메뉴 건너뛰기




Volumn 3, Issue 3, 2014, Pages 241-251

Action and therapeutic potential of oxyntomodulin

Author keywords

Body weight; GLP 1; Glucagon; Glucose metabolism; Oxyntomodulin

Indexed keywords

GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON RECEPTOR; OXYNTOMODULIN;

EID: 84897116945     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2013.12.001     Document Type: Review
Times cited : (156)

References (149)
  • 1
    • 0028817815 scopus 로고
    • UKPDS U.K. Prospective Diabetes Study Group
    • U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease
    • UKPDS U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group. Diabetes 1995, 44:1249-1258. 10.2337/diabetes.44.11.1249.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 3
    • 0034714634 scopus 로고    scopus 로고
    • Gut hormones as pharmaceuticals. From enteroglucagon to GLP-1 and GLP-2
    • Holst J.J. Gut hormones as pharmaceuticals. From enteroglucagon to GLP-1 and GLP-2. Regulatory Peptides 2000, 93:45-51. 10.1016/S0167-0115(00)00185-3.
    • (2000) Regulatory Peptides , vol.93 , pp. 45-51
    • Holst, J.J.1
  • 5
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck M.A., Kleine N., Orskov C., Holst J.J., Willms B., Creutzfeldt W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993, 36:741-744.
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 6
    • 0037667613 scopus 로고    scopus 로고
    • Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes
    • Meier J.J., Gallwitz B., Salmen S., Goetze O., Holst J.J., Schmidt W.E., et al. Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism 2003, 88:2719-2725.
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , pp. 2719-2725
    • Meier, J.J.1    Gallwitz, B.2    Salmen, S.3    Goetze, O.4    Holst, J.J.5    Schmidt, W.E.6
  • 7
    • 21344454659 scopus 로고    scopus 로고
    • Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects
    • Meier J.J., Kemmeries G., Holst J.J., Nauck M.A. Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects. Diabetes 2005, 54:2212-2218. 10.2337/diabetes.54.7.2212.
    • (2005) Diabetes , vol.54 , pp. 2212-2218
    • Meier, J.J.1    Kemmeries, G.2    Holst, J.J.3    Nauck, M.A.4
  • 8
    • 79959404178 scopus 로고    scopus 로고
    • Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans
    • Nauck M.A., Kemmeries G., Holst J.J., Meier J.J. Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. Diabetes 2011, 60:1561-1565. 10.2337/db10-0474.
    • (2011) Diabetes , vol.60 , pp. 1561-1565
    • Nauck, M.A.1    Kemmeries, G.2    Holst, J.J.3    Meier, J.J.4
  • 9
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis
    • Amori R.E., Lau J., Pittas A.G. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. Journal of the American Medical Association 2007, 298:194-206. 10.1001/jama.298.2.194.
    • (2007) Journal of the American Medical Association , vol.298 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3
  • 10
    • 0031724691 scopus 로고    scopus 로고
    • Influence of glucagon-like peptide-1 on fasting glycemia in type 2 diabetic patients treated with insulin after sulfonylurea secondary failure
    • Nauck M.A., Sauerwald A., Ritzel R., Holst J.J., Schmiegel W. Influence of glucagon-like peptide-1 on fasting glycemia in type 2 diabetic patients treated with insulin after sulfonylurea secondary failure. Diabetes Care 1998, 21:1925-1931.
    • (1998) Diabetes Care , vol.21 , pp. 1925-1931
    • Nauck, M.A.1    Sauerwald, A.2    Ritzel, R.3    Holst, J.J.4    Schmiegel, W.5
  • 12
    • 33745771673 scopus 로고    scopus 로고
    • Biologic actions and therapeutic potential of the glucagon-like peptides
    • Drucker D.J. Biologic actions and therapeutic potential of the glucagon-like peptides. Nature Clinical Practice. Endocrinology and Metabolism 2005, 1:22-31. 10.1038/ncpendmet0017.
    • (2005) Nature Clinical Practice. Endocrinology and Metabolism , vol.1 , pp. 22-31
    • Drucker, D.J.1
  • 13
    • 0020509994 scopus 로고
    • Molecular forms of human enteroglucagon in tissue and plasma: plasma responses to nutrient stimuli in health and in disorders of the upper gastrointestinal tract
    • Ghatei M.A., Uttenthal L.O., Christofides N.D., Bryant M.G., Bloom S.R. Molecular forms of human enteroglucagon in tissue and plasma: plasma responses to nutrient stimuli in health and in disorders of the upper gastrointestinal tract. Journal of Clinical Endocrinology and Metabolism 1983, 57:488-495. 10.1210/jcem-57-3-488.
    • (1983) Journal of Clinical Endocrinology and Metabolism , vol.57 , pp. 488-495
    • Ghatei, M.A.1    Uttenthal, L.O.2    Christofides, N.D.3    Bryant, M.G.4    Bloom, S.R.5
  • 14
    • 0030901415 scopus 로고    scopus 로고
    • Enteroglucagon
    • Holst J.J. Enteroglucagon. Annual Review of Physiology 1997, 59:257-271. 10.1146/annurev.physiol.59.1.257.
    • (1997) Annual Review of Physiology , vol.59 , pp. 257-271
    • Holst, J.J.1
  • 17
    • 0033304603 scopus 로고    scopus 로고
    • The glucagon-like peptides
    • Kieffer T.J., Habener J.F. The glucagon-like peptides. Endocrine Reviews 1999, 20:876-913. 10.1210/er.20.6.876.
    • (1999) Endocrine Reviews , vol.20 , pp. 876-913
    • Kieffer, T.J.1    Habener, J.F.2
  • 19
    • 84862734491 scopus 로고    scopus 로고
    • A beautiful cell (or two or three?)
    • Brubaker P.L. A beautiful cell (or two or three?). Endocrinology 2012, 153:2945-2948. 10.1210/en.2012-1549.
    • (2012) Endocrinology , vol.153 , pp. 2945-2948
    • Brubaker, P.L.1
  • 20
    • 84862743498 scopus 로고    scopus 로고
    • Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry
    • Habib A.M., Richards P., Cairns L.S., Rogers G.J., Bannon C.A., Parker, et al. Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry. Endocrinology 2012, 153:3054-3065. 10.1210/en.2011-2170.
    • (2012) Endocrinology , vol.153 , pp. 3054-3065
    • Habib, A.M.1    Richards, P.2    Cairns, L.S.3    Rogers, G.J.4    Bannon, C.A.5    Parker6
  • 21
    • 84957890116 scopus 로고
    • Origin and distribution of the hyperglycemic-glycogenolytic factor of the pancreas
    • Sutherland E.W., De Duve C. Origin and distribution of the hyperglycemic-glycogenolytic factor of the pancreas. Journal of Biological Chemistry 1948, 175:663-674.
    • (1948) Journal of Biological Chemistry , vol.175 , pp. 663-674
    • Sutherland, E.W.1    De Duve, C.2
  • 23
    • 0019527355 scopus 로고
    • 'Enteroglucagon': a specific effect on gastric glands isolated from the rat fundus. Evidence foran 'oxyntomodulin' action
    • Bataille D., Gespach C., Coudray A.M., Rosselin G. 'Enteroglucagon': a specific effect on gastric glands isolated from the rat fundus. Evidence foran 'oxyntomodulin' action. Bioscience Reports 1981, 1:151-155. 10.1007/BF01117012.
    • (1981) Bioscience Reports , vol.1 , pp. 151-155
    • Bataille, D.1    Gespach, C.2    Coudray, A.M.3    Rosselin, G.4
  • 24
    • 0019766354 scopus 로고
    • Bioactive enteroglucagon (oxyntomodulin): present knowledge on its chemical structure and its biological activities
    • Bataille D., Gespach C., Tatemoto K., Marie J.C., Coudray A.M., Rosselin G., et al. Bioactive enteroglucagon (oxyntomodulin): present knowledge on its chemical structure and its biological activities. Peptides 1981, 2(Suppl. 2):S41-S44. 10.1016/0196-9781(81)90008-5.
    • (1981) Peptides , vol.2 , Issue.SUPPL. 2
    • Bataille, D.1    Gespach, C.2    Tatemoto, K.3    Marie, J.C.4    Coudray, A.M.5    Rosselin, G.6
  • 26
    • 0020377971 scopus 로고
    • Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Characterization of the peptide
    • Bataille D., Tatemoto K., Gespach C., Jornvall H., Rosselin G., Mutt V. Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Characterization of the peptide. FEBS Letters 1982, 146:79-86. 10.1016/0014-5793(82)80709-6.
    • (1982) FEBS Letters , vol.146 , pp. 79-86
    • Bataille, D.1    Tatemoto, K.2    Gespach, C.3    Jornvall, H.4    Rosselin, G.5    Mutt, V.6
  • 27
    • 0023910424 scopus 로고
    • Oxyntomodulin (glicentin-(33-69)): pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs
    • Baldissera F.G., Holst J.J., Knuhtsen S., Hilsted L., Nielsen O.V. Oxyntomodulin (glicentin-(33-69)): pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs. Regulatory Peptides 1988, 21:151-166. 10.1016/0167-0115(88)90099-7.
    • (1988) Regulatory Peptides , vol.21 , pp. 151-166
    • Baldissera, F.G.1    Holst, J.J.2    Knuhtsen, S.3    Hilsted, L.4    Nielsen, O.V.5
  • 28
    • 0027220436 scopus 로고
    • Glucagon-like peptide-1-(7-36) amide, oxyntomodulin, and glucagon interact with a common receptor in a somatostatin-secreting cell line
    • Gros L., Thorens B., Bataille D., Kervran A. Glucagon-like peptide-1-(7-36) amide, oxyntomodulin, and glucagon interact with a common receptor in a somatostatin-secreting cell line. Endocrinology 1993, 133:631-638. 10.1210/en.133.2.631.
    • (1993) Endocrinology , vol.133 , pp. 631-638
    • Gros, L.1    Thorens, B.2    Bataille, D.3    Kervran, A.4
  • 29
    • 70349644658 scopus 로고    scopus 로고
    • Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice
    • Pocai A., Carrington P.E., Adams J.R., Wright M., Eiermann G., Zhu L., et al. Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice. Diabetes 2009, 58:2258-2266. 10.2337/db09-0278.
    • (2009) Diabetes , vol.58 , pp. 2258-2266
    • Pocai, A.1    Carrington, P.E.2    Adams, J.R.3    Wright, M.4    Eiermann, G.5    Zhu, L.6
  • 30
    • 4143116741 scopus 로고    scopus 로고
    • Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure
    • Baggio L.L., Huang Q., Brown T.J., Drucker D.J. Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology 2004, 127:546-558. 10.1053/j.gastro.2004.04.063.
    • (2004) Gastroenterology , vol.127 , pp. 546-558
    • Baggio, L.L.1    Huang, Q.2    Brown, T.J.3    Drucker, D.J.4
  • 31
    • 34250714898 scopus 로고    scopus 로고
    • Oxyntomodulin differentially affects glucagon-like peptide-1 receptor b-arrestin recruitment and signaling through Gα(s)
    • Jorgensen R., Kubale V., Vrecl M., Schwartz T.W., Elling C.E. Oxyntomodulin differentially affects glucagon-like peptide-1 receptor b-arrestin recruitment and signaling through Gα(s). Journal of Pharmacology and Experimental Therapeutics 2007, 322:148-154. 10.1124/jpet.107.120006.
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.322 , pp. 148-154
    • Jorgensen, R.1    Kubale, V.2    Vrecl, M.3    Schwartz, T.W.4    Elling, C.E.5
  • 32
    • 0029829540 scopus 로고    scopus 로고
    • Oxyntomodulin: a cAMP-dependent stimulus of rat parietal cell function via the receptor for glucagon-like peptide-1 (7-36)NH2
    • Schepp W., Dehne K., Riedel T., Schmidtler J., Schaffer K., Classen M. Oxyntomodulin: a cAMP-dependent stimulus of rat parietal cell function via the receptor for glucagon-like peptide-1 (7-36)NH2. Digestion 1996, 57:398-405. 10.1159/000201367.
    • (1996) Digestion , vol.57 , pp. 398-405
    • Schepp, W.1    Dehne, K.2    Riedel, T.3    Schmidtler, J.4    Schaffer, K.5    Classen, M.6
  • 34
    • 33749478768 scopus 로고    scopus 로고
    • Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese-enhanced magnetic resonance imaging
    • Chaudhri O.B., Parkinson J.R., Kuo Y.T., Druce M.R., Herlihy A.H., Bell J.D., et al. Differential hypothalamic neuronal activation following peripheral injection of GLP-1 and oxyntomodulin in mice detected by manganese-enhanced magnetic resonance imaging. Biochemical and Biophysical Research Communications 2006, 350:298-306. 10.1016/j.bbrc.2006.09.033.
    • (2006) Biochemical and Biophysical Research Communications , vol.350 , pp. 298-306
    • Chaudhri, O.B.1    Parkinson, J.R.2    Kuo, Y.T.3    Druce, M.R.4    Herlihy, A.H.5    Bell, J.D.6
  • 35
    • 57749169279 scopus 로고    scopus 로고
    • Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI)
    • Parkinson J.R., Chaudhri O.B., Kuo Y.T., Field B.C., Herlihy A.H., Dhillo W.S., Ghatei M.A., et al. Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI). NeuroImage 2009, 44:1022-1031. 10.1016/j.neuroimage.2008.09.047.
    • (2009) NeuroImage , vol.44 , pp. 1022-1031
    • Parkinson, J.R.1    Chaudhri, O.B.2    Kuo, Y.T.3    Field, B.C.4    Herlihy, A.H.5    Dhillo, W.S.6    Ghatei, M.A.7
  • 36
    • 84885669915 scopus 로고    scopus 로고
    • Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala
    • Parker J.A., McCullough K.A., Field B.C., Minnion J.S., Martin N.M., Ghatei M.A., et al. Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala. International Journal of Obesity (London) 2013, 37:1391-1398. 10.1038/ijo.2012.227.
    • (2013) International Journal of Obesity (London) , vol.37 , pp. 1391-1398
    • Parker, J.A.1    McCullough, K.A.2    Field, B.C.3    Minnion, J.S.4    Martin, N.M.5    Ghatei, M.A.6
  • 38
    • 23644443678 scopus 로고    scopus 로고
    • Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial
    • Wynne K., Park A.J., Small C.J., Patterson M., Ellis S.M., Murphy K.G., et al. Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial. Diabetes 2005, 54:2390-2395. 10.2337/diabetes.54.8.2390.
    • (2005) Diabetes , vol.54 , pp. 2390-2395
    • Wynne, K.1    Park, A.J.2    Small, C.J.3    Patterson, M.4    Ellis, S.M.5    Murphy, K.G.6
  • 41
    • 84872175094 scopus 로고    scopus 로고
    • Unraveling oxyntomodulin, GLP1's enigmatic brother
    • Pocai A. Unraveling oxyntomodulin, GLP1's enigmatic brother. Journal of Endocrinology 2012, 215:335-346. 10.1530/JOE-12-0368.
    • (2012) Journal of Endocrinology , vol.215 , pp. 335-346
    • Pocai, A.1
  • 46
    • 84864351901 scopus 로고    scopus 로고
    • The glucagon receptor is involved in mediating the body weight lowering effects of oxyntomodulin
    • Kosinski J.R., Hubert J., Carrington P.E., Chicchi G.G., Mu J., Miller C., et al. The glucagon receptor is involved in mediating the body weight lowering effects of oxyntomodulin. Obesity 2012, 20:1566-1571. 10.1038/oby.2012.67.
    • (2012) Obesity , vol.20 , pp. 1566-1571
    • Kosinski, J.R.1    Hubert, J.2    Carrington, P.E.3    Chicchi, G.G.4    Mu, J.5    Miller, C.6
  • 48
    • 54349119151 scopus 로고    scopus 로고
    • The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances β-cell function but does not inhibit gastric emptying in mice
    • Maida A., Lovshin J.A., Baggio L.L., Drucker D.J. The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances β-cell function but does not inhibit gastric emptying in mice. Endocrinology 2008, 149:5670-5678. 10.1210/en.2008-0336.
    • (2008) Endocrinology , vol.149 , pp. 5670-5678
    • Maida, A.1    Lovshin, J.A.2    Baggio, L.L.3    Drucker, D.J.4
  • 50
    • 84995739241 scopus 로고    scopus 로고
    • Oxyntomodulin has significant acute glucoregulatory effects comparable to liraglutide in subjects with type 2 diabetes
    • Shankar S.S., Shankar R.R., Mixson L., Pramanik B.S., Stoch A., Steinberg H.O., et al. Oxyntomodulin has significant acute glucoregulatory effects comparable to liraglutide in subjects with type 2 diabetes. Diabetes 2013, 62(Suppl. 1):A48. 10.2337/db13-1-387.
    • (2013) Diabetes , vol.62 , Issue.SUPPL. 1
    • Shankar, S.S.1    Shankar, R.R.2    Mixson, L.3    Pramanik, B.S.4    Stoch, A.5    Steinberg, H.O.6
  • 51
    • 33749339257 scopus 로고    scopus 로고
    • Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomized controlled trial
    • Wynne K., Park A.J., Small C.J., Meeran K., Ghatei M.A., Frost G.S., et al. Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomized controlled trial. International Journal of Obesity 2006, 30:1729-1736. 10.1038/sj.ijo.0803344.
    • (2006) International Journal of Obesity , vol.30 , pp. 1729-1736
    • Wynne, K.1    Park, A.J.2    Small, C.J.3    Meeran, K.4    Ghatei, M.A.5    Frost, G.S.6
  • 52
    • 0023714388 scopus 로고
    • Oxyntomodulin: a potential hormone from the distal gut. Pharmacokinetics and effects on gastric acid and insulin secretion in man
    • Schjoldager B.T., Baldissera F.G., Mortensen P.E., Holst J.J., Christiansen J. Oxyntomodulin: a potential hormone from the distal gut. Pharmacokinetics and effects on gastric acid and insulin secretion in man. European Journal of Clinical Investigation 1988, 18:499-503. 10.1111/j.1365-2362.1988.tb01046.x.
    • (1988) European Journal of Clinical Investigation , vol.18 , pp. 499-503
    • Schjoldager, B.T.1    Baldissera, F.G.2    Mortensen, P.E.3    Holst, J.J.4    Christiansen, J.5
  • 55
    • 77957592532 scopus 로고    scopus 로고
    • The mechanism of action for oxyntomodulin in the regulation of obesity
    • (Review)
    • Wynne K., Field B.C., Bloom S.R. The mechanism of action for oxyntomodulin in the regulation of obesity. Current Opinion in Investigational Drugs 2010, 11:1151-1157. (Review).
    • (2010) Current Opinion in Investigational Drugs , vol.11 , pp. 1151-1157
    • Wynne, K.1    Field, B.C.2    Bloom, S.R.3
  • 60
    • 0030960882 scopus 로고    scopus 로고
    • Reeve Oxyntomodulin stimulates intestinal glucose uptake in rats
    • Collie N.L., Zhu Z., Jordan S., Reeve Oxyntomodulin stimulates intestinal glucose uptake in rats. Gastroenterology 1997, 112:1961-1970.
    • (1997) Gastroenterology , vol.112 , pp. 1961-1970
    • Collie, N.L.1    Zhu, Z.2    Jordan, S.3
  • 61
    • 0031791027 scopus 로고    scopus 로고
    • Enteric glucagon 37 rather than pancreatic glucagon 29 stimulates glucose absorption in rat intestine
    • Stümpel F., Scholtka B., Hunger A., Jungermann K. Enteric glucagon 37 rather than pancreatic glucagon 29 stimulates glucose absorption in rat intestine. Gastroenterology 1998, 115:1163-1171.
    • (1998) Gastroenterology , vol.115 , pp. 1163-1171
    • Stümpel, F.1    Scholtka, B.2    Hunger, A.3    Jungermann, K.4
  • 62
    • 0029781929 scopus 로고    scopus 로고
    • The effect of GIP and glucagon-like peptides on intestinal basolateral membrane hexose transport
    • Cheeseman C.I., Tsang R. The effect of GIP and glucagon-like peptides on intestinal basolateral membrane hexose transport. American Journal of Physiology 1996, 271:G477-G482.
    • (1996) American Journal of Physiology , vol.271
    • Cheeseman, C.I.1    Tsang, R.2
  • 63
    • 0031405798 scopus 로고    scopus 로고
    • Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo
    • Cheeseman C.I. Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo. American Journal of Physiology 1997, 273:R1965-R1971.
    • (1997) American Journal of Physiology , vol.273
    • Cheeseman, C.I.1
  • 64
    • 42149181885 scopus 로고    scopus 로고
    • Structural diversity of G protein-coupled receptors and significance for drug discovery
    • (Review)
    • Lagerström M.C., Schiöth H.B. Structural diversity of G protein-coupled receptors and significance for drug discovery. Nature Reviews Drug Discovery 2008, 7:339-357. (Review). 10.1038/nrd2518.
    • (2008) Nature Reviews Drug Discovery , vol.7 , pp. 339-357
    • Lagerström, M.C.1    Schiöth, H.B.2
  • 65
    • 84881193006 scopus 로고    scopus 로고
    • Structure of the human glucagon class B G-protein-coupled receptor
    • Siu F.Y., He M., de Graaf C., Han G.W., Yang D., Zhang Z., et al. Structure of the human glucagon class B G-protein-coupled receptor. Nature 2013, 499:444-449. 10.1038/nature12393.
    • (2013) Nature , vol.499 , pp. 444-449
    • Siu, F.Y.1    He, M.2    de Graaf, C.3    Han, G.W.4    Yang, D.5    Zhang, Z.6
  • 67
    • 0027530401 scopus 로고
    • Glucagon acts in the liver to control spontaneous meal size in rats
    • Geary N., Le Sauter J., Noh U. Glucagon acts in the liver to control spontaneous meal size in rats. American Journal of Physiology 1993, 264:R116-R122.
    • (1993) American Journal of Physiology , vol.264
    • Geary, N.1    Le Sauter, J.2    Noh, U.3
  • 68
    • 84875409178 scopus 로고    scopus 로고
    • Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia
    • Tan T.M., Field B.C., McCullough K.A., Troke R.C., Chambers E.S., Salem V., et al. Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia. Diabetes 2013, 62:1131-1138. 10.2337/db12-0797.
    • (2013) Diabetes , vol.62 , pp. 1131-1138
    • Tan, T.M.1    Field, B.C.2    McCullough, K.A.3    Troke, R.C.4    Chambers, E.S.5    Salem, V.6
  • 69
    • 67651176104 scopus 로고    scopus 로고
    • Hypothalamic injection of oxyntomodulin suppresses circulating ghrelin-like immunoreactivity
    • Patterson M., Murphy K.G., Patel S.R., Patel N.A., Greenwood H.C., Cooke J.H., et al. Hypothalamic injection of oxyntomodulin suppresses circulating ghrelin-like immunoreactivity. Endocrinology 2009, 150:3513-3520. 10.1210/en.2008-0796.
    • (2009) Endocrinology , vol.150 , pp. 3513-3520
    • Patterson, M.1    Murphy, K.G.2    Patel, S.R.3    Patel, N.A.4    Greenwood, H.C.5    Cooke, J.H.6
  • 70
    • 34547650656 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion
    • Hagemann D., Holst J.J., Gethmann A., Banasch M., Schmidt W.E., Meier J.J. Glucagon-like peptide 1 (GLP-1) suppresses ghrelin levels in humans via increased insulin secretion. Regulatory Peptides 2007, 143:64-68.
    • (2007) Regulatory Peptides , vol.143 , pp. 64-68
    • Hagemann, D.1    Holst, J.J.2    Gethmann, A.3    Banasch, M.4    Schmidt, W.E.5    Meier, J.J.6
  • 73
    • 84872171201 scopus 로고    scopus 로고
    • Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents
    • Day J.W., Smiley D., Carrington P.E., Eiermann G., Chicchi G., Erion M.D., et al. Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents. Peptide Science 2012, 98:443-450. 10.1002/bip.22072.
    • (2012) Peptide Science , vol.98 , pp. 443-450
    • Day, J.W.1    Smiley, D.2    Carrington, P.E.3    Eiermann, G.4    Chicchi, G.5    Erion, M.D.6
  • 75
    • 84876556455 scopus 로고    scopus 로고
    • Role of fibroblast growth factor 21 in biology of glucagon
    • Berglund E.D., Unger R.H. Role of fibroblast growth factor 21 in biology of glucagon. Diabetes 2013, 62:1376. 10.2337/db12-1840.
    • (2013) Diabetes , vol.62 , pp. 1376
    • Berglund, E.D.1    Unger, R.H.2
  • 76
    • 84876558435 scopus 로고    scopus 로고
    • Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis?
    • Arafat A.M., Kaczmarek P., Skrzypski M., Pruszyńska-Oszmalek E., Kołodziejski P., Szczepankiewicz D., et al. Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis?. Diabetologia 2013, 56:588-597. 10.1007/s00125-012-2803-y.
    • (2013) Diabetologia , vol.56 , pp. 588-597
    • Arafat, A.M.1    Kaczmarek, P.2    Skrzypski, M.3    Pruszyńska-Oszmalek, E.4    Kołodziejski, P.5    Szczepankiewicz, D.6
  • 77
  • 78
    • 84883481988 scopus 로고    scopus 로고
    • The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
    • Gaich G., Chien J.Y., Fu H., Glass L.C., Deeg M.A., Holland W.L., et al. The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metabolism 2013, 18:333-340. 10.1016/j.cmet.2013.08.005.
    • (2013) Cell Metabolism , vol.18 , pp. 333-340
    • Gaich, G.1    Chien, J.Y.2    Fu, H.3    Glass, L.C.4    Deeg, M.A.5    Holland, W.L.6
  • 79
    • 84877260638 scopus 로고    scopus 로고
    • Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
    • Lin Z., Tian H., Lam K.S., Lin S., Hoo R.C., Konishi M., et al. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metabolism 2013, 17:779-789. 10.1016/j.cmet.2013.04.005.
    • (2013) Cell Metabolism , vol.17 , pp. 779-789
    • Lin, Z.1    Tian, H.2    Lam, K.S.3    Lin, S.4    Hoo, R.C.5    Konishi, M.6
  • 80
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
    • Dutchak P.A., Katafuchi T., Bookout A.L., Choi J.H., Yu R.T., Mangelsdorf D.J., et al. Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell 2012, 148:556-567. 10.1016/j.cell.2011.11.062.
    • (2012) Cell , vol.148 , pp. 556-567
    • Dutchak, P.A.1    Katafuchi, T.2    Bookout, A.L.3    Choi, J.H.4    Yu, R.T.5    Mangelsdorf, D.J.6
  • 81
    • 84883260199 scopus 로고    scopus 로고
    • A. Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
    • Adams A.C., Coskun T., Cheng C.C., Farrell O., Dubois L.S., Kharitonenkov S.L., A. Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones. Molecular Metabolism 2013, 2:205-214. 10.1016/j.molmet.2013.05.005.
    • (2013) Molecular Metabolism , vol.2 , pp. 205-214
    • Adams, A.C.1    Coskun, T.2    Cheng, C.C.3    Farrell, O.4    Dubois, L.S.5    Kharitonenkov, S.L.6
  • 82
    • 84863847308 scopus 로고    scopus 로고
    • Efficacy and tolerability of MK-0893, a glucagon receptor antagonist (GRA), in patients with type 2 diabetes (T2DM)
    • Engel S.S., Xu L., Andryuk P.J., Davies M.J., Amatruda J., Kaufman K., et al. Efficacy and tolerability of MK-0893, a glucagon receptor antagonist (GRA), in patients with type 2 diabetes (T2DM). Diabetes 2011, 60(Suppl. 1):A85. 10.2337/db11-1-378.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Engel, S.S.1    Xu, L.2    Andryuk, P.J.3    Davies, M.J.4    Amatruda, J.5    Kaufman, K.6
  • 84
    • 84868013714 scopus 로고    scopus 로고
    • Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling
    • Lockie S.H., Heppner K.M., Chaudhary N., Chabenne J.R., Morgan D.A., Veyrat-Durebex C., et al. Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes 2012, 61:2753-2762. 10.2337/db11-1556.
    • (2012) Diabetes , vol.61 , pp. 2753-2762
    • Lockie, S.H.1    Heppner, K.M.2    Chaudhary, N.3    Chabenne, J.R.4    Morgan, D.A.5    Veyrat-Durebex, C.6
  • 85
    • 53249142132 scopus 로고    scopus 로고
    • DURATION-1 Study Group. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study
    • Drucker D.J., Buse J.B., Taylor K., Kendall D.M., Trautmann M., Zhuang D., et al. DURATION-1 Study Group. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet 2008, 372:1240-1250. 10.1016/S0140-6736(08)61206-4.
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3    Kendall, D.M.4    Trautmann, M.5    Zhuang, D.6
  • 86
    • 0029903111 scopus 로고    scopus 로고
    • Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I
    • Orskov C., Poulsen S.S., Møller M., Holst J.J. Glucagon-like peptide I receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide I. Diabetes 1996, 45:832-835.
    • (1996) Diabetes , vol.45 , pp. 832-835
    • Orskov, C.1    Poulsen, S.S.2    Møller, M.3    Holst, J.J.4
  • 88
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff M., Matveyenko A.V., Gier B., Elashoff R., Butler P.C. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 2011, 141:150-156. 10.1053/j.gastro.2011.02.018.
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3    Elashoff, R.4    Butler, P.C.5
  • 89
    • 84879231610 scopus 로고    scopus 로고
    • A critical analysis of the clinical use of incretin-based therapies: the benefits by far outweigh the potential risks
    • Nauck M.A. A critical analysis of the clinical use of incretin-based therapies: the benefits by far outweigh the potential risks. Diabetes Care 2013, 36:2126-2132. 10.2337/dc12-2504.
    • (2013) Diabetes Care , vol.36 , pp. 2126-2132
    • Nauck, M.A.1
  • 90
    • 84878185729 scopus 로고    scopus 로고
    • A critical analysis of the clinical use of incretin-based therapies: are the GLP-1 therapies safe?
    • Butler P.C., Elashoff M., Elashoff R., Gale E.A. A critical analysis of the clinical use of incretin-based therapies: are the GLP-1 therapies safe?. Diabetes Care 2013, 36:2118-2125. 10.2337/dc12-2713.
    • (2013) Diabetes Care , vol.36 , pp. 2118-2125
    • Butler, P.C.1    Elashoff, M.2    Elashoff, R.3    Gale, E.A.4
  • 91
    • 0021894516 scopus 로고
    • Efficacy of pharmacologic glucagon in acute experimental pancreatitis
    • Eckhauser F.E., Knol J.A., Inman M.G., Strodel W.E. Efficacy of pharmacologic glucagon in acute experimental pancreatitis. Archives of Surgery 1985, 120:355-360.
    • (1985) Archives of Surgery , vol.120 , pp. 355-360
    • Eckhauser, F.E.1    Knol, J.A.2    Inman, M.G.3    Strodel, W.E.4
  • 92
    • 0021962116 scopus 로고
    • Studies on the effect of glucagon on human pancreatic secretion by analysis of endoscopically obtained pure pancreatic juice
    • Harada H., Kochi F., Hanafusa E., Kobayashi T., Oka H., Kimura I. Studies on the effect of glucagon on human pancreatic secretion by analysis of endoscopically obtained pure pancreatic juice. Gastroenterologia Japonica 1985, 20:28-36.
    • (1985) Gastroenterologia Japonica , vol.20 , pp. 28-36
    • Harada, H.1    Kochi, F.2    Hanafusa, E.3    Kobayashi, T.4    Oka, H.5    Kimura, I.6
  • 94
    • 84878352363 scopus 로고    scopus 로고
    • Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors
    • Butler A.E., Campbell-Thompson M., Gurlo T., Dawson D.W., Atkinson M., Butler P.C. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013, 62:2595-2604. 10.2337/db12-1686.
    • (2013) Diabetes , vol.62 , pp. 2595-2604
    • Butler, A.E.1    Campbell-Thompson, M.2    Gurlo, T.3    Dawson, D.W.4    Atkinson, M.5    Butler, P.C.6
  • 95
    • 84880091008 scopus 로고    scopus 로고
    • Incretin therapy and islet pathology: a time for caution
    • Kahn S.E. Incretin therapy and islet pathology: a time for caution. Diabetes 2013, 62:2178-2180. 10.2337/db13-0520.
    • (2013) Diabetes , vol.62 , pp. 2178-2180
    • Kahn, S.E.1
  • 96
    • 84891551684 scopus 로고    scopus 로고
    • Comment on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors
    • Heine R.J., Fu H., Kendall D.M., Moller D.E. Comment on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013, 62:e16-e17. 10.2337/db13-0690.
    • (2013) Diabetes , vol.62
    • Heine, R.J.1    Fu, H.2    Kendall, D.M.3    Moller, D.E.4
  • 97
    • 84891525097 scopus 로고    scopus 로고
    • Comment on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors
    • Engel S.S., Golm G.T., Lauring B. Comment on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013, 62:e18. 10.2337/db13-0525.
    • (2013) Diabetes , vol.62
    • Engel, S.S.1    Golm, G.T.2    Lauring, B.3
  • 98
    • 77950228684 scopus 로고    scopus 로고
    • Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
    • Bjerre Knudsen L., Madsen L.W., Andersen S., Almholt K., de Boer A.S., Drucker D.J., et al. Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. Endocrinology 2010, 151:1473-1486. 10.1210/en.2009-1272.
    • (2010) Endocrinology , vol.151 , pp. 1473-1486
    • Bjerre Knudsen, L.1    Madsen, L.W.2    Andersen, S.3    Almholt, K.4    de Boer, A.S.5    Drucker, D.J.6
  • 99
    • 79952284556 scopus 로고    scopus 로고
    • GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide
    • Hegedüs L., Moses A.C., Zdravkovic M., Le Thi T., Daniels G.H. GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide. Journal of Clinical Endocrinology and Metabolism 2011, 96:853-860.
    • (2011) Journal of Clinical Endocrinology and Metabolism , vol.96 , pp. 853-860
    • Hegedüs, L.1    Moses, A.C.2    Zdravkovic, M.3    Le Thi, T.4    Daniels, G.H.5
  • 101
    • 0029833629 scopus 로고    scopus 로고
    • Effects of glucagon and glucagon-like peptide-1-(7-36) amide on C cells from rat thyroid and medullary thyroid carcinoma CA-77 cell line
    • Crespel A., De Boisvilliers F., Gros L., Kervran A. Effects of glucagon and glucagon-like peptide-1-(7-36) amide on C cells from rat thyroid and medullary thyroid carcinoma CA-77 cell line. Endocrinology 1996, 137:3674-3680.
    • (1996) Endocrinology , vol.137 , pp. 3674-3680
    • Crespel, A.1    De Boisvilliers, F.2    Gros, L.3    Kervran, A.4
  • 105
    • 84885382735 scopus 로고    scopus 로고
    • Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo
    • Yabe D., Rokutan M., Miura Y., Komoto I., Usui R., Kuwata H., et al. Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo. Diabetes Research and Clinical Practice 2013, 102:e1-e4. 10.1016/j.diabres.2013.08.005.
    • (2013) Diabetes Research and Clinical Practice , vol.102
    • Yabe, D.1    Rokutan, M.2    Miura, Y.3    Komoto, I.4    Usui, R.5    Kuwata, H.6
  • 107
    • 0015935091 scopus 로고
    • The effect of epinephrine, glucagon, and the nutritional state on the oxidation of branched chain amino acids and pyruvate by isolated hearts and diaphragms of the rat
    • Buse M.G., Biggers J.F., Drier C., Buse J.F. The effect of epinephrine, glucagon, and the nutritional state on the oxidation of branched chain amino acids and pyruvate by isolated hearts and diaphragms of the rat. Journal of Biological Chemistry 1973, 248:697-706.
    • (1973) Journal of Biological Chemistry , vol.248 , pp. 697-706
    • Buse, M.G.1    Biggers, J.F.2    Drier, C.3    Buse, J.F.4
  • 110
    • 70350341465 scopus 로고    scopus 로고
    • Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: potential therapeutic benefits beyond glycaemic control?
    • Grieve D.J., Cassidy R.S., Green B.D. Emerging cardiovascular actions of the incretin hormone glucagon-like peptide-1: potential therapeutic benefits beyond glycaemic control?. British Journal of Pharmacology 2009, 157:1340-1351. 10.1111/j.1476-5381.2009.00376.x.
    • (2009) British Journal of Pharmacology , vol.157 , pp. 1340-1351
    • Grieve, D.J.1    Cassidy, R.S.2    Green, B.D.3
  • 111
    • 62449129181 scopus 로고    scopus 로고
    • LEAD-1 SU study group. Liraglutide, a once-daily human GLP-1 analog, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
    • Marre M., Shaw J., Brändle M., Bebakar W.M., Kamaruddin N.A., Strand J., et al. LEAD-1 SU study group. Liraglutide, a once-daily human GLP-1 analog, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabetic Medicine 2009, 26:268-278.
    • (2009) Diabetic Medicine , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brändle, M.3    Bebakar, W.M.4    Kamaruddin, N.A.5    Strand, J.6
  • 112
    • 62449169287 scopus 로고    scopus 로고
    • LEAD-2 Study Group. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study
    • Nauck M., Frid A., Hermansen K., Shah N.S., Tankova T., Mitha I.H., et al. LEAD-2 Study Group. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care 2009, 32:84-90.
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3    Shah, N.S.4    Tankova, T.5    Mitha, I.H.6
  • 113
    • 59449101432 scopus 로고    scopus 로고
    • LEAD-3 (Mono) Study Group. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A., Henry R., Ratner R., Garcia-Hernandez P.A., Rodriguez-Pattzi H., Olvera-Alvarez I., et al. LEAD-3 (Mono) Study Group. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009, 373:473-481.
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3    Garcia-Hernandez, P.A.4    Rodriguez-Pattzi, H.5    Olvera-Alvarez, I.6
  • 114
    • 67650066860 scopus 로고    scopus 로고
    • LEAD-4 Study Investigators. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • Zinman B., Gerich J., Buse J.B., Lewin A., Schwartz S., Raskin P., et al. LEAD-4 Study Investigators. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 2009, 32:1224-1230.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3    Lewin, A.4    Schwartz, S.5    Raskin, P.6
  • 115
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group. Liraglutide vs. insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial
    • Russell-Jones D., Vaag A., Schmitz O., Sethi B.K., Lalic N., Antic S., et al. Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group. Liraglutide vs. insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia 2009, 52:2046-2055.
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3    Sethi, B.K.4    Lalic, N.5    Antic, S.6
  • 116
    • 67649666737 scopus 로고    scopus 로고
    • LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse J.B., Rosenstock J., Sesti G., Schmidt W.E., Montanya E., Brett J.H., et al. LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009, 374:39-47.
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.E.4    Montanya, E.5    Brett, J.H.6
  • 117
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial
    • Pratley R.E., Nauck M., Bailey T., Montanya E., Cuddihy R., Filetti S., et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet 2010, 375:1447-1456.
    • (2010) Lancet , vol.375 , pp. 1447-1456
    • Pratley, R.E.1    Nauck, M.2    Bailey, T.3    Montanya, E.4    Cuddihy, R.5    Filetti, S.6
  • 118
    • 76949099016 scopus 로고    scopus 로고
    • Effect of exenatide on heart rate and blood pressure in subjects with type 2 diabetes mellitus: a double-blind, placebo-controlled, randomized pilot study
    • Gill A., Hoogwerf B.J., Burger J., Bruce S., Macconell L., Yan P., et al. Effect of exenatide on heart rate and blood pressure in subjects with type 2 diabetes mellitus: a double-blind, placebo-controlled, randomized pilot study. Cardiovascular Diabetology 2010, 9:6.
    • (2010) Cardiovascular Diabetology , vol.9 , pp. 6
    • Gill, A.1    Hoogwerf, B.J.2    Burger, J.3    Bruce, S.4    Macconell, L.5    Yan, P.6
  • 119
    • 76749161358 scopus 로고    scopus 로고
    • Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes
    • Okerson T., Yan P., Stonehouse A., Brodows R. Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes. American Journal of Hypertension 2010, 23:334-339.
    • (2010) American Journal of Hypertension , vol.23 , pp. 334-339
    • Okerson, T.1    Yan, P.2    Stonehouse, A.3    Brodows, R.4
  • 120
    • 79953035319 scopus 로고    scopus 로고
    • The effects of LY2189265, a long-acting glucagon-like peptide-1 analog, in a randomized, placebo-controlled, double-blind study of overweight/obese patients with type 2 diabetes: the EGO study
    • for the EGO Study Group
    • Umpierrez G.E., Blevins T., Rosenstock J., Cheng C., Anderson J.H., Bastyr E.J. The effects of LY2189265, a long-acting glucagon-like peptide-1 analog, in a randomized, placebo-controlled, double-blind study of overweight/obese patients with type 2 diabetes: the EGO study. Diabetes, Obesity and Metabolism 2011, 13:418-425. for the EGO Study Group.
    • (2011) Diabetes, Obesity and Metabolism , vol.13 , pp. 418-425
    • Umpierrez, G.E.1    Blevins, T.2    Rosenstock, J.3    Cheng, C.4    Anderson, J.H.5    Bastyr, E.J.6
  • 122
  • 123
    • 0034795019 scopus 로고    scopus 로고
    • Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant
    • Strazzullo P., Iacone R., Siani A., Barba G., Russo O., Russo P., et al. Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant. Journal of Molecular Medicine 2001, 79:574-580. 10.1007/s001090100257.
    • (2001) Journal of Molecular Medicine , vol.79 , pp. 574-580
    • Strazzullo, P.1    Iacone, R.2    Siani, A.3    Barba, G.4    Russo, O.5    Russo, P.6
  • 124
    • 84863843662 scopus 로고    scopus 로고
    • Inhibition of glucagon-induced hyperglycemia predicts glucose lowering efficacy antagonist, MK-0893, in type 2 diabetes (T2DM)
    • Ruddy M., Luncenford J., Li S., Cilissen C., Stoch A., Wagner J., et al. Inhibition of glucagon-induced hyperglycemia predicts glucose lowering efficacy antagonist, MK-0893, in type 2 diabetes (T2DM). Diabetes 2011, 60(Suppl. 1):A85. 10.2337/ db11-1-378.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Ruddy, M.1    Luncenford, J.2    Li, S.3    Cilissen, C.4    Stoch, A.5    Wagner, J.6
  • 125
    • 84871706890 scopus 로고    scopus 로고
    • Role of GLP-1 and DPP-4 in diabetic nephropathy and cardiovascular disease
    • Panchapakesan U., Mather A., Pollock C. Role of GLP-1 and DPP-4 in diabetic nephropathy and cardiovascular disease. Clinical Science 2013, 124:17-26. 10.1042/CS20120167.
    • (2013) Clinical Science , vol.124 , pp. 17-26
    • Panchapakesan, U.1    Mather, A.2    Pollock, C.3
  • 126
    • 84883765959 scopus 로고    scopus 로고
    • The SAVOR-TIMI 53 Steering Committee and Investigators: saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica B.M., Bhatt D.L., Braunwald E., Steg P.G., Davidson J., Hirshberg B. The SAVOR-TIMI 53 Steering Committee and Investigators: saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. New England Journal of Medicine 2013, 369:1317-1326. 10.1053/NEJMoa1307684.
    • (2013) New England Journal of Medicine , vol.369 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3    Steg, P.G.4    Davidson, J.5    Hirshberg, B.6
  • 127
    • 84897116954 scopus 로고    scopus 로고
    • Effect of GLP1R/GCGR dual agonist in monkeys
    • Lao J., Hansen B.C., DiMarchi R., Pocai A. Effect of GLP1R/GCGR dual agonist in monkeys. Diabetes 2013, 62(Suppl. 1):A257. 10.2337/db13-859-1394.
    • (2013) Diabetes , vol.62 , Issue.SUPPL. 1
    • Lao, J.1    Hansen, B.C.2    DiMarchi, R.3    Pocai, A.4
  • 128
    • 84888199705 scopus 로고    scopus 로고
    • Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery
    • 00187-2 (pii: S1471-4892)
    • Holst J.J. Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery. Current Opinion in Pharmacology 2013, 13:00187-2. (pii: S1471-4892). 10.1016/j.coph.2013.09.014.
    • (2013) Current Opinion in Pharmacology , vol.13
    • Holst, J.J.1
  • 129
    • 84860702051 scopus 로고    scopus 로고
    • Shedding pounds after going under the knife: metabolic insights from cutting the gut
    • Chandarana K., Batterham R.L. Shedding pounds after going under the knife: metabolic insights from cutting the gut. Nature Medicine 2012, 18:668-669. 10.1038/nm.2748.
    • (2012) Nature Medicine , vol.18 , pp. 668-669
    • Chandarana, K.1    Batterham, R.L.2
  • 130
    • 84555191794 scopus 로고    scopus 로고
    • Novel GLP-1 receptor agonists for diabetes
    • (Review)
    • Garber A.J. Novel GLP-1 receptor agonists for diabetes. Expert Opinion on Investigational Drugs 2012, 21:45-57. (Review). 10.1517/13543784.2012.638282.
    • (2012) Expert Opinion on Investigational Drugs , vol.21 , pp. 45-57
    • Garber, A.J.1
  • 131
    • 84883256420 scopus 로고    scopus 로고
    • Future directions for peptide therapeutics development
    • Kaspar A.A., Reichert J.M. Future directions for peptide therapeutics development. Drug Discovery Today 2013, 18:807-817. 10.1016/j.drudis.2013.05.011.
    • (2013) Drug Discovery Today , vol.18 , pp. 807-817
    • Kaspar, A.A.1    Reichert, J.M.2
  • 132
    • 57249103364 scopus 로고    scopus 로고
    • Intrapulmonary potential of polyethylene glycol-modified glucagon-like peptide-1s as a type 2 anti-diabetic agent
    • Lee K.C., Chae S.Y., Kim T.H., Lee S., Lee E.S., Youn Y.S. Intrapulmonary potential of polyethylene glycol-modified glucagon-like peptide-1s as a type 2 anti-diabetic agent. Regulatory Peptides 2009, 152:101-107. 10.1016/j.regpep.2008.09.008.
    • (2009) Regulatory Peptides , vol.152 , pp. 101-107
    • Lee, K.C.1    Chae, S.Y.2    Kim, T.H.3    Lee, S.4    Lee, E.S.5    Youn, Y.S.6
  • 133
    • 0036633358 scopus 로고    scopus 로고
    • New horizons - alternative routes for insulin therapy
    • Owens D.R. New horizons - alternative routes for insulin therapy. Nature Reviews. Drug Discovery 2002, 1:529-540. 10.1038/nrd836.
    • (2002) Nature Reviews. Drug Discovery , vol.1 , pp. 529-540
    • Owens, D.R.1
  • 134
    • 78650038239 scopus 로고    scopus 로고
    • Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets
    • Sloop K.W., Willard F.S., Brenner M.B., Ficorilli J., Valasek K., Showalter A.D., et al. Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes 2010, 59:3099-3107. 10.2337/db10-0689.
    • (2010) Diabetes , vol.59 , pp. 3099-3107
    • Sloop, K.W.1    Willard, F.S.2    Brenner, M.B.3    Ficorilli, J.4    Valasek, K.5    Showalter, A.D.6
  • 136
    • 77957890652 scopus 로고    scopus 로고
    • D-Ser2)Oxm(mPEG-PAL): a novel chemically modified analog of oxyntomodulin with antihyperglycaemic, insulinotropic and anorexigenic actions
    • Kerr B.D., Flatt P.R., Gault V.A. D-Ser2)Oxm(mPEG-PAL): a novel chemically modified analog of oxyntomodulin with antihyperglycaemic, insulinotropic and anorexigenic actions. Biochemical Pharmacology 2010, 80:1727-1735. 10.1016/j.bcp.2010.08.010.
    • (2010) Biochemical Pharmacology , vol.80 , pp. 1727-1735
    • Kerr, B.D.1    Flatt, P.R.2    Gault, V.A.3
  • 137
  • 138
    • 84877632331 scopus 로고    scopus 로고
    • A novel GIP-oxyntomodulin hybrid peptide acting through GIP, glucagon and GLP-1 receptors exhibits weight reducing and anti-diabetic properties
    • Bhat V.K., Kerr B.D., Flatt P.R., Gault V.A. A novel GIP-oxyntomodulin hybrid peptide acting through GIP, glucagon and GLP-1 receptors exhibits weight reducing and anti-diabetic properties. Biochemical Pharmacology 2013, 85:1655-1662. 10.1016/j.bcp.2013.03.009.
    • (2013) Biochemical Pharmacology , vol.85 , pp. 1655-1662
    • Bhat, V.K.1    Kerr, B.D.2    Flatt, P.R.3    Gault, V.A.4
  • 139
    • 84877763087 scopus 로고    scopus 로고
    • A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice
    • Bhat V.K., Kerr B.D., Vasu S., Flatt P.R., Gault V.A. A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice. Diabetologia 2013, 56:1417-1424. 10.1007/s00125-013-2892-2.
    • (2013) Diabetologia , vol.56 , pp. 1417-1424
    • Bhat, V.K.1    Kerr, B.D.2    Vasu, S.3    Flatt, P.R.4    Gault, V.A.5
  • 140
    • 84871353890 scopus 로고    scopus 로고
    • Receptor oligomerization in family B1 of G-protein-coupled receptors: focus on BRET investigations and the link between GPCR oligomerization and binding cooperativity
    • Roed S.N., Orgaard A., Jorgensen R., De Meyts P. Receptor oligomerization in family B1 of G-protein-coupled receptors: focus on BRET investigations and the link between GPCR oligomerization and binding cooperativity. Frontiers in Endocrinology 2012, 3:62. 10.3389/fendo.2012.00062.
    • (2012) Frontiers in Endocrinology , vol.3 , pp. 62
    • Roed, S.N.1    Orgaard, A.2    Jorgensen, R.3    De Meyts, P.4
  • 141
    • 84857432572 scopus 로고    scopus 로고
    • Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation
    • Schelshorn D., Joly F., Mutel S., Hampe C., Breton B., Mutel V., Lutjens R. Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation. Molecular Pharmacology 2012, 81:309-318. 10.1124/mol.111.074757.
    • (2012) Molecular Pharmacology , vol.81 , pp. 309-318
    • Schelshorn, D.1    Joly, F.2    Mutel, S.3    Hampe, C.4    Breton, B.5    Mutel, V.6    Lutjens, R.7
  • 143
    • 84891779790 scopus 로고    scopus 로고
    • Randomized trial of continuous subcutaneous delivery of exenatide by ITCA 650 versus twice-daily exenatide injections in metformin-treated type 2 diabetes
    • Henry R.R., Rosenstock J., Logan D.K., Alessi T.R., Luskey K., Baron M.A. Randomized trial of continuous subcutaneous delivery of exenatide by ITCA 650 versus twice-daily exenatide injections in metformin-treated type 2 diabetes. Diabetes Care 2013, 36:2559-2565. 10.2337/dc12-2410.
    • (2013) Diabetes Care , vol.36 , pp. 2559-2565
    • Henry, R.R.1    Rosenstock, J.2    Logan, D.K.3    Alessi, T.R.4    Luskey, K.5    Baron, M.A.6
  • 145
    • 84871617217 scopus 로고    scopus 로고
    • Oral delivery of therapeutic protein/peptide for diabetes--future perspectives
    • Rekha M.R., Sharma C.P. Oral delivery of therapeutic protein/peptide for diabetes--future perspectives. International Journal of Pharmaceutics 2013, 440:48-62. 10.1016/j.ijpharm.2012.03.056.
    • (2013) International Journal of Pharmaceutics , vol.440 , pp. 48-62
    • Rekha, M.R.1    Sharma, C.P.2
  • 146
    • 84862207266 scopus 로고    scopus 로고
    • Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
    • Astrup A., Carraro R., Finer N., Harper A., Kunesova M., Lean M.E., et al. Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide. International Journal of Obesity 2012, 36:843-854. 10.1038/ijo.2011.158.
    • (2012) International Journal of Obesity , vol.36 , pp. 843-854
    • Astrup, A.1    Carraro, R.2    Finer, N.3    Harper, A.4    Kunesova, M.5    Lean, M.E.6
  • 147
    • 80054690193 scopus 로고    scopus 로고
    • Four weeks of treatment with liraglutide reduces insulin dose without loss of glycemic control in type 1 diabetic patients with and without residual beta-cell function
    • Kielgast U., Krarup T., Holst J.J., Madsbad S. Four weeks of treatment with liraglutide reduces insulin dose without loss of glycemic control in type 1 diabetic patients with and without residual beta-cell function. Diabetes Care 2011, 34:1463-1468. 10.2337/dc11-0096.
    • (2011) Diabetes Care , vol.34 , pp. 1463-1468
    • Kielgast, U.1    Krarup, T.2    Holst, J.J.3    Madsbad, S.4
  • 148
    • 0023216411 scopus 로고
    • Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus
    • Amiel S.A., Tamborlane W.V., Simonson D.C., Sherwin R.S. Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus. New England Journal of Medicine 1987, 316:1376-1383. 10.1056/nejm198705283162205.
    • (1987) New England Journal of Medicine , vol.316 , pp. 1376-1383
    • Amiel, S.A.1    Tamborlane, W.V.2    Simonson, D.C.3    Sherwin, R.S.4
  • 149
    • 57249098943 scopus 로고    scopus 로고
    • The barrier of hypoglycemia in diabetes
    • Cryer P.E. The barrier of hypoglycemia in diabetes. Diabetes 2008, 57:3169-3176. 10.2337/db08-1084.
    • (2008) Diabetes , vol.57 , pp. 3169-3176
    • Cryer, P.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.