The inhibitory effects of peripheral administration of peptide YY 3-36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway

Brain Research

Volumn 1044, Issue 1, 2005, Pages 127-131

  Abbott, Caroline R ^a   Monteiro, Mariana ^a   Small, Caroline J ^a   Sajedi, Arshia ^a   Smith, Kirsty L ^a   Parkinson, James R C ^a   Ghatei, Mohammad A ^a   Bloom, Stephen R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Appetite; Brainstem; Glucagon like peptide 1; Hypothalamus; Peptide YY; Vagus nerve

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; PEPTIDE YY;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BRAIN NERVE CELL; CELL ACTIVATION; CONTROLLED STUDY; DIAPHRAGM; FEEDING; FOOD INTAKE; HYPOTHALAMUS; MALE; NERVE TRANSECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RODENT; TRUNCUS VAGOTOMY; VAGUS NERVE;

EID: 18144381593     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.03.011     Document Type: Article

References (22)

1. T.E. Adrian, G.L. Ferri, A.J. Bacarese-Hamilton, H.S. Fuessl, J.M. Polak, and S.R. Bloom Human distribution and release of a putative new gut hormone, peptide YY Gastroenterology 89 1985 1070 1077
2. R.L. Batterham, M.A. Cowley, C.J. Small, H. Herzog, M.A. Cohen, C.L. Dakin, A.M. Wren, A.E. Brynes, M.J. Low, M.A. Ghatei, R.D. Cone, and S.R. Bloom Gut hormone PYY(3-36) physiologically inhibits food intake Nature 418 2002 650 654
3. C. Broberger, M. Landry, H. Wong, J.N. Walsh, and T. Hokfelt Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus Neuroendocrinology 66 1997 393 408
4. R.D. Cone, M.A. Cowley, A.A. Butler, W. Fan, D.L. Marks, and M.J. Low The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis, Int J. Obes. Relat. Metab. Disord. 25 Suppl. 5 2001 S63 S67
5. J.N. Crawley, J.Z. Kiss, and E. Mezey Bilateral midbrain transections block the behavioral effects of cholecystokinin on feeding and exploration in rats Brain Res. 322 1984 316 321
6. C.L. Dakin, C.J. Small, R.L. Batterham, N.M. Neary, M.A. Cohen, M. Patterson, M.A. Ghatei, and S.R. Bloom Peripheral oxyntomodulin reduces food intake and body weight gain in rats Endocrinology 145 2004 2687 2695
7. Y. Date, N. Murakami, K. Toshinai, S. Matsukura, A. Niijima, H. Matsuo, K. Kangawa, and M. Nakazato The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats Gastroenterology 123 2002 1120 1128
8. A. Flint, A. Raben, A.K. Ersboll, J.J. Holst, and A. Astrup The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity Int. J. Obes. Relat. Metab. Disord. 25 2001 781 792
9. D. Grandt, M. Schimiczek, C. Beglinger, P. Layer, H. Goebell, V.E. Eysselein, and J.R. Reeve Jr. Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36 Regul. Pept. 51 1994 151 159
10. I.G. Halatchev, K.L. Ellacott, W. Fan, and R.D. Cone Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism Endocrinology 145 2004 2585 2590
11. N. Imeryuz, B.C. Yegen, A. Bozkurt, T. Coskun, M.L. Villanueva- Penacarrillo, and N.B. Ulusoy Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms Am. J. Physiol. 273 1997 G920 G927
12. P.J. Larsen, C. Fledelius, L.B. Knudsen, and M. Tang-Christensen Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats Diabetes 50 2001 2530 2539
13. A. Nakagawa, H. Satake, H. Nakabayashi, M. Nishizawa, K. Furuya, S. Nakano, T. Kigoshi, K. Nakayama, and K. Uchida Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells Auton. Neurosci. 110 2004 36 43
14. N. Nonaka, S. Shioda, M.L. Niehoff, and W.A. Banks Characterization of blood-brain barrier permeability to PYY3-36 in the mouse J. Pharmacol. Exp. Ther. 306 2003 948 953
15. U. Pedersen-Bjergaard, U. Host, H. Kelbaek, S. Schifter, J.F. Rehfeld, J. Faber, and N.J. Christensen Influence of meal composition on postprandial peripheral plasma concentrations of vasoactive peptides in man Scand. J. Clin. Lab. Invest. 56 1996 497 503
16. R.D. Reidelberger Abdominal vagal mediation of the satiety effects of exogenous and endogenous cholecystokinin in rats Am. J. Physiol. 263 1992 R1354 R1358
17. F.F. Rodriquez de Fonseca, M. Navarro, E. Alvarez, I. Roncero, J.A. Chowen, O. Maestre, R. Gomez, R.M. Munoz, J. Eng, and E. Blazquez Peripheral versus central effects of glucagon-like peptide-1 receptor agonists on satiety and body weight loss in Zucker obese rats Metabolism 49 2000 709 717
18. P.E. Sawchenko Central connections of the sensory and motor nuclei of the vagus nerve J. Auton. Nerv. Syst. 9 1983 13 26
19. P.J. Shughrue, M.V. Lane, and I. Merchenthaler Glucagon-like peptide-1 receptor (GLP1-R) mRNA in the rat hypothalamus Endocrinology 137 1996 5159 5162
20. G.P. Smith, C. Jerome, B.J. Cushin, R. Eterno, and K.J. Simansky Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat Science 213 1981 1036 1037
21. G.J. Ter Horst, B.P. de Boer, P.G. Luiten, and J.D. van Willigen Ascending projections from the solitary tract nucleus to the hypothalamus. A Phaseolus vulgaris lectin tracing study in the rat Neuroscience 31 1989 785 797
22. X. Zhang, T. Shi, K. Holmberg, M. Landry, W. Huang, H. Xiao, G. Ju, and T. Hokfelt Expression and regulation of the neuropeptide Y Y2 receptor in sensory and autonomic ganglia Proc. Natl. Acad. Sci. U. S. A. 94 1997 729 734