Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX3CR1)-deficient mice

Brain, Behavior, and Immunity

Volumn 31, Issue , 2013, Pages 134-142

  Corona, Angela W ^a   Norden, Diana M ^a   Skendelas, John P ^a   Huang, Yan ^a   O'Connor, Jason C ^b   Lawson, Marcus ^c   Dantzer, Robert ^c   Kelley, Keith W ^c   Godbout, Jonathan P ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

1 Methyl tryptophan; Depression; Fractalkine receptor; Indoleamine 2,3 dioxygenase; Kynurenine; Microglia

Indexed keywords

1 METHYLTRYPTOPHAN; 3 HYDROXYKYNURENINE; 5 HYDROXYINDOLEACETIC ACID; CHEMOKINE RECEPTOR CX3CR1; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; KYNURENINE; LIPOPOLYSACCHARIDE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID BLOOD LEVEL; AMINO ACID BRAIN LEVEL; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPRESSION; ENZYME ACTIVATION; ENZYME INHIBITION; HIPPOCAMPUS; LOCOMOTION; MACROPHAGE ACTIVATION; MICROGLIA; MOUSE; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; SLOW DRUG RELEASE; WEIGHT REDUCTION;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; DEPRESSION; HYDROXYINDOLEACETIC ACID; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; KYNURENINE; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; MOTOR ACTIVITY; RECEPTORS, CYTOKINE; RECEPTORS, HIV; SEROTONIN; TRYPTOPHAN;

EID: 84878145540     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2012.08.008     Document Type: Article

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