메뉴 건너뛰기




Volumn 200, Issue , 2016, Pages 235-242

Statins for the treatment of depression: A meta-analysis of randomized, double-blind, placebo-controlled trials

Author keywords

Depression; Depressive symptoms; Inflammation; Meta analysis; Randomized controlled trial; Statins; Systematic review; Treatment

Indexed keywords

ATORVASTATIN; CITALOPRAM; FLUOXETINE; MEVINOLIN; PLACEBO; SIMVASTATIN; ANTIDEPRESSANT AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

EID: 84968779745     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2016.04.047     Document Type: Article
Times cited : (105)

References (53)
  • 1
    • 84929573925 scopus 로고    scopus 로고
    • Simvastatin versus atorvastatin for improving mild to moderate depression in post-coronary artery bypass graft patients: A double-blind, placebo-controlled, randomized trial
    • S.H. Abbasi, P. Mohammadinejad, N. Shahmansouri, A. Salehiomran, A.A. Beglar, A. Zeinoddini, S. Forghani, and S. Akhondzadeh Simvastatin versus atorvastatin for improving mild to moderate depression in post-coronary artery bypass graft patients: a double-blind, placebo-controlled, randomized trial J. Affect. Disord. 183 2015 149 155
    • (2015) J. Affect. Disord. , vol.183 , pp. 149-155
    • Abbasi, S.H.1    Mohammadinejad, P.2    Shahmansouri, N.3    Salehiomran, A.4    Beglar, A.A.5    Zeinoddini, A.6    Forghani, S.7    Akhondzadeh, S.8
  • 3
    • 84928947027 scopus 로고    scopus 로고
    • Three paths to drug discovery in psychiatry
    • M. Berk, and A.A. Nierenberg Three paths to drug discovery in psychiatry Am. J. Psychiatry 172 2015 412 414
    • (2015) Am. J. Psychiatry , vol.172 , pp. 412-414
    • Berk, M.1    Nierenberg, A.A.2
  • 4
    • 79953689306 scopus 로고    scopus 로고
    • Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics
    • J. Bowden, J.F. Tierney, A.J. Copas, and S. Burdett Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics BMC Med. Res. Methodol. 11 2011 41
    • (2011) BMC Med. Res. Methodol. , vol.11 , pp. 41
    • Bowden, J.1    Tierney, J.F.2    Copas, A.J.3    Burdett, S.4
  • 5
    • 0036417357 scopus 로고    scopus 로고
    • Health-related quality of life and long-term therapy with pravastatin and tocopherol (Vitamin E) in older adults
    • C.M. Carlsson, K. Papcke-Benson, M. Carnes, P.E. McBride, and J.H. Stein Health-related quality of life and long-term therapy with pravastatin and tocopherol (vitamin E) in older adults Drugs Aging 19 2002 793 805
    • (2002) Drugs Aging , vol.19 , pp. 793-805
    • Carlsson, C.M.1    Papcke-Benson, K.2    Carnes, M.3    McBride, P.E.4    Stein, J.H.5
  • 6
    • 84906096199 scopus 로고    scopus 로고
    • Hyperlipidemia, statin use and the risk of developing depression: A nationwide retrospective cohort study
    • C.S. Chuang, T.Y. Yang, C.H. Muo, H.L. Su, F.C. Sung, and C.H. Kao Hyperlipidemia, statin use and the risk of developing depression: a nationwide retrospective cohort study Gen. Hosp. Psychiatry 36 2014 497 501
    • (2014) Gen. Hosp. Psychiatry , vol.36 , pp. 497-501
    • Chuang, C.S.1    Yang, T.Y.2    Muo, C.H.3    Su, H.L.4    Sung, F.C.5    Kao, C.H.6
  • 7
    • 84946710182 scopus 로고    scopus 로고
    • Future directions for pharmacotherapies for treatment-resistant bipolar disorder
    • S. Dodd, B.S. Fernandes, and O.M. Dean Future directions for pharmacotherapies for treatment-resistant bipolar disorder Curr. Neuropharmacol. 13 2015 656 662
    • (2015) Curr. Neuropharmacol. , vol.13 , pp. 656-662
    • Dodd, S.1    Fernandes, B.S.2    Dean, O.M.3
  • 8
    • 0033934949 scopus 로고    scopus 로고
    • Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis
    • S. Duval, and R. Tweedie Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis Biometrics 56 2000 455 463
    • (2000) Biometrics , vol.56 , pp. 455-463
    • Duval, S.1    Tweedie, R.2
  • 9
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • M. Egger, G. Davey Smith, M. Schneider, and C. Minder Bias in meta-analysis detected by a simple, graphical test BMJ 315 1997 629 634
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 10
    • 50249178514 scopus 로고    scopus 로고
    • Association between depressive symptoms and use of HMG-CoA reductase inhibitors (statins), corticosteroids and histamine H(2) receptor antagonists in community-dwelling older persons: Cross-sectional analysis of a population-based cohort
    • L. Feng, C.H. Tan, R.A. Merchant, and T.P. Ng Association between depressive symptoms and use of HMG-CoA reductase inhibitors (statins), corticosteroids and histamine H(2) receptor antagonists in community-dwelling older persons: cross-sectional analysis of a population-based cohort Drugs Aging 25 2008 795 805
    • (2008) Drugs Aging , vol.25 , pp. 795-805
    • Feng, L.1    Tan, C.H.2    Merchant, R.A.3    Ng, T.P.4
  • 12
    • 84887245389 scopus 로고    scopus 로고
    • Augmentation of fluoxetine with lovastatin for treating major depressive disorder, a randomized double-blind placebo controlled-clinical trial
    • A. Ghanizadeh, and A. Hedayati Augmentation of fluoxetine with lovastatin for treating major depressive disorder, a randomized double-blind placebo controlled-clinical trial Depress. Anxiety 30 2013 1084 1088
    • (2013) Depress. Anxiety , vol.30 , pp. 1084-1088
    • Ghanizadeh, A.1    Hedayati, A.2
  • 14
    • 0027527253 scopus 로고
    • Improvement in symptoms of depression and in an index of life stressors accompany treatment of severe hypertriglyceridemia
    • C.J. Glueck, M. Tieger, R. Kunkel, T. Tracy, J. Speirs, P. Streicher, and E. Illig Improvement in symptoms of depression and in an index of life stressors accompany treatment of severe hypertriglyceridemia Biol. Psychiatry 34 1993 240 252
    • (1993) Biol. Psychiatry , vol.34 , pp. 240-252
    • Glueck, C.J.1    Tieger, M.2    Kunkel, R.3    Tracy, T.4    Speirs, J.5    Streicher, P.6    Illig, E.7
  • 15
    • 1542381000 scopus 로고    scopus 로고
    • The UCSD Statin Study: A randomized controlled trial assessing the impact of statins on selected noncardiac outcomes
    • B.A. Golomb, M.H. Criqui, H.L. White, and J.E. Dimsdale The UCSD Statin Study: a randomized controlled trial assessing the impact of statins on selected noncardiac outcomes Control. Clin. Trials 25 2004 178 202
    • (2004) Control. Clin. Trials , vol.25 , pp. 178-202
    • Golomb, B.A.1    Criqui, M.H.2    White, H.L.3    Dimsdale, J.E.4
  • 16
    • 84929595120 scopus 로고    scopus 로고
    • Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression: A double-blind placebo-controlled trial
    • A. Gougol, N. Zareh-Mohammadi, S. Raheb, M. Farokhnia, S. Salimi, N. Iranpour, H. Yekehtaz, and S. Akhondzadeh Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression: a double-blind placebo-controlled trial J. Psychopharmacol. 29 2015 575 581
    • (2015) J. Psychopharmacol. , vol.29 , pp. 575-581
    • Gougol, A.1    Zareh-Mohammadi, N.2    Raheb, S.3    Farokhnia, M.4    Salimi, S.5    Iranpour, N.6    Yekehtaz, H.7    Akhondzadeh, S.8
  • 17
    • 0027464373 scopus 로고
    • Comparison of fluvastatin and lovastatin blood-brain barrier transfer using in vitro and in vivo methods
    • F. Guillot, P. Misslin, and M. Lemaire Comparison of fluvastatin and lovastatin blood-brain barrier transfer using in vitro and in vivo methods J. Cardiovasc. Pharmacol. 21 1993 339 346
    • (1993) J. Cardiovasc. Pharmacol. , vol.21 , pp. 339-346
    • Guillot, F.1    Misslin, P.2    Lemaire, M.3
  • 18
    • 84949292691 scopus 로고    scopus 로고
    • Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances
    • R. Haapakoski, K.P. Ebmeier, H. Alenius, and M. Kivimaki Innate and adaptive immunity in the development of depression: an update on current knowledge and technological advances Prog. Neuropsychopharmacol. Biol. Psychiatry 66 2015 63 72
    • (2015) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.66 , pp. 63-72
    • Haapakoski, R.1    Ebmeier, K.P.2    Alenius, H.3    Kivimaki, M.4
  • 19
    • 84912575754 scopus 로고    scopus 로고
    • In a randomized, double-blind clinical trial, adjuvant atorvastatin improved symptoms of depression and blood lipid values in patients suffering from severe major depressive disorder
    • M. Haghighi, S. Khodakarami, L. Jahangard, M. Ahmadpanah, H. Bajoghli, E. Holsboer-Trachsler, and S. Brand In a randomized, double-blind clinical trial, adjuvant atorvastatin improved symptoms of depression and blood lipid values in patients suffering from severe major depressive disorder J. Psychiatr. Res. 58 2014 109 114
    • (2014) J. Psychiatr. Res. , vol.58 , pp. 109-114
    • Haghighi, M.1    Khodakarami, S.2    Jahangard, L.3    Ahmadpanah, M.4    Bajoghli, H.5    Holsboer-Trachsler, E.6    Brand, S.7
  • 20
    • 0028352357 scopus 로고
    • Do cholesterol-lowering agents affect brain activity? A comparison of simvastatin, pravastatin, and placebo in healthy volunteers
    • R.W. Harrison, and C.H. Ashton Do cholesterol-lowering agents affect brain activity? A comparison of simvastatin, pravastatin, and placebo in healthy volunteers Br. J. Clin. Pharmacol. 37 1994 231 236
    • (1994) Br. J. Clin. Pharmacol. , vol.37 , pp. 231-236
    • Harrison, R.W.1    Ashton, C.H.2
  • 22
    • 84880857205 scopus 로고    scopus 로고
    • The relationship between depression, anxiety and cardiovascular disease: Findings from the Hertfordshire Cohort Study
    • R.I. Holt, D.I. Phillips, K.A. Jameson, C. Cooper, E.M. Dennison, and R.C. Peveler The relationship between depression, anxiety and cardiovascular disease: findings from the Hertfordshire Cohort Study J. Affect. Disord. 150 2013 84 90
    • (2013) J. Affect. Disord. , vol.150 , pp. 84-90
    • Holt, R.I.1    Phillips, D.I.2    Jameson, K.A.3    Cooper, C.4    Dennison, E.M.5    Peveler, R.C.6
  • 23
    • 0037295226 scopus 로고    scopus 로고
    • Does simvastatin affect mood and steroid hormone levels in hypercholesterolemic men? A randomized double-blind trial
    • M.T. Hyyppa, E. Kronholm, A. Virtanen, A. Leino, and A. Jula Does simvastatin affect mood and steroid hormone levels in hypercholesterolemic men? A randomized double-blind trial Psychoneuroendocrinology 28 2003 181 194
    • (2003) Psychoneuroendocrinology , vol.28 , pp. 181-194
    • Hyyppa, M.T.1    Kronholm, E.2    Virtanen, A.3    Leino, A.4    Jula, A.5
  • 24
    • 84922685331 scopus 로고    scopus 로고
    • Acute antidepressant and anxiolytic effects of simvastatin and its mechanisms in rats
    • F.S. Kilic, Y. Ozatik, B. Kaygisiz, C. Baydemir, and K. Erol Acute antidepressant and anxiolytic effects of simvastatin and its mechanisms in rats Neurosciences 17 2012 39 43
    • (2012) Neurosciences , vol.17 , pp. 39-43
    • Kilic, F.S.1    Ozatik, Y.2    Kaygisiz, B.3    Baydemir, C.4    Erol, K.5
  • 26
    • 0030583345 scopus 로고    scopus 로고
    • Having too much evidence (depression, suicide, and low serum cholesterol)
    • (Clinical research ed.)
    • M. Law Having too much evidence (depression, suicide, and low serum cholesterol) BMJ 313 1996 651 652 (Clinical research ed.)
    • (1996) BMJ , vol.313 , pp. 651-652
    • Law, M.1
  • 27
    • 84899150858 scopus 로고    scopus 로고
    • Unintended effects of statins from observational studies in the general population: Systematic review and meta-analysis.
    • A.F. Macedo, F.C. Taylor, J.P. Casas, A. Adler, D. Prieto-Merino, and S. Ebrahim Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis. BMC Med. 12 2014 51
    • (2014) BMC Med. , vol.12 , pp. 51
    • Macedo, A.F.1    Taylor, F.C.2    Casas, J.P.3    Adler, A.4    Prieto-Merino, D.5    Ebrahim, S.6
  • 33
    • 84873733024 scopus 로고    scopus 로고
    • The role of depression in the primary prevention of cardiovascular disease
    • A.E. O'Neil The role of depression in the primary prevention of cardiovascular disease Med. J. Aust. 197 2012 444 445
    • (2012) Med. J. Aust. , vol.197 , pp. 444-445
    • O'Neil, A.E.1
  • 35
    • 0041335277 scopus 로고    scopus 로고
    • Behavioral implications of lowering cholesterol levels: A double-blind pilot study
    • T. Ormiston, O.M. Wolkowitz, V.I. Reus, and F. Manfredi Behavioral implications of lowering cholesterol levels: a double-blind pilot study Psychosomatics 44 2003 412 414
    • (2003) Psychosomatics , vol.44 , pp. 412-414
    • Ormiston, T.1    Wolkowitz, O.M.2    Reus, V.I.3    Manfredi, F.4
  • 38
    • 84861758963 scopus 로고    scopus 로고
    • Somatic drugs for psychiatric diseases: Aspirin or simvastatin for depression?
    • J.G. Rahola Somatic drugs for psychiatric diseases: aspirin or simvastatin for depression? Curr. Neuropharmacol. 10 2012 139 158
    • (2012) Curr. Neuropharmacol. , vol.10 , pp. 139-158
    • Rahola, J.G.1
  • 39
    • 6044270588 scopus 로고    scopus 로고
    • Statins: Much more than just a lipid-lowering therapy
    • S.G. Raja, and G.D. Dreyfus Statins: much more than just a lipid-lowering therapy Indian Heart J. 56 2004 204 209
    • (2004) Indian Heart J. , vol.56 , pp. 204-209
    • Raja, S.G.1    Dreyfus, G.D.2
  • 42
    • 0032527557 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitor discontinuation syndrome: A randomized clinical trial
    • J.F. Rosenbaum, M. Fava, S.L. Hoog, R.C. Ascroft, and W.B. Krebs Selective serotonin reuptake inhibitor discontinuation syndrome: a randomized clinical trial Biol. Psychiatry 44 1998 77 87
    • (1998) Biol. Psychiatry , vol.44 , pp. 77-87
    • Rosenbaum, J.F.1    Fava, M.2    Hoog, S.L.3    Ascroft, R.C.4    Krebs, W.B.5
  • 43
    • 0031021211 scopus 로고    scopus 로고
    • Effect of pharmacologic lipid lowering on health-related quality of life in older persons: Results from the Cholesterol Reduction in Seniors Program (CRISP) Pilot Study
    • N.C. Santanello, B.L. Barber, W.B. Applegate, J. Elam, C. Curtis, D.B. Hunninghake, and D.J. Gordon Effect of pharmacologic lipid lowering on health-related quality of life in older persons: results from the Cholesterol Reduction in Seniors Program (CRISP) Pilot Study J. Am. Geriatr. Soc. 45 1997 8 14
    • (1997) J. Am. Geriatr. Soc. , vol.45 , pp. 8-14
    • Santanello, N.C.1    Barber, B.L.2    Applegate, W.B.3    Elam, J.4    Curtis, C.5    Hunninghake, D.B.6    Gordon, D.J.7
  • 44
    • 0037268286 scopus 로고    scopus 로고
    • Assessing publication bias in meta-analysis
    • K.L. Soeken, and A. Sripusanapan Assessing publication bias in meta-analysis Nurs. Res. 52 2003 57 60
    • (2003) Nurs. Res. , vol.52 , pp. 57-60
    • Soeken, K.L.1    Sripusanapan, A.2
  • 45
    • 80053005570 scopus 로고    scopus 로고
    • The use of statins after a cardiac intervention is associated with reduced risk of subsequent depression: Proof of concept for the inflammatory and oxidative hypotheses of depression?
    • L. Stafford, and M. Berk The use of statins after a cardiac intervention is associated with reduced risk of subsequent depression: proof of concept for the inflammatory and oxidative hypotheses of depression? J. Clin. Psychiatry 72 2011 1229 1235
    • (2011) J. Clin. Psychiatry , vol.72 , pp. 1229-1235
    • Stafford, L.1    Berk, M.2
  • 46
    • 0034645450 scopus 로고    scopus 로고
    • Long-term assessment of psychological well-being in a randomized placebo-controlled trial of cholesterol reduction with pravastatin. The LIPID Study investigators
    • R.A. Stewart, K.J. Sharples, F.M. North, D.B. Menkes, J. Baker, and J. Simes Long-term assessment of psychological well-being in a randomized placebo-controlled trial of cholesterol reduction with pravastatin. The LIPID Study investigators Arch. Intern. Med. 160 2000 3144 3152
    • (2000) Arch. Intern. Med. , vol.160 , pp. 3144-3152
    • Stewart, R.A.1    Sharples, K.J.2    North, F.M.3    Menkes, D.B.4    Baker, J.5    Simes, J.6
  • 47
    • 84888646210 scopus 로고    scopus 로고
    • Are depressive symptoms associated with cardiovascular mortality among older Chinese: A cohort study of 64,000 people in Hong Kong?
    • W.J. Sun, L. Xu, W.M. Chan, T.H. Lam, and C.M. Schooling Are depressive symptoms associated with cardiovascular mortality among older Chinese: a cohort study of 64,000 people in Hong Kong? Am. J. Geriatr. Psychiatry 21 2013 1107 1115
    • (2013) Am. J. Geriatr. Psychiatry , vol.21 , pp. 1107-1115
    • Sun, W.J.1    Xu, L.2    Chan, W.M.3    Lam, T.H.4    Schooling, C.M.5
  • 50
    • 84941217193 scopus 로고    scopus 로고
    • Inflammation markers and major depressive disorder in patients with chronic heart failure: Results from the sertraline against depression and heart disease in chronic heart failure study
    • G.L. Xiong, K. Prybol, S.H. Boyle, R. Hall, R.D. Streilein, D.C. Steffens, R. Krishnan, J.G. Rogers, C.M. O'Connor, and W. Jiang Inflammation markers and major depressive disorder in patients with chronic heart failure: results from the sertraline against depression and heart disease in chronic heart failure study Psychosom. Med. 77 2015 808 815
    • (2015) Psychosom. Med. , vol.77 , pp. 808-815
    • Xiong, G.L.1    Prybol, K.2    Boyle, S.H.3    Hall, R.4    Streilein, R.D.5    Steffens, D.C.6    Krishnan, R.7    Rogers, J.G.8    O'Connor, C.M.9    Jiang, W.10
  • 51
    • 0042835785 scopus 로고    scopus 로고
    • Lipid-lowering drugs and the risk of depression and suicidal behavior
    • C.C. Yang, S.S. Jick, and H. Jick Lipid-lowering drugs and the risk of depression and suicidal behavior Arch. Intern. Med. 163 2003 1926 1932
    • (2003) Arch. Intern. Med. , vol.163 , pp. 1926-1932
    • Yang, C.C.1    Jick, S.S.2    Jick, H.3
  • 52
    • 84880112650 scopus 로고    scopus 로고
    • The relationship between statins and depression: A review of the literature
    • H. You, W. Lu, S. Zhao, Z. Hu, and J. Zhang The relationship between statins and depression: a review of the literature Expert Opin. Pharmacother. 14 2013 1467 1476
    • (2013) Expert Opin. Pharmacother. , vol.14 , pp. 1467-1476
    • You, H.1    Lu, W.2    Zhao, S.3    Hu, Z.4    Zhang, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.