Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an Intrahippocampal Lipopolysaccharide injection

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Huang, Hei Jen ^a   Chen, Yen Hsu ^b   Liang, Keng Chen ^c   Jheng, Yu Syuan ^a   Jhao, Jhih Jhen ^a   Su, Ming Tsan ^b   Lee Chen, Guey Jen ^b   Hsieh Li, Hsiu Mei ^b  

^a NURSING AND MANAGEMENT COLLEGE   (Taiwan)

^b NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; CITRATE SODIUM; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; EXENDIN 4; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MANGANESE SUPEROXIDE DISMUTASE; STREPTOZOCIN; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BODY WEIGHT; CELL ACTIVATION; COGNITIVE DEFECT; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HIPPOCAMPUS; HYPERGLYCEMIA; INFLAMMATION; INSULIN BLOOD LEVEL; LEARNING; LOCUS CERULEUS; MALE; MONOAMINE NERVE CELL; MOUSE; NEUROPROTECTION; NONHUMAN; NORADRENERGIC NERVE; OXIDATIVE STRESS; RAPHE NUCLEUS; SEROTONINERGIC NERVE CELL; SPATIAL MEMORY; SPATIAL REFERENCE LEARNING;

ANIMALS; ANTIGENS, CD45; APOPTOSIS; ASTROCYTES; BLOOD GLUCOSE; COGNITION; COGNITION DISORDERS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HIPPOCAMPUS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INJECTIONS; INSULIN; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MALE; MEMBRANE PROTEINS; MEMORY; MICE; MICE, INBRED C57BL; NEURONS; NF-KAPPA B; PEPTIDES; SPATIAL BEHAVIOR; STREPTOZOCIN; SUPEROXIDE DISMUTASE; UP-REGULATION; VENOMS;

MUS;

EID: 84864201829     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039656     Document Type: Article

References (60)

1. Pavlovic DM, Pavlovic AM, (2008) [Dementia and diabetes mellitus]. Srp Arh Celok Lek 136: 170-175.
2. Nareika A, Im YB, Game BA, Slate EH, Sanders JJ, et al. (2008) High glucose enhances lipopolysaccharide-stimulated CD14 expression in U937 mononuclear cells by increasing nuclear factor kappaB and AP-1 activities. J Endocrinol 196: 45-55.
3. Yaffe K, (2007) Metabolic syndrome and cognitive disorders: is the sum greater than its parts? Alzheimer Dis Assoc Disord 21: 167-171.
4. Lichtenstein MP, Carriba P, Masgrau R, Pujol A, Galea E, (2010) Staging anti-inflammatory therapy in Alzheimer's disease. Front Aging Neurosci 2: 142.
5. Potter PE, (2010) Investigational medications for treatment of patients with Alzheimer disease. J Am Osteopath Assoc 110: S27-36.
6. Aid S, Silva AC, Candelario-Jalil E, Choi SH, Rosenberg GA, et al. (2010) Cyclooxygenase-1 and-2 differentially modulate lipopolysaccharide-induced blood-brain barrier disruption through matrix metalloproteinase activity. J Cereb Blood Flow Metab 30: 370-380.
7. Cameron B, Landreth GE, (2010) Inflammation, microglia, and Alzheimer's disease. Neurobiol Dis 37: 503-509.
8. Colton CA, Wilcock DM, Wink DA, Davis J, Van Nostrand WE, et al. (2008) The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. J Alzheimers Dis 15: 571-587.
9. Kacimi R, Giffard RG, Yenari MA, (2011) Endotoxin-activated microglia injure brain derived endothelial cells via NF-kappaB, JAK-STAT and JNK stress kinase pathways. J Inflamm (Lond) 8: 7.
10. Zablocka A, Siednienko J, Mitkiewicz M, Gorczyca WA, Lisowski J, et al. (2010) Proline-rich polypeptide complex (PRP) regulates secretion of inflammatory mediators by its effect on NF-kappaB activity. Biomed Pharmacother 64: 16-20.
11. Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW, (1993) Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J Immunol 150: 2659-2667.
12. Butterfield DA, Drake J, Pocernich C, Castegna A, (2001) Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends Mol Med 7: 548-554.
13. Morley JE, Farr SA, Kumar VB, Banks WA, (2002) Alzheimer's disease through the eye of a mouse. Acceptance lecture for the 2001 Gayle A. Olson and Richard D. Olson prize. Peptides 23: 589-599.
14. Booz GW, (2011) Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radic Biol Med 51: 1054-1061.
15. Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, et al. (2010) Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci U S A 107: 6058-6063.
16. Hwang J, Hwang H, Lee HW, Suk K, (2010) Microglia signaling as a target of donepezil. Neuropharmacology 58: 1122-1129.
17. Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Thiele A, et al. (2011) Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice. Neuroscience 176: 396-407.
18. Taepavarapruk P, Song C, (2010) Reductions of acetylcholine release and nerve growth factor expression are correlated with memory impairment induced by interleukin-1beta administrations: effects of omega-3 fatty acid EPA treatment. J Neurochem 112: 1054-1064.
19. Ferret-Bernard S, Remot A, Lacroix-Lamande S, Metton C, Bernardet N, et al. (2010) Cellular and molecular mechanisms underlying the strong neonatal IL-12 response of lamb mesenteric lymph node cells to R-848. PLoS One 5: e13705.
20. Elovich R, Drucker E, (2008) On drug treatment and social control: Russian narcology's great leap backwards. Harm Reduct J 5: 23.
21. Pell GS, Roth Y, Zangen A, (2011) Modulation of cortical excitability induced by repetitive transcranial magnetic stimulation: influence of timing and geometrical parameters and underlying mechanisms. Prog Neurobiol 93: 59-98.
22. Alhadeff AL, Rupprecht LE, Hayes MR, (2012) GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake. Endocrinology 153: 647-658.
23. Alvarez E, Roncero I, Chowen JA, Thorens B, Blazquez E, (1996) Expression of the glucagon-like peptide-1 receptor gene in rat brain. J Neurochem 66: 920-927.
24. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH, (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140: 918-934.
25. Francis PT, (2009) Altered glutamate neurotransmission and behaviour in dementia: evidence from studies of memantine. Curr Mol Pharmacol 2: 77-82.
26. O'Neil JN, Mouton PR, Tizabi Y, Ottinger MA, Lei DL, et al. (2007) Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. J Chem Neuroanat 34: 102-107.
27. de Oliveira AC, Andreotti S, Farias TD, Torres-Leal FL, de Proenca AR, et al. (2012) Metabolic Disorders and Adipose Tissue Insulin Responsiveness in Neonatally STZ-Induced Diabetic Rats Are Improved by Long-Term Melatonin Treatment. Endocrinology.
28. Saravanan R, Vengatash Babu K, Ramachandran V, (2012) Effect of Rebaudioside A, a diterpenoid on glucose homeostasis in STZ-induced diabetic rats. J Physiol Biochem.
29. Sharifi AM, Eslami H, Larijani B, Davoodi J, (2009) Involvement of caspase-8,-9, and-3 in high glucose-induced apoptosis in PC12 cells. Neurosci Lett 459: 47-51.
30. Cai Z, Zhao Y, Yao S, Bin Zhao B, (2011) Increases in beta-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-kappaB pathway activation. Pharmacol Rep 63: 381-391.
31. Dasu MR, Jialal I, (2011) Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. Am J Physiol Endocrinol Metab 300: E145-154.
32. Soetikno V, Sari FR, Veeraveedu PT, Thandavarayan RA, Harima M, et al. (2011) Curcumin ameliorates macrophage infiltration by inhibiting NF-kappaB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy. Nutr Metab (Lond) 8: 35.
33. Couturier J, Paccalin M, Morel M, Terro F, Milin S, et al. (2011) Prevention of the beta-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures. J Neuroinflammation 8: 72.
34. Daniluk J, Liu Y, Deng D, Chu J, Huang H, et al. (2012) An NF-kappaB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. J Clin Invest 122: 1519-1528.
35. Cai D, Liu T, (2012) Inflammatory cause of metabolic syndrome via brain stress and NF-kappaB. Aging (Albany NY) 4: 98-115.
36. Alvarez EO, Beauquis J, Revsin Y, Banzan AM, Roig P, et al. (2009) Cognitive dysfunction and hippocampal changes in experimental type 1 diabetes. Behav Brain Res 198: 224-230.
37. Kimura R, Okouchi M, Fujioka H, Ichiyanagi A, Ryuge F, et al. (2009) Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway. Neuroscience 162: 1212-1219.
38. Cai Z, Pang Y, Lin S, Rhodes PG, (2003) Differential roles of tumor necrosis factor-alpha and interleukin-1 beta in lipopolysaccharide-induced brain injury in the neonatal rat. Brain Res 975: 37-47.
39. Sy M, Kitazawa M, Medeiros R, Whitman L, Cheng D, et al. (2011) Inflammation induced by infection potentiates tau pathological features in transgenic mice. Am J Pathol 178: 2811-2822.
40. Alkam T, Nitta A, Mizoguchi H, Saito K, Seshima M, et al. (2008) Restraining tumor necrosis factor-alpha by thalidomide prevents the amyloid beta-induced impairment of recognition memory in mice. Behav Brain Res 189: 100-106.
41. Bales KR, Du Y, Dodel RC, Yan GM, Hamilton-Byrd E, et al. (1998) The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation. Brain Res Mol Brain Res 57: 63-72.
42. Cunningham C, Skelly DT, (2012) Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium? J Neuroimmune Pharmacol 7: 60-73.
43. Agostinho P, Cunha RA, Oliveira C, (2010) Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease. Curr Pharm Des 16: 2766-2778.
44. Perez JL, Carrero I, Gonzalo P, Arevalo-Serrano J, Sanz-Anquela JM, et al. (2010) Soluble oligomeric forms of beta-amyloid (Abeta) peptide stimulate Abeta production via astrogliosis in the rat brain. Exp Neurol 223: 410-421.
45. Verkhratsky A, Olabarria M, Noristani HN, Yeh CY, Rodriguez JJ, (2010) Astrocytes in Alzheimer's disease. Neurotherapeutics 7: 399-412.
46. Hertz L, Chen Y, Gibbs ME, Zang P, Peng L, (2004) Astrocytic adrenoceptors: a major drug target in neurological and psychiatric disorders? Curr Drug Targets CNS Neurol Disord 3: 239-267.
47. Muller N, Ackenheil M, (1998) Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry 22: 1-33.
48. Garwood CJ, Pooler AM, Atherton J, Hanger DP, Noble W, (2011) Astrocytes are important mediators of Abeta-induced neurotoxicity and tau phosphorylation in primary culture. Cell Death Dis 2: e167.
49. Wang G, Dinkins M, He Q, Zhu G, Poirier C, et al. (2012) Astrocytes secrete exosomes enriched with pro-apoptotic ceramide and prostate apoptosis response 4 (PAR-4): a potential mechanism of apoptosis induction in Alzheimer's disease (AD). J Biol Chem.
50. Clouatre DL, Rao SN, Preuss HG, (2011) Bitter Melon Extracts in Diabetic and Normal Rats Favorably Influence Blood Glucose and Blood Pressure Regulation. J Med Food.
51. Li Y, Hansotia T, Yusta B, Ris F, Halban PA, et al. (2003) Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 278: 471-478.
52. Ferdaoussi M, Abdelli S, Yang JY, Cornu M, Niederhauser G, et al. (2008) Exendin-4 protects beta-cells from interleukin-1 beta-induced apoptosis by interfering with the c-Jun NH2-terminal kinase pathway. Diabetes 57: 1205-1215.
53. Kang JH, Chang SY, Jang HJ, Kim DB, Ryu GR, et al. (2009) Exendin-4 inhibits interleukin-1beta-induced iNOS expression at the protein level, but not at the transcriptional and posttranscriptional levels, in RINm5F beta-cells. J Endocrinol 202: 65-75.
54. Brown SB, Libonati JR, Selak MA, Shannon RP, Simmons RA, (2010) Neonatal exendin-4 leads to protection from reperfusion injury and reduced rates of oxidative phosphorylation in the adult rat heart. Cardiovasc Drugs Ther 24: 197-205.
55. Lee CH, Yan B, Yoo KY, Choi JH, Kwon SH, et al. (2011) Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia. J Neurosci Res 89: 1103-1113.
56. Aisen PS, Schmeidler J, Pasinetti GM, (2002) Randomized pilot study of nimesulide treatment in Alzheimer's disease. Neurology 58: 1050-1054.
57. Rogers J, Kirby LC, Hempelman SR, Berry DL, McGeer PL, et al. (1993) Clinical trial of indomethacin in Alzheimer's disease. Neurology 43: 1609-1611.
58. Drucker TB, (2008) No physician bailout. Md Med 9: 5.
59. Janus C, Westaway D, (2001) Transgenic mouse models of Alzheimer's disease. Physiol Behav 73: 873-886.
60. Qin L, Wu X, Block ML, Liu Y, Breese GR, et al. (2007) Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55: 453-462.