CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice

Diabetologia

Volumn 57, Issue 7, 2014, Pages 1456-1465

  Kim, Dayea ^a   Kim, Jaeyoon ^b   Yoon, Jong Hyuk ^a   Ghim, Jaewang ^a   Yea, Kyungmoo ^a   Song, Parkyong ^a   Park, Soyeon ^a   Lee, Areum ^a   Hong, Chun Pyo ^a,c   Jang, Min Seong ^a,c   Kwon, Yonghoon ^a   Park, Sehoon ^a   Jang, Myoung Ho ^a,c   Berggren, Per Olof ^a,b   Suh, Pann Ghill ^d   Ryu, Sung Ho ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Institute for Basic Science   (South Korea)

^d Ulsan National Institute of Science and Technology   (South Korea)

Author keywords

Adipokines; Adipose tissue inflammation; CXCL12; Macrophage recruitment; SDF1

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; INSULIN; MACROPHAGE CHEMOTACTIC FACTOR; PLERIXAFOR; STROMAL CELL DERIVED FACTOR 1;

3T3 CELL LINE; ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMOTAXIS ASSAY; CONTROLLED STUDY; CYTOKINE RELEASE; EXPERIMENTAL OBESITY; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEUKOCYTE MIGRATION; MACROPHAGE FUNCTION; MACROPHAGE MIGRATION INHIBITION; MONOCYTE; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SYSTEMIC THERAPY; TANDEM MASS SPECTROMETRY; WHITE ADIPOSE TISSUE; ADIPOSE TISSUE; ANIMAL; CELL LINE; CHEMOTAXIS; MACROPHAGE; METABOLISM; OBESITY; PHYSIOLOGY; SECRETION (PROCESS);

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; CELL LINE; CHEMOKINE CXCL12; CHEMOTAXIS; INSULIN RESISTANCE; MACROPHAGES; MICE; OBESITY;

EID: 84903531205     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3237-5     Document Type: Article

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