Leptin Dysregulation Is Specifically Associated With Major Depression With Atypical Features: Evidence for a Mechanism Connecting Obesity and Depression

Biological Psychiatry

Volumn 81, Issue 9, 2017, Pages 807-814

  Milaneschi, Yuri ^a   Lamers, Femke ^a   Bot, Mariska ^a   Drent, Madeleine L ^a   Penninx, Brenda W J H ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Atypical; Epidemiology; Heterogeneity; Leptin; Major depression; Obesity

Indexed keywords

LEPTIN;

ADULT; AGED; ARTICLE; BODY MASS; BODY WEIGHT; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; DEPRESSION ASSESSMENT; ENERGY EXPENDITURE; FEMALE; FOOD INTAKE; HUMAN; HYPERLEPTINEMIA; HYPERPHAGIA; INVENTORY OF DEPRESSIVE SYMPTOMATOLOGY; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; NETHERLANDS; OBESITY; PARALYSIS; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; WAIST CIRCUMFERENCE; ADOLESCENT; BLOOD; COMPLICATION; DEPRESSIVE DISORDER, MAJOR; MIDDLE AGED; YOUNG ADULT;

ADIPOSITY; ADOLESCENT; ADULT; AGED; BODY MASS INDEX; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; LEPTIN; MALE; MIDDLE AGED; NETHERLANDS; OBESITY; YOUNG ADULT;

EID: 84952013183     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2015.10.023     Document Type: Article

References (44)

1. 1 Luppino, F.S., de Wit, L.M., Bouvy, P.F., Stijnen, T., Cuijpers, P., Penninx, B.W., Zitman, F.G., Overweight, obesity, and depression: A systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry 67 (2010), 220–229.
2. 2 Penninx, B.W., Milaneschi, Y., Lamers, F., Vogelzangs, N., Understanding the somatic consequences of depression: Biological mechanisms and the role of depression symptom profile. BMC Med, 11, 2013, 129.
3. 3 Lu, X.Y., The leptin hypothesis of depression: A potential link between mood disorders and obesity?. Curr Opin Pharmacol 7 (2007), 648–652.
4. 4 Morton, G.J., Meek, T.H., Schwartz, M.W., Neurobiology of food intake in health and disease. Nat Rev Neurosci 15 (2014), 367–378.
5. 5 Krishnan, V., Nestler, E.J., Linking molecules to mood: New insight into the biology of depression. Am J Psychiatry 167 (2010), 1305–1320.
6. 6 Farr, O.M., Tsoukas, M.A., Mantzoros, C.S., Leptin and the brain: Influences on brain development, cognitive functioning and psychiatric disorders. Metabolism 64 (2015), 114–130.
7. 7 Bouret, S.G., Neurodevelopmental actions of leptin. Brain Res 1350 (2010), 2–9.
8. 8 Licinio, J., Mantzoros, C., Negrao, A.B., Cizza, G., Wong, M.L., Bongiorno, P.B., et al. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 3 (1997), 575–579.
9. 9 Zupancic, M.L., Mahajan, A., Leptin as a neuroactive agent. Psychosom Med 73 (2011), 407–414.
10. 10 Milaneschi, Y., Simonsick, E.M., Vogelzangs, N., Strotmeyer, E.S., Yaffe, K., Harris, T.B., et al. Leptin, abdominal obesity, and onset of depression in older men and women. J Clin Psychiatry 73 (2012), 1205–1211.
11. 11 Milaneschi, Y., Sutin, A.R., Terracciano, A., Canepa, M., Gravenstein, K.S., Egan, J.M., et al. The association between leptin and depressive symptoms is modulated by abdominal adiposity. Psychoneuroendocrinology 42 (2014), 1–10.
12. 12 Hryhorczuk, C., Sharma, S., Fulton, S.E., Metabolic disturbances connecting obesity and depression. Front Neurosci, 7, 2013, 177.
13. 13 Carvalho, A.F., Rocha, D.Q., McIntyre, R.S., Mesquita, L.M., Kohler, C.A., Hyphantis, T.N., et al. Adipokines as emerging depression biomarkers: A systematic review and meta-analysis. J Psychiatr Res 59 (2014), 28–37.
14. 14 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th Edition: DSM-5. 2013, American Psychiatric Association, Washington, DC.
15. 15 Sullivan, P.F., Kessler, R.C., Kendler, K.S., Latent class analysis of lifetime depressive symptoms in the national comorbidity survey. Am J Psychiatry 155 (1998), 1398–1406.
16. 16 Sullivan, P.F., Prescott, C.A., Kendler, K.S., The subtypes of major depression in a twin registry. J Affect Disord 68 (2002), 273–284.
17. 17 Kendler, K.S., Eaves, L.J., Walters, E.E., Neale, M.C., Heath, A.C., Kessler, R.C., The identification and validation of distinct depressive syndromes in a population-based sample of female twins. Arch Gen Psychiatry 53 (1996), 391–399.
18. 18 Lamers, F., de Jonge, P., Nolen, W.A., Smit, J.H., Zitman, F.G., Beekman, A.T., Penninx, B.W., Identifying depressive subtypes in a large cohort study: Results from the Netherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry 71 (2010), 1582–1589.
19. 19 Lamers, F., Rhebergen, D., Merikangas, K.R., de Jonge, P., Beekman, A.T., Penninx, B.W., Stability and transitions of depressive subtypes over a 2-year follow-up. Psychol Med 42 (2012), 2083–2093.
20. 20 Lamers, F., Vogelzangs, N., Merikangas, K.R., de Jonge, P., Beekman, A.T., Penninx, B.W., Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. Mol Psychiatry 18 (2013), 692–699.
21. 21 Lasserre, A.M., Glaus, J., Vandeleur, C.L., Marques-Vidal, P., Vaucher, J., Bastardot, F., et al. Depression with atypical features and increase in obesity, body mass index, waist circumference, and fat mass: A prospective, population-based study. JAMA Psychiatry 71 (2014), 880–888.
22. 22 Gecici, O., Kuloglu, M., Atmaca, M., Tezcan, A.E., Tunckol, H., Emul, H.M., Ustundag, B., High serum leptin levels in depressive disorders with atypical features. Psychiatry Clin Neurosci 59 (2005), 736–738.
23. 23 Penninx, B.W., Beekman, A.T., Smit, J.H., Zitman, F.G., Nolen, W.A., Spinhoven, P., et al. The Netherlands Study of Depression and Anxiety (NESDA): Rationale, objectives and methods. Int J Methods Psychiatr Res 17 (2008), 121–140.
24. 24 World Health Organization. The Composite Interview Diagnostic Instrument. 1997, World Health Organization, Geneva.
25. 25 Rush, A.J., Gullion, C.M., Basco, M.R., Jarrett, R.B., Trivedi, M.H., The Inventory of Depressive Symptomatology (IDS): Psychometric properties. Psychol Med 26 (1996), 477–486.
26. 26 Milaneschi, Y., Lamers, F., Peyrot, W.J., Abdellaoui, A., Willemsen, G., Hottenga, J.J., et al. Polygenic dissection of major depression clinical heterogeneity. Mol Psychiatry 21 (2016), 516–522.
27. 27 Craig, C.L., Marshall, A.L., Sjostrom, M., Bauman, A.E., Booth, M.L., Ainsworth, B.E., et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 35 (2003), 1381–1395.
28. 28 World Health Organization Collaboration Centre for Drug Statistics Methodology. Anatomical Therapeutic Chemical (ATC) Classification System. 2007, World Health Organization, Oslo.
29. 29 Benjamini, Y., Hochberg, Y., Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 57 (1995), 289–300.
30. 30 Gold, P.W., The organization of the stress system and its dysregulation in depressive illness. Mol Psychiatry 20 (2015), 32–47.
31. 31 Munzberg, H., Myers, M.G. Jr, Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 8 (2005), 566–570.
32. 32 Koch, M., Horvath, T.L., Molecular and cellular regulation of hypothalamic melanocortin neurons controlling food intake and energy metabolism. Mol Psychiatry 19 (2014), 752–761.
33. 33 Ring, L.E., Zeltser, L.M., Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels. J Clin Invest 120 (2010), 2931–2941.
34. 34 Lu, X.Y., Kim, C.S., Frazer, A., Zhang, W., Leptin: A potential novel antidepressant. Proc Natl Acad Sci U S A 103 (2006), 1593–1598.
35. 35 Garza, J.C., Guo, M., Zhang, W., Lu, X.Y., Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3beta/beta-catenin signaling. Mol Psychiatry 17 (2012), 790–808.
36. 36 Yamada, N., Katsuura, G., Ochi, Y., Ebihara, K., Kusakabe, T., Hosoda, K., Nakao, K., Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology 152 (2011), 2634–2643.
37. 37 Guo, M., Huang, T.Y., Garza, J.C., Chua, S.C., Lu, X.Y., Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours. Int J Neuropsychopharmacol 16 (2013), 857–867.
38. 38 Guo, M., Lu, X.Y., Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates. Transl Psychiatry, 4, 2014, e486.
39. 39 Osborn, O., Olefsky, J.M., The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 18 (2012), 363–374.
40. 40 Paz-Filho, G., Mastronardi, C.A., Licinio, J., Leptin treatment: Facts and expectations. Metabolism 64 (2015), 146–156.
41. 41 Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., Cai, D., Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135 (2008), 61–73.
42. 42 Thaler, J.P., Yi, C.X., Schur, E.A., Guyenet, S.J., Hwang, B.H., Dietrich, M.O., et al. Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest 122 (2012), 153–162.
43. 43 Milaneschi, Y., Lamers, F., Mbarek, H., Hottenga, J.J., Boomsma, D.I., Penninx, B.W., The effect of FTO rs9939609 on major depression differs across MDD subtypes. Mol Psychiatry 19 (2014), 960–962.
44. 44 Vogelzangs, N., Beekman, A.T., van Reedt Dortland, A.K., Schoevers, R.A., Giltay, E.J., de Jonge, P., Penninx, B.W., Inflammatory and metabolic dysregulation and the 2-year course of depressive disorders in antidepressant users. Neuropsychopharmacology 39 (2014), 1624–1634.