TNFα mediates stress-induced depression by upregulating indoleamine 2,3-dioxygenase in a mouse model of unpredictable chronic mild stress

European Cytokine Network

Volumn 26, Issue 1, 2015, Pages 15-25

  Liu, Yu Ning ^a   Peng, Yun Li ^a   Lei Liu, ^a   Wu, Teng Yun ^a   Zhang, Yi ^a   Lian, Yong Jie ^a   Yang, Yuan Yuan ^a   Kelley, Keith W ^b   Jiang, Chun Lei ^a   Wang, Yun Xia ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

3 dioxygenase; Depression like behavior; Indoleamine 2; Minocycline; TNF ; Unpredictable chronic mild stress

Indexed keywords

INDOLEAMINE 2,3 DIOXYGENASE; INFLIXIMAB; INTERLEUKIN 18; INTERLEUKIN 1BETA; MINOCYCLINE; N METHYLTRYPTOPHAN; TUMOR NECROSIS FACTOR ALPHA; 1-METHYLTRYPTOPHAN; ANTIINFLAMMATORY AGENT; TRYPTOPHAN; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR ASSESSMENT; CELL DAMAGE; CHRONIC STRESS; CONTROLLED STUDY; DEPRESSION; FORCED SWIM TEST; IMMOBILITY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NISSL STAINING; NONHUMAN; PROTEIN EXPRESSION; SUCROSE PREFERENCE TEST; TAIL SUSPENSION TEST; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BRAIN CORTEX; CHRONIC DISEASE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMOBILIZATION; INFLAMMATION; MENTAL STRESS; METABOLISM; MOTOR ACTIVITY; NERVE CELL; PATHOLOGY; PREVENTION AND CONTROL; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CEREBRAL CORTEX; CHRONIC DISEASE; DEPRESSION; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HINDLIMB SUSPENSION; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INFLAMMATION; INFLIXIMAB; INTERLEUKIN-18; INTERLEUKIN-1BETA; MALE; MICE; MICE, INBRED BALB C; MINOCYCLINE; MOTOR ACTIVITY; NEURONS; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL; TRYPTOPHAN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84932118356     PISSN: 11485493     EISSN: 19524005     Source Type: Journal    
DOI: 10.1684/ecn.2015.0362     Document Type: Article

References (47)

1. Machado M, Iskedjian M, Ruiz I, Einarson TR. Remission, dropouts, and adverse drug reaction rates in major depressive disorder:a meta-analysis of head-to-head trials. Curr Med Res Opin 2006; 22: 1825-37.
2. Souery D, Papakostas GI, Trivedi MH. Treatment-resistant depression. J Clin Psychiatry 2006; 67(Suppl 6): 16-22.
3. Smith RS. The macrophage theory of depression. Med Hypotheses 1991; 35: 298-306.
4. Maes M. Evidence for an immune response in major depression:a reviewand hypothesis. Prog Neuropsychopharmacol Biol Psychiatry 1995; 19: 11-38.
5. Adler UC, Marques AH, Calil HM. Inflammatory aspects of depression. Inflamm Allergy Drug Targets 2008; 7: 19-23.
6. Raison CL, Capuron L, Miller AH. Cytokines sing the blues:inflammation and the pathogenesis of depression. Trends Immunol 2006; 27: 24-31.
7. Das UN. Is depression a low-grade systemic inflammatory condition? Am J Clin Nutr 2007; 85: 1665-6 [author reply 1666].
8. Raedler TJ. Inflammatory mechanisms in major depressive disorder. Curr Opin Psychiatry 2011; 24: 519-25.
9. Tynan RJ, Weidenhofer J, Hinwood M, Cairns MJ, Day TA, Walker FR. A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia. Brain Behav Immun 2012; 26: 469-79.
10. Kemeny ME, Schedlowski M. Understanding the interaction between psychosocial stress and immune-related diseases:a stepwise progression. Brain Behav Immun 2007; 21: 1009-18.
11. Steptoe A, Hamer M, Chida Y. The effects of acute psychological stress on circulating inflammatory factors in humans:a review and meta-analysis. Brain Behav Immun 2007; 21: 901-12.
12. Maes M, Song C, Lin A, et al. The effects of psychological stress on humans:increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine 1998; 10: 313-8.
13. Miller GE, Chen E, Sze J, et al. A functional genomic fingerprint of chronic stress in humans:blunted glucocorticoid and increased NF-kappaB signaling. Biol Psychiatry 2008; 64: 266-72.
14. Goshen I, Kreisel T, Ben-Menachem-Zidon O, et al. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry 2008; 13: 717-28.
15. Mikova O, Yakimova R, Bosmans E, Kenis G, Maes M. Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis. Eur Neuropsychopharmacol 2001; 11: 203-8.
16. Dowlati Y, Herrmann N, Swardfager W, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry 2010; 67: 446-57.
17. Tyring S, Gottlieb A, Papp K, et al. Etanercept and clinical outcomes, fatigue, and depression in psoriasis:double-blind placebo-controlled randomised phase III trial. Lancet 2006; 367: 29-35.
18. Bassukas ID, Hyphantis T, Gamvroulia C, Gaitanis G, Mavreas V. Infliximab for patients with plaque psoriasis and severe psychiatric comorbidity. J Eur Acad Dermatol Venereol 2008; 22: 257-8.
19. Leonard B, Maes M. Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev 2012; 36: 764-85.
20. Capuron L, Ravaud A, Neveu PJ, Miller AH, Maes M, Dantzer R. Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Mol Psychiatry 2002; 7: 468-73.
21. O’Connor JC, André C, Wang Y, et al. Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3- dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin. J Neurosci 2009; 29: 4200-9.
22. Bonaccorso S, Marino V, Puzella A, et al. Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonergic system. J Clin Psychopharmacol 2002; 22: 86-90.
23. Bonaccorso S, Marino V, Puzella A, et al. Interferon-gammadependent/independent expression of indoleamine 2,3-dioxygenase. Studies with interferon-gamma-knockout mice. Adv Exp Med Biol 1999; 467: 553-7.
24. Popov A, Abdullah Z, Wickenhauser C, et al. Indoleamine 2,3-dioxygenase-expressing dendritic cells form suppurative granulomas following Listeria monocytogenes infection. J Clin Invest 2006; 116: 3160-70.
25. Fujigaki S, Saito K, Sekikawa K, et al. Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFNgamma-independent mechanism. Eur J Immunol 2001; 31: 2313-8.
26. Peng YL, Liu YN, Liu L, Wang X, Jiang CL, Wang YX. Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress. J Neuroinflammation 2012; 9: 75.
27. Xiong W, MacTaggart J, Knispel R, Worth J, Persidsky Y, Baxter BT. Blocking TNF-alpha attenuates aneurysm formation in a murine model. J Immunol 2009; 183: 2741-6.
28. Hou W, Li S, Wu Y, Du X, Yuan F. Inhibition of indoleamine 2, 3-dioxygenase-mediated tryptophan catabolism accelerates crescentic glomerulonephritis. Clin Exp Immunol 2009; 156: 363-72.
29. Padi SS, Kulkarni SK. Minocycline prevents the development of neuropathic pain, but not acute pain:possible anti-inflammatory and antioxidant mechanisms. Eur J Pharmacol 2008; 601: 79-87.
30. Karson A, Demirtas¸ T, Bayramgürler D, Balci F, Utkan T. Chronic administration of infliximab (TNF-alpha inhibitor) decreases depression and anxiety-like behaviour in rat model of chronic mild stress. Basic Clin Pharmacol Toxicol 2013; 112: 335-40.
31. Bourin M, Chenu F, Ripoll N, David DJ. A proposal of decision tree to screen putative antidepressants using forced swim and tail suspension tests. Behav Brain Res 2005; 164: 266-9.
32. Datta SC, Opp MR. Lipopolysaccharide-induced increases in cytokines in discrete mouse brain regions are detectable using Luminex xMAP technology. J Neurosci Methods 2008; 175: 119-24.
33. Granger JI, Ratti PL, Datta SC, Raymond RM, Opp MR. Sepsisinduced morbidity in mice:effects on body temperature, body weight, cage activity, social behavior and cytokines in brain. Psychoneuroendocrinology 2013; 38: 1047-57.
34. Krabbe KS, Reichenberg A, Yirmiya R, Smed A, Pedersen BK, Bruunsgaard H. Low-dose endotoxemia and human neuropsychological functions. Brain Behav Immun 2005; 19: 453-60.
35. Kubera M, Obuchowicz E, Goehler L, Brzeszcz J, Maes M. In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35: 744-59.
36. Aronson AL. Pharmacotherapeutics of the newer tetracyclines. J Am Vet Med Assoc 1980; 176(10 Spec No): 1061-8.
37. Huang CY, Chen YL, Li AH, Lu JC, Wang HL. Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons. J Neuroinflammation 2014; 11: 7.
38. Du Y, Ma Z, Lin S, et al. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease. Proc Natl Acad Sci U S A 2001; 98: 14669-74.
39. Zhu S, Stavrovskaya IG, Drozda M, et al. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 2002; 417: 74-8.
40. Wang CX, Shuaib A. Involvement of inflammatory cytokines in central nervous system injury. Prog Neurobiol 2002; 67: 161-72.
41. McAfoose J, Baune BT. Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev 2009; 33: 355-66.
42. Zhao C, Ling Z, Newman MB, Bhatia A, Carvey PM. TNF-alpha knockout and minocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice. Neurobiol Dis 2007; 26: 36-46.
43. Raison CL, Borisov AS, Woolwine BJ, Massung B, Vogt G, Miller AH. Interferon-alpha effects on diurnal hypothalamic-pituitaryadrenal axis activity:relationship with proinflammatory cytokines and behavior. Mol Psychiatry 2010; 15: 535-47.
44. Maes MI, Meltzer HY, Scharpé S, et al. Relationships between lower plasma L-tryptophan levels and immune-inflammatory variables in depression. Psychiatry Res 1993; 49: 151-65.
45. Couch Y, Anthony DC, Dolgov O, et al. Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia. Brain Behav Immun 2013; 29: 136-46.
46. Lanquillon S, Krieg JC, Bening-Abu-Shach U, Vedder H. Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology 2000; 22: 370-9.
47. Sluzewska A, Sobieska M, Rybakowski JK. Changes in acute-phase proteins during lithium potentiation of antidepressants in refractory depression. Neuropsychobiology 1997; 35: 23-7.