Minireview: Inflammation and obesity pathogenesis: The hypothalamus heats up

Endocrinology

Volumn 151, Issue 9, 2010, Pages 4109-4115

  Thaler, Joshua P ^a   Schwartz, Michael W ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ANIMAL; BIOLOGICAL MODEL; GLUCOSE INTOLERANCE; HUMAN; HYPOTHALAMUS; INFLAMMATION; INSULIN RESISTANCE; METABOLISM; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; WEIGHT GAIN;

ANIMALS; GLUCOSE INTOLERANCE; HUMANS; HYPOTHALAMUS; INFLAMMATION; INSULIN RESISTANCE; LEPTIN; MODELS, BIOLOGICAL; OBESITY; WEIGHT GAIN;

EID: 77956013253     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0336     Document Type: Short Survey

References (58)

1. Flegal KM, Carroll MD, Ogden CL, Curtin LR 2010 Prevalence and trends in obesity among U.S. adults, 1999-2008. JAMA 303:235-241
2. Finkelstein EA, Trogdon JG, Cohen JW, Dietz W 2009 Annual medical spending attributable to obesity: payer- and service-specific estimates. Health Aff (Millwood) 28:w822-w831
3. Svetkey LP, Stevens VJ, Brantley PJ, Appel LJ, Hollis JF, Loria CM, Vollmer WM, Gullion CM, Funk K, Smith P, Samuel-Hodge C, Myers V, Lien LF, Laferriere D, Kennedy B, Jerome GJ, Heinith F, Harsha DW, Evans P, Erlinger TP, Dalcin AT, Coughlin J, Charleston J, Champagne CM, Bauck A, Ard JD, Aicher K 2008 Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial. JAMA 299:1139-1148 (Pubitemid 351398428)
4. Bessesen DH 2008 Update on obesity. J Clin Endocrinol Metab 93:2027-2034
5. Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H, Lystig T, Sullivan M, Bouchard C, Carlsson B, Bengtsson C, Dahlgren S, Gummesson A, Jacobson P, Karlsson J, Lindroos AK, Lönroth H, Näslund I, Olbers T, Stenlöf K, Torgerson J, Agren G, Carlsson LM 2007 Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 357:741-752 (Pubitemid 47295641)
6. Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, Lamonte MJ, Stroup AM, Hunt SC 2007 Long-term mortality after gastric bypass surgery. N Engl J Med 357:753-761
7. Leibel RL 2008 Molecular physiology of weight regulation in mice and humans. Int J Obes (Lond) 32(Suppl 7):S98-S108
8. Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL 2002 Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab 87:2391-2394
9. Levin BE, Keesey RE 1998 Defense of differing body weight set points in diet-induced obese and resistant rats. Am J Physiol 274:R412-R419 (Pubitemid 28103027)
10. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG 2000 Central nervous system control of food intake. Nature 404:661-671
11. Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW 2006 Central nervous system control of food intake and body weight. Nature 443:289-295
12. Farooqi S, O'Rahilly S 2006 Genetics of obesity in humans. Endocr Rev 27:710-718
13. Myers MG, Cowley MA, Münzberg H 2008 Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 70:537-556
14. Schenk S, Saberi M, Olefsky JM 2008 Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118:2992-3002
15. Shoelson SE, Lee J, Goldfine AB 2006 Inflammation and insulin resistance. J Clin Invest 116:1793-1801
16. Hotamisligil GS 2006 Inflammation and metabolic disorders. Nature 444:860-867
17. Wisse BE, Kim F, Schwartz MW 2007 Physiology. An integrative view of obesity. Science (New York, NY) 318:928-929
18. Unger RH, Scherer PE 2010 Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity. Trends Endocrinol Metab 21:345-352
19. Hotamisligil GS, Erbay E 2008 Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 8:923-934
20. Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR 2007 Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 56:16-23 (Pubitemid 46263103)
21. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante Jr AW 2003 Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808
22. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H 2003 Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830
23. Fessler MB, Rudel LL, Brown JM 2009 Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome. Curr Opin Lipidol 20:379-385
24. Zhang X, Dong F, Ren J, Driscoll MJ, Culver B 2005 High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex. Exp Neurol 191:318-325 (Pubitemid 40092875)
25. De Souza CT, Araujo EP, Bordin S, Ashimine R, Zollner RL, Boschero AC, Saad MJ, Velloso LA 2005 Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146:4192-4199
26. Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, Tsukumo DM, Anhe G, Amaral ME, Takahashi HK, Curi R, Oliveira HC, Carvalheira JB, Bordin S, Saad MJ, Velloso LA 2009 Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci 29:359-370
27. Ozcan L, Ergin AS, Lu A, Chung J, Sarkar S, Nie D, Myers Jr MG, Ozcan U 2009 Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 9:35-51
28. Posey KA, Clegg DJ, Printz RL, Byun J, Morton GJ, Vivekanandan-Giri A, Pennathur S, Baskin DG, Heinecke JW, Woods SC, Schwartz MW, Niswender KD 2009 Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab 296:E1003-E1012
29. Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D 2008 Hypothalamic IKKβ/NF-βB and ER stress link overnutrition to energy imbalance and obesity. Cell 135:61-73
30. Fam BC, Morris MJ, Hansen MJ, Kebede M, Andrikopoulos S, Proietto J, Thorburn AW 2007 Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity. Diabetes Obes Metab 9:840-852
31. Münzberg H, Flier JS, Bjørbaek C 2004 Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145:4880-4889 (Pubitemid 39551104)
32. Kleinridders A, Schenten D, Könner AC, Belgardt BF, Mauer J, Okamura T, Wunderlich FT, Medzhitov R, Brüning JC 2009 MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab 10:249-259
33. Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmée E, Cousin B, Sulpice T, Chamontin B, Ferrières J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R 2007 Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56:1761-1772
34. Boaz M, Lisy L, Zandman-Goddard G, Wainstein J 2009 The effect of anti-inflammatory (aspirin and/or statin) therapy on body weight in type 2 diabetic individuals: EAT, a retrospective study. Diabet Med 26:708-713
35. Belgardt BF, Mauer J, Wunderlich FT, Ernst MB, Pal M, Spohn G, Brönneke HS, Brodesser S, Hampel B, Schauss AC, Brüning JC 2010 Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc Natl Acad Sci USA 107:6028-6033
36. Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ 2010 Role of the hypothalamic-pituitary- thyroid axis in metabolic regulation by JNK1. Genes Dev 24:256-264
37. Howard JK, Flier JS 2006 Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab 17:365-371 (Pubitemid 44596259)
38. Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS 2004 Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 10:734-738
39. Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A 2004 Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med 10:739-743
40. Reed AS, Unger EK, Olofsson LE, Piper ML, Myers Jr MG, Xu AW 2010 Functional role of Socs3 up-regulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes 59:894-906
41. Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT 2009 Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. J Neurosci 29:11582-11593
42. Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB 2008 Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem 283:14230-14241
43. White CL, Whittington A, Barnes MJ, Wang Z, Bray GA, Morrison CD 2009 HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. Am J Physiol Endocrinol Metab 296:E291-E299
44. Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB 2006 Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12:917-924 (Pubitemid 44175143)
45. Banno R, Zimmer D, De Jonghe BC, Atienza M, Rak K, Yang W, Bence KK 2010 KK PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. J Clin Invest 120:720-734
46. Picardi PK, Calegari VC, Prada Pde O, Moraes JC, Araújo E, Marcondes MC, Ueno M, Carvalheira JB, Velloso LA, Saad MJ 2008 Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats. Endocrinology 149:3870-3880
47. Moraes JC, Coope A, Morari J, Cintra DE, Roman EA, Pauli JR, Romanatto T, Carvalheira JB, Oliveira AL, Saad MJ, Velloso LA 2009 High-fat diet induces apoptosis of hypothalamic neurons. PloS One 4:e5045
48. Sadagurski M, Norquay L, Farhang J, D'Aquino K, Copps K, White MF 2010 Human IL6 enhances leptin action in mice. Diabetologia 53:525-535
49. Thaler JP, Choi SJ, Sajan MP, Ogimoto K, Nguyen HT, Matsen M, Benoit SC, Wisse BE, Farese RV, Schwartz MW 2009 Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses. Endocrinology 150:5362-5372
50. Romanatto T, Cesquini M, Amaral ME, Roman EA, Moraes JC, Torsoni MA, Cruz-Neto AP, Velloso LA 2007 TNF-α acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient - effects on leptin and insulin signaling pathways. Peptides 28:1050-1058
51. Thaler JP, Choi SJ, Schwartz MW, Wisse BE 2010 Hypothalamic inflammation and energy homeostasis: resolving the paradox. Front Neuroendocrinol 31:79-84
52. Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, Hawn TR, Raines EW, Schwartz MW 2007 Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res 100:1589-1596
53. Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME 2008 Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity 16:1248-1255 (Pubitemid 351770507)
54. Choi SJ, Kim F, Schwartz MW, Wisse BE 2010 Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids. Am J Physiol Endocrinol Metab 298:E1122-E1130
55. Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ 2009 Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents. J Clin Invest 119:2577-2589
56. Pohl J, Woodside B, Luheshi GN 2009 Changes in hypothalamically mediated acute-phase inflammatory responses to lipopolysaccharide in diet-induced obese rats. Endocrinology 150:4901-4910
57. Goldfine AB, Silver R, Aldhahi W, Cai D, Tatro E, Lee J, Shoelson SE 2008 Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin Transl Sci 1:36-43
58. Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY 2007 Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 356:1517-1526