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Volumn 45, Issue 7, 2014, Pages 547-552

DPP-4 Inhibitor and PPARγ Agonist Restore the Loss of CA1 Dendritic Spines in Obese Insulin-resistant Rats

Author keywords

Dendritic spines; High fat diet; Insulin resistance; Pioglitazone; Vildagliptin

Indexed keywords

CHOLESTEROL; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCOSE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; VILDAGLIPTIN; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ADAMANTANE; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; INSULIN RECEPTOR; NEUROPROTECTIVE AGENT; NITRILE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PYRROLIDINE DERIVATIVE;

EID: 84915816950     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2014.09.002     Document Type: Article
Times cited : (34)

References (54)
  • 1
    • 34548241662 scopus 로고    scopus 로고
    • Molecular connexions between dementia and diabetes
    • Cole A.R., Astell A., Green C., et al. Molecular connexions between dementia and diabetes. Neurosci Biobehav Rev 2007, 31:1046-1063.
    • (2007) Neurosci Biobehav Rev , vol.31 , pp. 1046-1063
    • Cole, A.R.1    Astell, A.2    Green, C.3
  • 2
    • 84455185141 scopus 로고    scopus 로고
    • PPARgamma agonist improves neuronal insulin receptor function in hippocampus and brain mitochondria function in rats with insulin resistance induced by long term high-fat diets
    • Pipatpiboon N., Pratchayasakul W., Chattipakorn N., et al. PPARgamma agonist improves neuronal insulin receptor function in hippocampus and brain mitochondria function in rats with insulin resistance induced by long term high-fat diets. Endocrinology 2012, 153:329-338.
    • (2012) Endocrinology , vol.153 , pp. 329-338
    • Pipatpiboon, N.1    Pratchayasakul, W.2    Chattipakorn, N.3
  • 3
    • 79952698366 scopus 로고    scopus 로고
    • Effects of high-fat diet on insulin receptor function in rat hippocampus and the level of neuronal corticosterone
    • Pratchayasakul W., Kerdphoo S., Petsophonsakul P., et al. Effects of high-fat diet on insulin receptor function in rat hippocampus and the level of neuronal corticosterone. Life Sci 2011, 88:619-627.
    • (2011) Life Sci , vol.88 , pp. 619-627
    • Pratchayasakul, W.1    Kerdphoo, S.2    Petsophonsakul, P.3
  • 4
    • 84866365752 scopus 로고    scopus 로고
    • Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats
    • Pintana H., Apaijai N., Pratchayasakul W., et al. Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats. Life Sci 2012, 91:409-414.
    • (2012) Life Sci , vol.91 , pp. 409-414
    • Pintana, H.1    Apaijai, N.2    Pratchayasakul, W.3
  • 5
    • 84871921455 scopus 로고    scopus 로고
    • Hippocampal synaptic plasticity restoration and anti-apoptotic effect underlie berberine improvement of learning and memory in streptozotocin-diabetic rats
    • Kalalian-Moghaddam H., Baluchnejadmojarad T., Roghani M., et al. Hippocampal synaptic plasticity restoration and anti-apoptotic effect underlie berberine improvement of learning and memory in streptozotocin-diabetic rats. Eur J Pharmacol 2012, 698:259-266.
    • (2012) Eur J Pharmacol , vol.698 , pp. 259-266
    • Kalalian-Moghaddam, H.1    Baluchnejadmojarad, T.2    Roghani, M.3
  • 6
    • 84898044778 scopus 로고    scopus 로고
    • Effect of lead exprosure on synaptic structural plasticity in the hippocampus of postnatal Wistar rat
    • Chen Y., Yu D., Wei Q., et al. Wei Sheng Yan Jiu 2012, 41:394-398.
    • (2012) Wei Sheng Yan Jiu , vol.41 , pp. 394-398
    • Chen, Y.1    Yu, D.2    Wei, Q.3
  • 7
    • 36348975910 scopus 로고    scopus 로고
    • Dendritic spine plasticity: looking beyond development
    • Harms K.J., Dunaevsky A. Dendritic spine plasticity: looking beyond development. Brain Res 2007, 1184:65-71.
    • (2007) Brain Res , vol.1184 , pp. 65-71
    • Harms, K.J.1    Dunaevsky, A.2
  • 8
    • 77955604556 scopus 로고    scopus 로고
    • Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling
    • Chen Y., Rex C.S., Rice C.J., et al. Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling. Proc Natl Acad Sci USA 2010, 107:13123-13128.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 13123-13128
    • Chen, Y.1    Rex, C.S.2    Rice, C.J.3
  • 9
    • 10044236688 scopus 로고    scopus 로고
    • ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory
    • Grove M., Demyanenko G., Echarri A., et al. ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. Mol Cell Biol 2004, 24:10905-10922.
    • (2004) Mol Cell Biol , vol.24 , pp. 10905-10922
    • Grove, M.1    Demyanenko, G.2    Echarri, A.3
  • 10
    • 84859712559 scopus 로고    scopus 로고
    • Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease
    • Ricobaraza A., Cuadrado-Tejedor M., Marco S., et al. Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease. Hippocampus 2012, 22:1040-1050.
    • (2012) Hippocampus , vol.22 , pp. 1040-1050
    • Ricobaraza, A.1    Cuadrado-Tejedor, M.2    Marco, S.3
  • 11
    • 55549139200 scopus 로고    scopus 로고
    • Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats
    • Stranahan A.M., Norman E.D., Lee K., et al. Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 2008, 18:1085-1088.
    • (2008) Hippocampus , vol.18 , pp. 1085-1088
    • Stranahan, A.M.1    Norman, E.D.2    Lee, K.3
  • 12
    • 76749116176 scopus 로고    scopus 로고
    • Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice
    • D'Amico M., Di Filippo C., Marfella R., et al. Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice. Exp Gerontol 2010, 45:202-207.
    • (2010) Exp Gerontol , vol.45 , pp. 202-207
    • D'Amico, M.1    Di Filippo, C.2    Marfella, R.3
  • 13
    • 84861052705 scopus 로고    scopus 로고
    • Improvement in long term and visuo-spatial memory following chronic pioglitazone in mouse model of Alzheimer's disease
    • Gupta R., Gupta L.K. Improvement in long term and visuo-spatial memory following chronic pioglitazone in mouse model of Alzheimer's disease. Pharmacol Biochem Behav 2012, 102:184-190.
    • (2012) Pharmacol Biochem Behav , vol.102 , pp. 184-190
    • Gupta, R.1    Gupta, L.K.2
  • 14
    • 84864249514 scopus 로고    scopus 로고
    • Mechanisms underlying the rapid peroxisome proliferator-activated receptor-gamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease
    • Mandrekar-Colucci S., Karlo J.C., Landreth G.E. Mechanisms underlying the rapid peroxisome proliferator-activated receptor-gamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J Neurosci 2012, 32:10117-10128.
    • (2012) J Neurosci , vol.32 , pp. 10117-10128
    • Mandrekar-Colucci, S.1    Karlo, J.C.2    Landreth, G.E.3
  • 15
    • 13644271368 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling
    • Inestrosa N.C., Godoy J.A., Quintanilla R.A., et al. Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling. Exp Cell Res 2005, 304:91-104.
    • (2005) Exp Cell Res , vol.304 , pp. 91-104
    • Inestrosa, N.C.1    Godoy, J.A.2    Quintanilla, R.A.3
  • 16
    • 84864753094 scopus 로고    scopus 로고
    • PPARgamma agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus
    • Jiang L.Y., Tang S.S., Wang X.Y., et al. PPARgamma agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus. CNS Neurosci Ther 2012, 18:659-666.
    • (2012) CNS Neurosci Ther , vol.18 , pp. 659-666
    • Jiang, L.Y.1    Tang, S.S.2    Wang, X.Y.3
  • 17
    • 84856974594 scopus 로고    scopus 로고
    • Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats
    • 835.e13-835.e30
    • Wang B.W., Hok V., Della-Chiesa A., et al. Rosiglitazone enhances learning, place cell activity, and synaptic plasticity in middle-aged rats. Neurobiol Aging 2012, 33:835.e13-835.e30.
    • (2012) Neurobiol Aging , vol.33
    • Wang, B.W.1    Hok, V.2    Della-Chiesa, A.3
  • 18
    • 81355131875 scopus 로고    scopus 로고
    • Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP
    • Cowley T.R., O'Sullivan J., Blau C., et al. Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP. Neurobiol Aging 2012, 33:162-175.
    • (2012) Neurobiol Aging , vol.33 , pp. 162-175
    • Cowley, T.R.1    O'Sullivan, J.2    Blau, C.3
  • 19
    • 84874525661 scopus 로고    scopus 로고
    • DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption
    • Pipatpiboon N., Pintana H., Pratchayasakul W., et al. DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption. Eur J Neurosci 2013, 37:839-849.
    • (2013) Eur J Neurosci , vol.37 , pp. 839-849
    • Pipatpiboon, N.1    Pintana, H.2    Pratchayasakul, W.3
  • 20
    • 79957909052 scopus 로고    scopus 로고
    • Effect of pioglitazone on altered expression of Abeta metabolism-associated molecules in the brain of fructose-drinking rats, a rodent model of insulin resistance
    • Luo D., Hou X., Hou L., et al. Effect of pioglitazone on altered expression of Abeta metabolism-associated molecules in the brain of fructose-drinking rats, a rodent model of insulin resistance. Eur J Pharmacol 2011, 664:14-19.
    • (2011) Eur J Pharmacol , vol.664 , pp. 14-19
    • Luo, D.1    Hou, X.2    Hou, L.3
  • 21
    • 77954086355 scopus 로고    scopus 로고
    • Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats
    • Baraka A., El Ghotny S. Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats. Eur J Pharmacol 2010, 641:123-127.
    • (2010) Eur J Pharmacol , vol.641 , pp. 123-127
    • Baraka, A.1    El Ghotny, S.2
  • 22
    • 77957052236 scopus 로고    scopus 로고
    • Potential role of pioglitazone, caffeic acid and their combination against fatigue syndrome-induced behavioural, biochemical and mitochondrial alterations in mice
    • Kumar A., Vashist A., Kumar P. Potential role of pioglitazone, caffeic acid and their combination against fatigue syndrome-induced behavioural, biochemical and mitochondrial alterations in mice. Inflammopharmacology 2010, 18:241-251.
    • (2010) Inflammopharmacology , vol.18 , pp. 241-251
    • Kumar, A.1    Vashist, A.2    Kumar, P.3
  • 23
    • 79960001769 scopus 로고    scopus 로고
    • Cocaine alters dendritic spine density in cortical and subcortical brain regions of the postpartum and virgin female rat
    • Frankfurt M., Salas-Ramirez K., Friedman E., et al. Cocaine alters dendritic spine density in cortical and subcortical brain regions of the postpartum and virgin female rat. Synapse 2011, 65:955-961.
    • (2011) Synapse , vol.65 , pp. 955-961
    • Frankfurt, M.1    Salas-Ramirez, K.2    Friedman, E.3
  • 24
    • 84862741320 scopus 로고    scopus 로고
    • Estrogen-induced memory enhancements are blocked by acute bisphenol A in adult female rats: role of dendritic spines
    • Inagaki T., Frankfurt M., Luine V. Estrogen-induced memory enhancements are blocked by acute bisphenol A in adult female rats: role of dendritic spines. Endocrinology 2012, 153:3357-3367.
    • (2012) Endocrinology , vol.153 , pp. 3357-3367
    • Inagaki, T.1    Frankfurt, M.2    Luine, V.3
  • 25
    • 84885000646 scopus 로고    scopus 로고
    • Effects of exercise and diet change on cognition function and synaptic plasticity in high fat diet induced obese rats
    • Woo J., Shin K.O., Park S.Y., et al. Effects of exercise and diet change on cognition function and synaptic plasticity in high fat diet induced obese rats. Lipids Health Dis 2013, 12:144.
    • (2013) Lipids Health Dis , vol.12 , pp. 144
    • Woo, J.1    Shin, K.O.2    Park, S.Y.3
  • 26
    • 84877634220 scopus 로고    scopus 로고
    • Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats
    • Pancani T., Anderson K.L., Brewer L.D., et al. Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats. Neurobiol Aging 2013, 34:1977-1987.
    • (2013) Neurobiol Aging , vol.34 , pp. 1977-1987
    • Pancani, T.1    Anderson, K.L.2    Brewer, L.D.3
  • 28
    • 15244351255 scopus 로고    scopus 로고
    • Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes?
    • Steen E., Terry B.M., Rivera E.J., et al. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease-is this type 3 diabetes?. J Alzheimers Dis 2005, 7:63-80.
    • (2005) J Alzheimers Dis , vol.7 , pp. 63-80
    • Steen, E.1    Terry, B.M.2    Rivera, E.J.3
  • 29
    • 84888007002 scopus 로고    scopus 로고
    • Beta-Amyloid-induced cognitive dysfunction impairs glucose homeostasis by increasing insulin resistance and decreasing beta-cell mass in non-diabetic and diabetic rats
    • Park S., Kim da S., Kang S., et al. beta-Amyloid-induced cognitive dysfunction impairs glucose homeostasis by increasing insulin resistance and decreasing beta-cell mass in non-diabetic and diabetic rats. Metabolism 2013, 62:1749-1760.
    • (2013) Metabolism , vol.62 , pp. 1749-1760
    • Park, S.1    Kim da, S.2    Kang, S.3
  • 30
    • 84891553207 scopus 로고    scopus 로고
    • Dendritic spines: the locus of structural and functional plasticity
    • Sala C., Segal M. Dendritic spines: the locus of structural and functional plasticity. Physiol Rev 2014, 94:141-188.
    • (2014) Physiol Rev , vol.94 , pp. 141-188
    • Sala, C.1    Segal, M.2
  • 31
    • 84884511387 scopus 로고    scopus 로고
    • Structural plasticity of dendritic spines: the underlying mechanisms and its dysregulation in brain disorders
    • Lai K.O., Ip N.Y. Structural plasticity of dendritic spines: the underlying mechanisms and its dysregulation in brain disorders. Biochim Biophys Acta 2013, 1832:2257-2263.
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 2257-2263
    • Lai, K.O.1    Ip, N.Y.2
  • 32
    • 70349262248 scopus 로고    scopus 로고
    • Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice
    • Stranahan A.M., Lee K., Martin B., et al. Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus 2009, 19:951-961.
    • (2009) Hippocampus , vol.19 , pp. 951-961
    • Stranahan, A.M.1    Lee, K.2    Martin, B.3
  • 33
    • 79960016949 scopus 로고    scopus 로고
    • Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways
    • Lee C.C., Huang C.C., Hsu K.S. Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways. Neuropharmacology 2011, 61:867-879.
    • (2011) Neuropharmacology , vol.61 , pp. 867-879
    • Lee, C.C.1    Huang, C.C.2    Hsu, K.S.3
  • 34
    • 84901853714 scopus 로고    scopus 로고
    • Short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus
    • Calvo-Ochoa E., Hernandez-Ortega K., Ferrera P., et al. Short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus. J Cereb Blood Flow Metab 2014, 218:1001-1008.
    • (2014) J Cereb Blood Flow Metab , vol.218 , pp. 1001-1008
    • Calvo-Ochoa, E.1    Hernandez-Ortega, K.2    Ferrera, P.3
  • 35
    • 84878781836 scopus 로고    scopus 로고
    • DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats
    • Pintana H., Apaijai N., Chattipakorn N., et al. DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats. J Endocrinol 2013, 218:1-11.
    • (2013) J Endocrinol , vol.218 , pp. 1-11
    • Pintana, H.1    Apaijai, N.2    Chattipakorn, N.3
  • 36
    • 33751096969 scopus 로고    scopus 로고
    • Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain
    • Bjorkhem I. Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. J Intern Med 2006, 260:493-508.
    • (2006) J Intern Med , vol.260 , pp. 493-508
    • Bjorkhem, I.1
  • 37
    • 84866687889 scopus 로고    scopus 로고
    • Hypercholesterolemia accelerates intraneuronal accumulation of Abeta oligomers resulting in memory impairment in Alzheimer's disease model mice
    • Umeda T., Tomiyama T., Kitajima E., et al. Hypercholesterolemia accelerates intraneuronal accumulation of Abeta oligomers resulting in memory impairment in Alzheimer's disease model mice. Life Sci 2012, 91:1169-1176.
    • (2012) Life Sci , vol.91 , pp. 1169-1176
    • Umeda, T.1    Tomiyama, T.2    Kitajima, E.3
  • 38
    • 82855172098 scopus 로고    scopus 로고
    • Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress
    • de Oliveira J., Hort M.A., Moreira E.L., et al. Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress. Neuroscience 2011, 197:99-106.
    • (2011) Neuroscience , vol.197 , pp. 99-106
    • de Oliveira, J.1    Hort, M.A.2    Moreira, E.L.3
  • 39
    • 45249117903 scopus 로고    scopus 로고
    • High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
    • Thirumangalakudi L., Prakasam A., Zhang R., et al. High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem 2008, 106:475-485.
    • (2008) J Neurochem , vol.106 , pp. 475-485
    • Thirumangalakudi, L.1    Prakasam, A.2    Zhang, R.3
  • 40
    • 77957959900 scopus 로고    scopus 로고
    • Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits
    • Ullrich C., Pirchl M., Humpel C. Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits. Mol Cell Neurosci 2010, 45:408-417.
    • (2010) Mol Cell Neurosci , vol.45 , pp. 408-417
    • Ullrich, C.1    Pirchl, M.2    Humpel, C.3
  • 41
    • 77249147818 scopus 로고    scopus 로고
    • Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice
    • Hwang L.L., Wang C.H., Li T.L., et al. Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice. Obesity (Silver Spring) 2008, 18:463-469.
    • (2008) Obesity (Silver Spring) , vol.18 , pp. 463-469
    • Hwang, L.L.1    Wang, C.H.2    Li, T.L.3
  • 42
    • 67650650466 scopus 로고    scopus 로고
    • Mechanisms involved in cholesterol-induced neuronal insulin resistance
    • Taghibiglou C., Bradley C.A., Gaertner T., et al. Mechanisms involved in cholesterol-induced neuronal insulin resistance. Neuropharmacology 2009, 57:268-276.
    • (2009) Neuropharmacology , vol.57 , pp. 268-276
    • Taghibiglou, C.1    Bradley, C.A.2    Gaertner, T.3
  • 43
    • 84880415100 scopus 로고    scopus 로고
    • Spatial memory impairment and changes in hippocampal morphology are triggered by high-fat diets in adolescent mice. Is there a role of leptin?
    • Valladolid-Acebes I., Fole A., Martin M., et al. Spatial memory impairment and changes in hippocampal morphology are triggered by high-fat diets in adolescent mice. Is there a role of leptin?. Neurobiol Learn Mem 2013, 106:18-25.
    • (2013) Neurobiol Learn Mem , vol.106 , pp. 18-25
    • Valladolid-Acebes, I.1    Fole, A.2    Martin, M.3
  • 44
    • 36849040001 scopus 로고    scopus 로고
    • Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice
    • Flock G., Baggio L.L., Longuet C., et al. Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice. Diabetes 2007, 56:3006-3013.
    • (2007) Diabetes , vol.56 , pp. 3006-3013
    • Flock, G.1    Baggio, L.L.2    Longuet, C.3
  • 45
    • 1842478323 scopus 로고    scopus 로고
    • Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle
    • Acitores A., Gonzalez N., Sancho V., et al. Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle. J Endocrinol 2004, 180:389-398.
    • (2004) J Endocrinol , vol.180 , pp. 389-398
    • Acitores, A.1    Gonzalez, N.2    Sancho, V.3
  • 46
    • 12344301360 scopus 로고    scopus 로고
    • Effect of GLP-1 on glucose transport and its cell signalling in human myocytes
    • Gonzalez N., Acitores A., Sancho V., et al. Effect of GLP-1 on glucose transport and its cell signalling in human myocytes. Regul Pept 2005, 126:203-211.
    • (2005) Regul Pept , vol.126 , pp. 203-211
    • Gonzalez, N.1    Acitores, A.2    Sancho, V.3
  • 47
    • 0038445987 scopus 로고    scopus 로고
    • Cell signalling of the GLP-1 action in rat liver
    • Redondo A., Trigo M.V., Acitores A., et al. Cell signalling of the GLP-1 action in rat liver. Mol Cell Endocrinol 2003, 204:43-50.
    • (2003) Mol Cell Endocrinol , vol.204 , pp. 43-50
    • Redondo, A.1    Trigo, M.V.2    Acitores, A.3
  • 48
    • 23844504364 scopus 로고    scopus 로고
    • Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening
    • Srinivasan K., Viswanad B., Asrat L., et al. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res 2005, 52:313-320.
    • (2005) Pharmacol Res , vol.52 , pp. 313-320
    • Srinivasan, K.1    Viswanad, B.2    Asrat, L.3
  • 49
    • 84878865441 scopus 로고    scopus 로고
    • The PPARgamma agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model
    • Grommes C., Karlo J.C., Caprariello A., et al. The PPARgamma agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model. Cancer Chemother Pharmacol 2013, 71:929-936.
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 929-936
    • Grommes, C.1    Karlo, J.C.2    Caprariello, A.3
  • 50
    • 79961103714 scopus 로고    scopus 로고
    • The PPAR-gamma agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys
    • Swanson C.R., Joers V., Bondarenko V., et al. The PPAR-gamma agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys. J Neuroinflammation 2011, 8:91.
    • (2011) J Neuroinflammation , vol.8 , pp. 91
    • Swanson, C.R.1    Joers, V.2    Bondarenko, V.3
  • 51
    • 0030583115 scopus 로고    scopus 로고
    • Pioglitazone improves insulin signaling defects in skeletal muscle from Wistar fatty (fa/fa) rats
    • Hayakawa T., Shiraki T., Morimoto T., et al. Pioglitazone improves insulin signaling defects in skeletal muscle from Wistar fatty (fa/fa) rats. Biochem Biophys Res Commun 1996, 223:439-444.
    • (1996) Biochem Biophys Res Commun , vol.223 , pp. 439-444
    • Hayakawa, T.1    Shiraki, T.2    Morimoto, T.3
  • 52
    • 81155137697 scopus 로고    scopus 로고
    • Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3beta decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model
    • Ponce-Lopez T., Liy-Salmeron G., Hong E., et al. Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3beta decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model. Brain Res 2011, 1426:73-85.
    • (2011) Brain Res , vol.1426 , pp. 73-85
    • Ponce-Lopez, T.1    Liy-Salmeron, G.2    Hong, E.3
  • 53
    • 47549098083 scopus 로고    scopus 로고
    • Rosiglitazone attenuates the cognitive deficits induced by high fat diet feeding in rats
    • Pathan A.R., Gaikwad A.B., Viswanad B., et al. Rosiglitazone attenuates the cognitive deficits induced by high fat diet feeding in rats. Eur J Pharmacol 2008, 589:176-179.
    • (2008) Eur J Pharmacol , vol.589 , pp. 176-179
    • Pathan, A.R.1    Gaikwad, A.B.2    Viswanad, B.3
  • 54
    • 80054812684 scopus 로고    scopus 로고
    • Behavioral and biochemical investigations to explore pharmacological potential of PPAR-gamma agonists in vascular dementia of diabetic rats
    • Sharma B., Singh N. Behavioral and biochemical investigations to explore pharmacological potential of PPAR-gamma agonists in vascular dementia of diabetic rats. Pharmacol Biochem Behav 2011, 100:320-329.
    • (2011) Pharmacol Biochem Behav , vol.100 , pp. 320-329
    • Sharma, B.1    Singh, N.2


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