메뉴 건너뛰기




Volumn 22, Issue 5, 2016, Pages 359-376

Reappraisal of GIP Pharmacology for Metabolic Diseases

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR; GLUCOSE BLOOD LEVEL; HORMONE RECEPTOR; INSULIN;

EID: 84962046497     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2016.03.005     Document Type: Review
Times cited : (138)

References (135)
  • 1
    • 0002025725 scopus 로고
    • On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane
    • Moore B. On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane. Biochem. J. 1906, 1:28-38.
    • (1906) Biochem. J. , vol.1 , pp. 28-38
    • Moore, B.1
  • 2
    • 84944484435 scopus 로고
    • The mechanism of pancreatic secretion
    • Bayliss W.M., Starling E.H. The mechanism of pancreatic secretion. J. Physiol. 1902, 28:325-353.
    • (1902) J. Physiol. , vol.28 , pp. 325-353
    • Bayliss, W.M.1    Starling, E.H.2
  • 3
    • 0000197284 scopus 로고
    • Pancreatic extracts in the treatment of diabetes mellitus
    • Banting F.G., et al. Pancreatic extracts in the treatment of diabetes mellitus. Can. Med. Assoc. J. 1922, 12:141-146.
    • (1922) Can. Med. Assoc. J. , vol.12 , pp. 141-146
    • Banting, F.G.1
  • 4
    • 0002294149 scopus 로고
    • New interpretation of oral glucose tolerance
    • McIntyre N., et al. New interpretation of oral glucose tolerance. Lancet 1964, 2:20-21.
    • (1964) Lancet , vol.2 , pp. 20-21
    • McIntyre, N.1
  • 5
    • 33845344395 scopus 로고
    • Plasma insulin response to oral and intravenous glucose administration
    • Elrick H., et al. Plasma insulin response to oral and intravenous glucose administration. J. Clin. Endocrinol. Metab. 1964, 24:1076-1082.
    • (1964) J. Clin. Endocrinol. Metab. , vol.24 , pp. 1076-1082
    • Elrick, H.1
  • 6
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck M.A., et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J. Clin. Endocrinol. Metab. 1986, 63:492-498.
    • (1986) J. Clin. Endocrinol. Metab. , vol.63 , pp. 492-498
    • Nauck, M.A.1
  • 7
    • 79959781838 scopus 로고    scopus 로고
    • Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes
    • Holst J.J., et al. Loss of incretin effect is a specific, important, and early characteristic of type 2 diabetes. Diabetes Care 2011, 34(Suppl. 2):S251-S257.
    • (2011) Diabetes Care , vol.34 , pp. S251-S257
    • Holst, J.J.1
  • 8
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Nauck M., et al. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 1986, 29:46-52.
    • (1986) Diabetologia , vol.29 , pp. 46-52
    • Nauck, M.1
  • 9
    • 0014718760 scopus 로고
    • A multiparameter study on the action of preparations containing cholecystokinin-pancreozymin
    • Brown J.C., Pederson R.A. A multiparameter study on the action of preparations containing cholecystokinin-pancreozymin. Scand. J. Gastroenterol. 1970, 5:537-541.
    • (1970) Scand. J. Gastroenterol. , vol.5 , pp. 537-541
    • Brown, J.C.1    Pederson, R.A.2
  • 10
    • 0015015451 scopus 로고
    • A gastric inhibitory polypeptide. I. The amino acid composition and the tryptic peptides
    • Brown J.C. A gastric inhibitory polypeptide. I. The amino acid composition and the tryptic peptides. Can. J. Biochem. 1971, 49:255-261.
    • (1971) Can. J. Biochem. , vol.49 , pp. 255-261
    • Brown, J.C.1
  • 11
    • 0015791989 scopus 로고
    • Stimulation of insulin secretion by gastric inhibitory polypeptide in man
    • Dupre J., et al. Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J. Clin. Endocrinol. Metab. 1973, 37:826-828.
    • (1973) J. Clin. Endocrinol. Metab. , vol.37 , pp. 826-828
    • Dupre, J.1
  • 12
    • 0020520108 scopus 로고
    • Preservation of incretin activity after removal of gastric inhibitory polypeptide (GIP) from rat gut extracts by immunoadsorption
    • Ebert R., et al. Preservation of incretin activity after removal of gastric inhibitory polypeptide (GIP) from rat gut extracts by immunoadsorption. Diabetologia 1983, 24:449-454.
    • (1983) Diabetologia , vol.24 , pp. 449-454
    • Ebert, R.1
  • 13
    • 0019124304 scopus 로고
    • Gastric inhibitory polypeptide (GIP) and insulin release after small-bowel resection in man
    • Lauritsen K.B., et al. Gastric inhibitory polypeptide (GIP) and insulin release after small-bowel resection in man. Scand. J. Gastroenterol. 1980, 15:833-840.
    • (1980) Scand. J. Gastroenterol. , vol.15 , pp. 833-840
    • Lauritsen, K.B.1
  • 14
    • 0020026919 scopus 로고
    • Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem
    • Lund P.K., et al. Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem. Proc. Natl. Acad. Sci. U.S.A. 1982, 79:345-349.
    • (1982) Proc. Natl. Acad. Sci. U.S.A. , vol.79 , pp. 345-349
    • Lund, P.K.1
  • 15
    • 0020535282 scopus 로고
    • Exon duplication and divergence in the human preproglucagon gene
    • Bell G.I., et al. Exon duplication and divergence in the human preproglucagon gene. Nature 1983, 304:368-371.
    • (1983) Nature , vol.304 , pp. 368-371
    • Bell, G.I.1
  • 16
    • 0036068322 scopus 로고    scopus 로고
    • Inhibition of gastric inhibitory polypeptide signaling prevents obesity
    • Miyawaki K., et al. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat. Med. 2002, 8:738-742.
    • (2002) Nat. Med. , vol.8 , pp. 738-742
    • Miyawaki, K.1
  • 17
    • 0029834106 scopus 로고    scopus 로고
    • Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat
    • Tseng C.C., et al. Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat. J. Clin. Invest. 1996, 98:2440-2445.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2440-2445
    • Tseng, C.C.1
  • 18
    • 37149047560 scopus 로고    scopus 로고
    • GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet
    • McClean P.L., et al. GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet. Am. J. Physiol. Endocrinol. Metab. 2007, 293:E1746-E1755.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293 , pp. E1746-E1755
    • McClean, P.L.1
  • 19
    • 84952636828 scopus 로고    scopus 로고
    • Species-specific action of (Pro3)GIP - an efficacious agonist on human GIP receptor, but partial agonist and competitive antagonist on rat and mouse GIP receptors
    • Sparre-Ulrich A.H., et al. Species-specific action of (Pro3)GIP - an efficacious agonist on human GIP receptor, but partial agonist and competitive antagonist on rat and mouse GIP receptors. Br. J. Pharmacol. 2016, 173:27-38.
    • (2016) Br. J. Pharmacol. , vol.173 , pp. 27-38
    • Sparre-Ulrich, A.H.1
  • 20
    • 58149467276 scopus 로고    scopus 로고
    • Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
    • Hojberg P.V., et al. Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. Diabetologia 2009, 52:199-207.
    • (2009) Diabetologia , vol.52 , pp. 199-207
    • Hojberg, P.V.1
  • 21
    • 34547444040 scopus 로고    scopus 로고
    • Immunohistochemical distribution of glucose-dependent insulinotropic polypeptide in the adult rat brain
    • Nyberg J., et al. Immunohistochemical distribution of glucose-dependent insulinotropic polypeptide in the adult rat brain. J. Neurosci. Res. 2007, 85:2099-2119.
    • (2007) J. Neurosci. Res. , vol.85 , pp. 2099-2119
    • Nyberg, J.1
  • 22
    • 77951675095 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion
    • Fujita Y., et al. Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion. Gastroenterology 2010, 138:1966-1975.
    • (2010) Gastroenterology , vol.138 , pp. 1966-1975
    • Fujita, Y.1
  • 23
    • 33744954869 scopus 로고    scopus 로고
    • Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor
    • Ugleholdt R., et al. Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor. J. Biol. Chem. 2006, 281:11050-11057.
    • (2006) J. Biol. Chem. , vol.281 , pp. 11050-11057
    • Ugleholdt, R.1
  • 24
    • 77951463380 scopus 로고    scopus 로고
    • Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut
    • Fujita Y., et al. Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut. Am. J. Physiol. Gastrointest. Liver Physiol. 2010, 298:G608-G614.
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.298 , pp. G608-G614
    • Fujita, Y.1
  • 25
    • 79951776754 scopus 로고    scopus 로고
    • (1-42) in high-fat fed mice
    • (1-42) in high-fat fed mice. J. Endocrinol. 2011, 208:265-271.
    • (2011) J. Endocrinol. , vol.208 , pp. 265-271
    • Gault, V.A.1
  • 26
    • 84990057324 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic peptide stimulates glucagon-like peptide 1 production by pancreatic islets via interleukin-6, produced by alpha cells
    • Published online March 10, 2016
    • Timper K., et al. Glucose-dependent insulinotropic peptide stimulates glucagon-like peptide 1 production by pancreatic islets via interleukin-6, produced by alpha cells. Gastroenterology 2016, Published online March 10, 2016. 10.1053/j.gastro.2016.03.003.
    • (2016) Gastroenterology
    • Timper, K.1
  • 27
    • 0038574573 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia
    • Meier J.J., et al. Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia. Diabetologia 2003, 46:798-801.
    • (2003) Diabetologia , vol.46 , pp. 798-801
    • Meier, J.J.1
  • 28
    • 66649106652 scopus 로고    scopus 로고
    • Exogenous glucose-dependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes
    • Chia C.W., et al. Exogenous glucose-dependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes. Diabetes 2009, 58:1342-1349.
    • (2009) Diabetes , vol.58 , pp. 1342-1349
    • Chia, C.W.1
  • 29
    • 82255185915 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans
    • Christensen M., et al. Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans. Diabetes 2011, 60:3103-3109.
    • (2011) Diabetes , vol.60 , pp. 3103-3109
    • Christensen, M.1
  • 30
    • 84920059625 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycemia in type 1 diabetes
    • Christensen M., et al. Glucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycemia in type 1 diabetes. Diabetes 2015, 64:72-78.
    • (2015) Diabetes , vol.64 , pp. 72-78
    • Christensen, M.1
  • 31
    • 84859124238 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide signaling in pancreatic beta-cells and adipocytes
    • McIntosh C.H., et al. Glucose-dependent insulinotropic polypeptide signaling in pancreatic beta-cells and adipocytes. J. Diabetes Investig. 2012, 3:96-106.
    • (2012) J. Diabetes Investig. , vol.3 , pp. 96-106
    • McIntosh, C.H.1
  • 32
    • 84954396103 scopus 로고    scopus 로고
    • TCF1 links GIPR signaling to the control of beta cell function and survival
    • Campbell J.E., et al. TCF1 links GIPR signaling to the control of beta cell function and survival. Nat. Med. 2016, 22:84-90.
    • (2016) Nat. Med. , vol.22 , pp. 84-90
    • Campbell, J.E.1
  • 33
    • 67249096093 scopus 로고    scopus 로고
    • Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function
    • Shu L., et al. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum. Mol. Genet. 2009, 18:2388-2399.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 2388-2399
    • Shu, L.1
  • 34
    • 0037020242 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway
    • Ehses J.A., et al. Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway. J. Biol. Chem. 2002, 277:37088-37097.
    • (2002) J. Biol. Chem. , vol.277 , pp. 37088-37097
    • Ehses, J.A.1
  • 35
    • 15944419821 scopus 로고    scopus 로고
    • Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility
    • Miki T., et al. Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes 2005, 54:1056-1063.
    • (2005) Diabetes , vol.54 , pp. 1056-1063
    • Miki, T.1
  • 36
    • 23344449395 scopus 로고    scopus 로고
    • A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis
    • Kim S.J., et al. A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis. J. Biol. Chem. 2005, 280:28692-28700.
    • (2005) J. Biol. Chem. , vol.280 , pp. 28692-28700
    • Kim, S.J.1
  • 37
    • 0007866067 scopus 로고    scopus 로고
    • Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice
    • Miyawaki K., et al. Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:14843-14847.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 14843-14847
    • Miyawaki, K.1
  • 38
    • 33845997750 scopus 로고    scopus 로고
    • Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure
    • Hansotia T., et al. Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. J. Clin. Invest. 2007, 117:143-152.
    • (2007) J. Clin. Invest. , vol.117 , pp. 143-152
    • Hansotia, T.1
  • 39
    • 84902278779 scopus 로고    scopus 로고
    • The role of beta cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs
    • Smith E.P., et al. The role of beta cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs. Cell Metab. 2014, 19:1050-1057.
    • (2014) Cell Metab. , vol.19 , pp. 1050-1057
    • Smith, E.P.1
  • 40
    • 84906956323 scopus 로고    scopus 로고
    • A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity
    • Mohammad S., et al. A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity. Mol. Cell. Biol. 2014, 34:3618-3629.
    • (2014) Mol. Cell. Biol. , vol.34 , pp. 3618-3629
    • Mohammad, S.1
  • 41
    • 84920885272 scopus 로고    scopus 로고
    • Functional consequences of glucagon-like peptide-1 receptor cross-talk and trafficking
    • Roed S.N., et al. Functional consequences of glucagon-like peptide-1 receptor cross-talk and trafficking. J. Biol. Chem. 2015, 290:1233-1243.
    • (2015) J. Biol. Chem. , vol.290 , pp. 1233-1243
    • Roed, S.N.1
  • 42
    • 84857432572 scopus 로고    scopus 로고
    • Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation
    • Schelshorn D., et al. Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation. Mol. Pharmacol. 2012, 81:309-318.
    • (2012) Mol. Pharmacol. , vol.81 , pp. 309-318
    • Schelshorn, D.1
  • 43
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck M.A., et al. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J. Clin. Invest. 1993, 91:301-307.
    • (1993) J. Clin. Invest. , vol.91 , pp. 301-307
    • Nauck, M.A.1
  • 44
    • 0242383351 scopus 로고    scopus 로고
    • The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide - regardless of etiology and phenotype
    • Vilsboll T., et al. The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide - regardless of etiology and phenotype. J. Clin. Endocrinol. Metab. 2003, 88:4897-4903.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 4897-4903
    • Vilsboll, T.1
  • 45
    • 1442321740 scopus 로고    scopus 로고
    • Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo
    • Gault V.A., et al. Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. J. Endocrinol. 2002, 175:525-533.
    • (2002) J. Endocrinol. , vol.175 , pp. 525-533
    • Gault, V.A.1
  • 46
    • 0030876081 scopus 로고    scopus 로고
    • The pathogenesis of NIDDM involves a defective expression of the GIP receptor
    • Holst J.J., et al. The pathogenesis of NIDDM involves a defective expression of the GIP receptor. Diabetologia 1997, 40:984-986.
    • (1997) Diabetologia , vol.40 , pp. 984-986
    • Holst, J.J.1
  • 47
    • 0034118750 scopus 로고    scopus 로고
    • Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (βTC-3) cells to glucose-dependent insulinotropic polypeptide
    • Hinke S.A., et al. Role of glucose in chronic desensitization of isolated rat islets and mouse insulinoma (βTC-3) cells to glucose-dependent insulinotropic polypeptide. J. Endocrinol. 2000, 165:281-291.
    • (2000) J. Endocrinol. , vol.165 , pp. 281-291
    • Hinke, S.A.1
  • 48
    • 75749091912 scopus 로고    scopus 로고
    • Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    • Saxena R., et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat. Genet. 2010, 42:142-148.
    • (2010) Nat. Genet. , vol.42 , pp. 142-148
    • Saxena, R.1
  • 49
    • 0020411495 scopus 로고
    • Gastric inhibitory polypeptide release after oral glucose: relationship to glucose intolerance, diabetes mellitus, and obesity
    • Salera M., et al. Gastric inhibitory polypeptide release after oral glucose: relationship to glucose intolerance, diabetes mellitus, and obesity. J. Clin. Endocrinol. Metab. 1982, 55:329-336.
    • (1982) J. Clin. Endocrinol. Metab. , vol.55 , pp. 329-336
    • Salera, M.1
  • 50
    • 84891881674 scopus 로고    scopus 로고
    • Secretion of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes: systematic review and meta-analysis of clinical studies
    • Calanna S., et al. Secretion of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes: systematic review and meta-analysis of clinical studies. Diabetes Care 2013, 36:3346-3352.
    • (2013) Diabetes Care , vol.36 , pp. 3346-3352
    • Calanna, S.1
  • 51
    • 0035041250 scopus 로고    scopus 로고
    • Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    • Lynn F.C., et al. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes 2001, 50:1004-1011.
    • (2001) Diabetes , vol.50 , pp. 1004-1011
    • Lynn, F.C.1
  • 52
    • 34249724553 scopus 로고    scopus 로고
    • Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes
    • Xu G., et al. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes 2007, 56:1551-1558.
    • (2007) Diabetes , vol.56 , pp. 1551-1558
    • Xu, G.1
  • 53
    • 85027936258 scopus 로고    scopus 로고
    • Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21
    • Muller T.D., et al. Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21. J. Pept. Sci. 2012, 18:383-393.
    • (2012) J. Pept. Sci. , vol.18 , pp. 383-393
    • Muller, T.D.1
  • 54
    • 84890043525 scopus 로고    scopus 로고
    • Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans
    • 209ra151
    • Finan B., et al. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Sci. Transl. Med. 2013, 5:209ra151.
    • (2013) Sci. Transl. Med. , vol.5
    • Finan, B.1
  • 55
    • 77953177935 scopus 로고    scopus 로고
    • Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type 2 diabetes
    • Gupta D., et al. Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type 2 diabetes. Diabetes 2010, 59:1445-1450.
    • (2010) Diabetes , vol.59 , pp. 1445-1450
    • Gupta, D.1
  • 56
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • Speliotes E.K., et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 2010, 42:937-948.
    • (2010) Nat. Genet. , vol.42 , pp. 937-948
    • Speliotes, E.K.1
  • 57
    • 73949123418 scopus 로고    scopus 로고
    • Pharmacological characterization of human incretin receptor missense variants
    • Fortin J.P., et al. Pharmacological characterization of human incretin receptor missense variants. J. Pharmacol. Exp. Ther. 2010, 332:274-280.
    • (2010) J. Pharmacol. Exp. Ther. , vol.332 , pp. 274-280
    • Fortin, J.P.1
  • 58
    • 0027136670 scopus 로고
    • Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
    • Usdin T.B., et al. Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology 1993, 133:2861-2870.
    • (1993) Endocrinology , vol.133 , pp. 2861-2870
    • Usdin, T.B.1
  • 59
    • 0031730586 scopus 로고    scopus 로고
    • Functional GIP receptors are present on adipocytes
    • Yip R.G., et al. Functional GIP receptors are present on adipocytes. Endocrinology 1998, 139:4004-4007.
    • (1998) Endocrinology , vol.139 , pp. 4004-4007
    • Yip, R.G.1
  • 60
    • 0023767583 scopus 로고
    • The postprandial response of gastric inhibitory polypeptide to various dietary fats in man
    • Lardinois C.K., et al. The postprandial response of gastric inhibitory polypeptide to various dietary fats in man. J. Am. Coll. Nutr. 1988, 7:241-247.
    • (1988) J. Am. Coll. Nutr. , vol.7 , pp. 241-247
    • Lardinois, C.K.1
  • 61
    • 0028342792 scopus 로고
    • Regulation of glucose-dependent insulinotropic peptide gene expression by a glucose meal
    • Tseng C.C., et al. Regulation of glucose-dependent insulinotropic peptide gene expression by a glucose meal. Am. J. Physiol. 1994, 266:G887-G891.
    • (1994) Am. J. Physiol. , vol.266 , pp. G887-G891
    • Tseng, C.C.1
  • 62
    • 0022459812 scopus 로고
    • Immunoreactive gastric inhibitory polypeptide and K cell hyperplasia in obese hyperglycaemic (ob/ob) mice fed high fat and high carbohydrate cafeteria diets
    • Bailey C.J., et al. Immunoreactive gastric inhibitory polypeptide and K cell hyperplasia in obese hyperglycaemic (ob/ob) mice fed high fat and high carbohydrate cafeteria diets. Acta Endocrinol. (Copenh.) 1986, 112:224-229.
    • (1986) Acta Endocrinol. (Copenh.) , vol.112 , pp. 224-229
    • Bailey, C.J.1
  • 63
    • 0018672563 scopus 로고
    • Gastric inhibitory polypeptide enhanced lipoprotein lipase activity in cultured preadipocytes
    • Eckel R.H., et al. Gastric inhibitory polypeptide enhanced lipoprotein lipase activity in cultured preadipocytes. Diabetes 1979, 28:1141-1142.
    • (1979) Diabetes , vol.28 , pp. 1141-1142
    • Eckel, R.H.1
  • 64
    • 79953307026 scopus 로고    scopus 로고
    • Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPARgamma and histone acetylation
    • Kim S.J., et al. Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPARgamma and histone acetylation. J. Lipid Res. 2011, 52:759-770.
    • (2011) J. Lipid Res. , vol.52 , pp. 759-770
    • Kim, S.J.1
  • 65
    • 84856539533 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids
    • Gogebakan O., et al. Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids. Diabetes 2012, 61:292-300.
    • (2012) Diabetes , vol.61 , pp. 292-300
    • Gogebakan, O.1
  • 66
    • 0025808278 scopus 로고
    • Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue
    • Oben J., et al. Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue. J. Endocrinol. 1991, 130:267-272.
    • (1991) J. Endocrinol. , vol.130 , pp. 267-272
    • Oben, J.1
  • 67
    • 0025750777 scopus 로고
    • Effect of exogenous or endogenous gastric inhibitory polypeptide (GIP) on plasma triglyceride responses in rats
    • Ebert R., et al. Effect of exogenous or endogenous gastric inhibitory polypeptide (GIP) on plasma triglyceride responses in rats. Horm. Metab. Res. 1991, 23:517-521.
    • (1991) Horm. Metab. Res. , vol.23 , pp. 517-521
    • Ebert, R.1
  • 68
    • 0019407932 scopus 로고
    • Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs
    • Wasada T., et al. Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs. J. Clin. Invest. 1981, 68:1106-1107.
    • (1981) J. Clin. Invest. , vol.68 , pp. 1106-1107
    • Wasada, T.1
  • 69
    • 0022612639 scopus 로고
    • Direct metabolic effects of gastric inhibitory polypeptide (GIP): dissociation at physiological levels of effects on insulin-stimulated fatty acid and glucose incorporation in rat adipose tissue
    • Beck B., Max J.P. Direct metabolic effects of gastric inhibitory polypeptide (GIP): dissociation at physiological levels of effects on insulin-stimulated fatty acid and glucose incorporation in rat adipose tissue. Diabetologia 1986, 29:68.
    • (1986) Diabetologia , vol.29 , pp. 68
    • Beck, B.1    Max, J.P.2
  • 70
    • 84878250644 scopus 로고    scopus 로고
    • Link between GIP and osteopontin in adipose tissue and insulin resistance
    • Ahlqvist E., et al. Link between GIP and osteopontin in adipose tissue and insulin resistance. Diabetes 2013, 62:2088-2094.
    • (2013) Diabetes , vol.62 , pp. 2088-2094
    • Ahlqvist, E.1
  • 71
    • 36349012043 scopus 로고    scopus 로고
    • Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes
    • Kim S.J., et al. Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes. J. Biol. Chem. 2007, 282:34139-34147.
    • (2007) J. Biol. Chem. , vol.282 , pp. 34139-34147
    • Kim, S.J.1
  • 72
    • 84455173076 scopus 로고    scopus 로고
    • Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain
    • Ugleholdt R., et al. Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain. J. Biol. Chem. 2011, 286:44632-44645.
    • (2011) J. Biol. Chem. , vol.286 , pp. 44632-44645
    • Ugleholdt, R.1
  • 74
    • 84936166069 scopus 로고    scopus 로고
    • A randomized, controlled trial of 3.0 mg of liraglutide in weight management
    • Pi-Sunyer X., et al. A randomized, controlled trial of 3.0 mg of liraglutide in weight management. N. Engl. J. Med. 2015, 373:11-22.
    • (2015) N. Engl. J. Med. , vol.373 , pp. 11-22
    • Pi-Sunyer, X.1
  • 75
  • 76
    • 18244424871 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis
    • Pamir N., et al. Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis. Am. J. Physiol. Endocrinol. Metab. 2003, 284:E931-E939.
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.284 , pp. E931-E939
    • Pamir, N.1
  • 77
    • 84903207650 scopus 로고    scopus 로고
    • Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high-fat diet conditions
    • Nasteska D., et al. Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high-fat diet conditions. Diabetes 2014, 63:2332-2343.
    • (2014) Diabetes , vol.63 , pp. 2332-2343
    • Nasteska, D.1
  • 78
    • 49649125933 scopus 로고    scopus 로고
    • Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet
    • Althage M.C., et al. Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet. J. Biol. Chem. 2008, 283:18365-18376.
    • (2008) J. Biol. Chem. , vol.283 , pp. 18365-18376
    • Althage, M.C.1
  • 79
    • 52649128760 scopus 로고    scopus 로고
    • Vaccination against GIP for the treatment of obesity
    • Fulurija A., et al. Vaccination against GIP for the treatment of obesity. PLoS ONE 2008, 3:e3163.
    • (2008) PLoS ONE , vol.3 , pp. e3163
    • Fulurija, A.1
  • 80
    • 58249097085 scopus 로고    scopus 로고
    • Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes
    • Irwin N., et al. Active immunisation against gastric inhibitory polypeptide (GIP) improves blood glucose control in an animal model of obesity-diabetes. Biol. Chem. 2009, 390:75-80.
    • (2009) Biol. Chem. , vol.390 , pp. 75-80
    • Irwin, N.1
  • 81
    • 84959219566 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide immunoneutralization attenuates development of obesity in mice
    • Boylan M.O., et al. Gastric inhibitory polypeptide immunoneutralization attenuates development of obesity in mice. Am. J. Physiol. Endocrinol. Metab. 2015, 309:E1008-E1018.
    • (2015) Am. J. Physiol. Endocrinol. Metab. , vol.309 , pp. E1008-E1018
    • Boylan, M.O.1
  • 82
    • 84862804002 scopus 로고    scopus 로고
    • Biological and functional characteristics of a novel low-molecular weight antagonist of glucose-dependent insulinotropic polypeptide receptor, SKL-14959, in vitro and in vivo
    • Nakamura T., et al. Biological and functional characteristics of a novel low-molecular weight antagonist of glucose-dependent insulinotropic polypeptide receptor, SKL-14959, in vitro and in vivo. Diabetes Obes. Metab. 2012, 14:511-517.
    • (2012) Diabetes Obes. Metab. , vol.14 , pp. 511-517
    • Nakamura, T.1
  • 83
    • 84880072983 scopus 로고    scopus 로고
    • Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor
    • Ravn P., et al. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. J. Biol. Chem. 2013, 288:19760-19772.
    • (2013) J. Biol. Chem. , vol.288 , pp. 19760-19772
    • Ravn, P.1
  • 84
    • 33748453750 scopus 로고    scopus 로고
    • GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations
    • Deacon C.F., et al. GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations. Am. J. Physiol. Endocrinol. Metab. 2006, 291:E468-E475.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291 , pp. E468-E475
    • Deacon, C.F.1
  • 85
    • 0030747857 scopus 로고    scopus 로고
    • GIP(6-30amide) contains the high affinity binding region of GIP and is a potent inhibitor of GIP1-42 action in vitro
    • Gelling R.W., et al. GIP(6-30amide) contains the high affinity binding region of GIP and is a potent inhibitor of GIP1-42 action in vitro. Regul. Pept. 1997, 69:151-154.
    • (1997) Regul. Pept. , vol.69 , pp. 151-154
    • Gelling, R.W.1
  • 86
    • 0036289106 scopus 로고    scopus 로고
    • Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide
    • Gault V.A., et al. Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. Biochem. Biophys. Res. Commun. 2002, 290:1420-1426.
    • (2002) Biochem. Biophys. Res. Commun. , vol.290 , pp. 1420-1426
    • Gault, V.A.1
  • 87
    • 5044229968 scopus 로고    scopus 로고
    • Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice
    • Irwin N., et al. Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice. Biol. Chem. 2004, 385:845-852.
    • (2004) Biol. Chem. , vol.385 , pp. 845-852
    • Irwin, N.1
  • 88
    • 23644434110 scopus 로고    scopus 로고
    • Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes
    • Gault V.A., et al. Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes. Diabetes 2005, 54:2436-2446.
    • (2005) Diabetes , vol.54 , pp. 2436-2446
    • Gault, V.A.1
  • 89
    • 34447127048 scopus 로고    scopus 로고
    • Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets
    • Gault V.A., et al. Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets. Diabetologia 2007, 50:1752-1762.
    • (2007) Diabetologia , vol.50 , pp. 1752-1762
    • Gault, V.A.1
  • 90
    • 34249941340 scopus 로고    scopus 로고
    • Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice
    • Irwin N., et al. Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia 2007, 50:1532-1540.
    • (2007) Diabetologia , vol.50 , pp. 1532-1540
    • Irwin, N.1
  • 91
    • 84907068044 scopus 로고    scopus 로고
    • Selectivity of peptide ligands for the human incretin receptors expressed in HEK-293 cells
    • Al-Sabah S., et al. Selectivity of peptide ligands for the human incretin receptors expressed in HEK-293 cells. Eur. J. Pharmacol. 2014, 741:311-315.
    • (2014) Eur. J. Pharmacol. , vol.741 , pp. 311-315
    • Al-Sabah, S.1
  • 92
    • 84855544372 scopus 로고    scopus 로고
    • Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice
    • Faivre E., et al. Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice. Eur. J. Pharmacol. 2012, 674:294-306.
    • (2012) Eur. J. Pharmacol. , vol.674 , pp. 294-306
    • Faivre, E.1
  • 93
    • 0028349215 scopus 로고
    • Processing and metabolism of peptide-YY: pivotal roles of dipeptidylpeptidase-IV, aminopeptidase-P, and endopeptidase-24.11
    • Medeiros M.D., Turner A.J. Processing and metabolism of peptide-YY: pivotal roles of dipeptidylpeptidase-IV, aminopeptidase-P, and endopeptidase-24.11. Endocrinology 1994, 134:2088-2094.
    • (1994) Endocrinology , vol.134 , pp. 2088-2094
    • Medeiros, M.D.1    Turner, A.J.2
  • 94
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker D.J., Nauck M.A. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006, 368:1696-1705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 95
    • 84863615352 scopus 로고    scopus 로고
    • GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis
    • Kim S.J., et al. GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis. PLoS ONE 2012, 7:e40156.
    • (2012) PLoS ONE , vol.7
    • Kim, S.J.1
  • 96
    • 84856417736 scopus 로고    scopus 로고
    • GIP-dependent expression of hypothalamic genes
    • Ambati S., et al. GIP-dependent expression of hypothalamic genes. Physiol. Res. 2011, 60:941-950.
    • (2011) Physiol. Res. , vol.60 , pp. 941-950
    • Ambati, S.1
  • 97
    • 9944251348 scopus 로고    scopus 로고
    • Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development
    • Herbach N., et al. Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development. Regul. Pept. 2005, 125:103-117.
    • (2005) Regul. Pept. , vol.125 , pp. 103-117
    • Herbach, N.1
  • 98
    • 77951829073 scopus 로고    scopus 로고
    • Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function
    • Renner S., et al. Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function. Diabetes 2010, 59:1228-1238.
    • (2010) Diabetes , vol.59 , pp. 1228-1238
    • Renner, S.1
  • 99
    • 84899956174 scopus 로고    scopus 로고
    • Disruption of GIP/GIPR axis in human adipose tissue is linked to obesity and insulin resistance
    • Ceperuelo-Mallafre V., et al. Disruption of GIP/GIPR axis in human adipose tissue is linked to obesity and insulin resistance. J. Clin. Endocrinol. Metab. 2014, 99:E908-E919.
    • (2014) J. Clin. Endocrinol. Metab. , vol.99 , pp. E908-E919
    • Ceperuelo-Mallafre, V.1
  • 100
    • 0037253460 scopus 로고    scopus 로고
    • Improved biological activity of Gly2- and Ser2-substituted analogues of glucose-dependent insulinotrophic polypeptide
    • Gault V.A., et al. Improved biological activity of Gly2- and Ser2-substituted analogues of glucose-dependent insulinotrophic polypeptide. J. Endocrinol. 2003, 176:133-141.
    • (2003) J. Endocrinol. , vol.176 , pp. 133-141
    • Gault, V.A.1
  • 101
    • 13944276310 scopus 로고    scopus 로고
    • Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide
    • Irwin N., et al. Degradation, insulin secretion, and antihyperglycemic actions of two palmitate-derivitized N-terminal pyroglutamyl analogues of glucose-dependent insulinotropic polypeptide. J. Med. Chem. 2005, 48:1244-1250.
    • (2005) J. Med. Chem. , vol.48 , pp. 1244-1250
    • Irwin, N.1
  • 102
    • 23944450400 scopus 로고    scopus 로고
    • A novel, long-acting agonist of glucose-dependent insulinotropic polypeptide suitable for once-daily administration in type 2 diabetes
    • Irwin N., et al. A novel, long-acting agonist of glucose-dependent insulinotropic polypeptide suitable for once-daily administration in type 2 diabetes. J. Pharmacol. Exp. Ther. 2005, 314:1187-1194.
    • (2005) J. Pharmacol. Exp. Ther. , vol.314 , pp. 1187-1194
    • Irwin, N.1
  • 103
    • 34250221536 scopus 로고    scopus 로고
    • Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice
    • Irwin N., et al. Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice. J. Pept. Sci. 2007, 13:400-405.
    • (2007) J. Pept. Sci. , vol.13 , pp. 400-405
    • Irwin, N.1
  • 104
    • 69349096792 scopus 로고    scopus 로고
    • Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties
    • Kerr B.D., et al. Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties. Biochem. Pharmacol. 2009, 78:1008-1016.
    • (2009) Biochem. Pharmacol. , vol.78 , pp. 1008-1016
    • Kerr, B.D.1
  • 105
    • 84875989116 scopus 로고    scopus 로고
    • A novel acylated form of (d-Ala2)GIP with improved antidiabetic potential, lacking effect on body fat stores
    • Martin C.M., et al. A novel acylated form of (d-Ala2)GIP with improved antidiabetic potential, lacking effect on body fat stores. Biochim. Biophys. Acta 2013, 1830:3407-3413.
    • (2013) Biochim. Biophys. Acta , vol.1830 , pp. 3407-3413
    • Martin, C.M.1
  • 106
    • 0032587206 scopus 로고    scopus 로고
    • 2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity
    • 2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance and enhanced antihyperglycemic activity. Diabetes 1999, 48:758-765.
    • (1999) Diabetes , vol.48 , pp. 758-765
    • O'Harte, F.P.1
  • 107
    • 0036844953 scopus 로고    scopus 로고
    • Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes
    • Gault V.A., et al. Enhanced cAMP generation and insulin-releasing potency of two novel Tyr1-modified enzyme-resistant forms of glucose-dependent insulinotropic polypeptide is associated with significant antihyperglycaemic activity in spontaneous obesity-diabetes. Biochem. J. 2002, 367:913-920.
    • (2002) Biochem. J. , vol.367 , pp. 913-920
    • Gault, V.A.1
  • 108
    • 0036383414 scopus 로고    scopus 로고
    • Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP
    • O'Harte F.P., et al. Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of gastric inhibitory polypeptide: N-acetyl-GIP and pGlu-GIP. Diabetologia 2002, 45:1281-1291.
    • (2002) Diabetologia , vol.45 , pp. 1281-1291
    • O'Harte, F.P.1
  • 109
    • 0038818982 scopus 로고    scopus 로고
    • 2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo
    • 2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo. Metabolism 2003, 52:679-687.
    • (2003) Metabolism , vol.52 , pp. 679-687
    • Gault, V.A.1
  • 110
    • 77949693550 scopus 로고    scopus 로고
    • A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control
    • Widenmaier S.B., et al. A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control. PLoS ONE 2010, 5:e9590.
    • (2010) PLoS ONE , vol.5 , pp. e9590
    • Widenmaier, S.B.1
  • 111
    • 0036317496 scopus 로고    scopus 로고
    • 2]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats
    • 2]glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats. Diabetes 2002, 51:652-661.
    • (2002) Diabetes , vol.51 , pp. 652-661
    • Hinke, S.A.1
  • 112
    • 0034471749 scopus 로고    scopus 로고
    • Analogs of glucose-dependent insulinotropic polypeptide with increased dipeptidyl peptidase IV resistance
    • Kuhn-Wache K., et al. Analogs of glucose-dependent insulinotropic polypeptide with increased dipeptidyl peptidase IV resistance. Adv. Exp. Med. Biol. 2000, 477:187-195.
    • (2000) Adv. Exp. Med. Biol. , vol.477 , pp. 187-195
    • Kuhn-Wache, K.1
  • 113
    • 84925282923 scopus 로고    scopus 로고
    • A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
    • Finan B., et al. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nat. Med. 2015, 21:27-36.
    • (2015) Nat. Med. , vol.21 , pp. 27-36
    • Finan, B.1
  • 114
    • 38449111196 scopus 로고    scopus 로고
    • Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice
    • Lamont B.J., Drucker D.J. Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice. Diabetes 2008, 57:190-198.
    • (2008) Diabetes , vol.57 , pp. 190-198
    • Lamont, B.J.1    Drucker, D.J.2
  • 115
    • 84907546219 scopus 로고    scopus 로고
    • Long-acting glucose-dependent insulinotropic polypeptide ameliorates obesity-induced adipose tissue inflammation
    • Varol C., et al. Long-acting glucose-dependent insulinotropic polypeptide ameliorates obesity-induced adipose tissue inflammation. J. Immunol. 2014, 193:4002-4009.
    • (2014) J. Immunol. , vol.193 , pp. 4002-4009
    • Varol, C.1
  • 116
    • 0026596225 scopus 로고
    • 2 fragment with potent pancreatic amylase inhibitory activity
    • 2 fragment with potent pancreatic amylase inhibitory activity. Regul. Pept. 1992, 39:9-17.
    • (1992) Regul. Pept. , vol.39 , pp. 9-17
    • Rossowski, W.J.1
  • 117
    • 38349016316 scopus 로고    scopus 로고
    • A novel GIP receptor splice variant influences GIP sensitivity of pancreatic beta-cells in obese mice
    • Harada N., et al. A novel GIP receptor splice variant influences GIP sensitivity of pancreatic beta-cells in obese mice. Am. J. Physiol. Endocrinol. Metab. 2008, 294:E61-E68.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.294 , pp. E61-E68
    • Harada, N.1
  • 118
    • 84890562831 scopus 로고    scopus 로고
    • A novel long-acting glucose-dependent insulinotropic peptide analogue: enhanced efficacy in normal and diabetic rodents
    • Tatarkiewicz K., et al. A novel long-acting glucose-dependent insulinotropic peptide analogue: enhanced efficacy in normal and diabetic rodents. Diabetes Obes. Metab. 2014, 16:75-85.
    • (2014) Diabetes Obes. Metab. , vol.16 , pp. 75-85
    • Tatarkiewicz, K.1
  • 119
    • 44249085588 scopus 로고    scopus 로고
    • C-terminal mini-PEGylation of glucose-dependent insulinotropic polypeptide exhibits metabolic stability and improved glucose homeostasis in dietary-induced diabetes
    • Gault V.A., et al. C-terminal mini-PEGylation of glucose-dependent insulinotropic polypeptide exhibits metabolic stability and improved glucose homeostasis in dietary-induced diabetes. Biochem. Pharmacol. 2008, 75:2325-2333.
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 2325-2333
    • Gault, V.A.1
  • 120
    • 9444260482 scopus 로고    scopus 로고
    • Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects
    • Meier J.J., et al. Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. Diabetes 2004, 53(Suppl. 3):S220-S224.
    • (2004) Diabetes , vol.53 , pp. S220-S224
    • Meier, J.J.1
  • 121
    • 65549158383 scopus 로고    scopus 로고
    • Metabolic effects of sustained activation of the GLP-1 receptor alone and in combination with background GIP receptor antagonism in high fat-fed mice
    • Irwin N., et al. Metabolic effects of sustained activation of the GLP-1 receptor alone and in combination with background GIP receptor antagonism in high fat-fed mice. Diabetes Obes. Metab. 2009, 11:603-610.
    • (2009) Diabetes Obes. Metab. , vol.11 , pp. 603-610
    • Irwin, N.1
  • 122
    • 0027419106 scopus 로고
    • Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations
    • Nauck M.A., et al. Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations. J. Clin. Endocrinol. Metab. 1993, 76:912-917.
    • (1993) J. Clin. Endocrinol. Metab. , vol.76 , pp. 912-917
    • Nauck, M.A.1
  • 123
    • 79953165707 scopus 로고    scopus 로고
    • GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes
    • Mentis N., et al. GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes. Diabetes 2011, 60:1270-1276.
    • (2011) Diabetes , vol.60 , pp. 1270-1276
    • Mentis, N.1
  • 124
    • 84921442644 scopus 로고    scopus 로고
    • Peptide therapeutics: current status and future directions
    • Fosgerau K., Hoffmann T. Peptide therapeutics: current status and future directions. Drug Discov. Today 2015, 20:122-128.
    • (2015) Drug Discov. Today , vol.20 , pp. 122-128
    • Fosgerau, K.1    Hoffmann, T.2
  • 125
    • 84947020463 scopus 로고    scopus 로고
    • Emerging opportunities for the treatment of metabolic diseases: glucagon-like peptide-1 based multi-agonists
    • Finan B., et al. Emerging opportunities for the treatment of metabolic diseases: glucagon-like peptide-1 based multi-agonists. Mol. Cell. Endocrinol. 2015, 418:42-54.
    • (2015) Mol. Cell. Endocrinol. , vol.418 , pp. 42-54
    • Finan, B.1
  • 126
    • 84872171201 scopus 로고    scopus 로고
    • Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents
    • Day J.W., et al. Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents. Biopolymers 2012, 98:443-450.
    • (2012) Biopolymers , vol.98 , pp. 443-450
    • Day, J.W.1
  • 127
    • 0037417984 scopus 로고    scopus 로고
    • Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice
    • Gelling R.W., et al. Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:1438-1443.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 1438-1443
    • Gelling, R.W.1
  • 128
    • 84879414291 scopus 로고    scopus 로고
    • Emerging combinatorial hormone therapies for the treatment of obesity and T2DM
    • Sadry S.A., Drucker D.J. Emerging combinatorial hormone therapies for the treatment of obesity and T2DM. Nat. Rev. Endocrinol. 2013, 9:425-433.
    • (2013) Nat. Rev. Endocrinol. , vol.9 , pp. 425-433
    • Sadry, S.A.1    Drucker, D.J.2
  • 129
    • 34848872799 scopus 로고    scopus 로고
    • Obesity-associated improvements in metabolic profile through expansion of adipose tissue
    • Kim J.Y., et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J. Clin. Invest. 2007, 117:2621-2637.
    • (2007) J. Clin. Invest. , vol.117 , pp. 2621-2637
    • Kim, J.Y.1
  • 130
    • 84870302181 scopus 로고    scopus 로고
    • MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity
    • Kusminski C.M., et al. MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nat. Med. 2012, 18:1539-1549.
    • (2012) Nat. Med. , vol.18 , pp. 1539-1549
    • Kusminski, C.M.1
  • 131
    • 4143075930 scopus 로고    scopus 로고
    • Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin
    • Ye J.M., et al. Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin. Diabetologia 2004, 47:1306-1313.
    • (2004) Diabetologia , vol.47 , pp. 1306-1313
    • Ye, J.M.1
  • 132
    • 84944270712 scopus 로고    scopus 로고
    • Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model
    • Li Y., et al. Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model. Neuropharmacology 2016, 101:255-263.
    • (2016) Neuropharmacology , vol.101 , pp. 255-263
    • Li, Y.1
  • 133
    • 84959239661 scopus 로고    scopus 로고
    • A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson's disease by reducing chronic inflammation in the brain
    • Cao L., et al. A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson's disease by reducing chronic inflammation in the brain. Neuroreport 2016, 27:384-391.
    • (2016) Neuroreport , vol.27 , pp. 384-391
    • Cao, L.1
  • 134
    • 41849094819 scopus 로고    scopus 로고
    • Impact of glucose-dependent insulinotropic peptide on age-induced bone loss
    • Ding K.H., et al. Impact of glucose-dependent insulinotropic peptide on age-induced bone loss. J. Bone Miner. Res. 2008, 23:536-543.
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 536-543
    • Ding, K.H.1
  • 135
    • 84964464107 scopus 로고    scopus 로고
    • A novel GIP receptor agonist enhances the body weight lowering effect of liraglutide in diet-induced mice and has the potential for once-weekly administration in humans
    • Poerregaard P., et al. A novel GIP receptor agonist enhances the body weight lowering effect of liraglutide in diet-induced mice and has the potential for once-weekly administration in humans. Presented at the 51st EASD Annual Meeting 2015.
    • (2015) Presented at the 51st EASD Annual Meeting
    • Poerregaard, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.