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Volumn 228, Issue , 2013, Pages 294-300

The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease

Author keywords

GIP; Growth factor; Insulin; Neurodegeneration; Neuron; Neuroprotection

Indexed keywords

GASTRIC INHIBITORY POLYPEPTIDE; GLIAL FIBRILLARY ACIDIC PROTEIN; INCRETIN; INSULIN RECEPTOR;

EID: 84869234340     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.10.045     Document Type: Article
Times cited : (88)

References (47)
  • 1
    • 0141453824 scopus 로고    scopus 로고
    • The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease
    • Aisen P.S. The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease. Lancet Neurol 2002, 1:279-284.
    • (2002) Lancet Neurol , vol.1 , pp. 279-284
    • Aisen, P.S.1
  • 2
    • 0028103819 scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: implications for therapy
    • Aisen P.S., Davis K.L. Inflammatory mechanisms in Alzheimer's disease: implications for therapy. Am J Psychiatry 1994, 151:1105-1113.
    • (1994) Am J Psychiatry , vol.151 , pp. 1105-1113
    • Aisen, P.S.1    Davis, K.L.2
  • 3
    • 27844472159 scopus 로고    scopus 로고
    • Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?
    • Biessels G.J., Kappelle L.J. Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?. Biochem Soc Trans 2005, 33:1041-1044.
    • (2005) Biochem Soc Trans , vol.33 , pp. 1041-1044
    • Biessels, G.J.1    Kappelle, L.J.2
  • 6
    • 66049137664 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): cellular localization, lesion-affected expression, and impaired regenerative axonal growth
    • Buhren B.A., Gasis M., Thorens B., Muller H.W., Bosse F. Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): cellular localization, lesion-affected expression, and impaired regenerative axonal growth. J Neurosci Res 2009, 87:1858-1870.
    • (2009) J Neurosci Res , vol.87 , pp. 1858-1870
    • Buhren, B.A.1    Gasis, M.2    Thorens, B.3    Muller, H.W.4    Bosse, F.5
  • 7
    • 1842633868 scopus 로고    scopus 로고
    • The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease
    • Carro E., Torres A.I. The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease. Eur J Pharmacol 2004, 490:127-133.
    • (2004) Eur J Pharmacol , vol.490 , pp. 127-133
    • Carro, E.1    Torres, A.I.2
  • 8
    • 1842633868 scopus 로고    scopus 로고
    • The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease
    • Carro E., Torres-Aleman I. The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease. Eur J Pharmacol 2004, 490:127-133.
    • (2004) Eur J Pharmacol , vol.490 , pp. 127-133
    • Carro, E.1    Torres-Aleman, I.2
  • 9
    • 14944372848 scopus 로고    scopus 로고
    • NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models
    • Cole G.M., Morihara T., Lim G.P., Yang F., Begum A., Frautschy S.A. NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models. Ann N Y Acad Sci 2004, 1035:68-84.
    • (2004) Ann N Y Acad Sci , vol.1035 , pp. 68-84
    • Cole, G.M.1    Morihara, T.2    Lim, G.P.3    Yang, F.4    Begum, A.5    Frautschy, S.A.6
  • 10
    • 28444459842 scopus 로고    scopus 로고
    • Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation
    • Craft S. Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation. Neurobiol Aging 2005, 26(Suppl. 1):65-69.
    • (2005) Neurobiol Aging , vol.26 , Issue.SUPPL. 1 , pp. 65-69
    • Craft, S.1
  • 11
    • 34147173277 scopus 로고    scopus 로고
    • Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment
    • Craft S. Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res 2007, 4:147-152.
    • (2007) Curr Alzheimer Res , vol.4 , pp. 147-152
    • Craft, S.1
  • 12
    • 84855544372 scopus 로고    scopus 로고
    • Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice
    • Faivre E., Hamilton A., Holscher C. Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice. Eur J Pharmacol 2012, 674:294-306.
    • (2012) Eur J Pharmacol , vol.674 , pp. 294-306
    • Faivre, E.1    Hamilton, A.2    Holscher, C.3
  • 14
    • 77955982823 scopus 로고    scopus 로고
    • Role of the glucose-dependent insulinotropic polypeptide and its receptor in the central nervous system: therapeutic potential in neurological diseases
    • Figueiredo C.P., Pamplona F.A., Mazzuco T.L., Aguiar A.S., Walz R., Prediger R.D. Role of the glucose-dependent insulinotropic polypeptide and its receptor in the central nervous system: therapeutic potential in neurological diseases. Behav Pharmacol 2010, 21:394-408.
    • (2010) Behav Pharmacol , vol.21 , pp. 394-408
    • Figueiredo, C.P.1    Pamplona, F.A.2    Mazzuco, T.L.3    Aguiar, A.S.4    Walz, R.5    Prediger, R.D.6
  • 15
    • 0142026832 scopus 로고    scopus 로고
    • Potential roles of insulin and IGF-1 in Alzheimer's disease
    • Gasparini L., Xu H. Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends Neurosci 2003, 26:404-406.
    • (2003) Trends Neurosci , vol.26 , pp. 404-406
    • Gasparini, L.1    Xu, H.2
  • 16
    • 42249106405 scopus 로고    scopus 로고
    • Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid
    • Gault V.A., Holscher C. Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid. J Neurophysiol 2008, 99:1590-1595.
    • (2008) J Neurophysiol , vol.99 , pp. 1590-1595
    • Gault, V.A.1    Holscher, C.2
  • 17
    • 82755176046 scopus 로고    scopus 로고
    • Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
    • Gengler S., McClean P., McCurtin R., Gault V., Holscher C. Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol Aging 2012, 33:265-276.
    • (2012) Neurobiol Aging , vol.33 , pp. 265-276
    • Gengler, S.1    McClean, P.2    McCurtin, R.3    Gault, V.4    Holscher, C.5
  • 18
    • 14944371918 scopus 로고    scopus 로고
    • New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-{alpha} inhibitors, and GLP-1 receptor agonists
    • Greig N.H., Mattson M.P., Perry T., Chan S.L., Giordano T., Sambamurti K., Rogers J.T., Ovadia H., Lahiri D.K. New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-{alpha} inhibitors, and GLP-1 receptor agonists. Ann N Y Acad Sci 2004, 1035:290-315.
    • (2004) Ann N Y Acad Sci , vol.1035 , pp. 290-315
    • Greig, N.H.1    Mattson, M.P.2    Perry, T.3    Chan, S.L.4    Giordano, T.5    Sambamurti, K.6    Rogers, J.T.7    Ovadia, H.8    Lahiri, D.K.9
  • 19
    • 84859429769 scopus 로고    scopus 로고
    • The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease
    • Hamilton A., Holscher C. The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease. Brain Res 2012, 1449:83-93.
    • (2012) Brain Res , vol.1449 , pp. 83-93
    • Hamilton, A.1    Holscher, C.2
  • 20
    • 0019458387 scopus 로고
    • Insulin and insulin receptors in rodent brain
    • Havrankova J., Brownstein M., Roth J. Insulin and insulin receptors in rodent brain. Diabetologia 1981, 20(Suppl.):268-273.
    • (1981) Diabetologia , vol.20 , Issue.SUPPL. , pp. 268-273
    • Havrankova, J.1    Brownstein, M.2    Roth, J.3
  • 22
    • 79960866529 scopus 로고    scopus 로고
    • Proinflammatory cytokines, sickness behavior, and Alzheimer disease
    • Holmes C., Cunningham C., Zotova E., Culliford D., Perry V.H. Proinflammatory cytokines, sickness behavior, and Alzheimer disease. Neurology 2011, 77:212-218.
    • (2011) Neurology , vol.77 , pp. 212-218
    • Holmes, C.1    Cunningham, C.2    Zotova, E.3    Culliford, D.4    Perry, V.H.5
  • 23
    • 0344936729 scopus 로고    scopus 로고
    • Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis
    • Holscher C. Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis. Neurobiol Dis 1998, 5:129-141.
    • (1998) Neurobiol Dis , vol.5 , pp. 129-141
    • Holscher, C.1
  • 24
    • 77953880083 scopus 로고    scopus 로고
    • Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease
    • Holscher C. Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease. Recent Pat CNS Drug Discov 2010, 5:109-117.
    • (2010) Recent Pat CNS Drug Discov , vol.5 , pp. 109-117
    • Holscher, C.1
  • 25
    • 78649385516 scopus 로고    scopus 로고
    • The role of GLP-1 in neuronal activity and neurodegeneration
    • Holscher C. The role of GLP-1 in neuronal activity and neurodegeneration. Vitam Horm 2010, 84:331-354.
    • (2010) Vitam Horm , vol.84 , pp. 331-354
    • Holscher, C.1
  • 26
    • 79960881826 scopus 로고    scopus 로고
    • Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease
    • Holscher C. Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease. Biochem Soc Trans 2011, 39:891-897.
    • (2011) Biochem Soc Trans , vol.39 , pp. 891-897
    • Holscher, C.1
  • 27
    • 1842785179 scopus 로고    scopus 로고
    • Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
    • Hoyer S. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. Eur J Pharmacol 2004, 490:115-125.
    • (2004) Eur J Pharmacol , vol.490 , pp. 115-125
    • Hoyer, S.1
  • 28
    • 84872293106 scopus 로고    scopus 로고
    • Prazosin, an alpha(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease
    • Neurobiol Aging doi:10.1016/j.neurobiolaging.2012.09.010
    • Katsouri L, Vizcaychipi MP, McArthur S, Harrison I, Suarez-Calvet M, Lleo A, Lloyd DG, Ma D, Sastre M (2012) Prazosin, an alpha(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease. Neurobiol Agingdoi:10.1016/j.neurobiolaging.2012.09.010.
    • (2012)
    • Katsouri, L.1    Vizcaychipi, M.P.2    McArthur, S.3    Harrison, I.4    Suarez-Calvet, M.5    Lleo, A.6    Lloyd, D.G.7    Ma, D.8    Sastre, M.9
  • 30
    • 1842633862 scopus 로고    scopus 로고
    • Treatment of insulin resistance in diabetes mellitus
    • Lebovitz H.E., Banerji M.A. Treatment of insulin resistance in diabetes mellitus. Eur J Pharmacol 2004, 490:135-146.
    • (2004) Eur J Pharmacol , vol.490 , pp. 135-146
    • Lebovitz, H.E.1    Banerji, M.A.2
  • 32
    • 0034302872 scopus 로고    scopus 로고
    • Neuroinflammatory signaling upregulation in Alzheimer's disease
    • Lukiw W.J., Bazan N.G. Neuroinflammatory signaling upregulation in Alzheimer's disease. Neurochem Res 2000, 25:1173-1184.
    • (2000) Neurochem Res , vol.25 , pp. 1173-1184
    • Lukiw, W.J.1    Bazan, N.G.2
  • 33
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    • McClean P., Parthsarathy V., Faivre E., Hölscher C. The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J Neurosci 2011, 31:6587-6594.
    • (2011) J Neurosci , vol.31 , pp. 6587-6594
    • McClean, P.1    Parthsarathy, V.2    Faivre, E.3    Hölscher, C.4
  • 34
    • 71349085957 scopus 로고    scopus 로고
    • Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
    • Moloney A.M., Griffin R.J., Timmons S., O'Connor R., Ravid R., O'Neill C. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol Aging 2010, 31:224-243.
    • (2010) Neurobiol Aging , vol.31 , pp. 224-243
    • Moloney, A.M.1    Griffin, R.J.2    Timmons, S.3    O'Connor, R.4    Ravid, R.5    O'Neill, C.6
  • 36
    • 34547444040 scopus 로고    scopus 로고
    • Immunohistochemical distribution of glucose-dependent insulinotropic polypeptide in the adult rat brain
    • Nyberg J., Jacobsson C., Anderson M.F., Eriksson P.S. Immunohistochemical distribution of glucose-dependent insulinotropic polypeptide in the adult rat brain. J Neurosci Res 2007, 85:2099-2119.
    • (2007) J Neurosci Res , vol.85 , pp. 2099-2119
    • Nyberg, J.1    Jacobsson, C.2    Anderson, M.F.3    Eriksson, P.S.4
  • 37
    • 78651084780 scopus 로고    scopus 로고
    • Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice
    • Porter D.W., Irwin N., Flatt P.R., Holscher C., Gault V.A. Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice. Eur J Pharmacol 2010, 650:688-693.
    • (2010) Eur J Pharmacol , vol.650 , pp. 688-693
    • Porter, D.W.1    Irwin, N.2    Flatt, P.R.3    Holscher, C.4    Gault, V.A.5
  • 41
    • 0027136670 scopus 로고
    • Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
    • Usdin T.B., Mezey E., Button D.C., Brownstein M.J., Bonner T.I. Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology 1993, 133:2861-2870.
    • (1993) Endocrinology , vol.133 , pp. 2861-2870
    • Usdin, T.B.1    Mezey, E.2    Button, D.C.3    Brownstein, M.J.4    Bonner, T.I.5
  • 42
    • 79956137679 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin
    • Vaz A.R., Silva S.L., Barateiro A., Fernandes A., Falcao A.S., Brito M.A., Brites D. Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin. Exp Neurol 2011, 229:381-390.
    • (2011) Exp Neurol , vol.229 , pp. 381-390
    • Vaz, A.R.1    Silva, S.L.2    Barateiro, A.3    Fernandes, A.4    Falcao, A.S.5    Brito, M.A.6    Brites, D.7
  • 43
    • 1842734649 scopus 로고    scopus 로고
    • Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease
    • Watson G.S., Craft S. Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease. Eur J Pharmacol 2004, 490:97-113.
    • (2004) Eur J Pharmacol , vol.490 , pp. 97-113
    • Watson, G.S.1    Craft, S.2
  • 44
    • 18744438248 scopus 로고    scopus 로고
    • Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor
    • Xie L., Helmerhorst E., Taddei K., Plewright B., Van B.W., Martins R. Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor. J Neurosci 2002, 22:RC221.
    • (2002) J Neurosci , vol.22
    • Xie, L.1    Helmerhorst, E.2    Taddei, K.3    Plewright, B.4    Van, B.W.5    Martins, R.6
  • 45
    • 0033520869 scopus 로고    scopus 로고
    • GIP biology and fat metabolism
    • Yip R.G., Wolfe M.M. GIP biology and fat metabolism. Life Sci 2000, 66:91-103.
    • (2000) Life Sci , vol.66 , pp. 91-103
    • Yip, R.G.1    Wolfe, M.M.2
  • 46
    • 80055112704 scopus 로고    scopus 로고
    • The contribution of activated astrocytes to Abeta production: implications for Alzheimer's disease pathogenesis
    • Zhao J., O'Connor T., Vassar R. The contribution of activated astrocytes to Abeta production: implications for Alzheimer's disease pathogenesis. J Neuroinflammation 2011, 8:150.
    • (2011) J Neuroinflammation , vol.8 , pp. 150
    • Zhao, J.1    O'Connor, T.2    Vassar, R.3


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