Role of Adiposity-Driven Inflammation in Depressive Morbidity

Neuropsychopharmacology

Volumn 42, Issue 1, 2017, Pages 115-128

  Capuron, Lucile ^a,b   Lasselin, Julie ^c,d,e   Castanon, Nathalie ^a,b  

^a NutriNeuro Bordeaux University   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

^d KAROLINSKA INSTITUTE   (Sweden)

^e STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FAT; INFLIXIMAB;

BARIATRIC SURGERY; CLINICAL FEATURE; COMORBIDITY; DEPRESSION; DISEASE ASSOCIATION; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LOW CALORY DIET; MORBIDITY; NEUROPSYCHIATRY; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; WEIGHT LOSS PROGRAM; COMPLICATION; IMMUNOLOGY;

DEPRESSIVE DISORDER; HUMANS; INFLAMMATION; OVERWEIGHT;

EID: 84981186248     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2016.123     Document Type: Review

References (237)

1. Alciati A, D'Ambrosio A, Foschi D, Corsi F, Mellado C, Angst J (2007). Bipolarspectrum disorders in severely obese patients seeking surgical treatment. J AffectDisord 101: 131-138.
2. Alexander KS, Wu HQ, Schwarcz R, Bruno JP (2012). Acute elevations of brainkynurenic acid impair cognitive flexibility: normalization by the alpha7 positivemodulator galantamine. Psychopharmacology (Berl) 220: 627-637.
3. Almas A, Forsell Y, Iqbal R, Janszky I, Moller J (2015). Severity of depression,anxious distress and the risk of cardiovascular disease in a Swedish populationbasedcohort. PLoS One 10: e0140742.
4. Andre C, Dinel AL, Ferreira G, Laye S, Castanon N (2014). Diet-induced obesityprogressively alters cognition, anxiety-like behavior and lipopolysaccharideinduceddepressive-like behavior: focus on brain indoleamine 2,3-dioxygenaseactivation. Brain Behav Immun 41: 10-21.
5. Andre C, O'Connor JC, Kelley KW, Lestage J, Dantzer R, Castanon N (2008). Spatio-temporal differences in the profile of murine brain expression ofproinflammatory cytokines and indoleamine 2,3-dioxygenase in response toperipheral lipopolysaccharide administration. J Neuroimmunol 200: 90-99.
6. Anisman H, Merali Z, Hayley S (2008). Neurotransmitter, peptide and cytokineprocesses in relation to depressive disorder: comorbidity between depressionand neurodegenerative disorders. Prog Neurobiol 85: 1-74.
7. Armougom F, Henry M, Vialettes B, Raccah D, Raoult D (2009). Monitoring bacterialcommunity of human gut microbiota reveals an increase in Lactobacillus in obesepatients and Methanogens in anorexic patients. PLoS One 4: e7125.
8. Aron-Wisnewsky J, Dore J, Clement K (2012). The importance of the gut microbiotaafter bariatric surgery. Nat Rev Gastroenterol Hepatol 9: 590-598.
9. Barichello T, Generoso JS, Simoes LR, Elias SG, Tashiro MH, Dominguini D, et al. (2013). Inhibition of indoleamine 2,3-dioxygenase prevented cognitive impairmentin adult Wistar rats subjected to pneumococcal meningitis. Transl Res 162:390-397.
10. Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, et al. (2000). Elevated levels of interleukin-6 are reduced in serum and subcutaneousadipose tissue of obese women after weight loss. J Clin Endocrinol Metab 85:3338-3342.
11. Bazinet RP, Laye S (2014). Polyunsaturated fatty acids and their metabolites in brainfunction and disease. Nat Rev Neurosci 15: 771-785.
12. Belza A, Toubro S, Stender S, Astrup A (2009). Effect of diet-induced energy deficitand body fat reduction on high-sensitive CRP and other inflammatory markers inobese subjects. Int J Obes (Lond) 33: 456-464.
13. Bierhaus A, Wolf J, Andrassy M, Rohleder N, Humpert PM, Petrov D, et al. (2003). Amechanism converting psychosocial stress into mononuclear cell activation. ProcNatl Acad Sci USA 100: 1920-1925.
14. Blazquez E, Velazquez E, Hurtado-Carneiro V, Ruiz-Albusac JM (2014). Insulin in thebrain: its pathophysiological implications for States related with central insulinresistance, type 2 diabetes and Alzheimer's disease. Front Endocrinol (Lausanne)5: 161.
15. Blumenthal JA, Babyak MA, Doraiswamy PM, Watkins L, Hoffman BM, Barbour KAet al (2007). Exercise and pharmacotherapy in the treatment of major depressivedisorder. Psychosom Med 69: 587-596.
16. Boitard C, Cavaroc A, Sauvant J, Aubert A, Castanon N, Laye S, et al. (2014). Impairment of hippocampal-dependent memory induced by juvenile high-fat dietintake is associated with enhanced hippocampal inflammation in rats. Brain BehavImmun 40: 9-17.
17. Borsini A, Zunszain PA, Thuret S, Pariante CM (2015). The role of inflammatorycytokines as key modulators of neurogenesis. Trends Neurosci 38: 145-157.
18. Brandacher G, Hoeller E, Fuchs D, Weiss HG (2007). Chronic immune activationunderlies morbid obesity: is IDO a key player? Curr Drug Metab 8: 289-295.
19. Brinkworth GD, Buckley JD, Noakes M, Clifton PM, Wilson CJ (2009). Long-termeffects of a very low-carbohydrate diet and a low-fat diet on mood and cognitivefunction. Arch Intern Med 169: 1873-1880.
20. Bruce-Keller AJ, Salbaum JM, Luo M, Blanchard ET, Taylor CM, Welsh DA, et al. (2015). Obese-type gut microbiota induce neurobehavioral changes in theabsence of obesity. Biol Psychiatry 77: 607-615.
21. Brun P, Castagliuolo I, Di Leo V, Buda A, Pinzani M, Palu G, et al. (2007). Increasedintestinal permeability in obese mice: new evidence in the pathogenesis ofnonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 292:G518-G525.
22. Brunault P, Jacobi D, Miknius V, Bourbao-Tournois C, Huten N, Gaillard P, et al. (2012). High preoperative depression, phobic anxiety, and binge eating scoresand low medium-term weight loss in sleeve gastrectomy obese patients: apreliminary cohort study. Psychosomatics 53: 363-370.
23. Buckman LB, Hasty AH, Flaherty DK, Buckman CT, Thompson MM, Matlock BKet al (2013). Obesity induced by a high-fat diet is associated with increasedimmune cell entry into the central nervous system. Brain Behav Immun 35: 33-42.
24. Cai D, Liu T (2012). Inflammatory cause of metabolic syndrome via brain stress andNF-kappaB. Aging (Albany NY) 4: 98-115.
25. Campbell BM, Charych E, Lee AW, Moller T (2014). Kynurenines in CNS disease:regulation by inflammatory cytokines. Front Neurosci 8: 12.
26. Cancello R, Clement K (2006). Is obesity an inflammatory illness? Role of low-gradeinflammation and macrophage infiltration in human white adipose tissue. BJOG113: 1141-1147.
27. Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammationin high-fat diet-induced obesity and diabetes in mice. Diabetes 57: 1470-1481.
28. Cani PD, Osto M, Geurts L, Everard A (2012). Involvement of gut microbiota in thedevelopment of low-grade inflammation and type 2 diabetes associated withobesity. Gut Microbes 3: 279-288.
29. Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O, et al. (2009). Changes in gut microbiota control inflammation in obese mice through amechanism involving GLP-2-driven improvement of gut permeability. Gut 58:1091-1103.
30. Capuron L, Gumnick JF, Musselman DL, Lawson DH, Reemsnyder A, Nemeroff CBet al (2002). Neurobehavioral effects of interferon-alpha in cancer patients:phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology 26: 643-652.
31. Capuron L, Miller AH (2011a). Immune system to brain signaling: neuropsychopharmacologicalimplications. Pharmacol Ther 130: 226-238.
32. Capuron L, Pagnoni G, Drake DF, Woolwine BJ, Spivey JR, Crowe RJ, et al. (2012). Dopaminergic mechanisms of reduced basal ganglia responses tohedonic reward during interferon alfa administration. Arch Gen Psychiatry 69:1044-1053.
33. Capuron L, Poitou C, Machaux-Tholliez D, Frochot V, Bouillot JL, Basdevant A, et al. (2011b). Relationship between adiposity, emotional status and eating behaviour inobese women: role of inflammation. Psychol Med 41: 1517-1528.
34. Capuron L, Schroecksnadel S, Feart C, Aubert A, Higueret D, Barberger-Gateau Pet al (2011c). Chronic low-grade inflammation in elderly persons is associated withaltered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms. Biol Psychiatry 70: 175-182.
35. Capuron L, Su S, Miller AH, Bremner JD, Goldberg J, Vogt GJ, et al. (2008). Depressive symptoms and metabolic syndrome: is inflammation theunderlying link? Biol Psychiatry 64: 896-900.
36. Carpenter KM, Hasin DS, Allison DB, Faith MS (2000). Relationships between obesityand DSM-IV major depressive disorder, suicide ideation, and suicide attempts:results from a general population study. Am J Public Health 90: 251-257.
37. Castanon N, Lasselin J, Capuron L (2014). Neuropsychiatric comorbidity in obesity:role of inflammatory processes. Front Endocrinol (Lausanne) 5: 74.
38. Castanon N, Luheshi G, Laye S (2015). Role of neuroinflammation in the emotionaland cognitive alterations displayed by animal models of obesity. Front Neurosci 9:229.
39. Castanon N, Medina C, Mormede C, Dantzer R (2004). Chronic administration oftianeptine balances lipopolysaccharide-induced expression of cytokines in thespleen and hypothalamus of rats. Psychoneuroendocrinology 29: 778-790.
40. Celik C, Erdem M, Cayci T, Ozdemir B, Ozgur Akgul E, Kurt YG, et al. (2010). Theassociation between serum levels of neopterin and number of depressiveepisodes of major depression. Prog Neuropsychopharmacol Biol Psychiatry 34:372-375.
41. Chess AC, Landers AM, Bucci DJ (2009). L-kynurenine treatment alters contextualfear conditioning and context discrimination but not cue-specific fear conditioning. Behav Brain Res 201: 325-331.
42. Chirinos DA, Goldberg R, Gellman M, Mendez AJ, Gutt M, McCalla JR, et al. (2013). Leptin and its association with somatic depressive symptoms in patients with themetabolic syndrome. Ann Behav Med 46: 31-39.
43. Chou KL, Yu KM (2013). Atypical depressive symptoms and obesity in a nationalsample of older adults with major depressive disorder. Depress Anxiety 30:574-579.
44. Chuang JC, Krishnan V, Yu HG, Mason B, Cui H, Wilkinson MB, et al. (2010). A beta3-adrenergic-leptin-melanocortin circuit regulates behavioral and metabolicchanges induced by chronic stress. Biol Psychiatry 67: 1075-1082.
45. Cizza G, Ronsaville DS, Kleitz H, Eskandari F, Mistry S, Torvik S, et al. (2012). Clinicalsubtypes of depression are associated with specific metabolic parameters andcircadian endocrine profiles in women: the power study. PLoS One 7: e28912.
46. Clement K, Viguerie N, Poitou C, Carette C, Pelloux V, Curat CA, et al. (2004). Weightloss regulates inflammation-related genes in white adipose tissue of obesesubjects. FASEB J 18: 1657-1669.
47. Cline BH, Costa-Nunes JP, Cespuglio R, Markova N, Santos AI, Bukhman YV, et al. (2015). Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior,REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits inmouse models of depression. Front Behav Neurosci 9: 37.
48. Cline BH, Steinbusch HW, Malin D, Revishchin AV, Pavlova GV, Cespuglio R, et al. (2012). The neuronal insulin sensitizer dicholine succinate reduces stress-induceddepressive traits and memory deficit: possible role of insulin-like growth factor 2. BMC Neurosci 13: 110.
49. Corona AW, Huang Y, O'Connor JC, Dantzer R, Kelley KW, Popovich PG, et al. (2010). Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioralchanges induced by lipopolysaccharide. J Neuroinflammation 7: 93.
50. Corona AW, Norden DM, Skendelas JP, Huang Y, O'Connor JC, Lawson M, et al. (2013). Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharideinduced persistent microglial activation and depressive-like complications infractalkine receptor (CX(3)CR1)-deficient mice. Brain Behav Immun 31:134-142.
51. Cotillard A, Kennedy SP, Kong LC, Prifti E, Pons N, Le Chatelier E, et al. (2013). Dietary intervention impact on gut microbial gene richness. Nature 500: 585-588.
52. Crump C, Sundquist K, Winkleby MA, Sundquist J (2013). Comorbidities andmortality in bipolar disorder: a Swedish national cohort study. JAMA Psychiatry70: 931-939.
53. Cryan JF, Dinan TG (2012). Mind-altering microorganisms: the impact of the gutmicrobiota on brain and behaviour. Nat Rev Neurosci 13: 701-712.
54. Curtius HC, Niederwieser A, Levine RA, Lovenberg W, Woggon B, Angst J (1983). Successful treatment of depression with tetrahydrobiopterin. Lancet 1: 657-658.
55. da Silva Dias IC, Carabelli B, Ishii DK, de Morais H, de Carvalho MC, Rizzo de SouzaLE, et al. (2015). Indoleamine-2,3-dioxygenase/kynurenine pathway as a potentialpharmacological target to treat depression associated with diabetes. MolNeurobiol (in press).
56. Dahlgren J, Nilsson C, Jennische E, Ho HP, Eriksson E, Niklasson A, et al. (2001). Prenatal cytokine exposure results in obesity and gender-specific programming. Am J Physiol 81: E326-E334.
57. Daly M (2013). The relationship of C-reactive protein to obesity-related depressivesymptoms: a longitudinal study. Obesity 21: 248-250.
58. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW (2008). Frominflammation to sickness and depression: when the immune system subjugatesthe brain. Nat Rev Neurosci 9: 46-56.
59. Dantzer R, Walker AK (2014). Is there a role for glutamate-mediated excitotoxicity ininflammation-induced depression? J Neural Transm (Vienna) 121: 925-932.
60. Dawes AJ, Maggard-Gibbons M, Maher AR, Booth MJ, Miake-Lye I, Beroes JM, et al. (2016). Mental health conditions among patients seeking and undergoing bariatricsurgery: a meta-analysis. JAMA 315: 150-163.
61. De Souza CT, Araujo EP, Bordin S, Ashimine R, Zollner RL, Boschero AC, et al. (2005). Consumption of a fat-rich diet activates a proinflammatory response andinduces insulin resistance in the hypothalamus. Endocrinology 146: 4192-4199.
62. de Weijer BA, van de Giessen E, van Amelsvoort TA, Boot E, Braak B, Janssen IMet al (2011). Lower striatal dopamine D2/3 receptor availability in obese comparedwith non-obese subjects. EJNMMI Res 1: 37.
63. de Wit L, Luppino F, van Straten A, Penninx B, Zitman F, Cuijpers P (2010). Depression and obesity: a meta-analysis of community-based studies. PsychiatryRes 178: 230-235.
64. Dey A, Hao S, Erion JR, Wosiski-Kuhn M, Stranahan AM (2014). Glucocorticoidsensitization of microglia in a genetic mouse model of obesity and diabetes. J Neuroimmunol 269: 20-27.
65. Dinel AL, Andre C, Aubert A, Ferreira G, Laye S, Castanon N (2011). Cognitive andemotional alterations are related to hippocampal inflammation in a mouse modelof metabolic syndrome. PLoS One 6: e24325.
66. Dinel AL, Andre C, Aubert A, Ferreira G, Laye S, Castanon N (2014). Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenaseand depressive-like behavior are impaired in a mouse model of metabolicsyndrome. Psychoneuroendocrinology 40: 48-59.
67. Dixon JB, Dixon ME, O'Brien PE (2003). Depression in association with severeobesity: changes with weight loss. Arch Intern Med 163: 2058-2065.
68. Dixon JB, Hayden MJ, Lambert GW, Dawood T, Anderson ML, Dixon ME, et al. (2008). Raised CRP levels in obese patients: symptoms of depression have anindependent positive association. Obesity 16: 2010-2015.
69. Donath MY, Shoelson SE (2011). Type 2 diabetes as an inflammatory disease. NatRev Immunol 11: 98-107.
70. Duarte-Guerra LS, Coelho BM, Santo MA, Wang YP (2015). Psychiatric disordersamong obese patients seeking bariatric surgery: results of structured clinicalinterviews. Obes Surg 255: 830-837.
71. Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO (2005). Exercisetreatment for depression: efficacy and dose response. Am J Prev Med 28: 1-8.
72. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, et al. (2005). Diversity of the human intestinal microbial flora. Science 308: 1635-1638.
73. Emery CF, Fondow MD, Schneider CM, Christofi FL, Hunt C, Busby AK, et al. (2007). Gastric bypass surgery is associated with reduced inflammation and lessdepression: a preliminary investigation. Obes Surg 17: 759-763.
74. Erion JR, Wosiski-Kuhn M, Dey A, Hao S, Davis CL, Pollock NK, et al. (2014). Obesityelicits interleukin 1-mediated deficits in hippocampal synaptic plasticity. J Neurosci 34: 2618-2631.
75. Evans DL, Charney DS, Lewis L, Golden RN, Gorman JM, Krishnan KR, et al. (2005). Mood disorders in the medically ill: scientific review and recommendations. BiolPsychiatry 58: 175-189.
76. Favennec M, Hennart B, Caiazzo R, Leloire A, Yengo L, Verbanck M, et al. (2015). Thekynurenine pathway is activated in human obesity and shifted toward kynureninemonooxygenase activation. Obesity 23: 2066-2074.
77. Felger JC, Li L, Marvar PJ, Woolwine BJ, Harrison DG, Raison CL, et al. (2013). Tyrosine metabolism during interferon-alpha administration: association withfatigue and CSF dopamine concentrations. Brain Behav Immun 31: 153-160.
78. Felger JC, Miller AH (2012). Cytokine effects on the basal ganglia and dopaminefunction: the subcortical source of inflammatory malaise. Front Neuroendocrinol33: 315-327.
79. Finelli C, Padula MC, Martelli G, Tarantino G (2014). Could the improvement ofobesity-related co-morbidities depend on modified gut hormones secretion?World J Gastroenterol 20: 16649-16664.
80. Finkelstein JA, Chance WT, Fischer JE (1982). Brain serotonergic activity andplasma amino acid levels in genetically obese Zucker rats. Pharmacol BiochemBehav 17: 939-944.
81. Flint HJ (2011). Obesity and the gut microbiota. J Clin Gastroenterol 45(Suppl):S128-S132.
82. Forrest CM, Mackay GM, Oxford L, Millar K, Darlington LG, Higgins MJ, et al. (2011). Kynurenine metabolism predicts cognitive function in patients following cardiacbypass and thoracic surgery. J Neurochem 119: 136-152.
83. Fotuhi M, Do D, Jack C (2012). Modifiable factors that alter the size of thehippocampus with ageing. Nat Rev Neurol 8: 189-202.
84. Frenois F, Moreau M, O'Connor J, Lawson M, Micon C, Lestage J, et al. (2007). Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within themouse extended amygdala, hippocampus and hypothalamus, that parallel theexpression of depressive-like behavior. Psychoneuroendocrinology 32: 516-531.
85. Furet JP, Kong LC, Tap J, Poitou C, Basdevant A, Bouillot JL, et al. (2010). Differentialadaptation of human gut microbiota to bariatric surgery-induced weight loss: linkswith metabolic and low-grade inflammation markers. Diabetes 59: 3049-3057.
86. Gao Y, Ottaway N, Schriever SC, Legutko B, Garcia-Caceres C, de la Fuente E, et al. (2014). Hormones and diet, but not body weight, control hypothalamic microglialactivity. Glia 62: 17-25.
87. Ghasemi R, Dargahi L, Haeri A, Moosavi M, Mohamed Z, Ahmadiani A (2013a). Braininsulin dysregulation: implication for neurological and neuropsychiatric disorders. Mol Neurobiol 47: 1045-1065.
88. Ghasemi R, Haeri A, Dargahi L, Mohamed Z, Ahmadiani A (2013b). Insulin in thebrain: sources, localization and functions. Mol Neurobiol 47: 145-171.
89. Gibney SM, McGuinness B, Prendergast C, Harkin A, Connor TJ (2013). Poly I:C-induced activation of the immune response is accompanied by depression andanxiety-like behaviours, kynurenine pathway activation and reduced BDNFexpression. Brain Behav Immun 28: 170-181.
90. Godbout JP, Moreau M, Lestage J, Chen J, Sparkman NL, O'Connor J, et al. (2008). Aging exacerbates depressive-like behavior in mice in response to activation ofthe peripheral innate immune system. Neuropsychopharmacology 33:2341-2351.
91. Gold AB, Herrmann N, Swardfager W, Black SE, Aviv RI, Tennen G, et al. (2011). Therelationship between indoleamine 2,3-dioxygenase activity and post-strokecognitive impairment. J Neuroinflammation 8: 17.
92. Gomez-Pinilla F, Nguyen TT (2012). Natural mood foods: the actions of polyphenolsagainst psychiatric and cognitive disorders. Nutr Neurosci 15: 127-133.
93. Gregor MF, Hotamisligil GS (2011). Inflammatory mechanisms in obesity. Annu RevImmunol 29: 415-445.
94. Grenham S, Clarke G, Cryan JF, Dinan TG (2011). Brain-gut-microbe communicationin health and disease. Front Physiol 2: 94.
95. Grothe KB, Mundi MS, Himes SM, Sarr MG, Clark MM, Geske JR, et al. (2014). Bipolar disorder symptoms in patients seeking bariatric surgery. Obes Surg 24:1909-1914.
96. Gulaj E, Pawlak K, Bien B, Pawlak D (2010). Kynurenine and its metabolites inAlzheimer's disease patients. Adv Med Sci 55: 204-211.
97. Gupta D, Kurhe Y, Radhakrishnan M (2014). Antidepressant effects of insulin instreptozotocin induced diabetic mice: modulation of brain serotonin system. Physiol Behav 129: 73-78.
98. Hakeam HA, O'Regan PJ, Salem AM, Bamehriz FY, Jomaa LF (2009). Inhibitionof C-reactive protein in morbidly obese patients after laparoscopic sleevegastrectomy. Obes Surg 19: 456-460.
99. Hammond RA, Levine R (2010). The economic impact of obesity in theUnited States. Diabetes Metab Syndr Obes 3: 285-295.
100. Hare DL, Toukhsati SR, Johansson P, Jaarsma T (2014). Depression andcardiovascular disease: a clinical review. Eur Heart J 35: 1365-1372.
101. Haroon E, Raison CL, Miller AH (2012). Psychoneuroimmunology meets neuropsychopharmacology:translational implications of the impact of inflammation onbehavior. Neuropsychopharmacology 37: 137-162.
102. Hashimoto R, Mizutani M, Ohta T, Nakazawa K, Nagatsu T (1994). Changes inplasma tetrahydrobiopterin levels of depressives in depressive and remissionphases: reconfirmed by measurement with an internal standard. Neuropsychobiology29: 57-60.
103. Hasler G, Pine DS, Gamma A, Milos G, Ajdacic V, Eich D, et al. (2004). Theassociations between psychopathology and being overweight: a 20-yearprospective study. Psychol Med 34: 1047-1057.
104. Hemmati F, Ghasemi R, Mohamed Ibrahim N, Dargahi L, Mohamed Z, Raymond AA,Ahmadiani A (2014). Crosstalk between insulin and Toll-like receptor signalingpathways in the central nervous system. Mol Neurobiol 50: 797-810.
105. Henry CJ, Huang Y, Wynne AM, Godbout JP (2009). Peripheral lipopolysaccharide(LPS) challenge promotes microglial hyperactivity in aged mice that is associatedwith exaggerated induction of both pro-inflammatory IL-1beta and antiinflammatoryIL-10 cytokines. Brain Behav Immun 23: 309-317.
106. Heo M, Pietrobelli A, Fontaine KR, Sirey JA, Faith MS (2006). Depressive mood andobesity in US adults: comparison and moderation by sex, age, and race. Int JObes (Lond) 30: 513-519.
107. Herva A, Laitinen J, Miettunen J, Veijola J, Karvonen JT, Laksy K, et al. (2006). Obesityand depression: results from the longitudinal Northern Finland 1966 BirthCohort Study. Int J Obes (Lond) 30: 520-527.
108. Hoekstra R, van den Broek WW, Fekkes D, Bruijn JA, Mulder PG, Pepplinkhuizen L(2001). Effect of electroconvulsive therapy on biopterin and large neutralamino acids in severe, medication-resistant depression. Psychiatry Res 103:115-123.
109. Hotamisligil GS (2006). Inflammation and metabolic disorders. Nature 444: 860-867.
110. Hryhorczuk C, Sharma S, Fulton SE (2013). Metabolic disturbances connectingobesity and depression. Front Neurosci 7: 177.
111. Huang HJ, Chen YH, Liang KC, Jheng YS, Jhao JJ, Su MT, et al. (2012). Exendin-4protected against cognitive dysfunction in hyperglycemic mice receiving anintrahippocampal lipopolysaccharide injection. PLoS One 7: e39656.
112. Hyun E, Ramachandran R, Hollenberg MD, Vergnolle N (2011). Mechanisms behindthe anti-inflammatory actions of insulin. Crit Rev Immunol 31: 307-340.
113. Janowitz D, Wittfeld K, Terock J, Freyberger HJ, Hegenscheid K, Völzke H, et al. (2015). Association between waist circumference and gray matter volumein 2344 individuals from two adult community-based samples. Neuroimage 122:149-157.
114. Jokela M, Hamer M, Singh-Manoux A, Batty GD, Kivimaki M (2014). Association ofmetabolically healthy obesity with depressive symptoms: pooled analysis of eightstudies. Mol Psychiatry 19: 910-914.
115. Kan C, Silva N, Golden SH, Rajala U, Timonen M, Stahl D, et al. (2013). A systematicreview and meta-analysis of the association between depression and insulinresistance. Diabetes Care 36: 480-489.
116. Kanneganti TD, Dixit VD (2012). Immunological complications of obesity. NatImmunol 13: 707-712.
117. Kanoski SE, Davidson TL (2011). Western diet consumption and cognitiveimpairment: links to hippocampal dysfunction and obesity. Physiol Behav 103:59-68.
118. Kariharan T, Nanayakkara G, Parameshwaran K, Bagasrawala I, Ahuja M,Abdel-Rahman E, et al. (2015). Central activation of PPAR-gamma amelioratesdiabetes induced cognitive dysfunction and improves BDNF expression. Neurobiol Aging 36: 1451-1461.
119. Karson A, Demirtas T, Bayramgurler D, Balci F, Utkan T (2013). Chronicadministration of infliximab (TNF-alpha inhibitor) decreases depression andanxiety-like behaviour in rat model of chronic mild stress. Basic Clin PharmacolToxicol 112: 335-340.
120. Kasen S, Cohen P, Chen H, Must A (2008). Obesity and psychopathology inwomen: a three decade prospective study. Int J Obes (Lond ) 32: 558-566.
121. Kelley KW, O'Connor JC, Lawson MA, Dantzer R, Rodriguez-Zas SL, McCusker RH(2013). Aging leads to prolonged duration of inflammation-induced depressionlikebehavior caused by Bacillus Calmette-Guerin. Brain Behav Immun 32: 63-69.
122. Kendler KS, Karkowski LM, Prescott CA (1999). Causal relationship betweenstressful life events and the onset of major depression. Am J Psychiatry 156:837-841.
123. Kim B, Sullivan KA, Backus C, Feldman EL (2011). Cortical neurons develop insulinresistance and blunted Akt signaling: a potential mechanism contributing toenhanced ischemic injury in diabetes. Antioxid Redox Signal 14: 1829-1839.
124. Kim D, Kim J, Yoon JH, Ghim J, Yea K, Song P, et al. (2014). CXCL12 secreted fromadipose tissue recruits macrophages and induces insulin resistance in mice. Diabetologia 57: 1456-1465.
125. Kinzl JF, Schrattenecker M, Traweger C, Mattesich M, Fiala M, Biebl W (2006). Psychosocial predictors of weight loss after bariatric surgery. Obes Surg 16:1609-1614.
126. Kitagami T, Yamada K, Miura H, Hashimoto R, Nabeshima T, Ohta T (2003). Mechanism of systemically injected interferon-alpha impeding monoaminebiosynthesis in rats: role of nitric oxide as a signal crossing the blood-brainbarrier. Brain Res 978: 104-114.
127. Kleinridders A, Konner AC, Bruning JC (2009). CNS-targets in control of energy andglucose homeostasis. Curr Opin Pharmacol 9: 794-804.
128. Kloiber S, Ising M, Reppermund S, Horstmann S, Dose T, Majer M, et al. (2007). Overweight and obesity affect treatment response in major depression. BiolPsychiatry 62: 321-326.
129. Köhler O, Gasse C, Petersen L, Ingstrup KG, Nierenberg AA, Mors O, et al. (2016). The effect of concomitant treatment with SSRIs and statins: a populationbasedstudy. Am J Psychiatry (in press).
130. Kurhe Y, Mahesh R, Gupta D (2014). Effect of a selective cyclooxygenase type 2inhibitor celecoxib on depression associated with obesity in mice: an approachusing behavioral tests. Neurochem Res 39: 1395-1402.
131. Ladwig KH, Marten-Mittag B, Lowel H, Doring A, Koenig W (2003). Influence ofdepressive mood on the association of CRP and obesity in 3205 middle agedhealthy men. Brain Behav Immun 17: 268-275.
132. Lamers F, de Jonge P, Nolen WA, Smit JH, Zitman FG, Beekman AT, et al. (2010). Identifying depressive subtypes in a large cohort study: results from theNetherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry 71:1582-1589.
133. Lann D, LeRoith D (2007). Insulin resistance as the underlying cause for themetabolic syndrome. Med Clin North Am 91: 1063-1077, viii.
134. Lasselin J, Capuron L (2014a). Chronic low-grade inflammation in metabolicdisorders: relevance for behavioral symptoms. Neuroimmunomodulation 21:95-101.
135. Lasselin J, Magne E, Beau C, Ledaguenel P, Dexpert S, Aubert A, et al. (2014b). Adipose inflammation in obesity: relationship with circulating levels of inflammatorymarkers and association with surgery-induced weight loss. J Clin EndocrinolMetab 99: E53-E61.
136. Lasserre AM, Glaus J, Vandeleur CL, Marques-Vidal P, Vaucher J, Bastardot F, et al. (2014). Depression with atypical features and increase in obesity, body massindex, waist circumference, and fat mass: a prospective, population-based study. JAMA Psychiatry 71: 880-888.
137. Lawrence CB, Brough D, Knight EM (2012). Obese mice exhibit an alteredbehavioural and inflammatory response to lipopolysaccharide. Dis Model Mech 5:649-659.
138. Lawson MA, McCusker RH, Kelley KW (2013). Interleukin-1 beta converting enzymeis necessary for development of depression-like behavior following intracerebroventricularadministration of lipopolysaccharide to mice. J Neuroinflammation10: 54.
139. Laye S, Parnet P, Goujon E, Dantzer R (1994). Peripheral administration oflipopolysaccharide induces the expression of cytokine transcripts in the brain andpituitary of mice. Brain Res Mol Brain Res 27: 157-162.
140. Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G, et al. (2013). Richnessof human gut microbiome correlates with metabolic markers. Nature 500:541-546.
141. Ledochowski M, Murr C, Widner B, Fuchs D (1999). Association between insulinresistance, body mass and neopterin concentrations. Clin Chim Acta 282: 115-123.
142. Lee SH, Paz-Filho G, Mastronardi C, Licinio J, Wong ML (2016). Is increasedantidepressant exposure a contributory factor to the obesity pandemic? TranslPsychiatry 6: e759.
143. Lestage J, Verrier D, Palin K, Dantzer R (2002). The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheraladministration of lipopolysaccharide and superantigen. Brain Behav Immun 16:596-601.
144. Levitan RD, Davis C, Kaplan AS, Arenovich T, Phillips DI, Ravindran AV (2012). Obesity comorbidity in unipolar major depressive disorder: refining the corephenotype. J Clin Psychiatry 73: 1119-1124.
145. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI (2005). Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 102: 11070-11075.
146. Liu B, Kuang L, Liu J (2014). Bariatric surgery relieves type 2 diabetes andmodulates inflammatory factors and coronary endothelium eNOS/iNOS expressionin db/db mice. Can J Physiol Pharmacol 92: 70-77.
147. Liu YN, Peng YL, Liu L, Wu TY, Zhang Y, Lian YJ, et al. (2015). TNFalpha mediatesstress-induced depression by upregulating indoleamine 2,3-dioxygenasein a mouse model of unpredictable chronic mild stress. Eur Cytokine Netw 26:15-25.
148. Lojko D, Buzuk G, Owecki M, Ruchala M, Rybakowski JK (2015). Atypical features indepression: association with obesity and bipolar disorder. J Affect Disord 185:76-80.
149. Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, et al. (2010). Overweight, obesity, and depression: a systematic review and meta-analysis oflongitudinal studies. Arch Gen Psychiatry 67: 220-229.
150. Ma J, Xiao L (2010). Obesity and depression in US women: results from the 2005-2006 National Health and Nutritional Examination Survey. Obesity 18: 347-353.
151. Machado-Vieira R, Gold PW, Luckenbaugh DA, Ballard ED, Richards EM, Henter IDet al (2016). The role of adipokines in the rapid antidepressant effects of ketamine. Mol Psychiatry; doi:10. 1038/mp. 2016. 36 (in press).
152. Manco M, Fernandez-Real JM, Equitani F, Vendrell J, Valera Mora ME, Nanni G, et al. (2007). Effect of massive weight loss on inflammatory adipocytokines and theinnate immune system in morbidly obese women. J Clin Endocrinol Metab 92:483-490.
153. Mangge H, Summers KL, Meinitzer A, Zelzer S, Almer G, Prassl R, et al. (2014). Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role ofage and parameters of the metabolic syndrome. Obesity 22: 195-201.
154. Mansur RB, Rizzo LB, Santos CM, Asevedo E, Cunha GR, Noto MN, et al. (2016). Adipokines, metabolic dysfunction and illness course in bipolar disorder. J Psychiatr Res 74: 63-69.
155. Maric T, Woodside B, Luheshi GN (2014). The effects of dietary saturated fat onbasal hypothalamic neuroinflammation in rats. Brain Behav Immun 36: 35-45.
156. Martin DJ, Ul-Haq Z, Nicholl BI, Cullen B, Evans J, Gill JM, et al. (2016). Cardiometabolic disease and features of depression and bipolar disorder:population-based, cross-sectional study. Br J Psychiatry 208: 343-351.
157. Mather AA, Cox BJ, Enns MW, Sareen J (2009). Associations of obesity withpsychiatric disorders and suicidal behaviors in a nationally representative sample. J Psychosom Res 66: 277-285.
158. Mazarei G, Budac DP, Lu G, Lee H, Moller T, Leavitt BR (2013). The absence ofindoleamine 2,3-dioxygenase expression protects against NMDA receptormediatedexcitotoxicity in mouse brain. Exp Neurol 249: 144-148.
159. Mazzeschi C, Pazzagli C, Buratta L, Reboldi GP, Battistini D, Piana N, et al. (2012). Mutual interactions between depression/quality of life and adherence to amultidisciplinary lifestyle intervention in obesity. J Clin Endocrinol Metab 97:E2261-E2265.
160. McIntyre RS, Danilewitz M, Liauw SS, Kemp DE, Nguyen HT, Kahn LS, et al. (2010). Bipolar disorder and metabolic syndrome: an international perspective. J AffectDisord 126: 366-387.
161. McNelis JC, Olefsky JM (2014). Macrophages, immunity, and metabolic disease. Immunity 41: 36-48.
162. Meier TB, Drevets WC, Wurfel BE, Ford BN, Morris HM, Victor TA, et al. (2016). Relationship between neurotoxic kynurenine metabolites and reductions in rightmedial prefrontal cortical thickness in major depressive disorder. Brain BehavImmun 53: 39-48.
163. Milaneschi Y, Lamers F, Bot M, Drent ML, Penninx BW (2015). Leptin dysregulationis specifically associated with major depression with atypical features:evidence for a mechanism connecting obesity and depression. Biol Psychiatry. doi:10. 1016/j. biopsych. 2015. 10. 023 (in press).
164. Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, et al. (2009). Saturated fatty acids produce an inflammatory response predominantly throughthe activation of TLR4 signaling in hypothalamus: implications for the pathogenesisof obesity. J Neurosci 29: 359-370.
165. Mitchell JE, Selzer F, Kalarchian MA, Devlin MJ, Strain GW, Elder KA, et al. (2012). Psychopathology before surgery in the longitudinal assessment of bariatricsurgery-3 (LABS-3) psychosocial study. Surg Obes Relat Dis 8: 533-541.
166. Moreau M, Andre C, O'Connor JC, Dumich SA, Woods JA, Kelley KW, et al. (2008). Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode ofsickness behavior followed by chronic depressive-like behavior. Brain BehavImmun 22: 1087-1095.
167. Moreau M, Lestage J, Verrier D, Mormede C, Kelley KW, Dantzer R, et al. (2005). Bacille Calmette-Guerin inoculation induces chronic activation of peripheral andbrain indoleamine 2,3-dioxygenase in mice. J Infect Dis 192: 537-544.
168. Moy GA, McNay EC (2013). Caffeine prevents weight gain and cognitive impairmentcaused by a high-fat diet while elevating hippocampal BDNF. Physiol Behav 109:69-74.
169. Murr C, Widner B, Wirleitner B, Fuchs D (2002). Neopterin as a marker for immunesystem activation. Curr Drug Metab 3: 175-187.
170. Musselman DL, Lawson DH, Gumnick JF, Manatunga AK, Penna S, Goodkin RSet al (2001). Paroxetine for the prevention of depression induced by high-doseinterferon alfa. N Engl J Med 344: 961-966.
171. Nigatu YT, Bultmann U, Reijneveld SA (2015). The prospective association betweenobesity and major depression in the general population: does single or recurrentepisode matter? BMC Public Health 15: 350.
172. O'Connor JC, Andre C, Wang Y, Lawson MA, Szegedi SS, Lestage J, et al. (2009a). Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation ofindoleamine 2,3-dioxygenase and the induction of depressive-like behavior inmice in response to bacillus Calmette-Guerin. J Neurosci 29: 4200-4209.
173. O'Connor JC, Lawson MA, Andre C, Briley EM, Szegedi SS, Lestage J, et al. (2009b). Induction of IDO by bacille Calmette-Guerin is responsible for development ofmurine depressive-like behavior. J Immunol 182: 3202-3212.
174. O'Connor JC, Lawson MA, Andre C, Moreau M, Lestage J, Castanon N, et al. (2009c). Lipopolysaccharide-induced depressive-like behavior is mediated byindoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry 14: 511-522.
175. Oskooilar N, Wilcox CS, Tong ML, Grosz DE (2009). Body mass index and responseto antidepressants in depressed research subjects. J Clin Psychiatry 70:1609-1610.
176. Oxenkrug G, Tucker KL, Requintina P, Summergrad P (2011). Neopterin, a markerof interferon-gamma-inducible inflammation, correlates with pyridoxal-5'-phosphate,waist circumference, HDL-cholesterol, insulin resistance and mortality riskin adult Boston community dwellers of Puerto Rican origin. Am J NeuroprotNeuroregen 3: 48-52.
177. Oxenkrug GF (2010). Metabolic syndrome, age-associated neuroendocrinedisorders, and dysregulation of tryptophan-kynurenine metabolism. Ann NY AcadSci 1199: 1-14.
178. Pan L, McKain BW, Madan-Khetarpal S, McGuire M, Diler RS, Perel JM, et al. (2011). GTP-cyclohydrolase deficiency responsive to sapropterin and 5-HTP supplementation:relief of treatment-refractory depression and suicidal behaviour. BMJCase Rep pii: bcr0320113927.
179. Pannacciulli N, Del Parigi A, Chen K, Le DS, Reiman EM, Tataranni PA (2006). Brainabnormalities in human obesity: a voxel-based morphometric study. Neuroimage31: 1419-1425.
180. Park HS, Park JY, Yu R (2005). Relationship of obesity and visceral adiposity with serumconcentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract 69: 29-35.
181. Peake JM, Della Gatta P, Suzuki K, Nieman DC (2015). Cytokine expression andsecretion by skeletal muscle cells: regulatory mechanisms and exercise effects. Exerc Immunol Rev 21: 8-25.
182. Pedersen BK, Akerstrom TC, Nielsen AR, Fischer CP (2007). Role of myokines inexercise and metabolism. J Appl Physiol (1985) 103: 1093-1098.
183. Pedersen BK, Febbraio MA (2012). Muscles, exercise and obesity: skeletal muscleas a secretory organ. Nat Rev Endocrinol 8: 457-465.
184. Penninx BW, Milaneschi Y, Lamers F, Vogelzangs N (2013). Understanding thesomatic consequences of depression: biological mechanisms and the role ofdepression symptom profile. BMC Med 11: 129.
185. Petry NM, Barry D, Pietrzak RH, Wagner JA (2008). Overweight and obesity areassociated with psychiatric disorders: results from the National EpidemiologicSurvey on Alcohol and Related Conditions. Psychosom Med 70: 288-297.
186. Pickering RP, Grant BF, Chou SP, Compton WM (2007). Are overweight, obesity,and extreme obesity associated with psychopathology? Results from the nationalepidemiologic survey on alcohol and related conditions. J Clin Psychiatry 68:998-1009.
187. Pistell PJ, Morrison CD, Gupta S, Knight AG, Keller JN, Ingram DK, et al. (2010). Cognitive impairment following high fat diet consumption is associated with braininflammation. J Neuroimmunol 219: 25-32.
188. Pohl J, Woodside B, Luheshi GN (2009). Changes in hypothalamically mediatedacute-phase inflammatory responses to lipopolysaccharide in diet-inducedobese rats. Endocrinology 150: 4901-4910.
189. Pomytkin IA, Cline BH, Anthony DC, Steinbusch HW, Lesch KP, Strekalova T (2015). Endotoxaemia resulting from decreased serotonin tranporter (5-HTT) function: areciprocal risk factor for depression and insulin resistance? Behav Brain Res 276:111-117.
190. Raison CL, Dantzer R, Kelley KW, Lawson MA, Woolwine BJ, Vogt G, et al. (2010). CSF concentrations of brain tryptophan and kynurenines during immunestimulation with IFN-alpha: relationship to CNS immune responses anddepression. Mol Psychiatry 15: 393-403.
191. Raison CL, Rutherford RE, Woolwine BJ, Shuo C, Schettler P, Drake DF, et al. (2013). A randomized controlled trial of the tumor necrosis factor antagonist infliximab fortreatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA psychiatry 70: 31-41.
192. Ransohoff RM, Perry VH (2009). Microglial physiology: unique stimuli, specializedresponses. Annu Rev Immunol 27: 119-145.
193. Rao SR (2012). Inflammatory markers and bariatric surgery: a meta-analysis. Inflamm Res 61: 789-807.
194. Rapaport MH, Nierenberg AA, Schettler PJ, Kinkead B, Cardoos A, Walker R, et al. (2016). Inflammation as a predictive biomarker for response to omega-3 fattyacids in major depressive disorder: a proof-of-concept study. Mol Psychiatry 21:71-79.
195. Rizvi SJ, Grima E, Tan M, Rotzinger S, Lin P, McIntyre RS, et al. (2014). Treatmentresistantdepression in primary care across Canada. Can J Psychiatry 59:349-357.
196. Rummel C, Inoue W, Poole S, Luheshi GN (2010). Leptin regulates leukocyterecruitment into the brain following systemic LPS-induced inflammation. MolPsychiatry 15: 523-534.
197. Salagre E, Fernandes BS, Dodd S, Brownstein DJ, Berk M (2016). Statins for thetreatment of depression: a meta-analysis of randomized, double-blind, placebocontrolledtrials. J Affect Disord 200: 235-242.
198. Salazar A, Gonzalez-Rivera BL, Redus L, Parrott JM, O'Connor JC (2012). Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviorscaused by peripheral lipopolysaccharide immune challenge. Horm Behav 62:202-209.
199. Savitz J, Dantzer R, Wurfel BE, Victor TA, Ford BN, Bodurka J, et al. (2015a). Neuroprotective kynurenine metabolite indices are abnormally reduced andpositively associated with hippocampal and amygdalar volume in bipolar disorder. Psychoneuroendocrinology 52: 200-211.
200. Savitz J, Drevets WC, Smith CM, Victor TA, Wurfel BE, Bellgowan PS, et al. (2015b). Putative neuroprotective and neurotoxic kynurenine pathway metabolites areassociated with hippocampal and amygdalar volumes in subjects with majordepressive disorder. Neuropsychopharmacology 40: 463-471.
201. Savitz JB, Price JL, Drevets WC (2014). Neuropathological and neuromorphometricabnormalities in bipolar disorder: view from the medial prefrontal cortical network. Neurosci Biobehav Rev 42: 132-147.
202. Scheen AJ, Esser N, Paquot N (2015). Antidiabetic agents: potential antiinflammatoryactivity beyond glucose control. Diabetes Metab 41: 183-194.
203. Schmidt MI, Duncan BB (2003). Diabesity: an inflammatory metabolic condition. ClinChem Lab Med 41: 1120-1130.
204. Schneck AS, Iannelli A, Patouraux S, Rousseau D, Bonnafous S, Bailly-Maitre Bet al (2014). Effects of sleeve gastrectomy in high fat diet-induced obesemice: respective role of reduced caloric intake, white adipose tissue inflammationand changes in adipose tissue and ectopic fat depots. Surg Endosc 28:592-602.
205. Schwarcz R, Rassoulpour A, Wu HQ, Medoff D, Tamminga CA, Roberts RC (2001). Increased cortical kynurenate content in schizophrenia. Biol Psychiatry 50:521-530.
206. Sharma S, Fulton S (2013). Diet-induced obesity promotes depressive-likebehaviour that is associated with neural adaptations in brain reward circuitry. IntJ Obes (Lond) 37: 382-389.
207. Simon GE, Ludman EJ, Linde JA, Operskalski BH, Ichikawa L, Rohde P, et al. (2008). Association between obesity and depression in middle-aged women. Gen HospPsychiatry 30: 32-39.
208. Sinha R, Jastreboff AM (2013). Stress as a common risk factor for obesity andaddiction. Biol Psychiatry 73: 827-835.
209. Steiner J, Walter M, Gos T, Guillemin GJ, Bernstein HG, Sarnyai Z, et al. (2011). Severe depression is associated with increased microglial quinolinic acid insubregions of the anterior cingulate gyrus: evidence for an immune-modulatedglutamatergic neurotransmission? J Neuroinflammation 8: 94.
210. Stone TW, Forrest CM, Stoy N, Darlington LG (2012). Involvement of kynurenines inHuntington's disease and stroke-induced brain damage. J Neural Transm 119:261-274.
211. Stranahan AM, Arumugam TV, Cutler RG, Lee K, Egan JM, Mattson MP (2008). Diabetes impairs hippocampal function through glucocorticoid-mediated effectson new and mature neurons. Nat Neurosci 11: 309-317.
212. Stranahan AM, Lee K, Martin B, Maudsley S, Golden E, Cutler RG, et al. (2009). Voluntary exercise and caloric restriction enhance hippocampal dendritic spinedensity and BDNF levels in diabetic mice. Hippocampus 19: 951-961.
213. Su KP, Lai HC, Yang HT, Su WP, Peng CY, Chang JP, et al. (2014). Omega-3 fattyacids in the prevention of interferon-alpha-induced depression: results from arandomized, controlled trial. Biol Psychiatry 76: 559-566.
214. Tehrani AB, Nezami BG, Gewirtz A, Srinivasan S (2012). Obesity and its associateddisease: a role for microbiota? Neurogastroenterol Motil 24: 305-311.
215. Thaler JP, Schwartz MW (2010). Minireview: inflammation and obesity pathogenesis:the hypothalamus heats up. Endocrinology 151: 4109-4115.
216. Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, et al. (2012). Obesity is associated with hypothalamic injury in rodents and humans. J ClinInvest 122: 153-162.
217. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, et al. (2009). A core gut microbiome in obese and lean twins. Nature 457: 480-484.
218. Vannucchi G, Toni C, Maremmani I, Perugi G (2014). Does obesity predict bipolarityin major depressive patients? J Affect Disord 155: 118-122.
219. Velloso LA, Araujo EP, de Souza CT (2008). Diet-induced inflammation of thehypothalamus in obesity. Neuroimmunomodulation 15: 189-193.
220. Verdam FJ, Fuentes S, de Jonge C, Zoetendal EG, Erbil R, Greve JW, et al. (2013). Human intestinal microbiota composition is associated with local and systemicinflammation in obesity. Obesity 21: E607-E615.
221. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB (1999). ElevatedC-reactive protein levels in overweight and obese adults. JAMA 282: 2131-2135.
222. Volkow ND, Wang GJ, Baler RD (2011). Reward, dopamine and the control of foodintake: implications for obesity. Trends Cogn Sci 15: 37-46.
223. Walker AK, Budac DP, Bisulco S, Lee AW, Smith RA, Beenders B, et al. (2013). NMDAreceptor blockade by ketamine abrogates lipopolysaccharide-induced depressivelikebehavior in C57BL/6J mice. Neuropsychopharmacology 38: 1609-1616.
224. Wang GJ, Volkow ND, Logan J, Pappas NR, Wong CT, Zhu W, et al. (2001). Braindopamine and obesity. Lancet 357: 354-357.
225. Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, et al. (2013). Global burden of disease attributable to mental and substance use disorders:findings from the Global Burden of Disease Study 2010. Lancet 382: 1575-1586.
226. Woo YS, Seo HJ, McIntyre RS, Bahk WM (2016). Obesity and its potential effects onantidepressant treatment outcomes in patients with depressive disorders: aliterature review. Int J Mol Sci. E80.
227. Wosiski-Kuhn M, Erion JR, Gomez-Sanchez EP, Gomez-Sanchez CE, Stranahan AM(2014). Glucocorticoid receptor activation impairs hippocampal plasticity by suppressingBDNF expression in obese mice. Psychoneuroendocrinology 42: 165-177.
228. Wulsin LR, Singal BM (2003). Do depressive symptoms increase the risk for theonset of coronary disease? A systematic quantitative review. Psychosom Med 65:201-210.
229. Xie W, Cai L, Yu Y, Gao L, Xiao L, He Q, et al. (2014). Activation of brain indoleamine2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior inrats with chronic temporal lobe epilepsy. J Neuroinflammation 11: 41.
230. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. (2003). Chronicinflammation in fat plays a crucial role in the development of obesity-related insulinresistance. J Clin Invest 112: 1821-1830.
231. Yang PJ, Lee WJ, Tseng PH, Lee PH, Lin MT, Yang WS (2014). Bariatricsurgery decreased the serum level of an endotoxin-associated marker:lipopolysaccharide-binding protein. Surg Obes Relat Dis 10: 1182-1187.
232. Yates KF, Sweat V, Yau PL, Turchiano MM, Convit A (2012). Impact of metabolicsyndrome on cognition and brain: a selected review of the literature. ArteriosclerThromb Vasc Biol 32: 2060-2067.
233. Yokum S, Ng J, Stice E (2012). Relation of regional gray and white matter volumes tocurrent BMI and future increases in BMI: a prospective MRI study. Int J Obes(Lond) 36: 656-664.
234. Zeyda M, Huber J, Prager G, Stulnig TM (2011). Inflammation correlates withmarkers of T-cell subsets including regulatory T cells in adipose tissue from obesepatients. Obesity 19: 743-748.
235. Zhang H, Wang Y, Zhang J, Potter BJ, Sowers JR, Zhang C (2011). Bariatric surgeryreduces visceral adipose inflammation and improves endothelial function in type 2diabetic mice. Arterioscler Thromb Vasc Biol 31: 2063-2069.
236. Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D (2008). Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell135: 61-73.
237. Zunszain PA, Anacker C, Cattaneo A, Choudhury S, Musaelyan K, Myint AMet al (2012). Interleukin-1beta: a new regulator of the kynurenine pathwayaffecting human hippocampal neurogenesis. Neuropsychopharmacology 37:939-949.