메뉴 건너뛰기




Volumn 4, Issue 2, 2013, Pages 108-130

Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas

Author keywords

Diabetic complication; Glucagon like peptide 1; Glucose dependent insulinotropic polypeptide

Indexed keywords

ALBIGLUTIDE; ALOGLIPTIN; ANTIDIABETIC AGENT; DULAGLUTIDE; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; GLIMEPIRIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; INCRETIN; LINAGLIPTIN; LIRAGLUTIDE; LIXISENATIDE; PKF 275 055; PLACEBO; SAXAGLIPTIN; SITAGLIPTIN; UNCLASSIFIED DRUG; VILDAGLIPTIN;

EID: 84878360808     PISSN: 20401116     EISSN: 20401124     Source Type: Journal    
DOI: 10.1111/jdi.12065     Document Type: Review
Times cited : (223)

References (240)
  • 1
    • 84944484435 scopus 로고
    • The mechanism of pancreatic secretion
    • Bayliss WM, Starling EH. The mechanism of pancreatic secretion. J Physiol 1902; 28: 325-353.
    • (1902) J Physiol , vol.28 , pp. 325-353
    • Bayliss, W.M.1    Starling, E.H.2
  • 2
    • 0002025725 scopus 로고
    • On the treatment of Diabetus mellitus by acid extract of Duodenal Mucous Membrane
    • Moore B. On the treatment of Diabetus mellitus by acid extract of Duodenal Mucous Membrane. Biochem J 1906; 1: 28-38.
    • (1906) Biochem J , vol.1 , pp. 28-38
    • Moore, B.1
  • 3
    • 0003018873 scopus 로고
    • Contributiona a l'etude des variations physiologiques de la secretion interne du pancreas. relations entre les secretions externe et interne du pancreas
    • Zunz E, La Barre J. Contributiona a l'etude des variations physiologiques de la secretion interne du pancreas. relations entre les secretions externe et interne du pancreas. Arch Int Physiol Biochim 1929; 31: 20-44.
    • (1929) Arch Int Physiol Biochim , vol.31 , pp. 20-44
    • Zunz, E.1    La Barre, J.2
  • 4
    • 78650903000 scopus 로고    scopus 로고
    • GIP and GLP-1, the two incretin hormones: similarities and differences
    • Seino Y, Fukushima M, Yabe D. GIP and GLP-1, the two incretin hormones: similarities and differences. J Diabetes Invest 2010; 1: 9-23.
    • (2010) J Diabetes Invest , vol.1 , pp. 9-23
    • Seino, Y.1    Fukushima, M.2    Yabe, D.3
  • 5
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab 2006; 3: 153-165.
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 6
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007; 87: 1409-1439.
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 7
    • 9444244529 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes
    • Nauck MA, Baller B, Meier JJ. Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes. Diabetes 2004; 53(Suppl 3): S190-S196.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Nauck, M.A.1    Baller, B.2    Meier, J.J.3
  • 8
    • 20244385394 scopus 로고    scopus 로고
    • Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors
    • Hansotia T, Baggio LL, Delmeire D, et al. Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors. Diabetes 2004; 53: 1326-1335.
    • (2004) Diabetes , vol.53 , pp. 1326-1335
    • Hansotia, T.1    Baggio, L.L.2    Delmeire, D.3
  • 9
    • 0007866067 scopus 로고    scopus 로고
    • Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice
    • Miyawaki K, Yamada Y, Yano H, et al. Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice. Proc Natl Acad Sci USA 1999; 96: 14843-14847.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14843-14847
    • Miyawaki, K.1    Yamada, Y.2    Yano, H.3
  • 10
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
    • Scrocchi LA, Brown TJ, MaClusky N, et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med 1996; 2: 1254-1258.
    • (1996) Nat Med , vol.2 , pp. 1254-1258
    • Scrocchi, L.A.1    Brown, T.J.2    MaClusky, N.3
  • 11
    • 78650753885 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications
    • Nauck MA. Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications. Am J Med 2011; 124: S3-S18.
    • (2011) Am J Med , vol.124
    • Nauck, M.A.1
  • 12
    • 67651173077 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus
    • Lovshin JA, Drucker DJ. Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol 2009; 5: 262-269.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 262-269
    • Lovshin, J.A.1    Drucker, D.J.2
  • 13
    • 79959773411 scopus 로고    scopus 로고
    • DPP-4 inhibitors: impact on glycemic control and cardiovascular risk factors
    • Dicker D. DPP-4 inhibitors: impact on glycemic control and cardiovascular risk factors. Diabetes Care 2011; 34(Suppl 2): S276-S278.
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL. 2
    • Dicker, D.1
  • 14
    • 78649686908 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review
    • Deacon CF. Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes Obes Metab 2011; 13: 7-18.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 7-18
    • Deacon, C.F.1
  • 15
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis
    • Amori RE, Lau J, Pittas AG. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. JAMA 2007; 298: 194-206.
    • (2007) JAMA , vol.298 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3
  • 16
    • 77950880269 scopus 로고    scopus 로고
    • Dipeptydil peptidase-4 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials
    • Monami M, Iacomelli I, Marchionni N, et al. Dipeptydil peptidase-4 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis 2010; 20: 224-235.
    • (2010) Nutr Metab Cardiovasc Dis , vol.20 , pp. 224-235
    • Monami, M.1    Iacomelli, I.2    Marchionni, N.3
  • 17
    • 66149108722 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized clinical trials
    • Monami M, Marchionni N, Mannucci E. Glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized clinical trials. Eur J Endocrinol 2009; 160: 909-917.
    • (2009) Eur J Endocrinol , vol.160 , pp. 909-917
    • Monami, M.1    Marchionni, N.2    Mannucci, E.3
  • 18
    • 79953759251 scopus 로고    scopus 로고
    • Comparative evaluation of incretin-based antidiabetic medications and alternative therapies to be added to metformin in the case of monotherapy failure
    • Nauck MA, Vardarli I. Comparative evaluation of incretin-based antidiabetic medications and alternative therapies to be added to metformin in the case of monotherapy failure. J Diabetes Invest 2010; 1: 24-36.
    • (2010) J Diabetes Invest , vol.1 , pp. 24-36
    • Nauck, M.A.1    Vardarli, I.2
  • 19
    • 9644265449 scopus 로고    scopus 로고
    • Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes
    • Fukushima M, Suzuki H, Seino Y. Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes. Diabetes Res Clin Pract 2004; 66S: S37-S44.
    • (2004) Diabetes Res Clin Pract , vol.66 S
    • Fukushima, M.1    Suzuki, H.2    Seino, Y.3
  • 20
    • 84869217988 scopus 로고    scopus 로고
    • Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes: meta-analysis
    • Park H, Park C, Kim Y, et al. Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes: meta-analysis. Ann Pharmacother 2012; 46: 1453-1469.
    • (2012) Ann Pharmacother , vol.46 , pp. 1453-1469
    • Park, H.1    Park, C.2    Kim, Y.3
  • 21
    • 84876498178 scopus 로고    scopus 로고
    • Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and Non-Asians: a systematic review and meta-analysis
    • doi: 10.1007/s00125-012-2827-3.
    • Kim YG, Hahn S, Oh TJ, et al. Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and Non-Asians: a systematic review and meta-analysis. Diabetologia 2013; doi: 10.1007/s00125-012-2827-3.
    • (2013) Diabetologia
    • Kim, Y.G.1    Hahn, S.2    Oh, T.J.3
  • 22
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group.
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352: 837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 23
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group.
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329: 977-986.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 24
    • 29144453326 scopus 로고    scopus 로고
    • Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    • Nathan DM, Cleary PA, Backlund JY, et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 2005; 353: 2643-2653.
    • (2005) N Engl J Med , vol.353 , pp. 2643-2653
    • Nathan, D.M.1    Cleary, P.A.2    Backlund, J.Y.3
  • 25
    • 53749096863 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes
    • Holman RR, Paul SK, Bethel MA, et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008; 359: 1577-1589.
    • (2008) N Engl J Med , vol.359 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3
  • 26
    • 79953764336 scopus 로고    scopus 로고
    • Molecular mechanisms of diabetic vascular complications
    • Kitada M, Zhang Z, Mima A, et al. Molecular mechanisms of diabetic vascular complications. J Diabetes Invest 2010; 1: 77-89.
    • (2010) J Diabetes Invest , vol.1 , pp. 77-89
    • Kitada, M.1    Zhang, Z.2    Mima, A.3
  • 27
    • 80054110585 scopus 로고    scopus 로고
    • Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice
    • Nagashima M, Watanabe T, Terasaki M, et al. Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice. Diabetologia 2011; 54: 2649-2659.
    • (2011) Diabetologia , vol.54 , pp. 2649-2659
    • Nagashima, M.1    Watanabe, T.2    Terasaki, M.3
  • 28
    • 84859945433 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide prevents the progression of macrophage-driven atherosclerosis in diabetic apolipoprotein E-null mice
    • Nogi Y, Nagashima M, Terasaki M, et al. Glucose-dependent insulinotropic polypeptide prevents the progression of macrophage-driven atherosclerosis in diabetic apolipoprotein E-null mice. PLoS ONE 2012; 7: e35683.
    • (2012) PLoS ONE , vol.7
    • Nogi, Y.1    Nagashima, M.2    Terasaki, M.3
  • 29
    • 77951151612 scopus 로고    scopus 로고
    • Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    • Arakawa M, Mita T, Azuma K, et al. Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes 2010; 59: 1030-1037.
    • (2010) Diabetes , vol.59 , pp. 1030-1037
    • Arakawa, M.1    Mita, T.2    Azuma, K.3
  • 30
    • 84871686739 scopus 로고    scopus 로고
    • GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE-/- mice
    • Panjwani N, Mulvihill EE, Longuet C, et al. GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE-/- mice. Endocrinology 2013; 154: 127-139.
    • (2013) Endocrinology , vol.154 , pp. 127-139
    • Panjwani, N.1    Mulvihill, E.E.2    Longuet, C.3
  • 31
    • 79959237560 scopus 로고    scopus 로고
    • A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model
    • Gaspari T, Liu H, Welungoda I, et al. A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model. Diab Vasc Dis Res 2011; 8: 117-124.
    • (2011) Diab Vasc Dis Res , vol.8 , pp. 117-124
    • Gaspari, T.1    Liu, H.2    Welungoda, I.3
  • 32
    • 67650057935 scopus 로고    scopus 로고
    • A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules
    • Liu H, Dear AE, Knudsen LB, et al. A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules. J Endocrinol 2009; 201: 59-66.
    • (2009) J Endocrinol , vol.201 , pp. 59-66
    • Liu, H.1    Dear, A.E.2    Knudsen, L.B.3
  • 33
    • 79551607371 scopus 로고    scopus 로고
    • Effect of exenatide on inflammatory and oxidative stress markers in patients with type 2 diabetes mellitus
    • Wu JD, Xu XH, Zhu J, et al. Effect of exenatide on inflammatory and oxidative stress markers in patients with type 2 diabetes mellitus. Diabetes Technol Ther 2011; 13: 143-148.
    • (2011) Diabetes Technol Ther , vol.13 , pp. 143-148
    • Wu, J.D.1    Xu, X.H.2    Zhu, J.3
  • 34
    • 84862795550 scopus 로고    scopus 로고
    • Preventive effects of exenatide on endothelial dysfunction induced by ischemia-reperfusion injury via KATP channels
    • Ha SJ, Kim W, Woo JS, et al. Preventive effects of exenatide on endothelial dysfunction induced by ischemia-reperfusion injury via KATP channels. Arterioscler Thromb Vasc Biol 2012; 32: 474-480.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 474-480
    • Ha, S.J.1    Kim, W.2    Woo, J.S.3
  • 35
    • 77954948794 scopus 로고    scopus 로고
    • Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes
    • Koska J, Schwartz EA, Mullin MP, et al. Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes. Diabetes Care 2010; 33: 1028-1030.
    • (2010) Diabetes Care , vol.33 , pp. 1028-1030
    • Koska, J.1    Schwartz, E.A.2    Mullin, M.P.3
  • 36
    • 84865368343 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation
    • Shiraishi D, Fujiwara Y, Komohara Y, et al. Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation. Biochem Biophys Res Commun 2012; 425: 304-308.
    • (2012) Biochem Biophys Res Commun , vol.425 , pp. 304-308
    • Shiraishi, D.1    Fujiwara, Y.2    Komohara, Y.3
  • 37
    • 84855428526 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 activates endothelial nitric oxide synthase in human umbilical vein endothelial cells
    • Ding L, Zhang J. Glucagon-like peptide-1 activates endothelial nitric oxide synthase in human umbilical vein endothelial cells. Acta Pharmacol Sin 2012; 33: 75-81.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 75-81
    • Ding, L.1    Zhang, J.2
  • 38
    • 84859529626 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism
    • Chai W, Dong Z, Wang N, et al. Glucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism. Diabetes 2012; 61: 888-896.
    • (2012) Diabetes , vol.61 , pp. 888-896
    • Chai, W.1    Dong, Z.2    Wang, N.3
  • 39
    • 79958023978 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 protects microvascular endothelial cells by inactivating the PARP-1/iNOS/NO pathway
    • Liu FQ, Zhang XL, Gong L, et al. Glucagon-like peptide 1 protects microvascular endothelial cells by inactivating the PARP-1/iNOS/NO pathway. Mol Cell Endocrinol 2011; 339: 25-33.
    • (2011) Mol Cell Endocrinol , vol.339 , pp. 25-33
    • Liu, F.Q.1    Zhang, X.L.2    Gong, L.3
  • 40
    • 79551706382 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 improves proliferation and differentiation of endothelial progenitor cells via upregulating VEGF generation
    • Xiao-Yun X, Zhao-Hui M, Ke C, et al. Glucagon-like peptide-1 improves proliferation and differentiation of endothelial progenitor cells via upregulating VEGF generation. Med Sci Monit 2011;17: BR35-BR41.
    • (2011) Med Sci Monit , vol.17
    • Xiao-Yun, X.1    Zhao-Hui, M.2    Ke, C.3
  • 41
    • 77954384449 scopus 로고    scopus 로고
    • Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor
    • Erdogdu O, Nathanson D, Sjoholm A, et al. Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-, PKA- and PI3K/Akt-dependent pathways and requires GLP-1 receptor. Mol Cell Endocrinol 2010; 325: 26-35.
    • (2010) Mol Cell Endocrinol , vol.325 , pp. 26-35
    • Erdogdu, O.1    Nathanson, D.2    Sjoholm, A.3
  • 42
    • 84866546292 scopus 로고    scopus 로고
    • Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK-eNOS pathways
    • Han L, Yu Y, Sun X, et al. Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK-eNOS pathways. Diabetes Res Clin Pract 2012; 97: 453-460.
    • (2012) Diabetes Res Clin Pract , vol.97 , pp. 453-460
    • Han, L.1    Yu, Y.2    Sun, X.3
  • 43
    • 84858707110 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 analog liraglutide reduces TNF-alpha-induced oxidative stress and inflammation in endothelial cells
    • Shiraki A, Oyama J, Komoda H, et al. The glucagon-like peptide 1 analog liraglutide reduces TNF-alpha-induced oxidative stress and inflammation in endothelial cells. Atherosclerosis 2012; 221: 375-382.
    • (2012) Atherosclerosis , vol.221 , pp. 375-382
    • Shiraki, A.1    Oyama, J.2    Komoda, H.3
  • 44
    • 84863787414 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) protects vascular endothelial cells against advanced glycation end products (AGEs)-induced apoptosis
    • Zhan Y, Sun HL, Chen H, et al. Glucagon-like peptide-1 (GLP-1) protects vascular endothelial cells against advanced glycation end products (AGEs)-induced apoptosis. Med Sci Monit 2012; 18: BR286-BR291.
    • (2012) Med Sci Monit , vol.18
    • Zhan, Y.1    Sun, H.L.2    Chen, H.3
  • 45
    • 84862209599 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide (GIP) inhibits signaling pathways of advanced glycation end products (AGEs) in endothelial cells via its antioxidative properties
    • Ojima A, Matsui T, Maeda S, et al. Glucose-dependent insulinotropic polypeptide (GIP) inhibits signaling pathways of advanced glycation end products (AGEs) in endothelial cells via its antioxidative properties. Horm Metab Res 2012; 44: 501-505.
    • (2012) Horm Metab Res , vol.44 , pp. 501-505
    • Ojima, A.1    Matsui, T.2    Maeda, S.3
  • 46
    • 84862908699 scopus 로고    scopus 로고
    • A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice
    • Matsubara J, Sugiyama S, Sugamura K, et al. A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice. J Am Coll Cardiol 2012; 59: 265-276.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 265-276
    • Matsubara, J.1    Sugiyama, S.2    Sugamura, K.3
  • 47
    • 81855222104 scopus 로고    scopus 로고
    • Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis
    • Shah Z, Kampfrath T, Deiuliis JA, et al. Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation 2011; 124: 2338-2349.
    • (2011) Circulation , vol.124 , pp. 2338-2349
    • Shah, Z.1    Kampfrath, T.2    Deiuliis, J.A.3
  • 48
    • 80051785333 scopus 로고    scopus 로고
    • DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice
    • Ta NN, Schuyler CA, Li Y, et al. DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice. J Cardiovasc Pharmacol 2011; 58: 157-166.
    • (2011) J Cardiovasc Pharmacol , vol.58 , pp. 157-166
    • Ta, N.N.1    Schuyler, C.A.2    Li, Y.3
  • 49
    • 84862128306 scopus 로고    scopus 로고
    • Effects of PKF275-055, a dipeptidyl peptidase-4 inhibitor, on the development of atherosclerotic lesions in apolipoprotein E-null mice
    • Terasaki M, Nagashima M, Watanabe T, et al. Effects of PKF275-055, a dipeptidyl peptidase-4 inhibitor, on the development of atherosclerotic lesions in apolipoprotein E-null mice. Metabolism 2012; 61: 974-977.
    • (2012) Metabolism , vol.61 , pp. 974-977
    • Terasaki, M.1    Nagashima, M.2    Watanabe, T.3
  • 50
    • 84862027177 scopus 로고    scopus 로고
    • Vildagliptin inhibits oxidative stress and vascular damage in streptozotocin-induced diabetic rats
    • Maeda S, Matsui T, Yamagishi S. Vildagliptin inhibits oxidative stress and vascular damage in streptozotocin-induced diabetic rats. Int J Cardiol 2012; 158: 171-173.
    • (2012) Int J Cardiol , vol.158 , pp. 171-173
    • Maeda, S.1    Matsui, T.2    Yamagishi, S.3
  • 51
    • 77958195997 scopus 로고    scopus 로고
    • The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha
    • Fadini GP, Boscaro E, Albiero M, et al. The oral dipeptidyl peptidase-4 inhibitor sitagliptin increases circulating endothelial progenitor cells in patients with type 2 diabetes: possible role of stromal-derived factor-1alpha. Diabetes Care 2010; 33: 1607-1609.
    • (2010) Diabetes Care , vol.33 , pp. 1607-1609
    • Fadini, G.P.1    Boscaro, E.2    Albiero, M.3
  • 52
    • 84866179187 scopus 로고    scopus 로고
    • Sitagliptin exerts an antinflammatory action
    • Makdissi A, Ghanim H, Vora M, et al. Sitagliptin exerts an antinflammatory action. J Clin Endocrinol Metab 2012; 97: 3333-3341.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 3333-3341
    • Makdissi, A.1    Ghanim, H.2    Vora, M.3
  • 53
    • 84874111992 scopus 로고    scopus 로고
    • A dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients
    • Satoh-Asahara N, Sasaki Y, Wada H, et al. A dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients. Metabolism 2012; 62: 347-351.
    • (2012) Metabolism , vol.62 , pp. 347-351
    • Satoh-Asahara, N.1    Sasaki, Y.2    Wada, H.3
  • 54
    • 58949084130 scopus 로고    scopus 로고
    • Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury
    • Timmers L, Henriques JP, de Kleijn DP, et al. Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury. J Am Coll Cardiol 2009; 53: 501-510.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 501-510
    • Timmers, L.1    Henriques, J.P.2    de Kleijn, D.P.3
  • 55
    • 64649102619 scopus 로고    scopus 로고
    • GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
    • Noyan-Ashraf MH, Momen MA, Ban K, et al. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 2009; 58: 975-983.
    • (2009) Diabetes , vol.58 , pp. 975-983
    • Noyan-Ashraf, M.H.1    Momen, M.A.2    Ban, K.3
  • 56
    • 78649939959 scopus 로고    scopus 로고
    • Single dose GLP-1-Tf ameliorates myocardial ischemia/reperfusion injury
    • Matsubara M, Kanemoto S, Leshnower BG, et al. Single dose GLP-1-Tf ameliorates myocardial ischemia/reperfusion injury. J Surg Res 2011; 165: 38-45.
    • (2011) J Surg Res , vol.165 , pp. 38-45
    • Matsubara, M.1    Kanemoto, S.2    Leshnower, B.G.3
  • 57
    • 79955692561 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1), immediately prior to reperfusion, decreases neutrophil activation and reduces myocardial infarct size in rodents
    • Dokken BB, La Bonte LR, Davis-Gorman G, et al. Glucagon-like peptide-1 (GLP-1), immediately prior to reperfusion, decreases neutrophil activation and reduces myocardial infarct size in rodents. Horm Metab Res 2011; 43: 300-305.
    • (2011) Horm Metab Res , vol.43 , pp. 300-305
    • Dokken, B.B.1    La Bonte, L.R.2    Davis-Gorman, G.3
  • 58
    • 84858765882 scopus 로고    scopus 로고
    • Intracoronary glucagon-like peptide 1 preferentially augments glucose uptake in ischemic myocardium independent of changes in coronary flow
    • Moberly SP, Berwick ZC, Kohr M, et al. Intracoronary glucagon-like peptide 1 preferentially augments glucose uptake in ischemic myocardium independent of changes in coronary flow. Exp Biol Med (Maywood) 2012; 237: 334-342.
    • (2012) Exp Biol Med (Maywood) , vol.237 , pp. 334-342
    • Moberly, S.P.1    Berwick, Z.C.2    Kohr, M.3
  • 59
    • 80052072913 scopus 로고    scopus 로고
    • Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiency
    • Bao W, Aravindhan K, Alsaid H, et al. Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiency. PLoS ONE 2011; 6: e23570.
    • (2011) PLoS ONE , vol.6
    • Bao, W.1    Aravindhan, K.2    Alsaid, H.3
  • 60
    • 77950267745 scopus 로고    scopus 로고
    • Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor
    • Ban K, Kim KH, Cho CK, et al. Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor. Endocrinology 2010; 151: 1520-1531.
    • (2010) Endocrinology , vol.151 , pp. 1520-1531
    • Ban, K.1    Kim, K.H.2    Cho, C.K.3
  • 61
    • 0035980166 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes
    • Vila Petroff MG, Egan JM, Wang X, et al. Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes. Circ Res 2001; 89: 445-452.
    • (2001) Circ Res , vol.89 , pp. 445-452
    • Vila Petroff, M.G.1    Egan, J.M.2    Wang, X.3
  • 62
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • Ban K, Noyan-Ashraf MH, Hoefer J, et al. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 2008; 117: 2340-2350.
    • (2008) Circulation , vol.117 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3
  • 63
    • 1442311383 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    • Nikolaidis LA, Mankad S, Sokos GG, et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004; 109: 962-965.
    • (2004) Circulation , vol.109 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3
  • 64
    • 84857111888 scopus 로고    scopus 로고
    • Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease
    • Read PA, Khan FZ, Dutka DP. Cardioprotection against ischaemia induced by dobutamine stress using glucagon-like peptide-1 in patients with coronary artery disease. Heart 2011; 98: 408-413.
    • (2011) Heart , vol.98 , pp. 408-413
    • Read, P.A.1    Khan, F.Z.2    Dutka, D.P.3
  • 65
    • 84860807487 scopus 로고    scopus 로고
    • Exenatide reduces final infarct size in patients with ST-segment-elevation myocardial infarction and short-duration of ischemia
    • Lonborg J, Kelbaek H, Vejlstrup N, et al. Exenatide reduces final infarct size in patients with ST-segment-elevation myocardial infarction and short-duration of ischemia. Circ Cardiovasc Interv 2012; 5: 288-295.
    • (2012) Circ Cardiovasc Interv , vol.5 , pp. 288-295
    • Lonborg, J.1    Kelbaek, H.2    Vejlstrup, N.3
  • 66
    • 84863560602 scopus 로고    scopus 로고
    • Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction
    • Lonborg J, Vejlstrup N, Kelbaek H, et al. Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction. Eur Heart J 2012; 33: 1491-1499.
    • (2012) Eur Heart J , vol.33 , pp. 1491-1499
    • Lonborg, J.1    Vejlstrup, N.2    Kelbaek, H.3
  • 67
    • 79959966874 scopus 로고    scopus 로고
    • Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, pre-diabetic rats
    • Huisamen B, Genis A, Marais E, et al. Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, pre-diabetic rats. Cardiovasc Drugs Ther 2011; 25: 13-20.
    • (2011) Cardiovasc Drugs Ther , vol.25 , pp. 13-20
    • Huisamen, B.1    Genis, A.2    Marais, E.3
  • 68
    • 77951168113 scopus 로고    scopus 로고
    • Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice
    • Sauve M, Ban K, Momen MA, et al. Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice. Diabetes 2010; 59: 1063-1073.
    • (2010) Diabetes , vol.59 , pp. 1063-1073
    • Sauve, M.1    Ban, K.2    Momen, M.A.3
  • 69
    • 84878587722 scopus 로고    scopus 로고
    • The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats
    • doi:10.1016/j.ijcard.2011.12.007.
    • Hocher B, Sharkovska Y, Mark M, et al. The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats. Int J Cardiol 2012; doi:10.1016/j.ijcard.2011.12.007.
    • (2012) Int J Cardiol
    • Hocher, B.1    Sharkovska, Y.2    Mark, M.3
  • 70
    • 77951812608 scopus 로고    scopus 로고
    • The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA
    • Ye Y, Keyes KT, Zhang C, et al. The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA. Am J Physiol Heart Circ Physiol 2010; 298: H1454-H1465.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Ye, Y.1    Keyes, K.T.2    Zhang, C.3
  • 71
    • 80053358548 scopus 로고    scopus 로고
    • Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure
    • Yin M, Sillje HH, Meissner M, et al. Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure. Cardiovasc Diabetol 2011; 10: 85.
    • (2011) Cardiovasc Diabetol , vol.10 , pp. 85
    • Yin, M.1    Sillje, H.H.2    Meissner, M.3
  • 72
    • 80055110463 scopus 로고    scopus 로고
    • Effects of DPP-4 inhibition on cardiac metabolism and function in mice
    • Lenski M, Kazakov A, Marx N, et al. Effects of DPP-4 inhibition on cardiac metabolism and function in mice. J Mol Cell Cardiol 2011; 51: 906-918.
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 906-918
    • Lenski, M.1    Kazakov, A.2    Marx, N.3
  • 73
    • 79957455928 scopus 로고    scopus 로고
    • Parathyroid hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4(+) stem cells into the ischaemic heart
    • Huber BC, Brunner S, Segeth A, et al. Parathyroid hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4(+) stem cells into the ischaemic heart. Cardiovasc Res 2011; 90: 529-537.
    • (2011) Cardiovasc Res , vol.90 , pp. 529-537
    • Huber, B.C.1    Brunner, S.2    Segeth, A.3
  • 74
    • 84883781630 scopus 로고    scopus 로고
    • DPP-4 inhibition attenuates cardiac dysfunction and adverse remodelling following myocardial infarction in rats with experimental diabetes
    • doi: 10.1111/1755-5922.12005.
    • Connelly K, Zhang Y, Advani A, et al. DPP-4 inhibition attenuates cardiac dysfunction and adverse remodelling following myocardial infarction in rats with experimental diabetes. Cardiovasc Ther 2012; doi: 10.1111/1755-5922.12005.
    • (2012) Cardiovasc Ther
    • Connelly, K.1    Zhang, Y.2    Advani, A.3
  • 75
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • Nikolaidis LA, Elahi D, Hentosz T, et al. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 2004; 110: 955-961.
    • (2004) Circulation , vol.110 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3
  • 76
    • 58949102483 scopus 로고    scopus 로고
    • Chronic glucagon-like peptide-1 infusion sustains left ventricular systolic function and prolongs survival in the spontaneously hypertensive, heart failure-prone rat
    • Poornima I, Brown SB, Bhashyam S, et al. Chronic glucagon-like peptide-1 infusion sustains left ventricular systolic function and prolongs survival in the spontaneously hypertensive, heart failure-prone rat. Circ Heart Fail 2008; 1: 153-160.
    • (2008) Circ Heart Fail , vol.1 , pp. 153-160
    • Poornima, I.1    Brown, S.B.2    Bhashyam, S.3
  • 77
    • 78149493266 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure
    • Liu Q, Anderson C, Broyde A, et al. Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure. Cardiovasc Diabetol 2010; 9: 76.
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 76
    • Liu, Q.1    Anderson, C.2    Broyde, A.3
  • 78
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure
    • Sokos GG, Nikolaidis LA, Mankad S, et al. Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J Card Fail 2006; 12: 694-699.
    • (2006) J Card Fail , vol.12 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3
  • 79
    • 84862521094 scopus 로고    scopus 로고
    • Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety
    • Nathanson D, Ullman B, Lofstrom U, et al. Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety. Diabetologia 2012; 55: 926-935.
    • (2012) Diabetologia , vol.55 , pp. 926-935
    • Nathanson, D.1    Ullman, B.2    Lofstrom, U.3
  • 80
    • 84555209178 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition improves cardiorenal function in overpacing-induced heart failure
    • Gomez N, Touihri K, Matheeussen V, et al. Dipeptidyl peptidase IV inhibition improves cardiorenal function in overpacing-induced heart failure. Eur J Heart Fail 2012; 14: 14-21.
    • (2012) Eur J Heart Fail , vol.14 , pp. 14-21
    • Gomez, N.1    Touihri, K.2    Matheeussen, V.3
  • 81
    • 79960996273 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia
    • Teramoto S, Miyamoto N, Yatomi K, et al. Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia. J Cereb Blood Flow Metab 2011; 31: 1696-1705.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 1696-1705
    • Teramoto, S.1    Miyamoto, N.2    Yatomi, K.3
  • 82
    • 79955608846 scopus 로고    scopus 로고
    • Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia
    • Lee CH, Yan B, Yoo KY, et al. Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia. J Neurosci Res 2011; 89: 1103-1113.
    • (2011) J Neurosci Res , vol.89 , pp. 1103-1113
    • Lee, C.H.1    Yan, B.2    Yoo, K.Y.3
  • 83
    • 84858722980 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats
    • Darsalia V, Mansouri S, Ortsater H, et al. Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats. Clin Sci (Lond) 2012; 122: 473-483.
    • (2012) Clin Sci (Lond) , vol.122 , pp. 473-483
    • Darsalia, V.1    Mansouri, S.2    Ortsater, H.3
  • 84
    • 79955137934 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis
    • Faivre E, Gault VA, Thorens B, et al. Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis. J Neurophysiol 2011; 105: 1574-1580.
    • (2011) J Neurophysiol , vol.105 , pp. 1574-1580
    • Faivre, E.1    Gault, V.A.2    Thorens, B.3
  • 85
    • 42249106405 scopus 로고    scopus 로고
    • Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid
    • Gault VA, Holscher C. Protease-resistant glucose-dependent insulinotropic polypeptide agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid. J Neurophysiol 2008; 99: 1590-1595.
    • (2008) J Neurophysiol , vol.99 , pp. 1590-1595
    • Gault, V.A.1    Holscher, C.2
  • 86
    • 84855544372 scopus 로고    scopus 로고
    • Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice
    • Faivre E, Hamilton A, Holscher C. Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice. Eur J Pharmacol 2012; 674: 294-306.
    • (2012) Eur J Pharmacol , vol.674 , pp. 294-306
    • Faivre, E.1    Hamilton, A.2    Holscher, C.3
  • 87
    • 84875438002 scopus 로고    scopus 로고
    • The DPP-4 inhibitor linagliptin counteracts stroke in the normal and diabetic mouse brain: a comparison with glimepiride
    • doi: 10.2337/db12-0988.
    • Darsalia V, Ortsater H, Olverling A, et al. The DPP-4 inhibitor linagliptin counteracts stroke in the normal and diabetic mouse brain: a comparison with glimepiride. Diabetes 2012; doi: 10.2337/db12-0988.
    • (2012) Diabetes
    • Darsalia, V.1    Ortsater, H.2    Olverling, A.3
  • 88
    • 0038202937 scopus 로고    scopus 로고
    • Antihypertensive effect of glucagon-like peptide 1 in Dahl salt-sensitive rats
    • Yu M, Moreno C, Hoagland KM, et al. Antihypertensive effect of glucagon-like peptide 1 in Dahl salt-sensitive rats. J Hypertens 2003; 21: 1125-1135.
    • (2003) J Hypertens , vol.21 , pp. 1125-1135
    • Yu, M.1    Moreno, C.2    Hoagland, K.M.3
  • 89
    • 59649122584 scopus 로고    scopus 로고
    • Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model
    • Hirata K, Kume S, Araki S, et al. Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model. Biochem Biophys Res Commun 2009; 380: 44-49.
    • (2009) Biochem Biophys Res Commun , vol.380 , pp. 44-49
    • Hirata, K.1    Kume, S.2    Araki, S.3
  • 90
    • 77955106477 scopus 로고    scopus 로고
    • The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats
    • Liu Q, Adams L, Broyde A, et al. The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats. Cardiovasc Diabetol 2010; 9: 32.
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 32
    • Liu, Q.1    Adams, L.2    Broyde, A.3
  • 91
    • 79951677095 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition attenuates blood pressure rising in young spontaneously hypertensive rats
    • Pacheco BP, Crajoinas RO, Couto GK, et al. Dipeptidyl peptidase IV inhibition attenuates blood pressure rising in young spontaneously hypertensive rats. J Hypertens 2011; 29: 520-528.
    • (2011) J Hypertens , vol.29 , pp. 520-528
    • Pacheco, B.P.1    Crajoinas, R.O.2    Couto, G.K.3
  • 92
    • 84865492970 scopus 로고    scopus 로고
    • Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism
    • Liu L, Liu J, Wong WT, et al. Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension 2012; 60: 833-841.
    • (2012) Hypertension , vol.60 , pp. 833-841
    • Liu, L.1    Liu, J.2    Wong, W.T.3
  • 93
    • 77956920722 scopus 로고    scopus 로고
    • Liraglutide: effects beyond glycaemic control in diabetes treatment
    • McGill JB. Liraglutide: effects beyond glycaemic control in diabetes treatment. Int J Clin Pract Suppl 2010; 167: 28-34.
    • (2010) Int J Clin Pract Suppl , vol.167 , pp. 28-34
    • McGill, J.B.1
  • 94
    • 84871825708 scopus 로고    scopus 로고
    • Exenatide improves endothelial function assessed by flow mediated dilation technique in subjects with type 2 diabetes: results from an observational research
    • Irace C, De Luca S, Shehaj E, et al. Exenatide improves endothelial function assessed by flow mediated dilation technique in subjects with type 2 diabetes: results from an observational research. Diab Vasc Dis Res 2013; 10: 72-77.
    • (2013) Diab Vasc Dis Res , vol.10 , pp. 72-77
    • Irace, C.1    De Luca, S.2    Shehaj, E.3
  • 95
    • 0029859220 scopus 로고    scopus 로고
    • Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats
    • Tang-Christensen M, Larsen PJ, Goke R, et al. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am J Physiol 1996; 271: R848-R856.
    • (1996) Am J Physiol , vol.271
    • Tang-Christensen, M.1    Larsen, P.J.2    Goke, R.3
  • 96
    • 35848942800 scopus 로고    scopus 로고
    • Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
    • Schafer SA, Tschritter O, Machicao F, et al. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 2007; 50: 2443-2450.
    • (2007) Diabetologia , vol.50 , pp. 2443-2450
    • Schafer, S.A.1    Tschritter, O.2    Machicao, F.3
  • 97
    • 2942668372 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men
    • Gutzwiller JP, Tschopp S, Bock A, et al. Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men. J Clin Endocrinol Metab 2004; 89: 3055-3061.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3055-3061
    • Gutzwiller, J.P.1    Tschopp, S.2    Bock, A.3
  • 98
    • 84878065126 scopus 로고    scopus 로고
    • Pleiotropic effects of sitagliptin in the treatment of type 2 diabetes mellitus patients
    • Kubota A, Maeda H, Kanamori A, et al. Pleiotropic effects of sitagliptin in the treatment of type 2 diabetes mellitus patients. J Clin Med Res 2012; 4: 309-313.
    • (2012) J Clin Med Res , vol.4 , pp. 309-313
    • Kubota, A.1    Maeda, H.2    Kanamori, A.3
  • 99
    • 79955952000 scopus 로고    scopus 로고
    • Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes
    • Ogawa S, Ishiki M, Nako K, et al. Sitagliptin, a dipeptidyl peptidase-4 inhibitor, decreases systolic blood pressure in Japanese hypertensive patients with type 2 diabetes. Tohoku J Exp Med 2011; 223: 133-135.
    • (2011) Tohoku J Exp Med , vol.223 , pp. 133-135
    • Ogawa, S.1    Ishiki, M.2    Nako, K.3
  • 100
    • 17644373076 scopus 로고    scopus 로고
    • GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats
    • Qin X, Shen H, Liu M, et al. GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. Am J Physiol Gastrointest Liver Physiol 2005; 288: G943-G949.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Qin, X.1    Shen, H.2    Liu, M.3
  • 101
    • 77949273334 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice
    • Hsieh J, Longuet C, Baker CL, et al. The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice. Diabetologia 2010; 53: 552-561.
    • (2010) Diabetologia , vol.53 , pp. 552-561
    • Hsieh, J.1    Longuet, C.2    Baker, C.L.3
  • 102
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • Ding X, Saxena NK, Lin S, et al. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 2006; 43: 173-181.
    • (2006) Hepatology , vol.43 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3
  • 103
    • 84855317103 scopus 로고    scopus 로고
    • Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet
    • Mells JE, Fu PP, Sharma S, et al. Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet. Am J Physiol Gastrointest Liver Physiol 2012; 302: G225-G235.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302
    • Mells, J.E.1    Fu, P.P.2    Sharma, S.3
  • 104
    • 33244481977 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans
    • Meier JJ, Gethmann A, Gotze O, et al. Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans. Diabetologia 2006; 49: 452-458.
    • (2006) Diabetologia , vol.49 , pp. 452-458
    • Meier, J.J.1    Gethmann, A.2    Gotze, O.3
  • 105
    • 77956230708 scopus 로고    scopus 로고
    • Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus
    • Schwartz EA, Koska J, Mullin MP, et al. Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus. Atherosclerosis 2010; 212: 217-222.
    • (2010) Atherosclerosis , vol.212 , pp. 217-222
    • Schwartz, E.A.1    Koska, J.2    Mullin, M.P.3
  • 106
    • 33746690405 scopus 로고    scopus 로고
    • Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes
    • Matikainen N, Manttari S, Schweizer A, et al. Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes. Diabetologia 2006; 49: 2049-2057.
    • (2006) Diabetologia , vol.49 , pp. 2049-2057
    • Matikainen, N.1    Manttari, S.2    Schweizer, A.3
  • 107
    • 79951933599 scopus 로고    scopus 로고
    • Effect of sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes
    • Tremblay AJ, Lamarche B, Deacon CF, et al. Effect of sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes. Diabetes Obes Metab 2011; 13: 366-373.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 366-373
    • Tremblay, A.J.1    Lamarche, B.2    Deacon, C.F.3
  • 108
    • 84863988113 scopus 로고    scopus 로고
    • The effects of sitagliptin on gastric emptying in healthy humans - a randomised, controlled study
    • Stevens JE, Horowitz M, Deacon CF, et al. The effects of sitagliptin on gastric emptying in healthy humans - a randomised, controlled study. Aliment Pharmacol Ther 2012; 36: 379-390.
    • (2012) Aliment Pharmacol Ther , vol.36 , pp. 379-390
    • Stevens, J.E.1    Horowitz, M.2    Deacon, C.F.3
  • 109
    • 84857903646 scopus 로고    scopus 로고
    • DPP-4 inhibitors and lipids: systematic review and meta-analysis
    • Monami M, Lamanna C, Desideri CM, et al. DPP-4 inhibitors and lipids: systematic review and meta-analysis. Adv Ther 2012; 29: 14-25.
    • (2012) Adv Ther , vol.29 , pp. 14-25
    • Monami, M.1    Lamanna, C.2    Desideri, C.M.3
  • 110
    • 84971016692 scopus 로고    scopus 로고
    • The Nervous System and Diabetes
    • In: Kahn CR, Weir GC, King GL, eds). . 14th edn. Lippincott Williams and Wilkins, Boston
    • Freeman R. The Nervous System and Diabetes. In: Kahn CR, Weir GC, King GL, et al. (eds). Joslin's Diabetes Mellitus. 14th edn. Lippincott Williams and Wilkins, Boston, 2005: 951-974.
    • (2005) Joslin's Diabetes Mellitus , pp. 951-974
    • Freeman, R.1
  • 111
    • 80052882537 scopus 로고    scopus 로고
    • Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice
    • Himeno T, Kamiya H, Naruse K, et al. Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice. Diabetes 2011; 60: 2397-2406.
    • (2011) Diabetes , vol.60 , pp. 2397-2406
    • Himeno, T.1    Kamiya, H.2    Naruse, K.3
  • 112
    • 80054051051 scopus 로고    scopus 로고
    • Neuroprotective effect of the glucagon-like peptide-1 receptor agonist, synthetic exendin-4, in streptozotocin-induced diabetic rats
    • Liu WJ, Jin HY, Lee KA, et al. Neuroprotective effect of the glucagon-like peptide-1 receptor agonist, synthetic exendin-4, in streptozotocin-induced diabetic rats. Br J Pharmacol 2011; 164: 1410-1420.
    • (2011) Br J Pharmacol , vol.164 , pp. 1410-1420
    • Liu, W.J.1    Jin, H.Y.2    Lee, K.A.3
  • 113
    • 80053409431 scopus 로고    scopus 로고
    • GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice
    • Jolivalt CG, Fineman M, Deacon CF, et al. GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice. Diabetes Obes Metab 2011; 13: 990-1000.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 990-1000
    • Jolivalt, C.G.1    Fineman, M.2    Deacon, C.F.3
  • 114
    • 33846501672 scopus 로고    scopus 로고
    • Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy
    • Perry T, Holloway HW, Weerasuriya A, et al. Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. Exp Neurol 2007; 203: 293-301.
    • (2007) Exp Neurol , vol.203 , pp. 293-301
    • Perry, T.1    Holloway, H.W.2    Weerasuriya, A.3
  • 115
    • 66049137664 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): cellular localization, lesion-affected expression, and impaired regenerative axonal growth
    • Buhren BA, Gasis M, Thorens B, et al. Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): cellular localization, lesion-affected expression, and impaired regenerative axonal growth. J Neurosci Res 2009; 87: 1858-1870.
    • (2009) J Neurosci Res , vol.87 , pp. 1858-1870
    • Buhren, B.A.1    Gasis, M.2    Thorens, B.3
  • 116
    • 83955163338 scopus 로고    scopus 로고
    • Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy
    • Bianchi R, Cervellini I, Porretta-Serapiglia C, et al. Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy. J Pharmacol Exp Ther 2012; 340: 64-72.
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 64-72
    • Bianchi, R.1    Cervellini, I.2    Porretta-Serapiglia, C.3
  • 117
    • 71649102751 scopus 로고    scopus 로고
    • Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats
    • Jin HY, Liu WJ, Park JH, et al. Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats. Arch Med Res 2009; 40: 536-544.
    • (2009) Arch Med Res , vol.40 , pp. 536-544
    • Jin, H.Y.1    Liu, W.J.2    Park, J.H.3
  • 118
    • 84861987865 scopus 로고    scopus 로고
    • Therapeutic management of diabetic kidney disease
    • Koya D, Araki S, Haneda M. Therapeutic management of diabetic kidney disease. J Diabetes Invest 2011; 2: 248-254.
    • (2011) J Diabetes Invest , vol.2 , pp. 248-254
    • Koya, D.1    Araki, S.2    Haneda, M.3
  • 119
    • 84875962833 scopus 로고    scopus 로고
    • Current update in the management of diabetic nephropathy
    • Van Buren PN, Toto R. Current update in the management of diabetic nephropathy. Curr Diabetes Rev 2013; 9: 62-77.
    • (2013) Curr Diabetes Rev , vol.9 , pp. 62-77
    • Van Buren, P.N.1    Toto, R.2
  • 120
    • 79953826349 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes
    • Kodera R, Shikata K, Kataoka HU, et al. Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes. Diabetologia 2011; 54: 965-978.
    • (2011) Diabetologia , vol.54 , pp. 965-978
    • Kodera, R.1    Shikata, K.2    Kataoka, H.U.3
  • 121
    • 34047205064 scopus 로고    scopus 로고
    • Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice
    • Park CW, Kim HW, Ko SH, et al. Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice. J Am Soc Nephrol 2007; 18: 1227-1238.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1227-1238
    • Park, C.W.1    Kim, H.W.2    Ko, S.H.3
  • 122
    • 84866732695 scopus 로고    scopus 로고
    • GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases
    • Hendarto H, Inoguchi T, Maeda Y, et al. GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases. Metabolism 2012; 61: 1422-1434.
    • (2012) Metabolism , vol.61 , pp. 1422-1434
    • Hendarto, H.1    Inoguchi, T.2    Maeda, Y.3
  • 123
    • 80051800781 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 suppresses advanced glycation end product-induced monocyte chemoattractant protein-1 expression in mesangial cells by reducing advanced glycation end product receptor level
    • Ishibashi Y, Nishino Y, Matsui T, et al. Glucagon-like peptide-1 suppresses advanced glycation end product-induced monocyte chemoattractant protein-1 expression in mesangial cells by reducing advanced glycation end product receptor level. Metabolism 2011; 60: 1271-1277.
    • (2011) Metabolism , vol.60 , pp. 1271-1277
    • Ishibashi, Y.1    Nishino, Y.2    Matsui, T.3
  • 124
    • 84871309097 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits angiotensin II-induced mesangial cell damage via protein kinase A
    • Ishibashi Y, Matsui T, Ojima A, et al. Glucagon-like peptide-1 inhibits angiotensin II-induced mesangial cell damage via protein kinase A. Microvasc Res 2013; 182: 132-141.
    • (2013) Microvasc Res , vol.182 , pp. 132-141
    • Ishibashi, Y.1    Matsui, T.2    Ojima, A.3
  • 125
    • 84868034862 scopus 로고    scopus 로고
    • Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCbeta activation in diabetes
    • Mima A, Hiraoka-Yamomoto J, Li Q, et al. Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCbeta activation in diabetes. Diabetes 2012; 61: 2967-2979.
    • (2012) Diabetes , vol.61 , pp. 2967-2979
    • Mima, A.1    Hiraoka-Yamomoto, J.2    Li, Q.3
  • 126
    • 84862944057 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic rats
    • Liu WJ, Xie SH, Liu YN, et al. Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic rats. J Pharmacol Exp Ther 2012; 340: 248-255.
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 248-255
    • Liu, W.J.1    Xie, S.H.2    Liu, Y.N.3
  • 127
    • 84865703667 scopus 로고    scopus 로고
    • DPP4 inhibition improves functional outcome after renal ischemia-reperfusion injury
    • Glorie LL, Verhulst A, Matheeussen V, et al. DPP4 inhibition improves functional outcome after renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 2012; 303: F681-F688.
    • (2012) Am J Physiol Renal Physiol , vol.303
    • Glorie, L.L.1    Verhulst, A.2    Matheeussen, V.3
  • 128
    • 84855611505 scopus 로고    scopus 로고
    • Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat)
    • Mega C, de Lemos ET, Vala H, et al. Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat). Exp Diabetes Res 2011; 2011: 162092.
    • (2011) Exp Diabetes Res , vol.2011 , pp. 162092
    • Mega, C.1    de Lemos, E.T.2    Vala, H.3
  • 129
    • 84861972909 scopus 로고    scopus 로고
    • Exenatide reduces urinary transforming growth factor-beta(1) and type IV collagen excretion in patients with type 2 diabetes and microalbuminuria
    • Zhang H, Zhang X, Hu C, et al. Exenatide reduces urinary transforming growth factor-beta(1) and type IV collagen excretion in patients with type 2 diabetes and microalbuminuria. Kidney Blood Press Res 2012; 35: 483-488.
    • (2012) Kidney Blood Press Res , vol.35 , pp. 483-488
    • Zhang, H.1    Zhang, X.2    Hu, C.3
  • 130
    • 79251604529 scopus 로고    scopus 로고
    • Sitagliptin reduces albuminuria in patients with type 2 diabetes
    • Hattori S. Sitagliptin reduces albuminuria in patients with type 2 diabetes. Endocr J 2011; 58: 69-73.
    • (2011) Endocr J , vol.58 , pp. 69-73
    • Hattori, S.1
  • 132
    • 64449087059 scopus 로고    scopus 로고
    • Protection of exendin-4 analogue in early experimental diabetic retinopathy
    • Zhang Y, Wang Q, Zhang J, et al. Protection of exendin-4 analogue in early experimental diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2009; 247: 699-706.
    • (2009) Graefes Arch Clin Exp Ophthalmol , vol.247 , pp. 699-706
    • Zhang, Y.1    Wang, Q.2    Zhang, J.3
  • 133
    • 79952230999 scopus 로고    scopus 로고
    • Intravitreal injection of exendin-4 analogue protects retinal cells in early diabetic rats
    • Zhang Y, Zhang J, Wang Q, et al. Intravitreal injection of exendin-4 analogue protects retinal cells in early diabetic rats. Invest Ophthalmol Vis Sci 2011; 52: 278-285.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 278-285
    • Zhang, Y.1    Zhang, J.2    Wang, Q.3
  • 134
    • 84865250066 scopus 로고    scopus 로고
    • Protection of exenatide for retinal ganglion cells with different glucose concentrations
    • Fu Z, Kuang H-Y, Hao M, et al. Protection of exenatide for retinal ganglion cells with different glucose concentrations. Peptides 2012; 37: 25-31.
    • (2012) Peptides , vol.37 , pp. 25-31
    • Fu, Z.1    Kuang, H.-Y.2    Hao, M.3
  • 135
    • 84859444000 scopus 로고    scopus 로고
    • Protective effects of the dipeptidyl peptidase IV inhibitor sitagliptin in the blood-retinal barrier in a type 2 diabetes animal model
    • Goncalves A, Leal E, Paiva A, et al. Protective effects of the dipeptidyl peptidase IV inhibitor sitagliptin in the blood-retinal barrier in a type 2 diabetes animal model. Diabetes Obes Metab 2012; 14: 454-463.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 454-463
    • Goncalves, A.1    Leal, E.2    Paiva, A.3
  • 136
    • 0037972484 scopus 로고    scopus 로고
    • Upregulation of glucose-dependent insulinotropic polypeptide and its receptor in the retina of streptozotocin-induced diabetic rats
    • Cho GJ, Ryu S, Kim YH, et al. Upregulation of glucose-dependent insulinotropic polypeptide and its receptor in the retina of streptozotocin-induced diabetic rats. Curr Eye Res 2002; 25: 381-388.
    • (2002) Curr Eye Res , vol.25 , pp. 381-388
    • Cho, G.J.1    Ryu, S.2    Kim, Y.H.3
  • 137
    • 33847137721 scopus 로고    scopus 로고
    • Glucagon-related peptides in the mouse retina and the effects of deprivation of form vision
    • Mathis U, Schaeffel F. Glucagon-related peptides in the mouse retina and the effects of deprivation of form vision. Graefes Arch Clin Exp Ophthalmol 2007; 245: 267-275.
    • (2007) Graefes Arch Clin Exp Ophthalmol , vol.245 , pp. 267-275
    • Mathis, U.1    Schaeffel, F.2
  • 138
    • 0024368505 scopus 로고
    • The association of lifetime weight and weight control patterns with diabetes among men and women in an adult community
    • Holbrook TL, Barrett-Connor E, Wingard DL. The association of lifetime weight and weight control patterns with diabetes among men and women in an adult community. Int J Obes 1989; 13: 723-729.
    • (1989) Int J Obes , vol.13 , pp. 723-729
    • Holbrook, T.L.1    Barrett-Connor, E.2    Wingard, D.L.3
  • 139
    • 0019372096 scopus 로고
    • Diabetes incidence in Pima indians: contributions of obesity and parental diabetes
    • Knowler WC, Pettitt DJ, Savage PJ, et al. Diabetes incidence in Pima indians: contributions of obesity and parental diabetes. Am J Epidemiol 1981; 113: 144-156.
    • (1981) Am J Epidemiol , vol.113 , pp. 144-156
    • Knowler, W.C.1    Pettitt, D.J.2    Savage, P.J.3
  • 140
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403.
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3
  • 141
    • 0030935652 scopus 로고    scopus 로고
    • Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study
    • Pan XR, Li GW, Hu YH, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 1997; 20: 537-544.
    • (1997) Diabetes Care , vol.20 , pp. 537-544
    • Pan, X.R.1    Li, G.W.2    Hu, Y.H.3
  • 142
    • 0023634861 scopus 로고
    • Long-term effects of modest weight loss in type II diabetic patients
    • Wing RR, Koeske R, Epstein LH, et al. Long-term effects of modest weight loss in type II diabetic patients. Arch Intern Med 1987; 147: 1749-1753.
    • (1987) Arch Intern Med , vol.147 , pp. 1749-1753
    • Wing, R.R.1    Koeske, R.2    Epstein, L.H.3
  • 143
    • 84864244872 scopus 로고    scopus 로고
    • Metabolic syndrome, insulin resistance, and roles of inflammation-mechanisms and therapeutic targets
    • Romeo GR, Lee J, Shoelson SE. Metabolic syndrome, insulin resistance, and roles of inflammation-mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol 2012; 32: 1771-1776.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 1771-1776
    • Romeo, G.R.1    Lee, J.2    Shoelson, S.E.3
  • 144
    • 84861762003 scopus 로고    scopus 로고
    • Inflammation and metabolic dysfunction: links to cardiovascular diseases
    • Taube A, Schlich R, Sell H, et al. Inflammation and metabolic dysfunction: links to cardiovascular diseases. Am J Physiol Heart Circ Physiol 2012; 302: H2148-H2165.
    • (2012) Am J Physiol Heart Circ Physiol , vol.302
    • Taube, A.1    Schlich, R.2    Sell, H.3
  • 145
    • 33845539181 scopus 로고    scopus 로고
    • Pancreatic and extrapancreatic effects of gastric inhibitory polypeptide
    • Yamada Y, Miyawaki K, Tsukiyama K, et al. Pancreatic and extrapancreatic effects of gastric inhibitory polypeptide. Diabetes 2006; 55: S88-S91.
    • (2006) Diabetes , vol.55
    • Yamada, Y.1    Miyawaki, K.2    Tsukiyama, K.3
  • 146
    • 84859003663 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials
    • Vilsboll T, Christensen M, Junker AE, et al. Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ 2012; 344: d7771.
    • (2012) BMJ , vol.344
    • Vilsboll, T.1    Christensen, M.2    Junker, A.E.3
  • 147
    • 0020552646 scopus 로고
    • Gastric inhibitory polypeptide enhancement of the insulin effect on fatty acid incorporation into adipose tissue in the rat
    • Beck B, Max JP. Gastric inhibitory polypeptide enhancement of the insulin effect on fatty acid incorporation into adipose tissue in the rat. Regul Pept 1983; 7: 3-8.
    • (1983) Regul Pept , vol.7 , pp. 3-8
    • Beck, B.1    Max, J.P.2
  • 148
    • 0031730586 scopus 로고    scopus 로고
    • Functional GIP receptors are present on adipocytes
    • Yip RG, Boylan MO, Kieffer TJ, et al. Functional GIP receptors are present on adipocytes. Endocrinology 1998; 139: 4004-4007.
    • (1998) Endocrinology , vol.139 , pp. 4004-4007
    • Yip, R.G.1    Boylan, M.O.2    Kieffer, T.J.3
  • 149
    • 0036068322 scopus 로고    scopus 로고
    • Inhibition of gastric inhibitory polypeptide signaling prevents obesity
    • Miyawaki K, Yamada Y, Ban N, et al. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med 2002; 8: 738-742.
    • (2002) Nat Med , vol.8 , pp. 738-742
    • Miyawaki, K.1    Yamada, Y.2    Ban, N.3
  • 150
    • 52049090801 scopus 로고    scopus 로고
    • Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice
    • Naitoh R, Miyawaki K, Harada N, et al. Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice. Biochem Biophys Res Commun 2008; 376: 21-25.
    • (2008) Biochem Biophys Res Commun , vol.376 , pp. 21-25
    • Naitoh, R.1    Miyawaki, K.2    Harada, N.3
  • 151
    • 23944463919 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action
    • Zhou H, Yamada Y, Tsukiyama K, et al. Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action. Biochem Biophys Res Commun 2005; 335: 937-942.
    • (2005) Biochem Biophys Res Commun , vol.335 , pp. 937-942
    • Zhou, H.1    Yamada, Y.2    Tsukiyama, K.3
  • 152
    • 34447127048 scopus 로고    scopus 로고
    • Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets
    • Gault VA, McClean PL, Cassidy RS, et al. Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets. Diabetologia 2007; 50: 1752-1762.
    • (2007) Diabetologia , vol.50 , pp. 1752-1762
    • Gault, V.A.1    McClean, P.L.2    Cassidy, R.S.3
  • 153
    • 34249941340 scopus 로고    scopus 로고
    • Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice
    • Irwin N, McClean PL, O'Harte FP, et al. Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice. Diabetologia 2007; 50: 1532-1540.
    • (2007) Diabetologia , vol.50 , pp. 1532-1540
    • Irwin, N.1    McClean, P.L.2    O'Harte, F.P.3
  • 154
    • 37149047560 scopus 로고    scopus 로고
    • GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet
    • McClean PL, Irwin N, Cassidy RS, et al. GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet. Am J Physiol Endocrinol Metab 2007; 293: E1746-E1755.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • McClean, P.L.1    Irwin, N.2    Cassidy, R.S.3
  • 155
    • 49649125933 scopus 로고    scopus 로고
    • Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet
    • Althage MC, Ford EL, Wang S, et al. Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet. J Biol Chem 2008; 283: 18365-18376.
    • (2008) J Biol Chem , vol.283 , pp. 18365-18376
    • Althage, M.C.1    Ford, E.L.2    Wang, S.3
  • 156
    • 84455173076 scopus 로고    scopus 로고
    • Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain
    • Ugleholdt R, Pedersen J, Bassi MR, et al. Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain. J Biol Chem 2011; 286: 44632-44645.
    • (2011) J Biol Chem , vol.286 , pp. 44632-44645
    • Ugleholdt, R.1    Pedersen, J.2    Bassi, M.R.3
  • 157
    • 84863615352 scopus 로고    scopus 로고
    • GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis
    • Kim SJ, Nian C, Karunakaran S, et al. GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis. PLoS ONE 2012; 7: e40156.
    • (2012) PLoS ONE , vol.7
    • Kim, S.J.1    Nian, C.2    Karunakaran, S.3
  • 158
    • 36349012043 scopus 로고    scopus 로고
    • Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes
    • Kim SJ, Nian C, McIntosh CH. Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes. J Biol Chem 2007; 282: 34139-34147.
    • (2007) J Biol Chem , vol.282 , pp. 34139-34147
    • Kim, S.J.1    Nian, C.2    McIntosh, C.H.3
  • 159
    • 34247880256 scopus 로고    scopus 로고
    • Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a protein kinase B, LKB1, and AMP-activated protein kinase cascade
    • Kim SJ, Nian C, McIntosh CH. Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a protein kinase B, LKB1, and AMP-activated protein kinase cascade. J Biol Chem 2007; 282: 8557-8567.
    • (2007) J Biol Chem , vol.282 , pp. 8557-8567
    • Kim, S.J.1    Nian, C.2    McIntosh, C.H.3
  • 160
    • 84856539533 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids
    • Gogebakan O, Andres J, Biedasek K, et al. Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids. Diabetes 2012; 61: 292-300.
    • (2012) Diabetes , vol.61 , pp. 292-300
    • Gogebakan, O.1    Andres, J.2    Biedasek, K.3
  • 161
    • 79953307026 scopus 로고    scopus 로고
    • Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPARgamma and histone acetylation
    • Kim SJ, Nian C, McIntosh CH. Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPARgamma and histone acetylation. J Lipid Res 2011; 52: 759-770.
    • (2011) J Lipid Res , vol.52 , pp. 759-770
    • Kim, S.J.1    Nian, C.2    McIntosh, C.H.3
  • 162
    • 84555195145 scopus 로고    scopus 로고
    • Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice
    • Bates HE, Campbell JE, Ussher JR, et al. Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice. Diabetes 2012; 61: 40-48.
    • (2012) Diabetes , vol.61 , pp. 40-48
    • Bates, H.E.1    Campbell, J.E.2    Ussher, J.R.3
  • 163
    • 84861782461 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic peptide impairs insulin signaling via inducing adipocyte inflammation in glucose-dependent insulinotropic peptide receptor-overexpressing adipocytes
    • Nie Y, Ma RC, Chan JC, et al. Glucose-dependent insulinotropic peptide impairs insulin signaling via inducing adipocyte inflammation in glucose-dependent insulinotropic peptide receptor-overexpressing adipocytes. FASEB J 2012; 26: 2383-2393.
    • (2012) FASEB J , vol.26 , pp. 2383-2393
    • Nie, Y.1    Ma, R.C.2    Chan, J.C.3
  • 164
    • 0030884317 scopus 로고    scopus 로고
    • Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes
    • Montrose-Rafizadeh C, Yang H, Wang Y, et al. Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes. J Cell Physiol 1997; 172: 275-283.
    • (1997) J Cell Physiol , vol.172 , pp. 275-283
    • Montrose-Rafizadeh, C.1    Yang, H.2    Wang, Y.3
  • 165
    • 84857461922 scopus 로고    scopus 로고
    • Regulation of adipocyte formation by GLP-1/GLP-1R signaling
    • Challa TD, Beaton N, Arnold M, et al. Regulation of adipocyte formation by GLP-1/GLP-1R signaling. J Biol Chem 2012; 287: 6421-6430.
    • (2012) J Biol Chem , vol.287 , pp. 6421-6430
    • Challa, T.D.1    Beaton, N.2    Arnold, M.3
  • 166
    • 77951665710 scopus 로고    scopus 로고
    • Pharmacological management of appetite expression in obesity
    • Halford JC, Boyland EJ, Blundell JE, et al. Pharmacological management of appetite expression in obesity. Nat Rev Endocrinol 2010; 6: 255-269.
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 255-269
    • Halford, J.C.1    Boyland, E.J.2    Blundell, J.E.3
  • 167
    • 78649370533 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 gastrointestinal regulatory role in metabolism and motility
    • Hellstrom PM. Glucagon-like peptide-1 gastrointestinal regulatory role in metabolism and motility. Vitam Horm 2010; 84: 319-329.
    • (2010) Vitam Horm , vol.84 , pp. 319-329
    • Hellstrom, P.M.1
  • 168
    • 0028867442 scopus 로고
    • Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites
    • Goke R, Larsen PJ, Mikkelsen JD, et al. Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci 1995; 7: 2294-2300.
    • (1995) Eur J Neurosci , vol.7 , pp. 2294-2300
    • Goke, R.1    Larsen, P.J.2    Mikkelsen, J.D.3
  • 169
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • Turton MD, O'Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996; 379: 69-72.
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1    O'Shea, D.2    Gunn, I.3
  • 170
    • 82755164888 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake
    • McKay NJ, Kanoski SE, Hayes MR, et al. Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake. Am J Physiol Regul Integr Comp Physiol 2011; 301: R1755-R1764.
    • (2011) Am J Physiol Regul Integr Comp Physiol , vol.301
    • McKay, N.J.1    Kanoski, S.E.2    Hayes, M.R.3
  • 171
    • 0036784675 scopus 로고    scopus 로고
    • The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice
    • Rolin B, Larsen MO, Gotfredsen CF, et al. The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice. Am J Physiol Endocrinol Metab 2002; 283: E745-E752.
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Rolin, B.1    Larsen, M.O.2    Gotfredsen, C.F.3
  • 172
    • 33847072735 scopus 로고    scopus 로고
    • Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not
    • Raun K, von Voss P, Gotfredsen CF, et al. Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not. Diabetes 2007; 56: 8-15.
    • (2007) Diabetes , vol.56 , pp. 8-15
    • Raun, K.1    von Voss, P.2    Gotfredsen, C.F.3
  • 173
    • 34547951456 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human glucagon-like peptide-1 analog, minimizes food intake in severely obese minipigs
    • Raun K, von Voss P, Knudsen LB. Liraglutide, a once-daily human glucagon-like peptide-1 analog, minimizes food intake in severely obese minipigs. Obesity (Silver Spring) 2007; 15: 1710-1716.
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 1710-1716
    • Raun, K.1    von Voss, P.2    Knudsen, L.B.3
  • 174
    • 84865512243 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 agonist exendin-4 leads to reduction of weight and caloric intake in a rat model of hypothalamic obesity
    • Elfers CT, Simmons JH, Roth CL. Glucagon-like peptide-1 agonist exendin-4 leads to reduction of weight and caloric intake in a rat model of hypothalamic obesity. Horm Res Paediatr 2012; 78: 47-53.
    • (2012) Horm Res Paediatr , vol.78 , pp. 47-53
    • Elfers, C.T.1    Simmons, J.H.2    Roth, C.L.3
  • 175
    • 78649388633 scopus 로고    scopus 로고
    • Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis
    • Edholm T, Degerblad M, Gryback P, et al. Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis. Neurogastroenterol Motil 2010; 22: 1191-e315.
    • (2010) Neurogastroenterol Motil , vol.22
    • Edholm, T.1    Degerblad, M.2    Gryback, P.3
  • 176
    • 77952777813 scopus 로고    scopus 로고
    • Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans?
    • Asmar M, Bache M, Knop FK, et al. Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans? J Clin Endocrinol Metab 2010; 95: 2367-2375.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2367-2375
    • Asmar, M.1    Bache, M.2    Knop, F.K.3
  • 177
    • 84865070709 scopus 로고    scopus 로고
    • Effect of the once-daily human GLP-1 analogue liraglutide on appetite, energy intake, energy expenditure and gastric emptying in type 2 diabetes
    • Horowitz M, Flint A, Jones KL, et al. Effect of the once-daily human GLP-1 analogue liraglutide on appetite, energy intake, energy expenditure and gastric emptying in type 2 diabetes. Diabetes Res Clin Pract 2012; 97: 258-266.
    • (2012) Diabetes Res Clin Pract , vol.97 , pp. 258-266
    • Horowitz, M.1    Flint, A.2    Jones, K.L.3
  • 178
    • 0030068620 scopus 로고    scopus 로고
    • Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients
    • Willms B, Werner J, Holst JJ, et al. Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients. J Clin Endocrinol Metab 1996; 81: 327-332.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 327-332
    • Willms, B.1    Werner, J.2    Holst, J.J.3
  • 179
    • 79960741385 scopus 로고    scopus 로고
    • Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4
    • Kanoski SE, Fortin SM, Arnold M, et al. Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology 2011; 152: 3103-3112.
    • (2011) Endocrinology , vol.152 , pp. 3103-3112
    • Kanoski, S.E.1    Fortin, S.M.2    Arnold, M.3
  • 180
    • 66649088029 scopus 로고    scopus 로고
    • Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling
    • Hayes MR, Bradley L, Grill HJ. Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling. Endocrinology 2009; 150: 2654-2659.
    • (2009) Endocrinology , vol.150 , pp. 2654-2659
    • Hayes, M.R.1    Bradley, L.2    Grill, H.J.3
  • 181
    • 79952119299 scopus 로고    scopus 로고
    • Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation
    • Hayes MR, Leichner TM, Zhao S, et al. Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell Metab 2011; 13: 320-330.
    • (2011) Cell Metab , vol.13 , pp. 320-330
    • Hayes, M.R.1    Leichner, T.M.2    Zhao, S.3
  • 182
    • 84856102513 scopus 로고    scopus 로고
    • GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake
    • Alhadeff AL, Rupprecht LE, Hayes MR. GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake. Endocrinology 2012; 153: 647-658.
    • (2012) Endocrinology , vol.153 , pp. 647-658
    • Alhadeff, A.L.1    Rupprecht, L.E.2    Hayes, M.R.3
  • 183
    • 33748309091 scopus 로고    scopus 로고
    • Central glucagon like peptide-1 delays solid gastric emptying via central CRF and peripheral sympathetic pathway in rats
    • Nakade Y, Tsukamoto K, Pappas TN, et al. Central glucagon like peptide-1 delays solid gastric emptying via central CRF and peripheral sympathetic pathway in rats. Brain Res 2006; 1111: 117-121.
    • (2006) Brain Res , vol.1111 , pp. 117-121
    • Nakade, Y.1    Tsukamoto, K.2    Pappas, T.N.3
  • 184
    • 79959404178 scopus 로고    scopus 로고
    • Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans
    • Nauck MA, Kemmeries G, Holst JJ, et al. Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. Diabetes 2011; 60: 1561-1565.
    • (2011) Diabetes , vol.60 , pp. 1561-1565
    • Nauck, M.A.1    Kemmeries, G.2    Holst, J.J.3
  • 185
    • 84860243253 scopus 로고    scopus 로고
    • Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight
    • Jelsing J, Vrang N, Hansen G, et al. Liraglutide: short-lived effect on gastric emptying - long lasting effects on body weight. Diabetes Obes Metab 2012; 14: 531-538.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 531-538
    • Jelsing, J.1    Vrang, N.2    Hansen, G.3
  • 186
    • 1642395091 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide does not inhibit gastric emptying in humans
    • Meier JJ, Goetze O, Anstipp J, et al. Gastric inhibitory polypeptide does not inhibit gastric emptying in humans. Am J Physiol Endocrinol Metab 2004; 286: E621-E625.
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • Meier, J.J.1    Goetze, O.2    Anstipp, J.3
  • 187
    • 78650913178 scopus 로고    scopus 로고
    • The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice
    • Ogawa E, Hosokawa M, Harada N, et al. The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice. Biochem Biophys Res Commun 2011; 404: 115-120.
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 115-120
    • Ogawa, E.1    Hosokawa, M.2    Harada, N.3
  • 188
    • 84862883948 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease/steatohepatitis: epidemiology, pathogenesis, clinical presentation and treatment
    • Milic S, Stimac D. Nonalcoholic fatty liver disease/steatohepatitis: epidemiology, pathogenesis, clinical presentation and treatment. Dig Dis 2012; 30: 158-162.
    • (2012) Dig Dis , vol.30 , pp. 158-162
    • Milic, S.1    Stimac, D.2
  • 189
    • 84859404868 scopus 로고    scopus 로고
    • Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications
    • e6.
    • Cusi K. Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. Gastroenterology 2012; 142: 711-725.e6.
    • (2012) Gastroenterology , vol.142 , pp. 711-725
    • Cusi, K.1
  • 190
    • 81855213130 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: the therapeutic challenge of a global epidemic
    • Schattenberg JM, Schuppan D. Nonalcoholic steatohepatitis: the therapeutic challenge of a global epidemic. Curr Opin Lipidol 2011; 22: 479-488.
    • (2011) Curr Opin Lipidol , vol.22 , pp. 479-488
    • Schattenberg, J.M.1    Schuppan, D.2
  • 191
    • 84857185142 scopus 로고    scopus 로고
    • Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice
    • Lee J, Hong SW, Chae SW, et al. Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice. PLoS ONE 2012; 7: e31394.
    • (2012) PLoS ONE , vol.7
    • Lee, J.1    Hong, S.W.2    Chae, S.W.3
  • 192
    • 80052517174 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis
    • Svegliati-Baroni G, Saccomanno S, Rychlicki C, et al. Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis. Liver Int 2011; 31: 1285-1297.
    • (2011) Liver Int , vol.31 , pp. 1285-1297
    • Svegliati-Baroni, G.1    Saccomanno, S.2    Rychlicki, C.3
  • 193
    • 80053001967 scopus 로고    scopus 로고
    • GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy
    • Sharma S, Mells JE, Fu PP, et al. GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy. PLoS ONE 2011; 6: e25269.
    • (2011) PLoS ONE , vol.6
    • Sharma, S.1    Mells, J.E.2    Fu, P.P.3
  • 194
    • 77955027548 scopus 로고    scopus 로고
    • Active immunization against (Pro(3))GIP improves metabolic status in high-fat-fed mice
    • Montgomery IA, Irwin N, Flatt PR. Active immunization against (Pro(3))GIP improves metabolic status in high-fat-fed mice. Diabetes Obes Metab 2010; 12: 744-751.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 744-751
    • Montgomery, I.A.1    Irwin, N.2    Flatt, P.R.3
  • 195
    • 77951436599 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    • Gupta NA, Mells J, Dunham RM, et al. Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology 2010; 51: 1584-1592.
    • (2010) Hepatology , vol.51 , pp. 1584-1592
    • Gupta, N.A.1    Mells, J.2    Dunham, R.M.3
  • 196
    • 84862182799 scopus 로고    scopus 로고
    • Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect
    • Dhanesha N, Joharapurkar A, Shah G, et al. Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect. Pharmacol Rep 2012; 64: 140-149.
    • (2012) Pharmacol Rep , vol.64 , pp. 140-149
    • Dhanesha, N.1    Joharapurkar, A.2    Shah, G.3
  • 197
    • 78751642764 scopus 로고    scopus 로고
    • Exendin-4 improves hepatocyte injury by decreasing proliferation through blocking NGF/TrkA in diabetic mice
    • Gezginci-Oktayoglu S, Sacan O, Yanardag R, et al. Exendin-4 improves hepatocyte injury by decreasing proliferation through blocking NGF/TrkA in diabetic mice. Peptides 2011; 32: 223-231.
    • (2011) Peptides , vol.32 , pp. 223-231
    • Gezginci-Oktayoglu, S.1    Sacan, O.2    Yanardag, R.3
  • 198
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years
    • Klonoff DC, Buse JB, Nielsen LL, et al. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin 2008; 24: 275-286.
    • (2008) Curr Med Res Opin , vol.24 , pp. 275-286
    • Klonoff, D.C.1    Buse, J.B.2    Nielsen, L.L.3
  • 199
    • 79953213304 scopus 로고    scopus 로고
    • Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice
    • Shirakawa J, Fujii H, Ohnuma K, et al. Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice. Diabetes 2011; 60: 1246-1257.
    • (2011) Diabetes , vol.60 , pp. 1246-1257
    • Shirakawa, J.1    Fujii, H.2    Ohnuma, K.3
  • 200
    • 84862692484 scopus 로고    scopus 로고
    • Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity
    • Kern M, Kloting N, Niessen HG, et al. Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity. PLoS ONE 2012; 7: e38744.
    • (2012) PLoS ONE , vol.7
    • Kern, M.1    Kloting, N.2    Niessen, H.G.3
  • 201
    • 84857677922 scopus 로고    scopus 로고
    • Sitagliptin as a novel treatment agent for non-alcoholic Fatty liver disease patients with type 2 diabetes mellitus
    • Iwasaki T, Yoneda M, Inamori M, et al. Sitagliptin as a novel treatment agent for non-alcoholic Fatty liver disease patients with type 2 diabetes mellitus. Hepatogastroenterology 2011; 58: 2103-2105.
    • (2011) Hepatogastroenterology , vol.58 , pp. 2103-2105
    • Iwasaki, T.1    Yoneda, M.2    Inamori, M.3
  • 202
    • 84863555133 scopus 로고    scopus 로고
    • Effects of sitagliptin in diabetic patients with nonalcoholic steatohepatitis
    • Yilmaz Y, Yonal O, Deyneli O, et al. Effects of sitagliptin in diabetic patients with nonalcoholic steatohepatitis. Acta Gastroenterol Belg 2012; 75: 240-244.
    • (2012) Acta Gastroenterol Belg , vol.75 , pp. 240-244
    • Yilmaz, Y.1    Yonal, O.2    Deyneli, O.3
  • 203
    • 84867824917 scopus 로고    scopus 로고
    • Cognitive impairment in diabetic patients: Can diabetic control prevent cognitive decline?
    • Kawamura T, Umemura T, Hotta N. Cognitive impairment in diabetic patients: Can diabetic control prevent cognitive decline? J Diabetes Invest 2012; 3: 413-423.
    • (2012) J Diabetes Invest , vol.3 , pp. 413-423
    • Kawamura, T.1    Umemura, T.2    Hotta, N.3
  • 204
    • 20044362580 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation
    • Nyberg J, Anderson MF, Meister B, et al. Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation. J Neurosci 2005; 25: 1816-1825.
    • (2005) J Neurosci , vol.25 , pp. 1816-1825
    • Nyberg, J.1    Anderson, M.F.2    Meister, B.3
  • 205
    • 69549138878 scopus 로고    scopus 로고
    • Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
    • Abbas T, Faivre E, Holscher C. Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease. Behav Brain Res 2009; 205: 265-271.
    • (2009) Behav Brain Res , vol.205 , pp. 265-271
    • Abbas, T.1    Faivre, E.2    Holscher, C.3
  • 206
    • 78649745810 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test
    • Isacson R, Nielsen E, Dannaeus K, et al. The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test. Eur J Pharmacol 2011; 650: 249-255.
    • (2011) Eur J Pharmacol , vol.650 , pp. 249-255
    • Isacson, R.1    Nielsen, E.2    Dannaeus, K.3
  • 207
    • 77957915935 scopus 로고    scopus 로고
    • Chronic treatment of exendin-4 affects cell proliferation and neuroblast differentiation in the adult mouse hippocampal dentate gyrus
    • Li H, Lee CH, Yoo KY, et al. Chronic treatment of exendin-4 affects cell proliferation and neuroblast differentiation in the adult mouse hippocampal dentate gyrus. Neurosci Lett 2010; 486: 38-42.
    • (2010) Neurosci Lett , vol.486 , pp. 38-42
    • Li, H.1    Lee, C.H.2    Yoo, K.Y.3
  • 208
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    • McClean PL, Parthsarathy V, Faivre E, et al. The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J Neurosci 2011; 31: 6587-6594.
    • (2011) J Neurosci , vol.31 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3
  • 209
    • 79956037142 scopus 로고    scopus 로고
    • Encapsulated native and glucagon-like peptide-1 transfected human mesenchymal stem cells in a transgenic mouse model of Alzheimer's disease
    • Klinge PM, Harmening K, Miller MC, et al. Encapsulated native and glucagon-like peptide-1 transfected human mesenchymal stem cells in a transgenic mouse model of Alzheimer's disease. Neurosci Lett 2011; 497: 6-10.
    • (2011) Neurosci Lett , vol.497 , pp. 6-10
    • Klinge, P.M.1    Harmening, K.2    Miller, M.C.3
  • 210
    • 52249112474 scopus 로고    scopus 로고
    • Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-beta peptide (1-42)
    • Qin Z, Sun Z, Huang J, et al. Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-beta peptide (1-42). Neurosci Lett 2008; 444: 217-221.
    • (2008) Neurosci Lett , vol.444 , pp. 217-221
    • Qin, Z.1    Sun, Z.2    Huang, J.3
  • 211
    • 0038248960 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron
    • Perry T, Lahiri DK, Sambamurti K, et al. Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res 2003; 72: 603-612.
    • (2003) J Neurosci Res , vol.72 , pp. 603-612
    • Perry, T.1    Lahiri, D.K.2    Sambamurti, K.3
  • 212
    • 84859726053 scopus 로고    scopus 로고
    • An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Abeta oligomers
    • Bomfim TR, Forny-Germano L, Sathler LB, et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Abeta oligomers. J Clin Invest 2012; 122: 1339-1353.
    • (2012) J Clin Invest , vol.122 , pp. 1339-1353
    • Bomfim, T.R.1    Forny-Germano, L.2    Sathler, L.B.3
  • 213
    • 84867040244 scopus 로고    scopus 로고
    • Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions
    • Rampersaud N, Harkavyi A, Giordano G, et al. Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions. Neuropeptides 2012; 46: 183-193.
    • (2012) Neuropeptides , vol.46 , pp. 183-193
    • Rampersaud, N.1    Harkavyi, A.2    Giordano, G.3
  • 214
    • 84864201829 scopus 로고    scopus 로고
    • Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an intrahippocampal lipopolysaccharide injection
    • Huang HJ, Chen YH, Liang KC, et al. Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an intrahippocampal lipopolysaccharide injection. PLoS ONE 2012; 7: e39656.
    • (2012) PLoS ONE , vol.7
    • Huang, H.J.1    Chen, Y.H.2    Liang, K.C.3
  • 215
    • 84855548096 scopus 로고    scopus 로고
    • (Val(8)) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains
    • Li L, Zhang ZF, Holscher C, et al. (Val(8)) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. Eur J Pharmacol 2012; 674: 280-286.
    • (2012) Eur J Pharmacol , vol.674 , pp. 280-286
    • Li, L.1    Zhang, Z.F.2    Holscher, C.3
  • 216
    • 84859951837 scopus 로고    scopus 로고
    • Bone, sweet bone-osteoporotic fractures in diabetes mellitus
    • Hamann C, Kirschner S, Gunther KP, et al. Bone, sweet bone-osteoporotic fractures in diabetes mellitus. Nat Rev Endocrinol 2012; 8: 297-305.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 297-305
    • Hamann, C.1    Kirschner, S.2    Gunther, K.P.3
  • 217
    • 84865377626 scopus 로고    scopus 로고
    • DPP-4 inhibitors and prevention of bone fractures: effects beyond glyemic control
    • Yabe D, Seino Y. DPP-4 inhibitors and prevention of bone fractures: effects beyond glyemic control. J Diabetes Invest 2012; 3: 347-348.
    • (2012) J Diabetes Invest , vol.3 , pp. 347-348
    • Yabe, D.1    Seino, Y.2
  • 219
    • 33846866509 scopus 로고    scopus 로고
    • Effects of glucose-dependent insulinotropic peptide on osteoclast function
    • Zhong Q, Itokawa T, Sridhar S, et al. Effects of glucose-dependent insulinotropic peptide on osteoclast function. Am J Physiol Endocrinol Metab 2007; 292: E543-E548.
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Zhong, Q.1    Itokawa, T.2    Sridhar, S.3
  • 220
    • 33745658853 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion
    • Tsukiyama K, Yamada Y, Yamada C, et al. Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion. Mol Endocrinol 2006; 20: 1644-1651.
    • (2006) Mol Endocrinol , vol.20 , pp. 1644-1651
    • Tsukiyama, K.1    Yamada, Y.2    Yamada, C.3
  • 221
    • 34147142997 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass
    • Xie D, Zhong Q, Ding KH, et al. Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass. Bone 2007; 40: 1352-1360.
    • (2007) Bone , vol.40 , pp. 1352-1360
    • Xie, D.1    Zhong, Q.2    Ding, K.H.3
  • 222
    • 41849094819 scopus 로고    scopus 로고
    • Impact of glucose-dependent insulinotropic peptide on age-induced bone loss
    • Ding KH, Shi XM, Zhong Q, et al. Impact of glucose-dependent insulinotropic peptide on age-induced bone loss. J Bone Miner Res 2008; 23: 536-543.
    • (2008) J Bone Miner Res , vol.23 , pp. 536-543
    • Ding, K.H.1    Shi, X.M.2    Zhong, Q.3
  • 223
    • 0035947038 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects
    • Bollag RJ, Zhong Q, Ding KH, et al. Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects. Mol Cell Endocrinol 2001; 177: 35-41.
    • (2001) Mol Cell Endocrinol , vol.177 , pp. 35-41
    • Bollag, R.J.1    Zhong, Q.2    Ding, K.H.3
  • 224
    • 38549146030 scopus 로고    scopus 로고
    • The murine glucagon-like peptide-1 receptor is essential for control of bone resorption
    • Yamada C, Yamada Y, Tsukiyama K, et al. The murine glucagon-like peptide-1 receptor is essential for control of bone resorption. Endocrinology 2008; 149: 574-579.
    • (2008) Endocrinology , vol.149 , pp. 574-579
    • Yamada, C.1    Yamada, Y.2    Tsukiyama, K.3
  • 225
    • 67349094596 scopus 로고    scopus 로고
    • Effect of GLP-1 treatment on bone turnover in normal, type 2 diabetic, and insulin-resistant states
    • Nuche-Berenguer B, Moreno P, Esbrit P, et al. Effect of GLP-1 treatment on bone turnover in normal, type 2 diabetic, and insulin-resistant states. Calcif Tissue Int 2009; 84: 453-461.
    • (2009) Calcif Tissue Int , vol.84 , pp. 453-461
    • Nuche-Berenguer, B.1    Moreno, P.2    Esbrit, P.3
  • 226
    • 79954782586 scopus 로고    scopus 로고
    • GLP-1 and exendin-4 can reverse hyperlipidic-related osteopenia
    • Nuche-Berenguer B, Lozano D, Gutierrez-Rojas I, et al. GLP-1 and exendin-4 can reverse hyperlipidic-related osteopenia. J Endocrinol 2011; 209: 203-210.
    • (2011) J Endocrinol , vol.209 , pp. 203-210
    • Nuche-Berenguer, B.1    Lozano, D.2    Gutierrez-Rojas, I.3
  • 227
    • 71449084965 scopus 로고    scopus 로고
    • Exendin-4 exerts osteogenic actions in insulin-resistant and type 2 diabetic states
    • Nuche-Berenguer B, Moreno P, Portal-Nunez S, et al. Exendin-4 exerts osteogenic actions in insulin-resistant and type 2 diabetic states. Regul Pept 2010; 159: 61-66.
    • (2010) Regul Pept , vol.159 , pp. 61-66
    • Nuche-Berenguer, B.1    Moreno, P.2    Portal-Nunez, S.3
  • 228
    • 79951642368 scopus 로고    scopus 로고
    • Differential effects of PPAR-{gamma} activation versus chemical or genetic reduction of DPP-4 activity on bone quality in mice
    • Kyle KA, Willett TL, Baggio LL, et al. Differential effects of PPAR-{gamma} activation versus chemical or genetic reduction of DPP-4 activity on bone quality in mice. Endocrinology 2011; 152: 457-467.
    • (2011) Endocrinology , vol.152 , pp. 457-467
    • Kyle, K.A.1    Willett, T.L.2    Baggio, L.L.3
  • 229
    • 84857095236 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and bone fractures: a meta-analysis of randomized clinical trials
    • Monami M, Dicembrini I, Antenore A, et al. Dipeptidyl peptidase-4 inhibitors and bone fractures: a meta-analysis of randomized clinical trials. Diabetes Care 2011; 34: 2474-2476.
    • (2011) Diabetes Care , vol.34 , pp. 2474-2476
    • Monami, M.1    Dicembrini, I.2    Antenore, A.3
  • 230
    • 79951870602 scopus 로고    scopus 로고
    • Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes
    • Bunck MC, Eliasson B, Corner A, et al. Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes. Diabetes Obes Metab 2011; 13: 374-377.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 374-377
    • Bunck, M.C.1    Eliasson, B.2    Corner, A.3
  • 231
    • 10744224629 scopus 로고    scopus 로고
    • Role of gastrointestinal hormones in postprandial reduction of bone resorption
    • Henriksen DB, Alexandersen P, Bjarnason NH, et al. Role of gastrointestinal hormones in postprandial reduction of bone resorption. J Bone Miner Res 2003; 18: 2180-2189.
    • (2003) J Bone Miner Res , vol.18 , pp. 2180-2189
    • Henriksen, D.B.1    Alexandersen, P.2    Bjarnason, N.H.3
  • 232
    • 77950228684 scopus 로고    scopus 로고
    • Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
    • Bjerre Knudsen L, Madsen LW, Andersen S, et al. Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. Endocrinology 2010; 151: 1473-1486.
    • (2010) Endocrinology , vol.151 , pp. 1473-1486
    • Bjerre Knudsen, L.1    Madsen, L.W.2    Andersen, S.3
  • 233
    • 0029833629 scopus 로고    scopus 로고
    • Effects of glucagon and glucagon-like peptide-1-(7-36) amide on C cells from rat thyroid and medullary thyroid carcinoma CA-77 cell line
    • Crespel A, De Boisvilliers F, Gros L, et al. Effects of glucagon and glucagon-like peptide-1-(7-36) amide on C cells from rat thyroid and medullary thyroid carcinoma CA-77 cell line. Endocrinology 1996; 137: 3674-3680.
    • (1996) Endocrinology , vol.137 , pp. 3674-3680
    • Crespel, A.1    De Boisvilliers, F.2    Gros, L.3
  • 234
    • 33846964878 scopus 로고    scopus 로고
    • Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules
    • Costante G, Meringolo D, Durante C, et al. Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules. J Clin Endocrinol Metab 2007; 92: 450-455.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 450-455
    • Costante, G.1    Meringolo, D.2    Durante, C.3
  • 235
    • 0030590526 scopus 로고    scopus 로고
    • Expression of glucagon-like peptide 1 receptor in a murine C cell line: regulation of calcitonin gene by glucagon-like peptide 1
    • Lamari Y, Boissard C, Moukhtar MS, et al. Expression of glucagon-like peptide 1 receptor in a murine C cell line: regulation of calcitonin gene by glucagon-like peptide 1. FEBS Lett 1996; 393: 248-252.
    • (1996) FEBS Lett , vol.393 , pp. 248-252
    • Lamari, Y.1    Boissard, C.2    Moukhtar, M.S.3
  • 236
    • 84857422717 scopus 로고    scopus 로고
    • GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation
    • Madsen LW, Knauf JA, Gotfredsen C, et al. GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation. Endocrinology 2012; 153: 1538-1547.
    • (2012) Endocrinology , vol.153 , pp. 1538-1547
    • Madsen, L.W.1    Knauf, J.A.2    Gotfredsen, C.3
  • 237
    • 80053584184 scopus 로고    scopus 로고
    • Liraglutide in adults with type 2 diabetes: global perspective on safety, efficacy and patient preference
    • Yabe D, Seino Y. Liraglutide in adults with type 2 diabetes: global perspective on safety, efficacy and patient preference. Clin Med Insights Endocrinol Diabetes 2011; 4: 47-62.
    • (2011) Clin Med Insights Endocrinol Diabetes , vol.4 , pp. 47-62
    • Yabe, D.1    Seino, Y.2
  • 238
    • 79952284556 scopus 로고    scopus 로고
    • GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide
    • Hegedus L, Moses AC, Zdravkovic M, et al. GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide. J Clin Endocrinol Metab 2011; 96: 853-860.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 853-860
    • Hegedus, L.1    Moses, A.C.2    Zdravkovic, M.3
  • 239
    • 84855489636 scopus 로고    scopus 로고
    • Glucagon like peptide-1 receptor expression in the human thyroid gland
    • Gier B, Butler PC, Lai CK, et al. Glucagon like peptide-1 receptor expression in the human thyroid gland. J Clin Endocrinol Metab 2012; 97: 121-131.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 121-131
    • Gier, B.1    Butler, P.C.2    Lai, C.K.3
  • 240
    • 83655191987 scopus 로고    scopus 로고
    • Incretin receptors in non-neoplastic and neoplastic thyroid C cells in rodents and humans: relevance for incretin-based diabetes therapy
    • Waser B, Beetschen K, Pellegata NS, et al. Incretin receptors in non-neoplastic and neoplastic thyroid C cells in rodents and humans: relevance for incretin-based diabetes therapy. Neuroendocrinology 2011; 94: 291-301.
    • (2011) Neuroendocrinology , vol.94 , pp. 291-301
    • Waser, B.1    Beetschen, K.2    Pellegata, N.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.