • 84948709767 scopus 로고    scopus 로고
    • A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat
    • Han, L., Holscher, C., Xue, G.F., Li, G., and Li, D. (2016). A novel dual-glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor agonist is neuroprotective in transient focal cerebral ischemia in the rat. Neuro Report 27, 23-32.
    • (2016) Neuro Report , vol.27 , pp. 23-32
    • Han, L.1    Holscher, C.2    Xue, G.F.3    Li, G.4    Li, D.5
  • 92
    • 84962229876 scopus 로고    scopus 로고
    • The GLP-1 receptor agonist liraglutide reduces pathology-specific phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy
    • Hansen, H.H., Barkholt, P., Fabricius, K., Jelsing, J., Terwel, D., Pyke, C., Knudsen, L.B., and Vrang, N. (2015). The GLP-1 receptor agonist liraglutide reduces pathology-specific phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy. Brain Res. 1634, 157-170.
    • (2015) Brain Res. , vol.1634 , pp. 157-170
    • Hansen, H.H.1    Barkholt, P.2    Fabricius, K.3    Jelsing, J.4    Terwel, D.5    Pyke, C.6    Knudsen, L.B.7    Vrang, N.8
  • 93
    • 76449115696 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection
    • Harkavyi, A. and Whitton, P.S. (2010). Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection. Br. J. Pharmacol. 159, 495-501.
    • (2010) Br. J. Pharmacol. , vol.159 , pp. 495-501
    • Harkavyi, A.1    Whitton, P.S.2
  • 94
    • 0022576608 scopus 로고
    • Insulin antagonism is not a primary abnormality of amyotrophic lateral sclerosis but is related to disease severity
    • Harris, M.D., Davidson, M.B., and Rosenberg, C.S. (1986). Insulin antagonism is not a primary abnormality of amyotrophic lateral sclerosis but is related to disease severity. J. Clin. Endocrinol. Metab. 63, 41-46.
    • (1986) J. Clin. Endocrinol. Metab. , vol.63 , pp. 41-46
    • Harris, M.D.1    Davidson, M.B.2    Rosenberg, C.S.3
  • 95
    • 0036317496 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats
    • Hinke, S.A., Gelling, R.W., Pederson, R.A., Manhart, S., Nian, C., Demuth, H.U., and McIntosh, C.H. (2002). Dipeptidyl peptidase IV-resistant [D-Ala(2)]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats. Diabetes 51, 652-661.
    • (2002) Diabetes , vol.51 , pp. 652-661
    • Hinke, S.A.1    Gelling, R.W.2    Pederson, R.A.3    Manhart, S.4    Nian, C.5    Demuth, H.U.6    McIntosh, C.H.7
  • 96
    • 58149467276 scopus 로고    scopus 로고
    • Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
    • Hojberg, P.V., Vilsboll, T., Rabol, R., Knop, F.K., Bache, M., Krarup, T., Holst, J.J., and Madsbad, S. (2009). Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. Diabetologia 52, 199-207.
    • (2009) Diabetologia , vol.52 , pp. 199-207
    • Hojberg, P.V.1    Vilsboll, T.2    Rabol, R.3    Knop, F.K.4    Bache, M.5    Krarup, T.6    Holst, J.J.7    Madsbad, S.8
  • 97
    • 79960881826 scopus 로고    scopus 로고
    • Diabetes as a risk factor for Alzheimer's disease: Insulin signalling impairment in the brain as an alternative model of Alzheimer's disease
    • Holscher, C. (2011). Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease. Biochem. Soc. Trans. 39, 891-897.
    • (2011) Biochem. Soc. Trans. , vol.39 , pp. 891-897
    • Holscher, C.1
  • 98
    • 84897848470 scopus 로고    scopus 로고
    • Central effects of GLP-1: New opportunities for treatments of neurodegenerative diseases
    • Holscher, C. (2014a). Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases. J. Endocrinol. 221, T31-T41.
    • (2014) J. Endocrinol. , vol.221 , pp. T31-T41
    • Holscher, C.1
  • 99
    • 84897872830 scopus 로고    scopus 로고
    • First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease
    • Holscher, C. (2014b). First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease. Alzheimers Dementia 10, S33-S37.
    • (2014) Alzheimers Dementia , vol.10 , pp. S33-S37
    • Holscher, C.1
  • 100
    • 84897829368 scopus 로고    scopus 로고
    • The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease
    • Holscher, C. (2014c). The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease. Alzheimers Dementia 10, S47-S54.
    • (2014) Alzheimers Dementia , vol.10 , pp. S47-S54
    • Holscher, C.1
  • 101
    • 84896920228 scopus 로고    scopus 로고
    • Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases
    • Holscher, C. (2014d). Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases. Biochem. Soc. Trans. 42, 593-599.
    • (2014) Biochem. Soc. Trans. , vol.42 , pp. 593-599
    • Holscher, C.1
  • 102
    • 77954953382 scopus 로고    scopus 로고
    • New roles for insulin-like hormones in neuronal signalling and protection: New hopes for novel treatments of Alzheimer's disease?
    • Holscher, C. and Li, L. (2010). New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer's disease? Neurobiol. Aging 31, 1495-1502.
    • (2010) Neurobiol. Aging , vol.31 , pp. 1495-1502
    • Holscher, C.1    Li, L.2
  • 103
    • 79951626557 scopus 로고    scopus 로고
    • Neuroprotective properties of GLP-1: Theoretical and practical applications
    • Holst, J.J., Burcelin, R., and Nathanson, E. (2011). Neuroprotective properties of GLP-1: theoretical and practical applications. Curr. Med. Res. Opin. 27, 547-558.
    • (2011) Curr. Med. Res. Opin. , vol.27 , pp. 547-558
    • Holst, J.J.1    Burcelin, R.2    Nathanson, E.3
  • 105
    • 26044473385 scopus 로고    scopus 로고
    • Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents
    • Hunt, M.J. and Morton, A.J. (2005). Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents. Exp. Brain Res. 166, 220-229.
    • (2005) Exp. Brain Res. , vol.166 , pp. 220-229
    • Hunt, M.J.1    Morton, A.J.2
  • 106
    • 84858713174 scopus 로고    scopus 로고
    • Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis
    • Hunter, K. and Holscher, C. (2012). Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neurosci. 13, 33-38.
    • (2012) BMC Neurosci. , vol.13 , pp. 33-38
    • Hunter, K.1    Holscher, C.2
  • 107
    • 0033009587 scopus 로고    scopus 로고
    • Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes
    • Hurlbert, M.S., Zhou, W., Wasmeier, C., Kaddis, F.G., Hutton, J.C., and Freed, C.R. (1999). Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes. Diabetes 48, 649-651.
    • (1999) Diabetes , vol.48 , pp. 649-651
    • Hurlbert, M.S.1    Zhou, W.2    Wasmeier, C.3    Kaddis, F.G.4    Hutton, J.C.5    Freed, C.R.6
  • 108
    • 84919999219 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes, 2015: A patient-centered approach: Update to a position statement of the American diabetes association and the european association for the study of diabetes
    • Inzucchi, S.E., Bergenstal, R.M., Buse, J.B., Diamant, M., Ferrannini, E., Nauck, M., Peters, A.L., Tsapas, A., Wender, R., and Matthews, D.R. (2015). Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 38, 140-149.
    • (2015) Diabetes Care , vol.38 , pp. 140-149
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3    Diamant, M.4    Ferrannini, E.5    Nauck, M.6    Peters, A.L.7    Tsapas, A.8    Wender, R.9    Matthews, D.R.10
  • 109
    • 69849083075 scopus 로고    scopus 로고
    • Therapeutic potential for GIP receptor agonists and antagonists
    • Irwin, N. and Flatt, P.R. (2009). Therapeutic potential for GIP receptor agonists and antagonists. Best Pract. Res. Clin. Endocrinol. Metab. 23, 499-512.
    • (2009) Best Pract. Res. Clin. Endocrinol. Metab. , vol.23 , pp. 499-512
    • Irwin, N.1    Flatt, P.R.2
  • 110
    • 85008506589 scopus 로고    scopus 로고
    • New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders
    • Irwin, N. and Flatt, P.R. (2015). New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders. World J. Diabetes 6, 1285-1295.
    • (2015) World J. Diabetes , vol.6 , pp. 1285-1295
    • Irwin, N.1    Flatt, P.R.2
  • 111
    • 26844564654 scopus 로고    scopus 로고
    • Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37)
    • Irwin, N., Gault, V.A., Green, B.D., Greer, B., Harriott, P., Bailey, C.J., Flatt, P.R., and O'Harte, F.P. (2005a). Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37). Biol. Chem. 386, 679-687.
    • (2005) Biol. Chem. , vol.386 , pp. 679-687
    • Irwin, N.1    Gault, V.A.2    Green, B.D.3    Greer, B.4    Harriott, P.5    Bailey, C.J.6    Flatt, P.R.7    O'Harte, F.P.8
  • 112
    • 13944276310 scopus 로고    scopus 로고
    • Degradation, insulin secretion, and antihyperglycemic actions of two palmitatederivatized N-terminal pyroglutamyl analogues of glucosedependent insulinotropic polypeptide
    • Irwin, N., Green, B.D., Gault, V.A., Greer, B., Harriott, P., Bailey, C.J., Flatt, P.R., and O'Harte, F.P. (2005b). Degradation, insulin secretion, and antihyperglycemic actions of two palmitatederivatized N-terminal pyroglutamyl analogues of glucosedependent insulinotropic polypeptide. J. Med. Chem. 48, 1244-1250.
    • (2005) J. Med. Chem. , vol.48 , pp. 1244-1250
    • Irwin, N.1    Green, B.D.2    Gault, V.A.3    Greer, B.4    Harriott, P.5    Bailey, C.J.6    Flatt, P.R.7    O'Harte, F.P.8
  • 113
    • 32344432601 scopus 로고    scopus 로고
    • GIP(Lys16PAL) and GIP(Lys37PAL): Novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential
    • Irwin, N., O'Harte, F.P., Gault, V.A., Green, B.D., Greer, B., Harriott, P., Bailey, C.J., and Flatt, P.R. (2006). GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential. J. Med. Chem. 49, 1047-1054.
    • (2006) J. Med. Chem. , vol.49 , pp. 1047-1054
    • Irwin, N.1    O'Harte, F.P.2    Gault, V.A.3    Green, B.D.4    Greer, B.5    Harriott, P.6    Bailey, C.J.7    Flatt, P.R.8
  • 114
    • 33744996917 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits LPS-induced IL-1β production in cultured rat astrocytes
    • Iwai, T., Ito, S., Tanimitsu, K., Udagawa, S., and Oka, J. (2006). Glucagon-like peptide-1 inhibits LPS-induced IL-1β production in cultured rat astrocytes. Neurosci. Res. 55, 352-360.
    • (2006) Neurosci. Res. , vol.55 , pp. 352-360
    • Iwai, T.1    Ito, S.2    Tanimitsu, K.3    Udagawa, S.4    Oka, J.5
  • 115
    • 84943572590 scopus 로고    scopus 로고
    • Neuroprotective effect of selective DPP-4 inhibitor in experimental vascular dementia
    • Jain, S. and Sharma, B. (2015). Neuroprotective effect of selective DPP-4 inhibitor in experimental vascular dementia. Physiol. Behav. 152, 182-193.
    • (2015) Physiol. Behav. , vol.152 , pp. 182-193
    • Jain, S.1    Sharma, B.2
  • 116
    • 84900304623 scopus 로고    scopus 로고
    • Trials of antidiabetic drugs in amyotrophic lateral sclerosis: Proceed with caution?
    • Jawaid, A., Paganoni, S., Hauser, C., and Schulz, P.E. (2014). Trials of antidiabetic drugs in amyotrophic lateral sclerosis: proceed with caution? Neuro-degener. Dis. 13, 205-208.
    • (2014) Neuro-degener. Dis. , vol.13 , pp. 205-208
    • Jawaid, A.1    Paganoni, S.2    Hauser, C.3    Schulz, P.E.4
  • 117
    • 84866534106 scopus 로고    scopus 로고
    • Insulin and GLP-1 analog combinations in type 2 diabetes mellitus: A critical review
    • Jendle, J., Martin, S.A., and Milicevic, Z. (2012). Insulin and GLP-1 analog combinations in type 2 diabetes mellitus: a critical review. Expert Opin. Investig. Drugs 21, 1463-1474.
    • (2012) Expert Opin. Investig. Drugs , vol.21 , pp. 1463-1474
    • Jendle, J.1    Martin, S.A.2    Milicevic, Z.3
  • 118
    • 84952933744 scopus 로고    scopus 로고
    • Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease
    • Ji, C., Xue, G.F., Li, G., Li, D., and Holscher, C. (2016a). Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease. Rev. Neurosci. 27, 61-70.
    • (2016) Rev. Neurosci. , vol.27 , pp. 61-70
    • Ji, C.1    Xue, G.F.2    Li, G.3    Li, D.4    Holscher, C.5
  • 119
    • 84962236691 scopus 로고    scopus 로고
    • A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF
    • Ji, C., Xue, G.F., Lijun, C., Feng, P., Li, D., Li, L., Li, G., and Holscher, C. (2016b). A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF. Brain Res. 1634, 1-11.
    • (2016) Brain Res. , vol.1634 , pp. 1-11
    • Ji, C.1    Xue, G.F.2    Lijun, C.3    Feng, P.4    Li, D.5    Li, L.6    Li, G.7    Holscher, C.8
  • 121
    • 84918819081 scopus 로고    scopus 로고
    • Gemigliptin, a novel dipeptidyl peptidase-4 inhibitor, exhibits potent anti-glycation properties in vitro and in vivo
    • Jung, E., Kim, J., Kim, S.H., Kim, S., and Cho, M.H. (2014). Gemigliptin, a novel dipeptidyl peptidase-4 inhibitor, exhibits potent anti-glycation properties in vitro and in vivo. Eur. J. Pharmacol. 744, 98-102.
    • (2014) Eur. J. Pharmacol. , vol.744 , pp. 98-102
    • Jung, E.1    Kim, J.2    Kim, S.H.3    Kim, S.4    Cho, M.H.5
  • 122
    • 80052364474 scopus 로고    scopus 로고
    • Metformin treatment has no beneficial effect in a doseresponse survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice
    • Kaneb, H.M., Sharp, P.S., Rahmani-Kondori, N., and Wells, D.J. (2011). Metformin treatment has no beneficial effect in a doseresponse survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice. PLoS One 6, e24189.
    • (2011) PLoS One , vol.6 , pp. e24189
    • Kaneb, H.M.1    Sharp, P.S.2    Rahmani-Kondori, N.3    Wells, D.J.4
  • 123
    • 84872569583 scopus 로고    scopus 로고
    • GLP-1 secretion by microglial cells and decreased CNS expression in obesity
    • Kappe, C., Tracy, L.M., Patrone, C., Iverfeldt, K., and Sjoholm, A. (2012). GLP-1 secretion by microglial cells and decreased CNS expression in obesity. J. Neuroinflamm. 9, 276.
    • (2012) J. Neuroinflamm. , vol.9 , pp. 276
    • Kappe, C.1    Tracy, L.M.2    Patrone, C.3    Iverfeldt, K.4    Sjoholm, A.5
  • 124
    • 0036198285 scopus 로고    scopus 로고
    • Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
    • Kastin, A.J., Akerstrom, V., and Pan, W, (2002). Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J. Mol. Neurosci. 18, 7-14.
    • (2002) J. Mol. Neurosci. , vol.18 , pp. 7-14
    • Kastin, A.J.1    Akerstrom, V.2    Pan, W.3
  • 125
    • 84937763343 scopus 로고    scopus 로고
    • Alogliptin: A review of its use in patients with type 2 diabetes mellitus
    • Keating, G.M. (2015). Alogliptin: a review of its use in patients with type 2 diabetes mellitus. Drugs 75, 777-796.
    • (2015) Drugs , vol.75 , pp. 777-796
    • Keating, G.M.1
  • 126
    • 77957890652 scopus 로고    scopus 로고
    • 2)Oxm[mPEG-PAL]: A novel chemically modified analogue of oxyntomodulin with antihyperglycaemic, insulinotropic and anorexigenic actions
    • 2)Oxm[mPEG-PAL]: a novel chemically modified analogue of oxyntomodulin with antihyperglycaemic, insulinotropic and anorexigenic actions. Biochem. Pharmacol. 80, 1727-1735.
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 1727-1735
    • Kerr, B.D.1    Flatt, P.R.2    Gault, V.A.3
  • 127
    • 0025047857 scopus 로고
    • Metabolic clearance rates of oxyntomodulin and glucagon in the rat: Contribution of the kidney
    • Kervran, A., Dubrasquet, M., Blache, P., Martinez, J., and Bataille, D. (1990). Metabolic clearance rates of oxyntomodulin and glucagon in the rat: contribution of the kidney. Regul. Pept. 31, 41-52.
    • (1990) Regul. Pept. , vol.31 , pp. 41-52
    • Kervran, A.1    Dubrasquet, M.2    Blache, P.3    Martinez, J.4    Bataille, D.5
  • 128
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer, T.J., McIntosh, C.H., and Pederson, R.A. (1995). Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 136, 3585-3596.
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.2    Pederson, R.A.3
  • 129
    • 79959415768 scopus 로고    scopus 로고
    • Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual β-cell function
    • Kielgast, U., Holst, J.J., and Madsbad, S. (2011). Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual β-cell function. Diabetes 60, 1599-1607.
    • (2011) Diabetes , vol.60 , pp. 1599-1607
    • Kielgast, U.1    Holst, J.J.2    Madsbad, S.3
  • 130
    • 20444491588 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic β-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression
    • Kim, S.J., Winter, K., Nian, C., Tsuneoka, M., Koda, Y., and McIntosh, C.H. (2005). Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic β-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression. J. Biol. Chem. 280, 22297-22307.
    • (2005) J. Biol. Chem. , vol.280 , pp. 22297-22307
    • Kim, S.J.1    Winter, K.2    Nian, C.3    Tsuneoka, M.4    Koda, Y.5    McIntosh, C.H.6
  • 131
    • 70349334516 scopus 로고    scopus 로고
    • Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease
    • Kim, S., Moon, M., and Park, S. (2009). Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease. J. Endocrinol. 202, 431-439.
    • (2009) J. Endocrinol. , vol.202 , pp. 431-439
    • Kim, S.1    Moon, M.2    Park, S.3
  • 132
    • 84863615352 scopus 로고    scopus 로고
    • GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis
    • Kim, S.J., Nian, C., Karunakaran, S., Clee, S.M., Isales, C.M., and McIntosh, C.H. (2012). GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis. PLoS One 7, e40156.
    • (2012) PLoS One , vol.7 , pp. e40156
    • Kim, S.J.1    Nian, C.2    Karunakaran, S.3    Clee, S.M.4    Isales, C.M.5    McIntosh, C.H.6
  • 133
    • 84885950010 scopus 로고    scopus 로고
    • Gemigliptin, a novel dipeptidyl peptidase 4 inhibitor: First new anti-diabetic drug in the history of Korean pharmaceutical industry
    • Kim, S.H., Lee, S.H., and Yim, H.J. (2013). Gemigliptin, a novel dipeptidyl peptidase 4 inhibitor: first new anti-diabetic drug in the history of Korean pharmaceutical industry. Arch. Pharm. Res. 36, 1185-1188.
    • (2013) Arch. Pharm. Res. , vol.36 , pp. 1185-1188
    • Kim, S.H.1    Lee, S.H.2    Yim, H.J.3
  • 134
    • 67949112601 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway
    • Kimura, R., Okouchi, M., Fujioka, H., Ichiyanagi, A., Ryuge, F., Mizuno, T., Imaeda, K., Okayama, N., Kamiya, Y., Asai, K., et al. (2009). Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway. Neuroscience 162, 1212-1219.
    • (2009) Neuroscience , vol.162 , pp. 1212-1219
    • Kimura, R.1    Okouchi, M.2    Fujioka, H.3    Ichiyanagi, A.4    Ryuge, F.5    Mizuno, T.6    Imaeda, K.7    Okayama, N.8    Kamiya, Y.9    Asai, K.10
  • 135
    • 67649742213 scopus 로고    scopus 로고
    • Risk of incident Alzheimer's disease in diabetic patients: A systematic review of prospective trials
    • Kopf, D. and Frolich, L. (2009). Risk of incident Alzheimer's disease in diabetic patients: a systematic review of prospective trials. J. Alzheimers Dis. 16, 677-685.
    • (2009) J. Alzheimers Dis. , vol.16 , pp. 677-685
    • Kopf, D.1    Frolich, L.2
  • 137
    • 84888008405 scopus 로고    scopus 로고
    • Vildagliptin: An anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease
    • Kosaraju, J., Murthy, V., Khatwal, R.B., Dubala, A., Chinni, S., Muthureddy Nataraj, S.K., and Basavan, D. (2013b). Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease. J. Pharm. Pharmacol. 65, 1773-1784.
    • (2013) J. Pharm. Pharmacol. , vol.65 , pp. 1773-1784
    • Kosaraju, J.1    Murthy, V.2    Khatwal, R.B.3    Dubala, A.4    Chinni, S.5    Muthureddy Nataraj, S.K.6    Basavan, D.7
  • 138
    • 84891766932 scopus 로고    scopus 로고
    • A molecular connection of Pterocarpus marsupium, Eugenia jambolana and Gymnema sylvestre with dipeptidyl peptidase-4 in the treatment of diabetes
    • Kosaraju, J., Dubala, A., Chinni, S., Khatwal, R.B., Satish Kumar, M.N., and Basavan, D. (2014a). A molecular connection of Pterocarpus marsupium, Eugenia jambolana and Gymnema sylvestre with dipeptidyl peptidase-4 in the treatment of diabetes. Pharm. Biol. 52, 268-271.
    • (2014) Pharm. Biol. , vol.52 , pp. 268-271
    • Kosaraju, J.1    Dubala, A.2    Chinni, S.3    Khatwal, R.B.4    Satish Kumar, M.N.5    Basavan, D.6
  • 139
    • 84897429031 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition by Pterocarpus marsupium and Eugenia jambolana ameliorates streptozotocin induced Alzheimer's disease
    • Kosaraju, J., Madhunapantula, S.V., Chinni, S., Khatwal, R.B., Dubala, A., Muthureddy Nataraj, S.K., and Basavan, D. (2014b). Dipeptidyl peptidase-4 inhibition by Pterocarpus marsupium and Eugenia jambolana ameliorates streptozotocin induced Alzheimer's disease. Behav. Brain Res. 267, 55-65.
    • (2014) Behav. Brain Res. , vol.267 , pp. 55-65
    • Kosaraju, J.1    Madhunapantula, S.V.2    Chinni, S.3    Khatwal, R.B.4    Dubala, A.5    Muthureddy Nataraj, S.K.6    Basavan, D.7
  • 142
    • 0037787851 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV from bench to bedside: An update on structural properties, functions, and clinical aspects of the enzyme DPP IV
    • Lambeir, A.M., Durinx, C., Scharpe, S., and De Meester, I. (2003). Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit. Rev. Clin. Lab. Sci. 40, 209-294.
    • (2003) Crit. Rev. Clin. Lab. Sci. , vol.40 , pp. 209-294
    • Lambeir, A.M.1    Durinx, C.2    Scharpe, S.3    De Meester, I.4
  • 144
    • 84899064072 scopus 로고    scopus 로고
    • Effects of diabetes mellitus on amyotrophic lateral sclerosis: A systematic review
    • Lekoubou, A., Matsha, T.E., Sobngwi, E., and Kengne, A.P. (2014). Effects of diabetes mellitus on amyotrophic lateral sclerosis: a systematic review. BMC Res. Notes 7, 171.
    • (2014) BMC Res. Notes , vol.7 , pp. 171
    • Lekoubou, A.1    Matsha, T.E.2    Sobngwi, E.3    Kengne, A.P.4
  • 146
    • 36448936053 scopus 로고    scopus 로고
    • Common pathological processes in Alzheimer disease and type 2 diabetes: A review
    • Li, L. and Holscher, C. (2007). Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res. Rev. 56, 384-402.
    • (2007) Brain Res. Rev. , vol.56 , pp. 384-402
    • Li, L.1    Holscher, C.2
  • 149
    • 77953094551 scopus 로고    scopus 로고
    • Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells
    • Li, Y., Tweedie, D., Mattson, M.P., Holloway, H.W., and Greig, N.H. (2010b). Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells. J. Neurochem. 113, 1621-1631.
    • (2010) J. Neurochem. , vol.113 , pp. 1621-1631
    • Li, Y.1    Tweedie, D.2    Mattson, M.P.3    Holloway, H.W.4    Greig, N.H.5
  • 150
    • 84855548096 scopus 로고    scopus 로고
    • (Val(8)) glucagon-like peptide-1 prevents hyperphos phorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains
    • Li, L., Zhang, Z.F., Holscher, C., Gao, C., Jiang, Y.H., and Liu, Y.Z. (2012a). (Val(8)) glucagon-like peptide-1 prevents hyperphos phorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. Eur. J. Pharmacol. 674, 280-286.
    • (2012) Eur. J. Pharmacol. , vol.674 , pp. 280-286
    • Li, L.1    Zhang, Z.F.2    Holscher, C.3    Gao, C.4    Jiang, Y.H.5    Liu, Y.Z.6
  • 152
    • 84944270712 scopus 로고    scopus 로고
    • Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model
    • Li, Y., Liu, W., Li, L., and Holscher, C. (2016). Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model. Neuropharmacology 101, 255-263.
    • (2016) Neuropharmacology , vol.101 , pp. 255-263
    • Li, Y.1    Liu, W.2    Li, L.3    Holscher, C.4
  • 153
    • 77953726744 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects NSC-34 motor neurons against glucosamine through Epac-mediated glucose uptake enhancement
    • Lim, J.G., Lee, J.J., Park, S.H., Park, J.H., Kim, S.J., Cho, H.C., Baek, W.K., Kim, D.K., and Song, D.K. (2010). Glucagon-like peptide-1 protects NSC-34 motor neurons against glucosamine through Epac-mediated glucose uptake enhancement. Neurosci. Lett. 479, 13-17.
    • (2010) Neurosci. Lett. , vol.479 , pp. 13-17
    • Lim, J.G.1    Lee, J.J.2    Park, S.H.3    Park, J.H.4    Kim, S.J.5    Cho, H.C.6    Baek, W.K.7    Kim, D.K.8    Song, D.K.9
  • 156
    • 84936871959 scopus 로고    scopus 로고
    • Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    • Liu, W., Jalewa, J., Sharma, M., Li, G., Li, L., and Holscher, C. (2015a). Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Neuroscience 303, 42-50.
    • (2015) Neuroscience , vol.303 , pp. 42-50
    • Liu, W.1    Jalewa, J.2    Sharma, M.3    Li, G.4    Li, L.5    Holscher, C.6
  • 157
    • 84940650550 scopus 로고    scopus 로고
    • Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease
    • Liu, W., Li, Y., Jalewa, J., Saunders-Wood, T., Li, L., and Holscher, C. (2015b). Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease. Eur. J. Pharmacol. 765, 284-290.
    • (2015) Eur. J. Pharmacol. , vol.765 , pp. 284-290
    • Liu, W.1    Li, Y.2    Jalewa, J.3    Saunders-Wood, T.4    Li, L.5    Holscher, C.6
  • 158
    • 84874722479 scopus 로고    scopus 로고
    • The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease
    • Long-Smith, C.M., Manning, S., McClean, P.L., Coakley, M.F., O'Halloran, D.J., Holscher, C., and O'Neill, C. (2013). The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease. Neuromol. Med. 15, 102-114.
    • (2013) Neuromol. Med. , vol.15 , pp. 102-114
    • Long-Smith, C.M.1    Manning, S.2    McClean, P.L.3    Coakley, M.F.4    O'Halloran, D.J.5    Holscher, C.6    O'Neill, C.7
  • 159
    • 84862999162 scopus 로고    scopus 로고
    • Type 2 diabetes and cognitive impairment: Linking mechanisms
    • Luchsinger, J.A. (2012). Type 2 diabetes and cognitive impairment: linking mechanisms. J. Alzheimers Dis. 30 (Suppl 2), S185-S198.
    • (2012) J. Alzheimers Dis. , vol.30 , pp. S185-S198
    • Luchsinger, J.A.1
  • 160
    • 84901593760 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: Differences and similarities
    • Lund, A., Knop, F.K., and Vilsboll, T. (2014). Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: differences and similarities. Eur. J. Internal Med. 25, 407-414.
    • (2014) Eur. J. Internal Med. , vol.25 , pp. 407-414
    • Lund, A.1    Knop, F.K.2    Vilsboll, T.3
  • 161
    • 84919363202 scopus 로고    scopus 로고
    • Comparison of stability, cellular, glucose-lowering and appetite suppressing effects of oxyntomodulin analogues modified at the N-terminus
    • Lynch, A.M., Pathak, N., Flatt, Y.E., Gault, V.A., O'Harte, F.P., Irwin, N., and Flatt, P.R. (2014). Comparison of stability, cellular, glucose-lowering and appetite suppressing effects of oxyntomodulin analogues modified at the N-terminus. Eur. J. Pharmacol. 743, 69-78.
    • (2014) Eur. J. Pharmacol. , vol.743 , pp. 69-78
    • Lynch, A.M.1    Pathak, N.2    Flatt, Y.E.3    Gault, V.A.4    O'Harte, F.P.5    Irwin, N.6    Flatt, P.R.7
  • 163
    • 67650729973 scopus 로고    scopus 로고
    • βAmyloid oligomers induce phosphorylation of and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: Suppression by ω 3 fatty acids and curcumin
    • Ma, Q.L., Yang, F., Rosario, E.R., Ubeda, O.J., Beech, W., Gant, D.J., Chen, P.P., Hudspeth, B., Chen, C., Zhao, Y., et al. (2009). β Amyloid oligomers induce phosphorylation of and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by ω 3 fatty acids and curcumin. J. Neurosci. 29, 9078-9089.
    • (2009) J. Neurosci. , vol.29 , pp. 9078-9089
    • Ma, Q.L.1    Yang, F.2    Rosario, E.R.3    Ubeda, O.J.4    Beech, W.5    Gant, D.J.6    Chen, P.P.7    Hudspeth, B.8    Chen, C.9    Zhao, Y.10
  • 164
    • 54349119151 scopus 로고    scopus 로고
    • The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances β-cell function but does not inhibit gastric emptying in mice
    • Maida, A., Lovshin, J.A., Baggio, L.L., and Drucker, D.J. (2008). The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances β-cell function but does not inhibit gastric emptying in mice. Endocrinology 149, 5670-5678.
    • (2008) Endocrinology , vol.149 , pp. 5670-5678
    • Maida, A.1    Lovshin, J.A.2    Baggio, L.L.3    Drucker, D.J.4
  • 165
    • 33746192085 scopus 로고    scopus 로고
    • A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones
    • Marenah, L., McCluskey, J.T., Abdel-Wahab, Y.H., O'Harte, F.P., McClenaghan, N.H., and Flatt, P.R. (2006). A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones. Biol. Chem. 387, 941-947.
    • (2006) Biol. Chem. , vol.387 , pp. 941-947
    • Marenah, L.1    McCluskey, J.T.2    Abdel-Wahab, Y.H.3    O'Harte, F.P.4    McClenaghan, N.H.5    Flatt, P.R.6
  • 167
    • 63249091158 scopus 로고    scopus 로고
    • Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease
    • Martin, B., Golden, E., Carlson, O.D., Pistell, P., Zhou, J., Kim, W., Frank, B.P., Thomas, S., Chadwick, W.A., Greig, N.H., et al. (2009). Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease. Diabetes 58, 318-328.
    • (2009) Diabetes , vol.58 , pp. 318-328
    • Martin, B.1    Golden, E.2    Carlson, O.D.3    Pistell, P.4    Zhou, J.5    Kim, W.6    Frank, B.P.7    Thomas, S.8    Chadwick, W.A.9    Greig, N.H.10
  • 168
    • 84866419565 scopus 로고    scopus 로고
    • Euglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington disease is related to their physiological efficacy
    • Martin, B., Chadwick, W., Cong, W.N., Pantaleo, N., Daimon, C.M., Golden, E.J., Becker, K.G., Wood, W.H. 3rd, Carlson, O.D., Egan, J.M., et al. (2012). Euglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington disease is related to their physiological efficacy. J. Biol. Chem. 287, 31766-31782.
    • (2012) J. Biol. Chem. , vol.287 , pp. 31766-31782
    • Martin, B.1    Chadwick, W.2    Cong, W.N.3    Pantaleo, N.4    Daimon, C.M.5    Golden, E.J.6    Becker, K.G.7    Wood, W.H.8    Carlson, O.D.9    Egan, J.M.10
  • 169
    • 84931292010 scopus 로고    scopus 로고
    • Mechanisms of neurodegeration in type 2 diabetes and the neuroprotective potential of dipeptidyl peptidase 4 inhibitors
    • Matteucci, E. and Giampietro, O. (2015). Mechanisms of neurodegeration in type 2 diabetes and the neuroprotective potential of dipeptidyl peptidase 4 inhibitors. Curr. Med. Chem. 22, 1573-1581.
    • (2015) Curr. Med. Chem. , vol.22 , pp. 1573-1581
    • Matteucci, E.1    Giampietro, O.2
  • 170
    • 0032870219 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide stimulates glucocorticoid secretion in rats, acting through specific receptors coupled with the adenylate cyclase-dependent signaling pathway
    • Mazzocchi, G., Rebuffat, P., Meneghelli, V., Malendowicz, L.K., Tortorella, C., Gottardo, G., and Nussdorfer, G.G. (1999). Gastric inhibitory polypeptide stimulates glucocorticoid secretion in rats, acting through specific receptors coupled with the adenylate cyclase-dependent signaling pathway. Peptides 20, 589-594.
    • (1999) Peptides , vol.20 , pp. 589-594
    • Mazzocchi, G.1    Rebuffat, P.2    Meneghelli, V.3    Malendowicz, L.K.4    Tortorella, C.5    Gottardo, G.6    Nussdorfer, G.G.7
  • 171
    • 84886592674 scopus 로고    scopus 로고
    • Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease
    • McClean, P.L. and Holscher, C. (2014a). Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease. Neuropharmacology 76, 57-67.
    • (2014) Neuropharmacology , vol.76 , pp. 57-67
    • McClean, P.L.1    Holscher, C.2
  • 172
    • 84907302200 scopus 로고    scopus 로고
    • Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease
    • McClean, P.L. and Holscher, C. (2014b). Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease. Neuropharmacology 86C, 241-258.
    • (2014) Neuropharmacology , vol.86 C , pp. 241-258
    • McClean, P.L.1    Holscher, C.2
  • 173
    • 77649187436 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease
    • McClean, P.L., Gault, V.A., Harriott, P., and Holscher, C. (2010). Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease. Eur. J. Pharmacol. 630, 158-162.
    • (2010) Eur. J. Pharmacol. , vol.630 , pp. 158-162
    • McClean, P.L.1    Gault, V.A.2    Harriott, P.3    Holscher, C.4
  • 174
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    • McClean, P.L., Parthsarathy, V., Faivre, E., and Holscher, C. (2011). The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J. Neurosci. 31, 6587-6594.
    • (2011) J. Neurosci. , vol.31 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3    Holscher, C.4
  • 175
    • 61349172037 scopus 로고    scopus 로고
    • Glucosedependent insulinotropic polypeptide (gastric inhibitory polypeptide; GIP)
    • McIntosh, C.H., Widenmaier, S., and Kim, S.J. (2009). Glucosedependent insulinotropic polypeptide (gastric inhibitory polypeptide; GIP). Vitam Horm 80, 409-471.
    • (2009) Vitam Horm , vol.80 , pp. 409-471
    • McIntosh, C.H.1    Widenmaier, S.2    Kim, S.J.3
  • 176
    • 1442350411 scopus 로고    scopus 로고
    • Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects
    • Meier, J.J., Nauck, M.A., Kranz, D., Holst, J.J., Deacon, C.F., Gaeckler, D., Schmidt, W.E., and Gallwitz, B. (2004). Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects. Diabetes 53, 654-662.
    • (2004) Diabetes , vol.53 , pp. 654-662
    • Meier, J.J.1    Nauck, M.A.2    Kranz, D.3    Holst, J.J.4    Deacon, C.F.5    Gaeckler, D.6    Schmidt, W.E.7    Gallwitz, B.8
  • 177
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides
    • Mentlein, R. (1999). Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides. Regul. Pept. 85, 9-24.
    • (1999) Regul. Pept. , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 178
    • 0033545166 scopus 로고    scopus 로고
    • Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
    • Merchenthaler, I., Lane, M., and Shughrue, P. (1999). Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J. Comp. Neurol. 403, 261-280.
    • (1999) J. Comp. Neurol. , vol.403 , pp. 261-280
    • Merchenthaler, I.1    Lane, M.2    Shughrue, P.3
  • 179
    • 45749095401 scopus 로고    scopus 로고
    • Incretin mimetics and dipeptidyl peptidase 4 inhibitors in clinical trials for the treatment of type 2 diabetes
    • Mikhail, N. (2008). Incretin mimetics and dipeptidyl peptidase 4 inhibitors in clinical trials for the treatment of type 2 diabetes. Expert Opin. Investig. Drugs 17, 845-853.
    • (2008) Expert Opin. Investig. Drugs , vol.17 , pp. 845-853
    • Mikhail, N.1
  • 180
    • 77952100141 scopus 로고    scopus 로고
    • Casecontrol study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan
    • Miyake, Y., Tanaka, K., Fukushima, W., Sasaki, S., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., et al.; Fukuoka Kinki Parkinson's Disease Study G (2010). Casecontrol study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan. J. Neurol. Sci. 293, 82-86.
    • (2010) J. Neurol. Sci. , vol.293 , pp. 82-86
    • Miyake, Y.1    Tanaka, K.2    Fukushima, W.3    Sasaki, S.4    Kiyohara, C.5    Tsuboi, Y.6    Yamada, T.7    Oeda, T.8    Miki, T.9    Kawamura, N.10
  • 181
    • 71349085957 scopus 로고    scopus 로고
    • Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
    • Moloney, A.M., Griffin, R.J., Timmons, S., O'Connor, R., Ravid, R., and O'Neill, C. (2010). Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol. Aging 31, 224-243.
    • (2010) Neurobiol. Aging , vol.31 , pp. 224-243
    • Moloney, A.M.1    Griffin, R.J.2    Timmons, S.3    O'Connor, R.4    Ravid, R.5    O'Neill, C.6
  • 182
    • 38649121744 scopus 로고    scopus 로고
    • Towards a pathway definition of Parkinson's disease: A complex disorder with links to cancer, diabetes and inflammation
    • Moran, L.B. and Graeber, M.B. (2008). Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation. Neurogenetics 9, 1-13.
    • (2008) Neurogenetics , vol.9 , pp. 1-13
    • Moran, L.B.1    Graeber, M.B.2
  • 183
    • 0028344810 scopus 로고
    • Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease
    • Moroo, I., Yamada, T., Makino, H., Tooyama, I., McGeer, P.L., McGeer, E.G., and Hirayama, K. (1994). Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease. Acta Neuropathol. 87, 343-348.
    • (1994) Acta Neuropathol. , vol.87 , pp. 343-348
    • Moroo, I.1    Yamada, T.2    Makino, H.3    Tooyama, I.4    McGeer, P.L.5    McGeer, E.G.6    Hirayama, K.7
  • 184
    • 54549097933 scopus 로고    scopus 로고
    • Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease
    • Morris, J.K., Zhang, H., Gupte, A.A., Bomhoff, G.L., Stanford, J.A., and Geiger, P.C. (2008). Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease. Brain Res. 1240, 185-195.
    • (2008) Brain Res. , vol.1240 , pp. 185-195
    • Morris, J.K.1    Zhang, H.2    Gupte, A.A.3    Bomhoff, G.L.4    Stanford, J.A.5    Geiger, P.C.6
  • 188
    • 84941166485 scopus 로고    scopus 로고
    • Investigation of potential pharmacokinetic interactions between teneligliptin and metformin in steady-state conditions in healthy adults
    • Nakamaru, Y., Hayashi, Y., Davies, M., Jurgen Heuer, H., Hisanaga, N., and Akimoto, K. (2015). Investigation of potential pharmacokinetic interactions between teneligliptin and metformin in steady-state conditions in healthy adults. Clin. Ther. 37, 2007-2018.
    • (2015) Clin. Ther. , vol.37 , pp. 2007-2018
    • Nakamaru, Y.1    Hayashi, Y.2    Davies, M.3    Jurgen Heuer, H.4    Hisanaga, N.5    Akimoto, K.6
  • 190
    • 78650753885 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus: Properties, functions, and clinical implications
    • Nauck, M.A. (2011). Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications. Am. J. Med. 124, S3-S18.
    • (2011) Am. J. Med. , vol.124 , pp. S3-S18
    • Nauck, M.A.1
  • 193
    • 34547444040 scopus 로고    scopus 로고
    • Immunohistochemical distribution of glucose-dependent insulinotropic polypeptide in the adult rat brain
    • Nyberg, J., Jacobsson, C., Anderson, M.F., and Eriksson, P.S. (2007). Immunohistochemical distribution of glucose-dependent insulinotropic polypeptide in the adult rat brain. J. Neurosci. Res. 85, 2099-2119.
    • (2007) J. Neurosci. Res. , vol.85 , pp. 2099-2119
    • Nyberg, J.1    Jacobsson, C.2    Anderson, M.F.3    Eriksson, P.S.4
  • 194
    • 0032587206 scopus 로고    scopus 로고
    • 2-terminally modified gastric inhibitory polypeptide exhibits aminopeptidase resistance and enhanced antihyperglycemic activity
    • 2-terminally modified gastric inhibitory polypeptide exhibits aminopeptidase resistance and enhanced antihyperglycemic activity. Diabetes 48, 758-765.
    • (1999) Diabetes , vol.48 , pp. 758-765
    • O'Harte, F.P.1    Mooney, M.H.2    Flatt, P.R.3
  • 195
    • 0034131227 scopus 로고    scopus 로고
    • Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide
    • O'Harte, F.P., Mooney, M.H., Kelly, C.M., and Flatt, P.R. (2000). Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide. J. Endocrinol. 165, 639-648.
    • (2000) J. Endocrinol. , vol.165 , pp. 639-648
    • O'Harte, F.P.1    Mooney, M.H.2    Kelly, C.M.3    Flatt, P.R.4
  • 196
    • 0036383414 scopus 로고    scopus 로고
    • Improved stability, insulinreleasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP
    • O'Harte, F.P., Gault, V.A., Parker, J.C., Harriott, P., Mooney, M.H., Bailey, C.J., and Flatt, P.R. (2002). Improved stability, insulinreleasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP. Diabetologia 45, 1281-1291.
    • (2002) Diabetologia , vol.45 , pp. 1281-1291
    • O'Harte, F.P.1    Gault, V.A.2    Parker, J.C.3    Harriott, P.4    Mooney, M.H.5    Bailey, C.J.6    Flatt, P.R.7
  • 197
    • 84991366687 scopus 로고    scopus 로고
    • Agerelated decrease in glucagon-like peptide-1 in mouse prefrontal cortex but not in hippocampus despite the preservation of its receptor
    • Ohshima, R., Hotsumi, K., Holscher, C., and Seki, K. (2015). Agerelated decrease in glucagon-like peptide-1 in mouse prefrontal cortex but not in hippocampus despite the preservation of its receptor. Am. J. Biosci. 1, 11-27.
    • (2015) Am. J. Biosci. , vol.1 , pp. 11-27
    • Ohshima, R.1    Hotsumi, K.2    Holscher, C.3    Seki, K.4
  • 198
    • 0029765475 scopus 로고    scopus 로고
    • Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day
    • Orskov, C., Wettergren, A., and Holst, J.J. (1996). Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. Scand. J. Gastroenterol. 31, 665-670.
    • (1996) Scand. J. Gastroenterol. , vol.31 , pp. 665-670
    • Orskov, C.1    Wettergren, A.2    Holst, J.J.3
  • 200
    • 57749169279 scopus 로고    scopus 로고
    • Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI)
    • Parkinson, J.R., Chaudhri, O.B., Kuo, Y.T., Field, B.C., Herlihy, A.H., Dhillo, W.S., Ghatei, M.A., Bloom, S.R., and Bell, J.D. (2009). Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI). Neuro Image 44, 1022-1031.
    • (2009) Neuro Image , vol.44 , pp. 1022-1031
    • Parkinson, J.R.1    Chaudhri, O.B.2    Kuo, Y.T.3    Field, B.C.4    Herlihy, A.H.5    Dhillo, W.S.6    Ghatei, M.A.7    Bloom, S.R.8    Bell, J.D.9
  • 201
    • 84874085243 scopus 로고    scopus 로고
    • The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain
    • Parthsarathy, V. and Holscher, C. (2013). The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain. Eur. J. Pharmacol. 700, 42-50.
    • (2013) Eur. J. Pharmacol. , vol.700 , pp. 42-50
    • Parthsarathy, V.1    Holscher, C.2
  • 202
    • 84934990816 scopus 로고    scopus 로고
    • Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice
    • Pathak, N.M., Pathak, V., Lynch, A.M., Irwin, N., Gault, V.A., and Flatt, P.R. (2015). Stable oxyntomodulin analogues exert positive effects on hippocampal neurogenesis and gene expression as well as improving glucose homeostasis in high fat fed mice. Mol. Cell. Endocrinol. 412, 95-103.
    • (2015) Mol. Cell. Endocrinol. , vol.412 , pp. 95-103
    • Pathak, N.M.1    Pathak, V.2    Lynch, A.M.3    Irwin, N.4    Gault, V.A.5    Flatt, P.R.6
  • 203
    • 84907032242 scopus 로고    scopus 로고
    • Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice
    • Patil, S.P., Jain, P.D., Ghumatkar, P.J., Tambe, R., and Sathaye, S. (2014). Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice. Neuroscience 277, 747-754.
    • (2014) Neuroscience , vol.277 , pp. 747-754
    • Patil, S.P.1    Jain, P.D.2    Ghumatkar, P.J.3    Tambe, R.4    Sathaye, S.5
  • 205
    • 3442896818 scopus 로고    scopus 로고
    • A new Alzheimer's disease interventive strategy: GLP-1
    • Perry, T.A. and Greig, N.H. (2004). A new Alzheimer's disease interventive strategy: GLP-1. Curr. Drug Targets 5, 565-571.
    • (2004) Curr. Drug Targets , vol.5 , pp. 565-571
    • Perry, T.A.1    Greig, N.H.2
  • 206
    • 0036721026 scopus 로고    scopus 로고
    • Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4
    • Perry, T., Haughey, N.J., Mattson, M.P., Egan, J.M., and Greig, N.H. (2002a). Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J. Pharmacol. Exp. Ther. 302, 881-888.
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 881-888
    • Perry, T.1    Haughey, N.J.2    Mattson, M.P.3    Egan, J.M.4    Greig, N.H.5
  • 207
    • 0036182251 scopus 로고    scopus 로고
    • A novel neurotrophic property of glucagonlike peptide 1: A promoter of nerve growth factor-mediated differentiation in PC12 cells
    • Perry, T., Lahiri, D.K., Chen, D., Zhou, J., Shaw, K.T., Egan, J.M., and Greig, N.H. (2002b). A novel neurotrophic property of glucagonlike peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J. Pharmacol. Exp. Ther. 300, 958-966.
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 958-966
    • Perry, T.1    Lahiri, D.K.2    Chen, D.3    Zhou, J.4    Shaw, K.T.5    Egan, J.M.6    Greig, N.H.7
  • 208
    • 0038248960 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 decreases endogenous amyloid-β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron
    • Perry, T., Lahiri, D.K., Sambamurti, K., Chen, D., Mattson, M.P., Egan, J.M., and Greig, N.H. (2003). Glucagon-like peptide-1 decreases endogenous amyloid-β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron. J. Neurosci. Res. 72, 603-612.
    • (2003) J. Neurosci. Res. , vol.72 , pp. 603-612
    • Perry, T.1    Lahiri, D.K.2    Sambamurti, K.3    Chen, D.4    Mattson, M.P.5    Egan, J.M.6    Greig, N.H.7
  • 209
    • 0023394123 scopus 로고
    • Reduction in insulin receptors in amyotrophic lateral sclerosis correlates with reduced insulin sensitivity
    • Perurena, O.H. and Festoff, B.W. (1987). Reduction in insulin receptors in amyotrophic lateral sclerosis correlates with reduced insulin sensitivity. Neurology 37, 1375-1379.
    • (1987) Neurology , vol.37 , pp. 1375-1379
    • Perurena, O.H.1    Festoff, B.W.2
  • 210
    • 33747602312 scopus 로고    scopus 로고
    • Hypothalamic-endocrine aspects in Huntington's disease
    • Petersen, A. and Bjorkqvist, M. (2006). Hypothalamic-endocrine aspects in Huntington's disease. Eur. J. Neurosci. 24, 961-967.
    • (2006) Eur. J. Neurosci. , vol.24 , pp. 961-967
    • Petersen, A.1    Bjorkqvist, M.2
  • 211
    • 84879166768 scopus 로고    scopus 로고
    • Clinical potential of lixisenatide once daily treatment for type 2 diabetes mellitus
    • Petersen, A.B. and Christensen, M. (2013). Clinical potential of lixisenatide once daily treatment for type 2 diabetes mellitus. Diabetes Metab. Syndr. Obes. Targets Ther. 6, 217-231.
    • (2013) Diabetes Metab. Syndr. Obes. Targets Ther. , vol.6 , pp. 217-231
    • Petersen, A.B.1    Christensen, M.2
  • 212
    • 84878781836 scopus 로고    scopus 로고
    • DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats
    • Pintana, H., Apaijai, N., Chattipakorn, N., and Chattipakorn, S.C. (2013). DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats. J. Endocrinol. 218, 1-11.
    • (2013) J. Endocrinol. , vol.218 , pp. 1-11
    • Pintana, H.1    Apaijai, N.2    Chattipakorn, N.3    Chattipakorn, S.C.4
  • 213
    • 84874525661 scopus 로고    scopus 로고
    • DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption
    • Pipatpiboon, N., Pintana, H., Pratchayasakul, W., Chattipakorn, N., and Chattipakorn, S.C. (2013). DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption. Eur. J. Neurosci. 37, 839-849.
    • (2013) Eur. J. Neurosci. , vol.37 , pp. 839-849
    • Pipatpiboon, N.1    Pintana, H.2    Pratchayasakul, W.3    Chattipakorn, N.4    Chattipakorn, S.C.5
  • 214
    • 84895736410 scopus 로고    scopus 로고
    • Sitagliptin: A review of its use in patients with type 2 diabetes mellitus
    • Plosker, G.L. (2014). Sitagliptin: a review of its use in patients with type 2 diabetes mellitus. Drugs 74, 223-242.
    • (2014) Drugs , vol.74 , pp. 223-242
    • Plosker, G.L.1
  • 215
    • 84897116945 scopus 로고    scopus 로고
    • Action and therapeutic potential of oxyntomodulin
    • Pocai, A. (2014). Action and therapeutic potential of oxyntomodulin. Mol. Metab. 3, 241-251.
    • (2014) Mol. Metab. , vol.3 , pp. 241-251
    • Pocai, A.1
  • 217
    • 0017369458 scopus 로고
    • Abnormal glucose tolerance and arginine tolerance tests in Huntington's disease
    • Podolsky, S. and Leopold, N.A. (1977). Abnormal glucose tolerance and arginine tolerance tests in Huntington's disease. Gerontology 23, 55-63.
    • (1977) Gerontology , vol.23 , pp. 55-63
    • Podolsky, S.1    Leopold, N.A.2
  • 218
    • 78651084780 scopus 로고    scopus 로고
    • Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice
    • Porter, D.W., Irwin, N., Flatt, P.R., Holscher, C., and Gault, V.A. (2011). Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice. Eur. J. Pharmacol. 650, 688-693.
    • (2011) Eur. J. Pharmacol. , vol.650 , pp. 688-693
    • Porter, D.W.1    Irwin, N.2    Flatt, P.R.3    Holscher, C.4    Gault, V.A.5
  • 221
    • 84867040244 scopus 로고    scopus 로고
    • Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions
    • Rampersaud, N., Harkavyi, A., Giordano, G., Lever, R., Whitton, J., and Whitton, P.S. (2012). Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions. Neuropeptides 46, 183-193.
    • (2012) Neuropeptides , vol.46 , pp. 183-193
    • Rampersaud, N.1    Harkavyi, A.2    Giordano, G.3    Lever, R.4    Whitton, J.5    Whitton, P.S.6
  • 222
    • 84953371067 scopus 로고    scopus 로고
    • G protein-coupled receptors as new therapeutic targets for type 2 diabetes
    • Reimann, F. and Gribble, F.M. (2016). G protein-coupled receptors as new therapeutic targets for type 2 diabetes. Diabetologia 59, 229-233.
    • (2016) Diabetologia , vol.59 , pp. 229-233
    • Reimann, F.1    Gribble, F.M.2
  • 224
    • 52249111564 scopus 로고    scopus 로고
    • Emerging role of dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes
    • Richter, B., Bandeira-Echtler, E., Bergerhoff, K., and Lerch, C. (2008). Emerging role of dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes. Vasc. Health Risk Manage. 4, 753-768.
    • (2008) Vasc. Health Risk Manage. , vol.4 , pp. 753-768
    • Richter, B.1    Bandeira-Echtler, E.2    Bergerhoff, K.3    Lerch, C.4
  • 225
    • 0017377640 scopus 로고
    • Hypersecretion of gastric inhibitory polypeptide following oral glucose in diabetes mellitus
    • Ross, S.A., Brown, J.C., and Dupre, J. (1977). Hypersecretion of gastric inhibitory polypeptide following oral glucose in diabetes mellitus. Diabetes 26, 525-529.
    • (1977) Diabetes , vol.26 , pp. 525-529
    • Ross, S.A.1    Brown, J.C.2    Dupre, J.3
  • 226
    • 79960035951 scopus 로고    scopus 로고
    • Incretin analogues as a novel treatment strategy for Alzheimer's disease
    • Sakurai, T. (2011). Incretin analogues as a novel treatment strategy for Alzheimer's disease. Nihon Rinsho Jpn. J. Clin. Med. 69, 848-852.
    • (2011) Nihon Rinsho Jpn. J. Clin. Med. , vol.69 , pp. 848-852
    • Sakurai, T.1
  • 227
    • 84862748768 scopus 로고    scopus 로고
    • Neuroprotective and neurotrophic actions of glucagon-like peptide-1: An emerging opportunity to treat neurodegenerative and cerebrovascular disorders
    • Salcedo, I., Tweedie, D., Li, Y., and Greig, N.H. (2012). Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders. Br. J. Pharmacol. 166, 1586-1599.
    • (2012) Br. J. Pharmacol. , vol.166 , pp. 1586-1599
    • Salcedo, I.1    Tweedie, D.2    Li, Y.3    Greig, N.H.4
  • 228
    • 23644439921 scopus 로고    scopus 로고
    • Contribution of site-specific PEGylation to the dipeptidyl peptidase IV stability of glucosedependent insulinotropic polypeptide
    • Salhanick, A.I., Clairmont, K.B., Buckholz, T.M., Pellegrino, C.M., Ha, S., and Lumb, KJ. (2005). Contribution of site-specific PEGylation to the dipeptidyl peptidase IV stability of glucosedependent insulinotropic polypeptide. Bioorg. Med. Chem. Lett. 15, 4114-4117.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 4114-4117
    • Salhanick, A.I.1    Clairmont, K.B.2    Buckholz, T.M.3    Pellegrino, C.M.4    Ha, S.5    Lumb, K.J.6
  • 229
    • 84875235515 scopus 로고    scopus 로고
    • Shared dysregulated pathways lead to Parkinson's disease and diabetes
    • Santiago, J.A. and Potashkin, J.A. (2013). Shared dysregulated pathways lead to Parkinson's disease and diabetes. Trends Mol. Med. 19, 176-186.
    • (2013) Trends Mol. Med. , vol.19 , pp. 176-186
    • Santiago, J.A.1    Potashkin, J.A.2
  • 230
    • 84959495258 scopus 로고    scopus 로고
    • Dulaglutide (LY-2189265) for the treatment of type 2 diabetes
    • Scheen, A.J. (2016). Dulaglutide (LY-2189265) for the treatment of type 2 diabetes. Expert Rev. Clin. Pharmacol. 9, 385-399.
    • (2016) Expert Rev. Clin. Pharmacol. , vol.9 , pp. 385-399
    • Scheen, A.J.1
  • 231
    • 79956139625 scopus 로고    scopus 로고
    • Diabetes and the risk of developing Parkinson's disease in Denmark
    • Schernhammer, E., Hansen, J., Rugbjerg, K., Wermuth, L., and Ritz, B. (2011). Diabetes and the risk of developing Parkinson's disease in Denmark. Diabetes Care 34, 1102-1108.
    • (2011) Diabetes Care , vol.34 , pp. 1102-1108
    • Schernhammer, E.1    Hansen, J.2    Rugbjerg, K.3    Wermuth, L.4    Ritz, B.5
  • 232
  • 233
    • 84906923428 scopus 로고    scopus 로고
    • Proteomic analysis of the human brain in Huntington's disease indicates pathogenesis by molecular processes linked to other neurodegenerative diseases and to type-2 diabetes
    • Schonberger, S.J., Jezdic, D., Faull, R.L., and Cooper, G.J. (2013). Proteomic analysis of the human brain in Huntington's disease indicates pathogenesis by molecular processes linked to other neurodegenerative diseases and to type-2 diabetes. J. Huntingtons Dis. 2, 89-99.
    • (2013) J. Huntingtons Dis. , vol.2 , pp. 89-99
    • Schonberger, S.J.1    Jezdic, D.2    Faull, R.L.3    Cooper, G.J.4
  • 234
    • 84878360808 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas
    • Seino, Y. and Yabe, D. (2013). Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: incretin actions beyond the pancreas. J. Diabetes Invest. 4, 108-130.
    • (2013) J. Diabetes Invest. , vol.4 , pp. 108-130
    • Seino, Y.1    Yabe, D.2
  • 235
    • 84904388473 scopus 로고    scopus 로고
    • The extra-pancreatic effects of GLP-1 receptor agonists: A focus on the cardiovascular, gastrointestinal and central nervous systems
    • Seufert, J. and Gallwitz, B. (2014). The extra-pancreatic effects of GLP-1 receptor agonists: a focus on the cardiovascular, gastrointestinal and central nervous systems. Diabetes Obes. Metab. 16, 673-688.
    • (2014) Diabetes Obes. Metab. , vol.16 , pp. 673-688
    • Seufert, J.1    Gallwitz, B.2
  • 236
    • 84897003731 scopus 로고    scopus 로고
    • Neuroprotective and anti-apoptotic effects of Liraglutide on SH-SY5Y cells exposed to methylglyoxal stress
    • Sharma, M., Jalewa, J., and Holscher, C. (2013). Neuroprotective and anti-apoptotic effects of Liraglutide on SH-SY5Y cells exposed to methylglyoxal stress. J. Neurochem. 128, 459-471.
    • (2013) J. Neurochem. , vol.128 , pp. 459-471
    • Sharma, M.1    Jalewa, J.2    Holscher, C.3
  • 237
    • 84942435321 scopus 로고    scopus 로고
    • Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats
    • Solmaz, V., Cinar, B.P., Yigitturk, G., Cavusoglu, T., Taskiran, D., and Erbas, O. (2015). Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats. Eur. J. Pharmacol. 765, 482-487.
    • (2015) Eur. J. Pharmacol. , vol.765 , pp. 482-487
    • Solmaz, V.1    Cinar, B.P.2    Yigitturk, G.3    Cavusoglu, T.4    Taskiran, D.5    Erbas, O.6
  • 239
  • 240
    • 84876680630 scopus 로고    scopus 로고
    • Therapeutic potential of N-acetyl-glucagon-like peptide-1 in primary motor neuron cultures derived from non-transgenic and SOD1-G93A ALS mice
    • Sun, H., Knippenberg, S., Thau, N., Ragancokova, D., Korner, S., Huang, D., Dengler, R., Dohler, K., and Petri, S. (2013). Therapeutic potential of N-acetyl-glucagon-like peptide-1 in primary motor neuron cultures derived from non-transgenic and SOD1-G93A ALS mice. Cell. Mol. Neurobiol. 33, 347-357.
    • (2013) Cell. Mol. Neurobiol. , vol.33 , pp. 347-357
    • Sun, H.1    Knippenberg, S.2    Thau, N.3    Ragancokova, D.4    Korner, S.5    Huang, D.6    Dengler, R.7    Dohler, K.8    Petri, S.9
  • 241
    • 84930702045 scopus 로고    scopus 로고
    • Risk of amyotrophic lateral sclerosis in patients with diabetes: A nationwide population-based cohort study
    • Sun, Y., Lu, C.J., Chen, R.C., Hou, W.H., and Li, C.Y. (2015). Risk of amyotrophic lateral sclerosis in patients with diabetes: a nationwide population-based cohort study. J. Epidemiol. Jpn. Epidemiol. Assoc. 25, 445-451.
    • (2015) J. Epidemiol. Jpn. Epidemiol. Assoc. , vol.25 , pp. 445-451
    • Sun, Y.1    Lu, C.J.2    Chen, R.C.3    Hou, W.H.4    Li, C.Y.5
  • 244
    • 84859718265 scopus 로고    scopus 로고
    • Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
    • Talbot, K., Wang, H.Y., Kazi, H., Han, L.Y., Bakshi, K.P., Stucky, A., Fuino, R.L., Kawaguchi, K.R., Samoyedny, A.J., Wilson, R.S., et al. (2012). Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J. Clin. Invest. 122, 1316-1338.
    • (2012) J. Clin. Invest. , vol.122 , pp. 1316-1338
    • Talbot, K.1    Wang, H.Y.2    Kazi, H.3    Han, L.Y.4    Bakshi, K.P.5    Stucky, A.6    Fuino, R.L.7    Kawaguchi, K.R.8    Samoyedny, A.J.9    Wilson, R.S.10
  • 245
    • 79951824233 scopus 로고    scopus 로고
    • The ϵ3 and ϵ4 alleles of human APOE differentially Affect phosphorylation in hyperinsulinemic and pioglitazone treated mice
    • To, A.W., Ribe, E.M., Chuang, T.T., Schroeder, J.E., and Lovestone, S. (2011). The ϵ3 and ϵ4 alleles of human APOE differentially Affect phosphorylation in hyperinsulinemic and pioglitazone treated mice. PLoS One 6, e16991.
    • (2011) PLoS One , vol.6 , pp. e16991
    • To, A.W.1    Ribe, E.M.2    Chuang, T.T.3    Schroeder, J.E.4    Lovestone, S.5
  • 246
    • 70349923522 scopus 로고    scopus 로고
    • Albiglutide, an albumin-based fusion of glucagon-like peptide 1 for the potential treatment of type 2 diabetes
    • Tomkin, G.H. (2009). Albiglutide, an albumin-based fusion of glucagon-like peptide 1 for the potential treatment of type 2 diabetes. Curr. Opin. Mol. Ther. 11, 579-588.
    • (2009) Curr. Opin. Mol. Ther. , vol.11 , pp. 579-588
    • Tomkin, G.H.1
  • 247
    • 36348935683 scopus 로고    scopus 로고
    • Soluble Aβ inhibits specific signal transduction cascades common to the insulin receptor pathway
    • Townsend, M., Mehta, T., and Selkoe, D.J. (2007). Soluble Aβ inhibits specific signal transduction cascades common to the insulin receptor pathway. J. Biol. Chem. 282, 33305-33312.
    • (2007) J. Biol. Chem. , vol.282 , pp. 33305-33312
    • Townsend, M.1    Mehta, T.2    Selkoe, D.J.3
  • 248
    • 84908099303 scopus 로고    scopus 로고
    • Albiglutide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes
    • Trujillo, J.M. and Nuffer, W. (2014). Albiglutide: a new GLP-1 receptor agonist for the treatment of type 2 diabetes. Ann. Pharmacother. 48, 1494-1501.
    • (2014) Ann. Pharmacother. , vol.48 , pp. 1494-1501
    • Trujillo, J.M.1    Nuffer, W.2
  • 249
    • 0036687655 scopus 로고    scopus 로고
    • Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in β (INS-1)-cells
    • Trumper, A., Trumper, K., and Horsch, D. (2002). Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in β (INS-1)-cells. J. Endocrinol. 174, 233-246.
    • (2002) J. Endocrinol. , vol.174 , pp. 233-246
    • Trumper, A.1    Trumper, K.2    Horsch, D.3
  • 250
    • 0034838323 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide is a growth factor for β (INS-1) cells by pleiotropic signaling
    • Trumper, A., Trumper, K., Trusheim, H., Arnold, R., Goke, B., and Horsch, D. (2001). Glucose-dependent insulinotropic polypeptide is a growth factor for β (INS-1) cells by pleiotropic signaling. Mol. Endocrinol. 15, 1559-1570.
    • (2001) Mol. Endocrinol. , vol.15 , pp. 1559-1570
    • Trumper, A.1    Trumper, K.2    Trusheim, H.3    Arnold, R.4    Goke, B.5    Horsch, D.6
  • 252
    • 66249143015 scopus 로고    scopus 로고
    • Liraglutide: A new treatment for type 2 diabetes
    • Vilsboll, T. (2009). Liraglutide: a new treatment for type 2 diabetes. Drugs Today 45, 101-113.
    • (2009) Drugs Today , vol.45 , pp. 101-113
    • Vilsboll, T.1
  • 253
    • 77956301808 scopus 로고    scopus 로고
    • Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: Role of peripherally secreted and centrally produced peptides
    • Vrang, N. and Larsen, P.J. (2010). Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides. Prog. Neurobiol. 92, 442-462.
    • (2010) Prog. Neurobiol. , vol.92 , pp. 442-462
    • Vrang, N.1    Larsen, P.J.2
  • 254
    • 77957126457 scopus 로고    scopus 로고
    • Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats
    • Wang, X.H., Li, L., Holscher, C., Pan, Y.F., Chen, X.R., and Qi, J..S (2010). Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats. Neuroscience 170, 1239-1248.
    • (2010) Neuroscience , vol.170 , pp. 1239-1248
    • Wang, X.H.1    Li, L.2    Holscher, C.3    Pan, Y.F.4    Chen, X.R.5    Qi, J.S.6
  • 255
    • 84873718532 scopus 로고    scopus 로고
    • Val(8)-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats
    • Wang, X.H., Yang, W., Holscher, C., Wang, Z.J., Cai, H.Y., Li, Q.S., and Qi, J.S. (2013). Val(8)-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats. J. Neurosci. Res. 91, 568-577.
    • (2013) J. Neurosci. Res. , vol.91 , pp. 568-577
    • Wang, X.H.1    Yang, W.2    Holscher, C.3    Wang, Z.J.4    Cai, H.Y.5    Li, Q.S.6    Qi, J.S.7
  • 256
    • 23644443678 scopus 로고    scopus 로고
    • Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: A double-blind, randomized, controlled trial
    • Wynne, K., Park, A.J., Small, C.J., Patterson, M., Ellis, S.M., Murphy, K.G., Wren, A.M., Frost, G.S., Meeran, K., Ghatei, M.A., et al. (2005). Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial. Diabetes 54, 2390-2395.
    • (2005) Diabetes , vol.54 , pp. 2390-2395
    • Wynne, K.1    Park, A.J.2    Small, C.J.3    Patterson, M.4    Ellis, S.M.5    Murphy, K.G.6    Wren, A.M.7    Frost, G.S.8    Meeran, K.9    Ghatei, M.A.10
  • 257
    • 33749339257 scopus 로고    scopus 로고
    • Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: A randomised controlled trial
    • Wynne, K., Park, A.J., Small, C.J., Meeran, K., Ghatei, M.A., Frost, G.S., and Bloom, S.R. (2006). Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial. Int. J. Obes. (Lond.) 30, 1729-1736.
    • (2006) Int. J. Obes. (Lond.) , vol.30 , pp. 1729-1736
    • Wynne, K.1    Park, A.J.2    Small, C.J.3    Meeran, K.4    Ghatei, M.A.5    Frost, G.S.6    Bloom, S.R.7
  • 258
    • 84892690389 scopus 로고    scopus 로고
    • The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of and neurofilament proteins and insulin signaling pathways in mice
    • Xiong, H., Zheng, C., Wang, J., Song, J., Zhao, G., Shen, H., and Deng, Y. (2013). The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of and neurofilament proteins and insulin signaling pathways in mice. J. Alzheimers Dis. 37, 623-635.
    • (2013) J. Alzheimers Dis. , vol.37 , pp. 623-635
    • Xiong, H.1    Zheng, C.2    Wang, J.3    Song, J.4    Zhao, G.5    Shen, H.6    Deng, Y.7
  • 261
    • 84933502701 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, double-blind, phase 3 trial to evaluate the efficacy and safety of anagliptin in drug-naive patients with type 2 diabetes
    • Yang, H.K., Min, K.W., Park, S.W., Chung, C.H., Park, K.S., Choi, S.H., Song, K.H., Kim, D.M., Lee, M.K., Sung, Y.A., et al. (2015). A randomized, placebo-controlled, double-blind, phase 3 trial to evaluate the efficacy and safety of anagliptin in drug-naive patients with type 2 diabetes. Endocr. J. 62, 449-462.
    • (2015) Endocr. J. , vol.62 , pp. 449-462
    • Yang, H.K.1    Min, K.W.2    Park, S.W.3    Chung, C.H.4    Park, K.S.5    Choi, S.H.6    Song, K.H.7    Kim, D.M.8    Lee, M.K.9    Sung, Y.A.10
  • 263
    • 84938150642 scopus 로고    scopus 로고
    • Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson's disease mouse model
    • Zhang, Y., Chen, Y., Li, L., and Holscher, C. (2015a). Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson's disease mouse model. Behav. Brain Res. 293, 107-113.
    • (2015) Behav. Brain Res. , vol.293 , pp. 107-113
    • Zhang, Y.1    Chen, Y.2    Li, L.3    Holscher, C.4
  • 264
    • 84942296710 scopus 로고    scopus 로고
    • Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS1 transgenic model of Alzheimer's disease
    • Zhang, Y., Yin, F., Liu, J., Liu, Z., Guo, L., Xia, Z., and Zidichouski, J. (2015b). Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS1 transgenic model of Alzheimer's disease. Neurochem. Int. 89, 7-16.
    • (2015) Neurochem. Int. , vol.89 , pp. 7-16
    • Zhang, Y.1    Yin, F.2    Liu, J.3    Liu, Z.4    Guo, L.5    Xia, Z.6    Zidichouski, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.