SCOPUS 정보 검색 플랫폼

Volumn 21, Issue 22, 2013, Pages 7064-7073

A PEGylated analog of the gut hormone oxyntomodulin with long-lasting antihyperglycemic, insulinotropic and anorexigenic activity

(12) Bianchi, Elisabetta a Carrington, Paul E b Ingallinella, Paolo a,c Finotto, Marco a Santoprete, Alessia a Petrov, Aleksandr b Eiermann, George b Kosinski, Jennifer b Marsh, Donald J b Pocai, Alessandro b Sinharoy, Ranabir b,d Pessi, Antonello a,e,f

a IRBM (Italy)

b MERCK RESEARCH LABORATORIES (United States)

c Diasorin SpA (Italy)

d JANSSEN RESEARCH AND DEVELOPMENT (Belgium)

e PeptiPharma (Italy)

f CEINGE BIOTECNOLOGIE AVANZATE (Italy)

Author keywords

Diabetes; GLP 1 receptor agonist; Incretin; Obesity; Oxyntomodulin; PEG

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; MACROGOL; OXYNTOMODULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIGENIC ACTIVITY; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG RESPONSE; DRUG SYNTHESIS; FEMALE; FOOD INTAKE; GLUCOSE TOLERANCE TEST; INSULIN LIKE ACTIVITY; MOUSE; NONHUMAN; OBESITY; WEIGHT REDUCTION;

MUS; RODENTIA;

DIABETES; GLP-1 RECEPTOR AGONIST; INCRETIN; OBESITY; OXYNTOMODULIN; PEG;

ANIMALS; APPETITE DEPRESSANTS; BODY WEIGHT; EATING; GLUCOSE TOLERANCE TEST; HALF-LIFE; HYPOGLYCEMIC AGENTS; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OXYNTOMODULIN; POLYETHYLENE GLYCOLS; PRIMATES; RECEPTORS, GLUCAGON;

EID: 84885843073 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.09.016 Document Type: Article

Times cited : (38)

References (39)

1
- 33845405222
- S.E. Kahn, S.M. Haffner, M.A. Heise, W.H. Herman, R.R. Holman, N.P. Jones, B.G. Kravitz, J.M. Lachin, M.C. O'Neill, B. Zinman, and G.N. Viberti N. England J. Med. 355 2006 2427
- (2006) N. England J. Med. , vol.355 , pp. 2427
- Kahn, S.E.¹ Haffner, S.M.² Heise, M.A.³ Herman, W.H.⁴ Holman, R.R.⁵ Jones, N.P.⁶ Kravitz, B.G.⁷ Lachin, J.M.⁸ O'Neill, M.C.⁹ Zinman, B.¹⁰ Viberti, G.N.¹¹

2
- 84555191794
- A.J. Garber Expert Opin. Investig. Drugs 21 2012 45
- (2012) Expert Opin. Investig. Drugs , vol.21 , pp. 45
- Garber, A.J.¹

3
- 84856354755
- B. Gallwitz Handb. Exp. Pharmacol. 209 2012 185
- (2012) Handb. Exp. Pharmacol. , vol.209 , pp. 185
- Gallwitz, B.¹

4
- 70349308687
- J.W. Day, N. Ottaway, J.T. Patterson, V. Gelfanov, D. Smiley, J. Gidda, H. Findeisen, D. Bruemmer, D.J. Drucker, N. Chaudhary, J. Holland, J. Hembree, W. Abplanalp, E. Grant, J. Ruehl, H. Wilson, H. Kirchner, S.H. Lockie, S. Hofmann, S.C. Woods, R. Nogueiras, P.T. Pfluger, D. Perez-Tilve, R. DiMarchi, and M.H. Tschop Nat. Chem. Biol. 5 2009 749
- (2009) Nat. Chem. Biol. , vol.5 , pp. 749
- Day, J.W.¹ Ottaway, N.² Patterson, J.T.³ Gelfanov, V.⁴ Smiley, D.⁵ Gidda, J.⁶ Findeisen, H.⁷ Bruemmer, D.⁸ Drucker, D.J.⁹ Chaudhary, N.¹⁰ Holland, J.¹¹ Hembree, J.¹² Abplanalp, W.¹³ Grant, E.¹⁴ Ruehl, J.¹⁵ Wilson, H.¹⁶ Kirchner, H.¹⁷ Lockie, S.H.¹⁸ Hofmann, S.¹⁹ Woods, S.C.²⁰ more..

5
- 70349644658
- A. Pocai, P.E. Carrington, J.R. Adams, M. Wright, G. Eiermann, L. Zhu, X. Du, A. Petrov, M.E. Lassman, G. Jiang, F. Liu, C. Miller, L.M. Tota, G. Zhou, X. Zhang, M.M. Sountis, A. Santoprete, E. Capito, G.G. Chicchi, N. Thornberry, E. Bianchi, A. Pessi, D.J. Marsh, and R. SinhaRoy Diabetes 58 2009 2258
- (2009) Diabetes , vol.58 , pp. 2258
- Pocai, A.¹ Carrington, P.E.² Adams, J.R.³ Wright, M.⁴ Eiermann, G.⁵ Zhu, L.⁶ Du, X.⁷ Petrov, A.⁸ Lassman, M.E.⁹ Jiang, G.¹⁰ Liu, F.¹¹ Miller, C.¹² Tota, L.M.¹³ Zhou, G.¹⁴ Zhang, X.¹⁵ Sountis, M.M.¹⁶ Santoprete, A.¹⁷ Capito, E.¹⁸ Chicchi, G.G.¹⁹ Thornberry, N.²⁰ more..

6
- 0030901415
- J.J. Holst Annu. Rev. Physiol. 59 1997 257
- (1997) Annu. Rev. Physiol. , vol.59 , pp. 257
- Holst, J.J.¹

7
- 0023910424
- F.G. Baldissera, J.J. Holst, S. Knuhtsen, L. Hilsted, and O.V. Nielsen Regul. Pept. 21 1988 151
- (1988) Regul. Pept. , vol.21 , pp. 151
- Baldissera, F.G.¹ Holst, J.J.² Knuhtsen, S.³ Hilsted, L.⁴ Nielsen, O.V.⁵

8
- 0027220436
- L. Gros, B. Thorens, D. Bataille, and A. Kervran Endocrinology 133 1993 631
- (1993) Endocrinology , vol.133 , pp. 631
- Gros, L.¹ Thorens, B.² Bataille, D.³ Kervran, A.⁴

9
- 0036889316
- C.L. Dakin, C.J. Small, A.J. Park, A. Seth, M.A. Ghatei, and S.R. Bloom Am. J. Physiol. Endocrinol. Metab. 283 2002 E1173
- (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283 , pp. 1173
- Dakin, C.L.¹ Small, C.J.² Park, A.J.³ Seth, A.⁴ Ghatei, M.A.⁵ Bloom, S.R.⁶

10
- 2542460293
- C.L. Dakin, C.J. Small, R.L. Batterham, N.M. Neary, M.A. Cohen, M. Patterson, M.A. Ghatei, and S.R. Bloom Endocrinology 145 2004 2687
- (2004) Endocrinology , vol.145 , pp. 2687
- Dakin, C.L.¹ Small, C.J.² Batterham, R.L.³ Neary, N.M.⁴ Cohen, M.A.⁵ Patterson, M.⁶ Ghatei, M.A.⁷ Bloom, S.R.⁸

11
- 33749339257
- K. Wynne, A.J. Park, C.J. Small, K. Meeran, M.A. Ghatei, G.S. Frost, and S.R. Bloom Int. J. Obes. 30 2006 1729
- (2006) Int. J. Obes. , vol.30 , pp. 1729
- Wynne, K.¹ Park, A.J.² Small, C.J.³ Meeran, K.⁴ Ghatei, M.A.⁵ Frost, G.S.⁶ Bloom, S.R.⁷

12
- 23644443678
- K. Wynne, A.J. Park, C.J. Small, M. Patterson, S.M. Ellis, K.G. Murphy, A.M. Wren, G.S. Frost, K. Meeran, M.A. Ghatei, and S.R. Bloom Diabetes 54 2005 2390
- (2005) Diabetes , vol.54 , pp. 2390
- Wynne, K.¹ Park, A.J.² Small, C.J.³ Patterson, M.⁴ Ellis, S.M.⁵ Murphy, K.G.⁶ Wren, A.M.⁷ Frost, G.S.⁸ Meeran, K.⁹ Ghatei, M.A.¹⁰ Bloom, S.R.¹¹

13
- 84863953711
- X. Du, J.R. Kosinski, J. Lao, X. Shen, A. Petrov, G.G. Chicchi, G.J. Eiermann, and A. Pocai Am. J. Physiol. Endocrinol. Metab. 303 2012 E265
- (2012) Am. J. Physiol. Endocrinol. Metab. , vol.303 , pp. 265
- Du, X.¹ Kosinski, J.R.² Lao, J.³ Shen, X.⁴ Petrov, A.⁵ Chicchi, G.G.⁶ Eiermann, G.J.⁷ Pocai, A.⁸

14
- 84864351901
- J.R. Kosinski, J. Hubert, P.E. Carrington, G.G. Chicchi, J. Mu, C. Miller, J. Cao, E. Bianchi, A. Pessi, R. Sinharoy, D.J. Marsh, and A. Pocai Obesity 20 2012 1566
- (2012) Obesity , vol.20 , pp. 1566
- Kosinski, J.R.¹ Hubert, J.² Carrington, P.E.³ Chicchi, G.G.⁴ Mu, J.⁵ Miller, C.⁶ Cao, J.⁷ Bianchi, E.⁸ Pessi, A.⁹ Sinharoy, R.¹⁰ Marsh, D.J.¹¹ Pocai, A.¹²

15
- 0025047857
- A. Kervran, M. Dubrasquet, P. Blache, J. Martinez, and D. Bataille Regul. Pept. 31 1990 41
- (1990) Regul. Pept. , vol.31 , pp. 41
- Kervran, A.¹ Dubrasquet, M.² Blache, P.³ Martinez, J.⁴ Bataille, D.⁵

16
- 0037928769
- L. Zhu, C. Tamvakopoulos, D. Xie, J. Dragovic, X. Shen, J.E. Fenyk-Melody, K. Schmidt, A. Bagchi, P.R. Griffin, N.A. Thornberry, and R. SinhaRoy J. Biol. Chem. 278 2003 22418
- (2003) J. Biol. Chem. , vol.278 , pp. 22418
- Zhu, L.¹ Tamvakopoulos, C.² Xie, D.³ Dragovic, J.⁴ Shen, X.⁵ Fenyk-Melody, J.E.⁶ Schmidt, K.⁷ Bagchi, A.⁸ Griffin, P.R.⁹ Thornberry, N.A.¹⁰ Sinharoy, R.¹¹

17
- 79952464908
- A. Santoprete, E. Capitò, P.E. Carrington, A. Pocai, M. Finotto, A. Langella, P. Ingallinella, K. Zytko, S. Bufali, S. Cianetti, M. Veneziano, F. Bonelli, L. Zhu, E. Monteagudo, D.J. Marsh, R. Sinharoy, E. Bianchi, and A. Pessi J. Pept. Sci. 17 2011 270
- (2011) J. Pept. Sci. , vol.17 , pp. 270
- Santoprete, A.¹ Capitò, E.² Carrington, P.E.³ Pocai, A.⁴ Finotto, M.⁵ Langella, A.⁶ Ingallinella, P.⁷ Zytko, K.⁸ Bufali, S.⁹ Cianetti, S.¹⁰ Veneziano, M.¹¹ Bonelli, F.¹² Zhu, L.¹³ Monteagudo, E.¹⁴ Marsh, D.J.¹⁵ Sinharoy, R.¹⁶ Bianchi, E.¹⁷ Pessi, A.¹⁸

18
- 77957890652
- B.D. Kerr, P.R. Flatt, and V.A. Gault Biochem. Pharmacol. 80 2010 1727
- (2010) Biochem. Pharmacol. , vol.80 , pp. 1727
- Kerr, B.D.¹ Flatt, P.R.² Gault, V.A.³

19
- 63849300305
- M.R. Druce, J.S. Minnion, B.C. Field, S.R. Patel, J.C. Shillito, M. Tilby, K.E. Beale, K.G. Murphy, M.A. Ghatei, and S.R. Bloom Endocrinology 150 2009 1712
- (2009) Endocrinology , vol.150 , pp. 1712
- Druce, M.R.¹ Minnion, J.S.² Field, B.C.³ Patel, S.R.⁴ Shillito, J.C.⁵ Tilby, M.⁶ Beale, K.E.⁷ Murphy, K.G.⁸ Ghatei, M.A.⁹ Bloom, S.R.¹⁰

20
- 77957578888
- Y.L. Liu, H.E. Ford, M.R. Druce, J.S. Minnion, B.C. Field, J.C. Shillito, J. Baxter, K.G. Murphy, M.A. Ghatei, and S.R. Bloom Int. J. Obes. 34 2010 1715
- (2010) Int. J. Obes. , vol.34 , pp. 1715
- Liu, Y.L.¹ Ford, H.E.² Druce, M.R.³ Minnion, J.S.⁴ Field, B.C.⁵ Shillito, J.C.⁶ Baxter, J.⁷ Murphy, K.G.⁸ Ghatei, M.A.⁹ Bloom, S.R.¹⁰

21
- 77950501202
- D.J. Drucker, A. Dritselis, and P. Kirkpatrick Nat. Rev. Drug Disc. 9 2010 267
- (2010) Nat. Rev. Drug Disc. , vol.9 , pp. 267
- Drucker, D.J.¹ Dritselis, A.² Kirkpatrick, P.³

22
- 34247598752
- K.J. Lumb, L.B. DeCarr, L.F. Milardo, M.R. Mays, T.M. Buckholz, S.E. Fisk, C.M. Pellegrino, A.A. Ortiz, and C.D. Mahle J. Med. Chem. 50 2007 2264
- (2007) J. Med. Chem. , vol.50 , pp. 2264
- Lumb, K.J.¹ Decarr, L.B.² Milardo, L.F.³ Mays, M.R.⁴ Buckholz, T.M.⁵ Fisk, S.E.⁶ Pellegrino, C.M.⁷ Ortiz, A.A.⁸ Mahle, C.D.⁹

23
- 0345283166
- P. Esposito, L. Barbero, P. Caccia, P. Caliceti, M. D'Antonio, G. Piquet, and F.M. Veronese Adv. Drug Deliv. Rev. 55 2003 1279
- (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 1279
- Esposito, P.¹ Barbero, L.² Caccia, P.³ Caliceti, P.⁴ D'Antonio, M.⁵ Piquet, G.⁶ Veronese, F.M.⁷

24
- 42949175115
- L.P. Miranda, K.A. Winters, C.V. Gegg, A. Patel, J. Aral, J. Long, J. Zhang, S. Diamond, M. Guido, S. Stanislaus, M. Ma, H. Li, M.J. Rose, L. Poppe, and M.M. Véniant J. Med. Chem. 51 2008 2758
- (2008) J. Med. Chem. , vol.51 , pp. 2758
- Miranda, L.P.¹ Winters, K.A.² Gegg, C.V.³ Patel, A.⁴ Aral, J.⁵ Long, J.⁶ Zhang, J.⁷ Diamond, S.⁸ Guido, M.⁹ Stanislaus, S.¹⁰ Ma, M.¹¹ Li, H.¹² Rose, M.J.¹³ Poppe, L.¹⁴ Véniant, M.M.¹⁵

25
- 33744964247
- C.Q. Pan, J.M. Buxton, S.L. Yung, I. Tom, L. Yang, H. Chen, M. MacDougall, A. Bell, T.H. Claus, K.B. Clairmont, and J.P. Whelan J. Biol. Chem. 281 2006 12506
- (2006) J. Biol. Chem. , vol.281 , pp. 12506
- Pan, C.Q.¹ Buxton, J.M.² Yung, S.L.³ Tom, I.⁴ Yang, L.⁵ Chen, H.⁶ Macdougall, M.⁷ Bell, A.⁸ Claus, T.H.⁹ Clairmont, K.B.¹⁰ Whelan, J.P.¹¹

26
- 35548958265
- A.A. Ortiz, L.F. Milardo, L.B. DeCarr, T.M. Buckholz, M.R. Mays, T.H. Claus, J.N. Livingston, C.D. Mahle, and K.J. Lumb J. Pharmacol. Exp. Ther. 323 2007 692
- (2007) J. Pharmacol. Exp. Ther. , vol.323 , pp. 692
- Ortiz, A.A.¹ Milardo, L.F.² Decarr, L.B.³ Buckholz, T.M.⁴ Mays, M.R.⁵ Claus, T.H.⁶ Livingston, J.N.⁷ Mahle, C.D.⁸ Lumb, K.J.⁹

27
- 84863990336
- P. Ingallinella, A.M. Peier, A. Pocai, A. Di Marco, K. Desai, K. Zytko, Y. Qian, X. Du, A. Cellucci, E. Monteagudo, R. Laufer, E. Bianchi, D.J. Marsh, and A. Pessi Bioorg. Med. Chem. 20 2012 4751
- (2012) Bioorg. Med. Chem. , vol.20 , pp. 4751
- Ingallinella, P.¹ Peier, A.M.² Pocai, A.³ Di Marco, A.⁴ Desai, K.⁵ Zytko, K.⁶ Qian, Y.⁷ Du, X.⁸ Cellucci, A.⁹ Monteagudo, E.¹⁰ Laufer, R.¹¹ Bianchi, E.¹² Marsh, D.J.¹³ Pessi, A.¹⁴

28
- 0037362655
- J.M. Harris, and R.B. Chess Nat. Rev. Drug Disc. 2 2003 214
- (2003) Nat. Rev. Drug Disc. , vol.2 , pp. 214
- Harris, J.M.¹ Chess, R.B.²

29
- 55749111387
- C.S. Fishburn J. Pharm. Sci. 97 2008 4167
- (2008) J. Pharm. Sci. , vol.97 , pp. 4167
- Fishburn, C.S.¹

30
- 45949123116
- H. Rink Tetrahedron Lett. 28 1987 3787
- (1987) Tetrahedron Lett. , vol.28 , pp. 3787
- Rink, H.¹

31
- 0001275595
- M.S. Bernatowicz, S.B. Daniels, and H. Koster Tetrahedron Lett. 30 1989 4645
- (1989) Tetrahedron Lett. , vol.30 , pp. 4645
- Bernatowicz, M.S.¹ Daniels, S.B.² Koster, H.³

32
- 0026667852
- N.A. Sole, and G. Barany J. Org. Chem. 57 1992 5399
- (1992) J. Org. Chem. , vol.57 , pp. 5399
- Sole, N.A.¹ Barany, G.²

33
- 84872171201
- J.W. Day, V. Gelfanov, D. Smiley, P.E. Carrington, G. Eiermann, G. Chicchi, M.D. Erion, J. Gidda, N.A. Thornberry, M.H. Tschöp, D.J. Marsh, R. SinhaRoy, R. DiMarchi, and A. Pocai J. Pept. Sci. 98 2012 443
- (2012) J. Pept. Sci. , vol.98 , pp. 443
- Day, J.W.¹ Gelfanov, V.² Smiley, D.³ Carrington, P.E.⁴ Eiermann, G.⁵ Chicchi, G.⁶ Erion, M.D.⁷ Gidda, J.⁸ Thornberry, N.A.⁹ Tschöp, M.H.¹⁰ Marsh, D.J.¹¹ Sinharoy, R.¹² Dimarchi, R.¹³ Pocai, A.¹⁴

34
- 80053187244
- J.T. Patterson, J.W. Day, V.M. Gelfanov, and R.D. DiMarchi J. Pept. Sci. 17 2011 659
- (2011) J. Pept. Sci. , vol.17 , pp. 659
- Patterson, J.T.¹ Day, J.W.² Gelfanov, V.M.³ Dimarchi, R.D.⁴

35
- 23744478185
- G.M. Keating Drugs 65 2005 1681
- (2005) Drugs , vol.65 , pp. 1681
- Keating, G.M.¹

36
- 79955014687
- T.H. Kim, H.H. Jiang, S. Lee, Y.S. Youn, C.W. Park, Y. Byun, X. Chen, and K.C. Lee Bioconjugate Chem. 22 2011 625
- (2011) Bioconjugate Chem. , vol.22 , pp. 625
- Kim, T.H.¹ Jiang, H.H.² Lee, S.³ Youn, Y.S.⁴ Park, C.W.⁵ Byun, Y.⁶ Chen, X.⁷ Lee, K.C.⁸

37
- 84870606111
- A. Kirkpatrick, J. Heo, R. Abrol, and W.A. Goddard Proc. Nat. Acad. Sci. U.S.A. 109 2012 19988
- (2012) Proc. Nat. Acad. Sci. U.S.A. , vol.109 , pp. 19988
- Kirkpatrick, A.¹ Heo, J.² Abrol, R.³ Goddard, W.A.⁴

38
- 84879389894
- J. Xu, J. Bussiere, J. Yie, A. Sickmier, P. An, E. Belouski, S. Stanislaus, and K.W. Walker Bioconjugate Chem. 24 2013 915
- (2013) Bioconjugate Chem. , vol.24 , pp. 915
- Xu, J.¹ Bussiere, J.² Yie, J.³ Sickmier, A.⁴ An, P.⁵ Belouski, E.⁶ Stanislaus, S.⁷ Walker, K.W.⁸

39
- 73649107900
- C.R. Underwood, P. Garibay, L.B. Knudsen, S. Hastrup, G.H. Peters, R. Rudolph, and S. Reedtz-Runge J. Biol. Chem. 285 2010 723
- (2010) J. Biol. Chem. , vol.285 , pp. 723
- Underwood, C.R.¹ Garibay, P.² Knudsen, L.B.³ Hastrup, S.⁴ Peters, G.H.⁵ Rudolph, R.⁶ Reedtz-Runge, S.⁷

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.