메뉴 건너뛰기




Volumn 42, Issue 2, 2014, Pages 593-599

Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

Author keywords

Memory; Neurodegeneration; Oxidative stress; Synaptic plasticity

Indexed keywords

EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GROWTH FACTOR; INCRETIN; INSULIN; LIRAGLUTIDE; SIGNAL PEPTIDE;

EID: 84896920228     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20140016     Document Type: Review
Times cited : (85)

References (67)
  • 1
    • 0028344810 scopus 로고
    • Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease
    • DOI 10.1007/s004010050096
    • Moroo, I., Yamada, T., Makino, H., Tooyama, I., McGeer, P.L., McGeer, E.G. and Hirayama, K. (1994) Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease. Acta Neuropathol. 87, 343-348 (Pubitemid 24091615)
    • (1994) Acta Neuropathologica , vol.87 , Issue.4 , pp. 343-348
    • Moroo, I.1    Yamada, T.2    Makino, H.3    Tooyama, I.4    McGreer, P.L.5    McGeer, E.G.6    Hirayama, K.7
  • 2
    • 84864855869 scopus 로고    scopus 로고
    • Parkinson's disease, insulin resistance and novel agents of neuroprotection
    • Aviles-Olmos, I., Limousin, P., Lees, A. and Foltynie, T. (2013) Parkinson's disease, insulin resistance and novel agents of neuroprotection. Brain 136, 374-384
    • (2013) Brain , vol.136 , pp. 374-384
    • Aviles-Olmos, I.1    Limousin, P.2    Lees, A.3    Foltynie, T.4
  • 3
    • 27844578300 scopus 로고    scopus 로고
    • Insulin and cognitive function in humans: Experimental data and therapeutic considerations
    • Strachan, M.W. (2005) Insulin and cognitive function in humans: experimental data and therapeutic considerations. Biochem. Soc. Trans. 33, 1037-1040
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 1037-1040
    • Strachan, M.W.1
  • 4
    • 33644585223 scopus 로고    scopus 로고
    • Therapy insight: Type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease
    • Haan, M.N. (2006) Therapy insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease. Nat. Clin. Pract. Neurol. 2, 159-166
    • (2006) Nat. Clin. Pract. Neurol. , vol.2 , pp. 159-166
    • Haan, M.N.1
  • 5
    • 5344256250 scopus 로고    scopus 로고
    • Hyperinsulinemia and risk of Alzheimer disease
    • Luchsinger, J.A., Tang, M.X., Shea, S. and Mayeux, R. (2004) Hyperinsulinemia and risk of Alzheimer disease. Neurology 63, 1187-1192 (Pubitemid 39350015)
    • (2004) Neurology , vol.63 , Issue.7 , pp. 1187-1192
    • Luchsinger, J.A.1    Tang, M.-X.2    Shea, S.3    Mayeux, R.4
  • 6
    • 3543067962 scopus 로고    scopus 로고
    • Neurodegenerative disorders associated with diabetes mellitus
    • Ristow, M. (2004) Neurodegenerative disorders associated with diabetes mellitus. J. Mol. Med. 82, 510-529
    • (2004) J. Mol. Med. , vol.82 , pp. 510-529
    • Ristow, M.1
  • 9
    • 0842309993 scopus 로고    scopus 로고
    • Increased Risk of Type 2 Diabetes in Alzheimer Disease
    • DOI 10.2337/diabetes.53.2.474
    • Janson, J., Laedtke, T., Parisi, J.E., O'Brien, P., Petersen, R.C. and Butler, P.C. (2004) Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 53, 474-481 (Pubitemid 38174565)
    • (2004) Diabetes , vol.53 , Issue.2 , pp. 474-481
    • Janson, J.1    Laedtke, T.2    Parisi, J.E.3    O'Brien, P.4    Petersen, R.C.5    Butler, P.C.6
  • 10
  • 14
    • 71349085957 scopus 로고    scopus 로고
    • Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
    • Moloney, A.M., Griffin, R.J., Timmons, S., O'Connor, R., Ravid, R. and O'Neill, C. (2010) Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol. Aging 31, 224-243
    • (2010) Neurobiol. Aging , vol.31 , pp. 224-243
    • Moloney, A.M.1    Griffin, R.J.2    Timmons, S.3    O'Connor, R.4    Ravid, R.5    O'Neill, C.6
  • 15
    • 84859718265 scopus 로고    scopus 로고
    • Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
    • Talbot, K., Wang, H.Y., Kazi, H., Han, L.Y., Bakshi, K.P., Stucky, A., Fuino, R.L., Kawaguchi, K.R., Samoyedny, A.J., Wilson, R.S. et al. (2012) Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J. Clin. Invest. 122, 1316-1338
    • (2012) J. Clin. Invest. , vol.122 , pp. 1316-1338
    • Talbot, K.1    Wang, H.Y.2    Kazi, H.3    Han, L.Y.4    Bakshi, K.P.5    Stucky, A.6    Fuino, R.L.7    Kawaguchi, K.R.8    Samoyedny, A.J.9    Wilson, R.S.10
  • 16
    • 54549097933 scopus 로고    scopus 로고
    • Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease
    • Morris, J.K., Zhang, H., Gupte, A.A., Bomhoff, G.L., Stanford, J.A. and Geiger, P.C. (2008) Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease. Brain Res. 1240, 185-195
    • (2008) Brain Res. , vol.1240 , pp. 185-195
    • Morris, J.K.1    Zhang, H.2    Gupte, A.A.3    Bomhoff, G.L.4    Stanford, J.A.5    Geiger, P.C.6
  • 18
    • 77956134398 scopus 로고    scopus 로고
    • Four weeks administration of liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance
    • Porter, D.W., Kerr, B.D., Flatt, P.R., Hölscher, C. and Gault, V.A. (2010) Four weeks administration of liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance. Diabetes Obes. Metab. 12, 891-899
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 891-899
    • Porter, D.W.1    Kerr, B.D.2    Flatt, P.R.3    Hölscher, C.4    Gault, V.A.5
  • 20
    • 6344250713 scopus 로고    scopus 로고
    • Insulin and the CNS: Effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans
    • DOI 10.1016/j.physbeh.2004.07.022, PII S0031938404003488
    • Stockhorst, U., de Fries, D., Steingrueber, H.J. and Scherbaum, W.A. (2004) Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. Physiol. Behav. 83, 47-54 (Pubitemid 39387693)
    • (2004) Physiology and Behavior , vol.83 , Issue.1 SPEC. ISS. , pp. 47-54
    • Stockhorst, U.1    De Fries, D.2    Steingrueber, H.-J.3    Scherbaum, W.A.4
  • 21
    • 1842785179 scopus 로고    scopus 로고
    • Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
    • Hoyer, S. (2004) Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. Eur. J. Pharmacol. 490, 115-125
    • (2004) Eur. J. Pharmacol. , vol.490 , pp. 115-125
    • Hoyer, S.1
  • 22
    • 1842684434 scopus 로고    scopus 로고
    • Insulin-like growth factor-I, cognition and brain aging
    • van Dam, P. and Aleman, A. (2004) Insulin-like growth factor-I, cognition and brain aging. Eur. J. Pharmacol. 490, 87-95
    • (2004) Eur. J. Pharmacol. , vol.490 , pp. 87-95
    • Van Dam, P.1    Aleman, A.2
  • 24
    • 1842734649 scopus 로고    scopus 로고
    • Modulation of memory by insulin and glucose: Neuropsychological observations in Alzheimer's disease
    • DOI 10.1016/j.ejphar.2004.02.048, PII S0014299904002055
    • Watson, G.S. and Craft, S. (2004) Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease. Eur. J. Pharmacol. 490, 97-113 (Pubitemid 38482164)
    • (2004) European Journal of Pharmacology , vol.490 , Issue.1-3 , pp. 97-113
    • Watson, G.S.1    Craft, S.2
  • 25
    • 1842633872 scopus 로고    scopus 로고
    • Insulin and the insulin receptor in experimental models of learning and memory
    • DOI 10.1016/j.ejphar.2004.02.045, PII S001429990400202X
    • Zhao, W.Q., Chen, H., Quon, M.J. and Alkon, D.L.W. (2004) Insulin and the insulin receptor in experimental models of learning and memory. Eur. J. Pharmacol. 490, 71-81 (Pubitemid 38482161)
    • (2004) European Journal of Pharmacology , vol.490 , Issue.1-3 , pp. 71-81
    • Zhao, W.-Q.1    Chen, H.2    Quon, M.J.3    Alkon, D.L.4
  • 29
    • 34147173277 scopus 로고    scopus 로고
    • Insulin resistance and Alzheimer's disease pathogenesis: Potential mechanisms and implications for treatment
    • Craft, S. (2007) Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Curr. Alzheimer Res. 4, 147-152
    • (2007) Curr. Alzheimer Res. , vol.4 , pp. 147-152
    • Craft, S.1
  • 32
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • DOI 10.1016/S0140-6736(06)69705-5, PII S0140673606697055
    • Drucker, D.J. and Nauck, M.A. (2006) The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368, 1696-1705 (Pubitemid 46048557)
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 33
    • 2642519637 scopus 로고    scopus 로고
    • Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors
    • Holst, J.J. (2004) Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors. Expert Opin. Emerg. Drugs 9, 155-166
    • (2004) Expert Opin. Emerg. Drugs , vol.9 , pp. 155-166
    • Holst, J.J.1
  • 34
    • 84878808238 scopus 로고    scopus 로고
    • Pharmacology, physiology, and mechanisms of incretin hormone action
    • Campbell, J.E. and Drucker, D.J. (2013) Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab. 17, 819-837
    • (2013) Cell Metab. , vol.17 , pp. 819-837
    • Campbell, J.E.1    Drucker, D.J.2
  • 35
    • 79953040963 scopus 로고    scopus 로고
    • An overview of once-weekly glucagon-like peptide-1 receptor agonists: Available efficacy and safety data and perspectives for the future
    • Madsbad, S., Kielgast, U., Asmar, M., Deacon, C.F., Torekov, S.S. and Holst, J.J. (2011) An overview of once-weekly glucagon-like peptide-1 receptor agonists: available efficacy and safety data and perspectives for the future. Diabetes Obes. Metab. 13, 394-407
    • (2011) Diabetes Obes. Metab. , vol.13 , pp. 394-407
    • Madsbad, S.1    Kielgast, U.2    Asmar, M.3    Deacon, C.F.4    Torekov, S.S.5    Holst, J.J.6
  • 36
    • 84878869094 scopus 로고    scopus 로고
    • Lixisenatide: First global approval
    • Elkinson, S. and Keating, G.M. (2013) Lixisenatide: first global approval. Drugs 73, 383-391
    • (2013) Drugs , vol.73 , pp. 383-391
    • Elkinson, S.1    Keating, G.M.2
  • 38
    • 33846501672 scopus 로고    scopus 로고
    • Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy
    • DOI 10.1016/j.expneurol.2006.09.028, PII S0014488606005474
    • Perry, T., Holloway, H.W., Weerasuriya, A., Mouton, P.R., Duffy, K., Mattison, J.A. and Greig, N.H. (2007) Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. Exp. Neurol. 203, 293-301 (Pubitemid 46157226)
    • (2007) Experimental Neurology , vol.203 , Issue.2 , pp. 293-301
    • Perry, T.1    Holloway, H.W.2    Weerasuriya, A.3    Mouton, P.R.4    Duffy, K.5    Mattison, J.A.6    Greig, N.H.7
  • 39
    • 69549128161 scopus 로고    scopus 로고
    • Receptors for the insulin-like peptide GLP-1 are expressed on neurons in the CNS
    • Hamilton, A. and Hölscher, C. (2009) Receptors for the insulin-like peptide GLP-1 are expressed on neurons in the CNS. NeuroReport 20, 1161-1166
    • (2009) NeuroReport , vol.20 , pp. 1161-1166
    • Hamilton, A.1    Hölscher, C.2
  • 41
    • 84897003731 scopus 로고    scopus 로고
    • Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress
    • Sharma, M., Jalewa, J. and Hölscher, C. (2014) Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress. J. Neurochem. 128, 459-471
    • (2014) J. Neurochem. , vol.128 , pp. 459-471
    • Sharma, M.1    Jalewa, J.2    Hölscher, C.3
  • 42
    • 44149122563 scopus 로고    scopus 로고
    • GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by β-amyloid
    • Gault, V. and Hölscher, C. (2008) GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by β-amyloid. Eur. J. Pharmacol. 587, 112-117
    • (2008) Eur. J. Pharmacol. , vol.587 , pp. 112-117
    • Gault, V.1    Hölscher, C.2
  • 43
    • 77649187436 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease
    • McClean, P.L., Gault, V.A., Harriott, P. and Hölscher, C. (2010) Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease. Eur. J. Pharmacol. 630, 158-162
    • (2010) Eur. J. Pharmacol. , vol.630 , pp. 158-162
    • McClean, P.L.1    Gault, V.A.2    Harriott, P.3    Hölscher, C.4
  • 44
    • 0037349072 scopus 로고    scopus 로고
    • Entry of exendin-4 into brain is rapid but may be limited at high doses
    • Kastin, A.J. and Akerstrom, V. (2003) Entry of exendin-4 into brain is rapid but may be limited at high doses. Int. J. Obes. Relat. Metab. Disord. 27, 313-318
    • (2003) Int. J. Obes. Relat. Metab. Disord. , vol.27 , pp. 313-318
    • Kastin, A.J.1    Akerstrom, V.2
  • 45
    • 0036198285 scopus 로고    scopus 로고
    • Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
    • Kastin, A.J., Akerstrom, V. and Pan, W. (2002) Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier. J. Mol. Neurosci. 18, 7-14 (Pubitemid 34252619)
    • (2002) Journal of Molecular Neuroscience , vol.18 , Issue.1-2 , pp. 7-14
    • Kastin, A.J.1    Akerstrom, V.2    Pan, W.3
  • 47
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    • McClean, P., Parthsarathy, V., Faivre, E. and Hölscher, C. (2011) The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J. Neurosci. 31, 6587-6594
    • (2011) J. Neurosci. , vol.31 , pp. 6587-6594
    • McClean, P.1    Parthsarathy, V.2    Faivre, E.3    Hölscher, C.4
  • 48
    • 84858713174 scopus 로고    scopus 로고
    • Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis
    • Hunter, K. and Hölscher, C. (2012) Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neurosci. 13, 33
    • (2012) BMC Neurosci. , vol.13 , pp. 33
    • Hunter, K.1    Hölscher, C.2
  • 49
    • 84886592674 scopus 로고    scopus 로고
    • Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease
    • McClean, P.L. and Hölscher, C. (2014) Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease. Neuropharmacology 76, 57-67
    • (2014) Neuropharmacology , vol.76 , pp. 57-67
    • McClean, P.L.1    Hölscher, C.2
  • 50
    • 79960881826 scopus 로고    scopus 로고
    • Diabetes as a risk factor for Alzheimer's disease: Insulin signalling impairment in the brain as an alternative model of Alzheimer's disease
    • Hölscher, C. (2011) Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease. Biochem. Soc. Trans. 39, 891-897
    • (2011) Biochem. Soc. Trans. , vol.39 , pp. 891-897
    • Hölscher, C.1
  • 51
    • 82755176046 scopus 로고    scopus 로고
    • Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
    • Gengler, S., McClean, P., McCurtin, R., Gault, V. and Hölscher, C. (2012) Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol. Aging 33, 265-276
    • (2012) Neurobiol. Aging , vol.33 , pp. 265-276
    • Gengler, S.1    McClean, P.2    McCurtin, R.3    Gault, V.4    Hölscher, C.5
  • 52
    • 77950352189 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation reduces amyloid-β peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease
    • Li, Y., Duffy, K., Ottinger, M., Ray, B., Bailey, J., Holloway, H., Tweedie, D., Perry, T., Mattson, M., Kapogiannis, D. et al. (2010) GLP-1 receptor stimulation reduces amyloid-β peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J. Alzheimer's Dis. 19, 1205-1219
    • (2010) J. Alzheimer's Dis. , vol.19 , pp. 1205-1219
    • Li, Y.1    Duffy, K.2    Ottinger, M.3    Ray, B.4    Bailey, J.5    Holloway, H.6    Tweedie, D.7    Perry, T.8    Mattson, M.9    Kapogiannis, D.10
  • 53
    • 84869090452 scopus 로고    scopus 로고
    • Liraglutide protects against β-amyloid induced impairment of spatial learning and memory in rats
    • Han, W.-N., Hölscher, C., Yuan, L., Yang, W., Wang, X.-h., Wu, M.-N. and Qi, J.-S. (2013) Liraglutide protects against β-amyloid induced impairment of spatial learning and memory in rats. Neurobiol. Aging 32, 576-588
    • (2013) Neurobiol. Aging , vol.32 , pp. 576-588
    • Han, W.-N.1    Hölscher, C.2    Yuan, L.3    Yang, W.4    Wang, X.-H.5    Wu, M.-N.6    Qi, J.-S.7
  • 54
    • 50649110233 scopus 로고    scopus 로고
    • Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes
    • Courrèges, J.P., Vilsboll, T., Zdravkovic, M., Le-Thi, T., Krarup, T., Schmitz, O., Verhoeven, R., Bugáñová, I. and Madsbad, S. (2008) Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes. Diabet. Med. 25, 1129-1131
    • (2008) Diabet. Med. , vol.25 , pp. 1129-1131
    • Courrèges, J.P.1    Vilsboll, T.2    Zdravkovic, M.3    Le-Thi, T.4    Krarup, T.5    Schmitz, O.6    Verhoeven, R.7    Bugáñová, I.8    Madsbad, S.9
  • 55
    • 0038248960 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 decreases endogenous amyloid-β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron
    • DOI 10.1002/jnr.10611
    • Perry, T., Lahiri, D.K., Sambamurti, K., Chen, D., Mattson, M.P., Egan, J.M. and Greig, N.H. (2003) Glucagon-like peptide-1 decreases endogenous amyloid-β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron. J. Neurosci. Res. 72, 603-612 (Pubitemid 36578646)
    • (2003) Journal of Neuroscience Research , vol.72 , Issue.5 , pp. 603-612
    • Perry, T.1    Lahiri, D.K.2    Sambamurti, K.3    Chen, D.4    Mattson, M.P.5    Egan, J.M.6    Greig, N.H.7
  • 56
    • 22144491473 scopus 로고    scopus 로고
    • Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer's disease
    • DOI 10.2174/1567205054367892
    • Perry, T. and Greig, N.H. (2005) Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer's disease. Curr. Alzheimer Res. 2, 377-385 (Pubitemid 40980196)
    • (2005) Current Alzheimer Research , vol.2 , Issue.3 , pp. 377-385
    • Perry, T.1    Greig, N.H.2
  • 57
    • 78651084780 scopus 로고    scopus 로고
    • Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice
    • Porter, D.W., Irwin, N., Flatt, P.R., Hölscher, C. and Gault, V.A. (2010) Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice. Eur. J. Pharmacol. 650, 688-693
    • (2010) Eur. J. Pharmacol. , vol.650 , pp. 688-693
    • Porter, D.W.1    Irwin, N.2    Flatt, P.R.3    Hölscher, C.4    Gault, V.A.5
  • 58
    • 79751479118 scopus 로고    scopus 로고
    • Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain
    • Hamilton, A., Patterson, S., Porter, D., Gault, V.A. and Hölscher, C. (2011) Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. J. Neurosci. Res. 89, 481-489
    • (2011) J. Neurosci. Res. , vol.89 , pp. 481-489
    • Hamilton, A.1    Patterson, S.2    Porter, D.3    Gault, V.A.4    Hölscher, C.5
  • 60
    • 45549108268 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease
    • Harkavyi, A., Abuirmeileh, A., Lever, R., Kingsbury, A.E., Biggs, C.S. and Whitton, P.S. (2008) Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease. J. Neuroinflammation 5, 19
    • (2008) J. Neuroinflammation , vol.5 , pp. 19
    • Harkavyi, A.1    Abuirmeileh, A.2    Lever, R.3    Kingsbury, A.E.4    Biggs, C.S.5    Whitton, P.S.6
  • 61
    • 0037435524 scopus 로고    scopus 로고
    • The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism
    • Pressley, J.C., Louis, E.D., Tang, M.X., Cote, L., Cohen, P.D., Glied, S. and Mayeux, R. (2003) The impact of comorbid disease and injuries on resource use and expenditures in parkinsonism. Neurology 60, 87-93 (Pubitemid 36070650)
    • (2003) Neurology , vol.60 , Issue.1 , pp. 87-93
    • Pressley, J.C.1    Louis, E.D.2    Tang, M.-X.3    Cote, L.4    Cohen, P.D.5    Glied, S.6    Mayeux, R.7
  • 63
    • 34548499151 scopus 로고    scopus 로고
    • Exercise builds brain health: Key roles of growth factor cascades and inflammation
    • DOI 10.1016/j.tins.2007.06.011, PII S0166223607001786
    • Cotman, C.W., Berchtold, N.C. and Christie, L.A. (2007) Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends Neurosci. 30, 464-472 (Pubitemid 47374831)
    • (2007) Trends in Neurosciences , vol.30 , Issue.9 , pp. 464-472
    • Cotman, C.W.1    Berchtold, N.C.2    Christie, L.-A.3
  • 64
    • 20444453676 scopus 로고    scopus 로고
    • Hope for AD with NGF gene-therapy trial
    • Bradbury, J. (2005) Hope for AD with NGF gene-therapy trial. Lancet Neurol. 4, 335
    • (2005) Lancet Neurol. , vol.4 , pp. 335
    • Bradbury, J.1
  • 66
    • 65949122960 scopus 로고    scopus 로고
    • Ex vivo gene therapy using intravitreal injection of GDNF-secreting mouse embryonic stem cells in a rat model of retinal degeneration
    • Gregory-Evans, K., Chang, F., Hodges, M.D. and Gregory-Evans, C.Y. (2009) Ex vivo gene therapy using intravitreal injection of GDNF-secreting mouse embryonic stem cells in a rat model of retinal degeneration. Mol. Vis. 15, 962-973
    • (2009) Mol. Vis. , vol.15 , pp. 962-973
    • Gregory-Evans, K.1    Chang, F.2    Hodges, M.D.3    Gregory-Evans, C.Y.4
  • 67
    • 84865849218 scopus 로고    scopus 로고
    • Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection
    • Hölscher, C. (2012) Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection. CNS Drugs 26, 871-882
    • (2012) CNS Drugs , vol.26 , pp. 871-882
    • Hölscher, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.