Neuropsychiatric comorbidity in obesity: Role of inflammatory processes

Frontiers in Endocrinology

Volumn 5, Issue MAY, 2014, Pages

  Castanon, Nathalie ^a,b   Lasselin, Julie ^a,b,c   Capuron, Lucile ^a,b  

^a NutriNeuro Bordeaux University   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Cognition; Cytokines; Gut brain axis; Inflammation; Mood; Neuroinflammation; Neuropsychiatric symptoms; Obesity

Indexed keywords

ALPHA INTERFERON; BRAIN DERIVED NEUROTROPHIC FACTOR; C REACTIVE PROTEIN; INTERLEUKIN 6; NEUROTRANSMITTER; TUMOR NECROSIS FACTOR ALPHA;

ANXIETY DISORDER; BACTEROIDETES; BIFIDOBACTERIUM; BODY MASS; COGNITIVE DEFECT; COMORBIDITY; CYTOKINE PRODUCTION; GENETIC MODEL; IMMUNOCOMPETENCE; INFLAMMATION; INSULIN RESISTANCE; INTESTINE FLORA; MEMORY; METABOLIC DISORDER; METABOLIC SYNDROME X; MOOD DISORDER; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROLOGIC DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PROBLEM SOLVING; PROTEIN EXPRESSION; QUALITY OF LIFE; REVIEW; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

EID: 84905499874     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2014.00074     Document Type: Review

References (139)

1. Roberts RO, Geda YE, Knopman DS, Cha RH, Boeve BF, Ivnik RJ, et al. Metabolic syndrome, inflammation, and nonamnestic mild cognitive impairment in older persons: a population-based study. Alzheimer Dis Assoc Disord (2010) 24:11-8. doi:10.1097/WAD.0b013e3181a4485c
2. Goldbacher EM, Bromberger J, Matthews KA. Lifetime history of major depression predicts the development of the metabolic syndrome in middle-aged women. Psychosom Med (2009) 71:266-72. doi:10.1097/PSY.0b013e318197a4d5
3. Lasselin J, Capuron L. Chronic low-grade inflammation in metabolic disorders: relevance for behavioral symptoms. Neuroimmunomodulation (2014) 21:95-101. doi:10.1159/000356535
4. Lin HY, Huang CK, Tai CM, Kao YH, Tsai CC, Hsuan CF, et al. Psychiatric disorders of patients seeking obesity treatment. BMC Psychiatry (2013) 13:1. doi:10.1186/1471-244X-13-1
5. Evans DL, Charney DS, Lewis L, Golden RN, Gorman JM, Krishnan KR, et al. Mood disorders in the medically ill: scientific review and recommendations. Biol Psychiatry (2005) 58:175-89. doi:10.1016/j.biopsych.2005.05.001
6. Boeka AG, Lokken KL. Neuropsychological performance of a clinical sample of extremely obese individuals. Arch Clin Neuropsychol (2008) 23:467-74. doi:10.1016/j.acn.2008.03.003
7. Fagundo AB, de la Torre R, Jimenez-Murcia S, Aguera Z, Granero R, Tarrega S, et al. Executive functions profile in extreme eating/weight conditions: from anorexia nervosa to obesity. PLoS One (2012) 7:e43382. doi:10.1371/journal.pone.0043382
8. Fergenbaum JH, Bruce S, Lou W, Hanley AJ, Greenwood C, Young TK. Obesity and lowered cognitive performance in a Canadian First Nations population. Obesity (Silver Spring) (2009) 17:1957-63. doi:10.1038/oby.2009.161
9. Lokken KL, Boeka AG, Yellumahanthi K, Wesley M, Clements RH. Cognitive performance of morbidly obese patients seeking bariatric surgery. Am Surg (2010) 76:55-9.
10. Elias MF, Elias PK, Sullivan LM, Wolf PA, D'Agostino RB. Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study. Int J Obes Relat Metab Disord (2003) 27:260-8. doi:10.1038/sj.ijo.802225
11. Gunstad J, Paul RH, Cohen RA, Tate DF, Gordon E. Obesity is associated with memory deficits in young and middle-aged adults. Eat Weight Disord (2006) 11:e15-9. doi:10.1007/BF03327747
12. Cournot M, Marquie JC, Ansiau D, Martinaud C, Fonds H, Ferrieres J, et al. Relation between body mass index and cognitive function in healthy middle-aged men and women. Neurology (2006) 67:1208-14. doi:10.1212/01.wnl.0000238082.13860.50
13. Dahl AK, Hassing LB, Fransson EI, Gatz M, Reynolds CA, Pedersen NL. Body mass index across midlife and cognitive change in late life. Int J Obes (Lond) (2013) 37:296-302. doi:10.1038/ijo.2012.37
14. Sabia S, Kivimaki M, Shipley MJ, Marmot MG, Singh-Manoux A. Body mass index over the adult life course and cognition in late midlife: the Whitehall II Cohort Study. Am J Clin Nutr (2009) 89:601-7. doi:10.3945/ajcn.2008.26482
15. Siervo M, Arnold R, Wells JC, Tagliabue A, Colantuoni A, Albanese E, et al. Intentional weight loss in overweight and obese individuals and cognitive function: a systematic review and meta-analysis. Obes Rev (2011) 12:968-83. doi:10.1111/j.1467-789X.2011.00903.x
16. Alosco ML, Spitznagel MB, Strain G, Devlin M, Cohen R, Paul R, et al. Improved memory function two years after bariatric surgery. Obesity (Silver Spring) (2014) 22:32-8. doi:10.1002/oby.20494
17. Miller LA, Crosby RD, Galioto R, Strain G, Devlin MJ, Wing R, et al. Bariatric surgery patients exhibit improved memory function 12 months postoperatively. Obes Surg (2013) 23:1527-35. doi:10.1007/s11695-013-0970-7
18. Brinkworth GD, Buckley JD, Noakes M, Clifton PM, Wilson CJ. Long-term effects of a very low-carbohydrate diet and a low-fat diet on mood and cognitive function. Arch Intern Med (2009) 169:1873-80. doi:10.1001/archinternmed.2009.329
19. Halyburton AK, Brinkworth GD, Wilson CJ, Noakes M, Buckley JD, Keogh JB, et al. Low- and high-carbohydrate weight-loss diets have similar effects on mood but not cognitive performance. Am J Clin Nutr (2007) 86:580-7.
20. Andersen JR, Aasprang A, Bergsholm P, Sletteskog N, Vage V, Natvig GK. Anxiety and depression in association with morbid obesity: changes with improved physical health after duodenal switch. Health Qual Life Outcomes (2010) 8:52. doi:10.1186/1477-7525-8-52
21. Dixon JB, Dixon ME, O'Brien PE. Depression in association with severe obesity: changes with weight loss. Arch Intern Med (2003) 163:2058-65. doi:10.1001/archinte.163.17.2058
22. Thonney B, Pataky Z, Badel S, Bobbioni-Harsch E, Golay A. The relationship between weight loss and psychosocial functioning among bariatric surgery patients. Am J Surg (2010) 199:183-8. doi:10.1016/j.amjsurg.2008.12.028
23. Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry (2010) 67:220-9. doi:10.1001/archgenpsychiatry.2010.2
24. Guxens M, Mendez MA, Julvez J, Plana E, Forns J, Basagana X, et al. Cognitive function and overweight in preschool children. Am J Epidemiol (2009) 170:438-46. doi:10.1093/aje/kwp140
25. Osika W, Montgomery SM, Longitudinal Birth Cohort Study. Physical control and coordination in childhood and adult obesity: Longitudinal Birth Cohort Study. BMJ (2008) 337:a699. doi:10.1136/bmj.a699
26. Davis C, Levitan RD, Muglia P, Bewell C, Kennedy JL. Decision-making deficits and overeating: a risk model for obesity. Obes Res (2004) 12:929-35. doi:10.1038/oby.2004.113
27. Kanasaki K, Koya D. Biology of obesity: lessons from animal models of obesity. J Biomed Biotechnol (2011) 2011:197636. doi:10.1155/2011/197636
28. Stranahan AM, Arumugam TV, Cutler RG, Lee K, Egan JM, Mattson MP. Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat Neurosci (2008) 11:309-17. doi:10.1038/nn2055
29. Stranahan AM, Lee K, Martin B, Maudsley S, Golden E, Cutler RG, et al. Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus (2009) 19:951-61. doi:10.1002/hipo.20577
30. Erion JR, Wosiski-Kuhn M, Dey A, Hao S, Davis CL, Pollock NK, et al. Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity. J Neurosci (2014) 34:2618-31. doi:10.1523/JNEUROSCI.4200-13.2014
31. Kanoski SE, Davidson TL. Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiol Behav (2011) 103:59-68. doi:10.1016/j.physbeh.2010.12.003
32. Boitard C, Cavaroc A, Sauvant J, Aubert A, Castanon N, Layé S, et al. Impairment of hippocampal-dependent memory induced by juvenile high-fat diet intake is associated with enhanced hippocampal inflammation in rats. Brain Behav Immun (2014). doi:10.1016/j.bbi.2014.03.005
33. Boitard C, Etchamendy N, Sauvant J, Aubert A, Tronel S, Marighetto A, et al. Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice. Hippocampus (2012) 22:2095-100. doi:10.1002/hipo.22032
34. Valladolid-Acebes I, Merino B, Principato A, Fole A, Barbas C, Lorenzo MP, et al. High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission. Am J Physiol Endocrinol Metab (2012) 302:E396-402. doi:10.1152/ajpendo.00343.2011
35. Molteni R, Barnard RJ, Ying Z, Roberts CK, Gomez-Pinilla F. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience (2002) 112:803-14. doi:10.1016/S0306-4522(02)00123-9
36. Dinel AL, Andre C, Aubert A, Ferreira G, Laye S, Castanon N. Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome. PLoS One (2011) 6:e24325. doi:10.1371/journal.pone.0024325
37. Dinel AL, André C, Aubert A, Ferreira G, Layé S, Castanon N. Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome. Psychoneuroendocrinology (2014) 40:48-59. doi:10.1016/j.psyneuen.2013.10.014
38. Sharma S, Fulton S. Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry. Int J Obes (Lond) (2013) 37:382-9. doi:10.1038/ijo.2012.48
39. Aguliar-Valles A, Kim J, Jung S, Woodside B, Luheshi GN. Role of brain transmigrating neutrophils in depression-like behavior during systemic infection. Mol Psychiatry (2014) 19:599-606. doi:10.1038/mp.2013.154
40. André C, Dinel AL, Ferreira G, Layé S, Castanon N. Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2,3-dioxygenase activation. Brain Behav Immun (2014). doi:10.1016/j.bbi.2014.03.012
41. Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology (2007) 132:2169-80. doi:10.1053/j.gastro.2007.03.059
42. Nieman DC, Henson DA, Nehlsen-Cannarella SL, Ekkens M, Utter AC, Butterworth DE, et al. Influence of obesity on immune function. J Am Diet Assoc (1999) 99:294-9. doi:10.1016/S0002-8223(99)00077-2
43. Cancello R, Clement K. Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG (2006) 113:1141-7. doi:10.1111/j.1471-0528.2006.01004.x
44. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol (2011) 29:415-45. doi:10.1146/annurev-immunol-031210-101322
45. Brooks GC, Blaha MJ, Blumenthal RS. Relation of C-reactive protein to abdominal adiposity. Am J Cardiol (2010) 106:56-61. doi:10.1016/j.amjcard.2010.02.017
46. Hermsdorff HH, Zulet MA, Puchau B, Martinez JA. Central adiposity rather than total adiposity measurements are specifically involved in the inflammatory status from healthy young adults. Inflammation (2011) 34:161-70. doi:10.1007/s10753-010-9219-y
47. Thorand B, Baumert J, Doring A, Herder C, Kolb H, Rathmann W, et al. Sex differences in the relation of body composition to markers of inflammation. Atherosclerosis (2006) 184:216-24. doi:10.1016/j.atherosclerosis.2005.04.011
48. Thewissen MM, Damoiseaux JG, Duijvestijn AM, van Greevenbroek MM, van der Kallen CJ, Feskens EJ, et al. Abdominal fat mass is associated with adaptive immune activation: the CODAM Study. Obesity (Silver Spring) (2011) 19:1690-8. doi:10.1038/oby.2010.337
49. Belza A, Toubro S, Stender S, Astrup A. Effect of diet-induced energy deficit and body fat reduction on high-sensitive CRP and other inflammatory markers in obese subjects. Int J Obes (Lond) (2009) 33:456-64. doi:10.1038/ijo.2009.27
50. Dalmas E, Rouault C, Abdennour M, Rovere C, Rizkalla S, Bar-Hen A, et al. Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction. Am J Clin Nutr (2011) 94:450-8. doi:10.3945/ajcn.111.013771
51. Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R, et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA (2003) 289:1799-804. doi:10.1001/jama.289.14.1799
52. Hakeam HA, O'Regan PJ, Salem AM, Bamehriz FY, Jomaa LF. Inhibition of C-reactive protein in morbidly obese patients after laparoscopic sleeve gastrectomy. Obes Surg (2009) 19:456-60. doi:10.1007/s11695-008-9729-y
53. Manco M, Fernandez-Real JM, Equitani F, Vendrell J, Valera Mora ME, Nanni G, et al. Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women. J Clin Endocrinol Metab (2007) 92:483-90. doi:10.1210/jc.2006-0960
54. Viana EC, Araujo-Dasilio KL, Miguel GP, Bressan J, Lemos EM, Moyses MR, et al. Gastric bypass and sleeve gastrectomy: the same impact on IL-6 and TNF-alpha. Prospective clinical trial. Obes Surg (2013) 23:1252-61. doi:10.1007/s11695-013-0894-2
55. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr (2004) 92:347-55. doi:10.1079/BJN20041213
56. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest (2003) 112:1785-8. doi:10.1172/JCI200320514
57. Lasselin J, Magne E, Beau C, Ledaguenel P, Dexpert S, Aubert A, et al. Adipose inflammation in obesity: relationship with circulating levels of inflammatory markers and association with surgery-induced weight loss. J Clin Endocrinol Metab (2014) 99:E53-61. doi:10.1210/jc.2013-2673
58. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 112:1796-808. doi:10.1172/JCI19246
59. Cancello R, Henegar C, Viguerie N, Taleb S, Poitou C, Rouault C, et al. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes (2005) 54:2277-86. doi:10.2337/diabetes.54.8.2277
60. Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, Wabitsch M, et al. T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol (2008) 28:1304-10. doi:10.1161/ATVBAHA.108.165100
61. Deiuliis J, Shah Z, Shah N, Needleman B, Mikami D, Narula V, et al. Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers. PLoS One (2011) 6:e16376. doi:10.1371/journal.pone.0016376
62. Zeyda M, Huber J, Prager G, Stulnig TM. Inflammation correlates with markers of T-cell subsets including regulatory T cells in adipose tissue from obese patients. Obesity (Silver Spring) (2011) 19:743-8. doi:10.1038/oby.2010.123
63. Goossens GH, Blaak EE, Theunissen R, Duijvestijn AM, Clement K, Tervaert JW, et al. Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans. Mol Immunol (2012) 50:142-9. doi:10.1016/j.molimm.2012.01.005
64. Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut (2009) 58:1091-103. doi:10.1136/gut.2008.165886
65. Flint HJ. Obesity and the gut microbiota. J Clin Gastroenterol (2011) 45(Suppl):S128-32. doi:10.1097/MCG.0b013e31821f44c4
66. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A (2005) 102:11070-5. doi:10.1073/pnas.0504978102
67. Verdam FJ, Fuentes S, de Jonge C, Zoetendal EG, Erbil R, Greve JW, et al. Human intestinal microbiota composition is associated with local and systemic inflammation in obesity. Obesity (Silver Spring) (2013) 21:E607-15. doi:10.1002/oby.20466
68. Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes (2007) 56:1761-72. doi:10.2337/db06-1491
69. Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes (2008) 57:1470-81. doi:10.2337/db07-1403
70. Furet JP, Kong LC, Tap J, Poitou C, Basdevant A, Bouillot JL, et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes (2010) 59:3049-57. doi:10.2337/db10-0253
71. Aron-Wisnewsky J, Dore J, Clement K. The importance of the gut microbiota after bariatric surgery. Nat Rev Gastroenterol Hepatol (2012) 9:590-8. doi:10.1038/nrgastro.2012.161
72. Yang PJ, Lee WJ, Tseng PH, Lee PH, Lin MT, Yang WS. Bariatric surgery decreased the serum level of an endotoxin-associated marker: lipopolysaccharide-binding protein. Surg Obes Relat Dis (2014). doi:10.1016/j.soard.2014.02.022
73. Velloso LA, Araújo EP, de Souza CT. Diet-induced inflammation of the hypothalamus in obesity. Neuroimmunomodulation (2008) 15:189-93. doi:10.1159/000153423
74. Lawrence CB, Brough D, Knight EM. Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide. Dis Model Mech (2012) 5:649-59. doi:10.1242/dmm.009068
75. Rummel C, Inoue W, Poole S, Luheshi GN. Leptin regulates leukocyte recruitment into the brain following systemic LPS-induced inflammation. Mol Psychiatry (2010) 15:523-34. doi:10.1038/mp.2009.98
76. Cai D, Liu T. Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB. Aging (Albany NY) (2012) 4:98-115.
77. De Souza CT, Araujo EP, Bordin S, Ashimine R, Zollner RL, Boschero AC, et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology (2005) 146:4192-9. doi:10.1210/en.2004-1520
78. Gao Y, Ottaway N, Schriever SC, Legutko B, García-Cáceres C, de la Fuente E, et al. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia (2014) 62:17-25. doi:10.1002/glia.22580
79. Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, et al. Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest (2012) 122:153-62. doi:10.1172/JCI59660
80. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest (2006) 116:3015-25. doi:10.1172/JCI28898
81. Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci (2009) 29:359-70. doi:10.1523/JNEUROSCI.2760-08.2009
82. Kleinridders A, Schenten D, Könner AC, Belgardt BF, Mauer J, Okamura T, et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 10:249-59. doi:10.1016/j.cmet.2009.08.013
83. Lann D, LeRoith D. Insulin resistance as the underlying cause for the metabolic syndrome. Med Clin North Am (2007) 91:1063-77, viii. doi:10.1016/j.mcna.2007.06.012
84. Hotamisligil GS. Inflammation and metabolic disorders. Nature (2006) 444:860-7. doi:10.1038/nature05485
85. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 112:1821-30. doi:10.1172/JCI19451
86. Thaler JP, Choi SJ, Schwartz MW, Wisse BE. Hypothalamic inflammation and energy homeostasis: resolving the paradox. Front Neuroendocrinol (2010) 31:79-84. doi:10.1016/j.yfrne.2009.10.002
87. Capuron L, Miller AH. Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther (2011) 130:226-38. doi:10.1016/j.pharmthera.2011.01.014
88. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci (2008) 9:46-56. doi:10.1038/nrn2297
89. Musselman DL, Lawson DH, Gumnick JF, Manatunga AK, Penna S, Goodkin RS, et al. Paroxetine for the prevention of depression induced by high-dose interferon alfa. N Engl J Med (2001) 344:961-6. doi:10.1056/NEJM200103293441303
90. Capuron L, Gumnick JF, Musselman DL, Lawson DH, Reemsnyder A, Nemeroff CB, et al. Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology (2002) 26:643-52. doi:10.1016/S0893-133X(01)00407-9
91. Capuron L, Schroecksnadel S, Feart C, Aubert A, Higueret D, Barberger-Gateau P, et al. Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms. Biol Psychiatry (2011) 70:175-82. doi:10.1016/j.biopsych.2010.12.006
92. Raison CL, Dantzer R, Kelley KW, Lawson MA, Woolwine BJ, Vogt G, et al. CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol Psychiatry (2010) 15:393-403. doi:10.1038/mp.2009.116
93. Myint AM, Kim YK, Verkerk R, Scharpe S, Steinbusch H, Leonard B. Kynurenine pathway in major depression: evidence of impaired neuroprotection. J Affect Disord (2007) 98:143-51. doi:10.1016/j.jad.2006.07.013
94. Stone TW, Forrest CM, Stoy N, Darlington LG. Involvement of kynurenines in Huntington's disease and stroke-induced brain damage. J Neural Transm (2012) 119:261-74. doi:10.1007/s00702-011-0676-8
95. Schwarcz R, Rassoulpour A, Wu HQ, Medoff D, Tamminga CA, Roberts RC. Increased cortical kynurenate content in schizophrenia. Biol Psychiatry (2001) 50:521-30. doi:10.1016/S0006-3223(01)01078-2
96. Gulaj E, Pawlak K, Bien B, Pawlak D. Kynurenine and its metabolites in Alzheimer's disease patients. Adv Med Sci (2010) 55:204-11. doi:10.2478/v10039-010-0023-6
97. Henry CJ, Huang Y, Wynne AM, Godbout JP. Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines. Brain Behav Immun (2009) 23:309-17. doi:10.1016/j.bbi.2008.09.002
98. O'Connor JC, Lawson MA, Andre C, Moreau M, Lestage J, Castanon N, et al. Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry (2009) 14:511-22. doi:10.1038/sj.mp.4002148
99. O'Connor JC, Lawson MA, Andre C, Briley EM, Szegedi SS, Lestage J, et al. Induction of IDO by bacille Calmette-Guerin is responsible for development of murine depressive-like behavior. J Immunol (2009) 182:3202-12. doi:10.4049/jimmunol.0802722
100. O'Connor JC, Andre C, Wang Y, Lawson MA, Szegedi SS, Lestage J, et al. Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin. J Neurosci (2009) 29:4200-9. doi:10.1523/JNEUROSCI.5032-08.2009
101. Salazar A, Gonzalez-Rivera BL, Redus L, Parrott JM, O'Connor JC. Indoleamine 2,3-dioxygenase mediates anhedonia and anxiety-like behaviors caused by peripheral lipopolysaccharide immune challenge. Horm Behav (2012) 62:202-9. doi:10.1016/j.yhbeh.2012.03.010
102. Walker AK, Budac DP, Bisulco S, Lee AW, Smith RA, Beenders B, et al. NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice. Neuropsychopharmacology (2013) 38:1609-16. doi:10.1038/npp.2013.71
103. Andre C, O'Connor JC, Kelley KW, Lestage J, Dantzer R, Castanon N. Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration. J Neuroimmunol (2008) 200:90-9. doi:10.1016/j.jneuroim.2008.06.011
104. Corona AW, Huang Y, O'Connor JC, Dantzer R, Kelley KW, Popovich PG, et al. Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide. J Neuroinflammation (2010) 7:93. doi:10.1186/1742-2094-7-93
105. Frenois F, Moreau M, O'Connor J, Lawson M, Micon C, Lestage J, et al. Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior. Psychoneuroendocrinology (2007) 32:516-31. doi:10.1016/j.psyneuen.2007.03.005
106. Fu X, Zunich SM, O'Connor JC, Kavelaars A, Dantzer R, Kelley KW. Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures. J Neuroinflammation (2010) 7:43. doi:10.1186/1742-2094-7-43
107. Gibney SM, McGuinness B, Prendergast C, Harkin A, Connor TJ. Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression. Brain Behav Immun (2013) 28:170-81. doi:10.1016/j.bbi.2012.11.010
108. Shelton RC, Miller AH. Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression. Prog Neurobiol (2010) 91:275-99. doi:10.1016/j.pneurobio.2010.04.004
109. Ladwig KH, Marten-Mittag B, Lowel H, Doring A, Koenig W. Influence of depressive mood on the association of CRP and obesity in 3205 middle aged healthy men. Brain Behav Immun (2003) 17:268-75. doi:10.1016/S0889-1591(03)00056-4
110. Dixon JB, Hayden MJ, Lambert GW, Dawood T, Anderson ML, Dixon ME, et al. Raised CRP levels in obese patients: symptoms of depression have an independent positive association. Obesity (Silver Spring) (2008) 16:2010-5. doi:10.1038/oby.2008.271
111. Capuron L, Su S, Miller AH, Bremner JD, Goldberg J, Vogt GJ, et al. Depressive symptoms and metabolic syndrome: is inflammation the underlying link? Biol Psychiatry (2008) 64:896-900. doi:10.1016/j.biopsych.2008.05.019
112. Chirinos DA, Goldberg R, Gellman M, Mendez AJ, Gutt M, McCalla JR, et al. Leptin and its association with somatic depressive symptoms in patients with the metabolic syndrome. Ann Behav Med (2013) 46:31-9. doi:10.1007/s12160-013-9479-5
113. Daly M. The relationship of C-reactive protein to obesity-related depressive symptoms: a longitudinal study. Obesity (Silver Spring) (2013) 21:248-50. doi:10.1002/oby.20051
114. Capuron L, Poitou C, Machaux-Tholliez D, Frochot V, Bouillot JL, Basdevant A, et al. Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation. Psychol Med (2011) 41:1517-28. doi:10.1017/S0033291710001984
115. Emery CF, Fondow MD, Schneider CM, Christofi FL, Hunt C, Busby AK, et al. Gastric bypass surgery is associated with reduced inflammation and less depression: a preliminary investigation. Obes Surg (2007) 17:759-63. doi:10.1007/s11695-007-9140-0
116. Sweat V, Starr V, Bruehl H, Arentoft A, Tirsi A, Javier E, et al. C-reactive protein is linked to lower cognitive performance in overweight and obese women. Inflammation (2008) 31:198-207. doi:10.1007/s10753-008-9065-3
117. Yaffe K, Kanaya A, Lindquist K, Simonsick EM, Harris T, Shorr RI, et al. The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA (2004) 292:2237-42. doi:10.1001/jama.292.18.2237
118. Pistell PJ, Morrison CD, Gupta S, Knight AG, Keller JN, Ingram DK, et al. Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol (2010) 219:25-32. doi:10.1016/j.jneuroim.2009.11.010
119. Dey A, Hao S, Erion JR, Wosiski-Kuhn M, Stranahan AM. Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes. J Neuroimmunol (2014) 269:20-7. doi:10.1016/j.jneuroim.2014.01.013
120. Yates KF, Sweat V, Yau PL, Turchiano MM, Convit A. Impact of metabolic syndrome on cognition and brain: a selected review of the literature. Arterioscler Thromb Vasc Biol (2012) 32:2060-7. doi:10.1161/ATVBAHA.112.252759
121. Volkow ND, Wang GJ, Baler RD. Reward, dopamine and the control of food intake: implications for obesity. Trends Cogn Sci (2011) 15:37-46. doi:10.1016/j.tics.2010.11.001
122. Volkow ND, Wang GJ, Tomasi D, Baler RD. The addictive dimensionality of obesity. Biol Psychiatry (2013) 73:811-8. doi:10.1016/j.biopsych.2012.12.020
123. de Weijer BA, van de Giessen E, van Amelsvoort TA, Boot E, Braak B, Janssen IM, et al. Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects. EJNMMI Res (2011) 1:37. doi:10.1186/2191-219X-1-37
124. Wang GJ, Volkow ND, Logan J, Pappas NR, Wong CT, Zhu W, et al. Brain dopamine and obesity. Lancet (2001) 357:354-7. doi:10.1016/S0140-6736(00)03643-6
125. Tomasi D, Volkow ND. Brain activation and neurochemistry. Proc Natl Acad Sci U S A (2013) 110:10888-9. doi:10.1073/pnas.1309471110
126. Felger JC, Miller AH. Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Front Neuroendocrinol (2012) 33:315-27. doi:10.1016/j.yfrne.2012.09.003
127. Capuron L, Pagnoni G, Drake DF, Woolwine BJ, Spivey JR, Crowe RJ, et al. Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon alfa administration. Arch Gen Psychiatry (2012) 69:1044-53. doi:10.1001/archgenpsychiatry.2011.2094
128. Capuron L, Pagnoni G, Demetrashvili MF, Lawson DH, Fornwalt FB, Woolwine B, et al. Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy. Neuropsychopharmacology (2007) 32:2384-92. doi:10.1038/sj.npp.1301362
129. Brydon L, Harrison NA, Walker C, Steptoe A, Critchley HD. Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans. Biol Psychiatry (2008) 63:1022-9. doi:10.1016/j.biopsych.2007.12.007
130. Mattsson C, Reynolds RM, Simonyte K, Olsson T, Walker BR. Combined receptor antagonist stimulation of the hypothalamic-pituitary-adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men. J Clin Endocrinol Metab (2009) 94:1347-52. doi:10.1210/jc.2008-2054
131. Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nat Neurosci (2007) 10:1089-93. doi:10.1038/nn1971
132. Yamada K, Nabeshima T. Brain-derived neurotrophic factor/TrkB signaling in memory processes. J Pharmacol Sci (2003) 91:267-70. doi:10.1254/jphs.91.267
133. Barrientos RM, Sprunger DB, Campeau S, Watkins LR, Rudy JW, Maier SF. BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration. J Neuroimmunol (2004) 155:119-26. doi:10.1016/j.jneuroim.2004.06.009
134. Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry (2006) 59:1116-27. doi:10.1016/j.biopsych.2006.02.013
135. Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T, et al. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry (2008) 13:717-28. doi:10.1038/sj.mp.4002055
136. Corripio R, Gonzalez-Clemente JM, Jacobo PS, Silvia N, Lluis G, Joan V, et al. Plasma brain-derived neurotrophic factor in prepubertal obese children: results from a 2-year lifestyle intervention programme. Clin Endocrinol (Oxf) (2012) 77:715-20. doi:10.1111/j.1365-2265.2012.04431.x
137. Moy GA, McNay EC. Caffeine prevents weight gain and cognitive impairment caused by a high-fat diet while elevating hippocampal BDNF. Physiol Behav (2013) 109:69-74. doi:10.1016/j.physbeh.2012.11.008
138. Grenham S, Clarke G, Cryan JF, Dinan TG. Brain-gut-microbe communication in health and disease. Front Physiol (2011) 2:94. doi:10.3389/fphys.2011.00094
139. Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci (2012) 13:701-12. doi:10.1038/nrn3346