Neuropathological and neuromorphometric abnormalities in bipolar disorder: View from the medial prefrontal cortical network

Neuroscience and Biobehavioral Reviews

Volumn 42, Issue , 2014, Pages 132-147

  Savitz, Jonathan B ^a,b   Price, Joseph L ^c   Drevets, Wayne C ^a,d  

^a LAUREATE INSTITUTE FOR BRAIN RESEARCH   (United States)

^b UNIVERSITY OF TULSA   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d JOHNSON AND JOHNSON   (United States)

Author keywords

Bipolar disorder; Depression; Developmental; Gene expression; Magnetic resonance imaging; Medial prefrontal cortex; Neuron; Neuropathology; Oligodendrocyte; Postmortem

Indexed keywords

ANTERIOR CINGULATE; AUTOPSY; BIPOLAR DEPRESSION; BIPOLAR DISORDER; BIPOLAR I DISORDER; BIPOLAR II DISORDER; BIPOLAR MANIA; BRAIN SIZE; CELL COUNT; CELL DENSITY; CELL SIZE; CHRONIC DISEASE; DENDRITE; DEVELOPMENTAL DISORDER; GABAERGIC SYSTEM; GENE EXPRESSION; GLIA CELL; HISTOPATHOLOGY; HUMAN; INTERNEURON; MEDIAL PREFRONTAL CORTEX; NERVE CELL NETWORK; NERVE DEGENERATION; NEUROIMAGING; NEUROPATHOLOGY; NEUROPIL; NUCLEAR MAGNETIC RESONANCE IMAGING; OLIGODENDROGLIA; ORBITAL CORTEX; PREFRONTAL CORTEX; PRIORITY JOURNAL; RECURRENT DISEASE; REVIEW; ANIMAL; GLIA; NERVE CELL; NERVE TRACT; PATHOLOGY;

ANIMALS; BIPOLAR DISORDER; HUMANS; NEURAL PATHWAYS; NEUROGLIA; NEURONS; PREFRONTAL CORTEX;

EID: 84896029352     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2014.02.008     Document Type: Review

References (209)

1. Abel K.M., Wicks S., Susser E.S., Dalman C., Pedersen M.G., Mortensen P.B., Webb R.T. Birth weight, schizophrenia, and adult mental disorder: is risk confined to the smallest babies?. Arch. Gen. Psychiatry 2010, 67:923-930.
2. Adler C.M., Adams J., DelBello M.P., Holland S.K., Schmithorst V., Levine A., Jarvis K., Strakowski S.M. Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: a diffusion tensor imaging study. Am. J. Psychiatry 2006, 163:322-324.
3. Aminoff S.R., Hellvin T., Lagerberg T.V., Berg A.O., Andreassen O.A., Melle I. Neurocognitive features in subgroups of bipolar disorder. Bipolar Disord. 2013, 15:272-283.
4. Arts B., Jabben N., Krabbendam L., van Os J. Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychol. Med. 2007, 1-15.
5. Arts B., Jabben N., Krabbendam L., van Os J. A 2-year naturalistic study on cognitive functioning in bipolar disorder. Acta Psychiatr. Scand. 2011, 123:190-205.
6. Balanza-Martinez V., Tabares-Seisdedos R., Selva-Vera G., Martinez-Aran A., Torrent C., Salazar-Fraile J., Leal-Cercos C., Vieta E., Gomez-Beneyto M. Persistent cognitive dysfunctions in bipolar I disorder and schizophrenic patients: a 3-year follow-up study. Psychother. Psychosom. 2005, 74:113-119.
7. Bearden C.E., Glahn D.C., Caetano S., Olvera R.L., Fonseca M., Najt P., Hunter K., Pliszka S.R., Soares J.C. Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. Bipolar Disord. 2007, 9(Suppl. 1):145-159.
8. Bearden C.E., Thompson P.M., Dalwani M., Hayashi K.M., Lee A.D., Nicoletti M., Trakhtenbroit M., Glahn D.C., Brambilla P., Sassi R.B., Mallinger A.G., Frank E., Kupfer D.J., Soares J.C. Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Biol. Psychiatry 2007, 62:7-16.
9. Beasley C.L., Zhang Z.J., Patten I., Reynolds G.P. Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins. Biol. Psychiatry 2002, 52:708-715.
10. Benes F.M., Todtenkopf M.S., Logiotatos P., Williams M. Glutamate decarboxylase(65)-immunoreactive terminals in cingulate and prefrontal cortices of schizophrenic and bipolar brain. J. Chem. Neuroanat. 2000, 20:259-269.
11. Benes F.M., Vincent S.L., Todtenkopf M. The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects. Biol. Psychiatry 2001, 50:395-406.
12. Beneyto M., Meador-Woodruff J.H. Lamina-specific abnormalities of AMPA receptor trafficking and signaling molecule transcripts in the prefrontal cortex in schizophrenia. Synapse 2006, 60:585-598.
13. Berk M., Brnabic A., Dodd S., Kelin K., Tohen M., Malhi G.S., Berk L., Conus P., McGorry P.D. Does stage of illness impact treatment response in bipolar disorder? Empirical treatment data and their implication for the staging model and early intervention. Bipolar Disord. 2011, 13:87-98.
14. Berk M., Hallam K.T., McGorry P.D. The potential utility of a staging model as a course specifier: a bipolar disorder perspective. J. Affect. Disord. 2007, 100:279-281.
15. Beyer J.L., Taylor W.D., MacFall J.R., Kuchibhatla M., Payne M.E., Provenzale J.M., Cassidy F., Krishnan K.R. Cortical white matter microstructural abnormalities in bipolar disorder. Neuropsychopharmacology 2005, 30:2225-2229.
16. Bielau H., Steiner J., Mawrin C., Trubner K., Brisch R., Meyer-Lotz G., Brodhun M., Dobrowolny H., Baumann B., Gos T., Bernstein H.G., Bogerts B. Dysregulation of GABAergic neurotransmission in mood disorders: a postmortem study. Ann. N. Y. Acad. Sci. 2007, 1096:157-169.
17. Bitanihirwe B.K., Lim M.P., Woo T.U. N-methyl-d-aspartate receptor expression in parvalbumin-containing inhibitory neurons in the prefrontal cortex in bipolar disorder. Bipolar Disord. 2010, 12:95-101.
18. Boes A.D., McCormick L.M., Coryell W.H., Nopoulos P. Rostral anterior cingulate cortex volume correlates with depressed mood in normal healthy children. Biol. Psychiatry 2008, 63:391-397.
19. Bond D.J., Ha T.H., Lang D.J., Su W., Torres I.J., Honer W.G., Lam R.W., Yatham L.N. Body mass index-related regional gray and white matter volume reductions in first-episode mania patients. Biol. Psychiatry 2013.
20. Bora E., Vahip S., Akdeniz F., Gonul A.S., Eryavuz A., Ogut M., Alkan M. The effect of previous psychotic mood episodes on cognitive impairment in euthymic bipolar patients. Bipolar Disord. 2007, 9:468-477.
21. Bora E., Yucel M., Pantelis C. Neurocognitive markers of psychosis in bipolar disorder: a meta-analytic study. J. Affect. Disord. 2010, 127:1-9.
22. Bora E., Yucel M., Pantelis C., Berk M. Meta-analytic review of neurocognition in bipolar II disorder. Acta Psychiatr. Scand. 2011, 123:165-174.
23. Botteron K.N., Vannier M.W., Geller B., Todd R.D., Lee B.C. Preliminary study of magnetic resonance imaging characteristics in 8- to 16-year-olds with mania. J. Am. Acad. Child Adolesc. Psychiatry 1995, 34:742-749.
24. Bouras C., Kovari E., Hof P.R., Riederer B.M., Giannakopoulos P. Anterior cingulate cortex pathology in schizophrenia and bipolar disorder. Acta Neuropathol. 2001, 102:373-379.
25. Brooks J.O., Bonner J.C., Rosen A.C., Wang P.W., Hoblyn J.C., Hill S.J., Ketter T.A. Dorsolateral and dorsomedial prefrontal gray matter density changes associated with bipolar depression. Psychiatry Res. 2009, 172:200-204.
26. Brunoni A.R., Kemp A.H., Dantas E.M., Goulart A.C., Nunes M.A., Boggio P.S., Mill J.G., Lotufo P.A., Fregni F., Bensenor I.M. Heart rate variability is a trait marker of major depressive disorder: evidence from the sertraline vs. electric current therapy to treat depression clinical study. Int. J. Neuropsychopharmacol. 2013, 16:1937-1949.
27. Bush G., Luu P., Posner M.I. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn. Sci. 2000, 4:215-222.
28. Carney R.M., Freedland K.E., Veith R.C. Depression, the autonomic nervous system, and coronary heart disease. Psychosom. Med. 2005, 67:S29-S33.
29. Cassidy C., Buchy L., Bodnar M., Dell'elce J., Choudhry Z., Fathalli F., Sengupta S., Fox R., Malla A., Lepage M., Iyer S., Joober R. Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis. J. Psychiatry Neurosci. 2013, 38:120242.
30. Cavanagh J.T., Van Beck M., Muir W., Blackwood D.H. Case-control study of neurocognitive function in euthymic patients with bipolar disorder: an association with mania. Br. J. Psychiatry 2002, 180:320-326.
31. Cecil K.M., DelBello M.P., Morey R., Strakowski S.M. Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar Disord. 2002, 4:357-365.
32. Cerqueira J.J., Mailliet F., Almeida O.F., Jay T.M., Sousa N. The prefrontal cortex as a key target of the maladaptive response to stress. J. Neurosci. 2007, 27:2781-2787.
33. Chan W.Y., Yang G.L., Chia M.Y., Woon P.S., Lee J., Keefe R., Sitoh Y.Y., Nowinski W.L., Sim K. Cortical and subcortical white matter abnormalities in adults with remitted first-episode mania revealed by Tract-Based Spatial Statistics. Bipolar Disord. 2010, 12:383-389.
34. Chana G., Landau S., Beasley C., Everall I.P., Cotter D. Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density. Biol. Psychiatry 2003, 53:1086-1098.
35. Chang K., Adleman N., Dienes K., Barnea-Goraly N., Reiss A., Ketter T. Decreased N-acetylaspartate in children with familial bipolar disorder. Biol. Psychiatry 2003, 53:1059-1065.
36. Chaves O.C., Lombardo L.E., Bearden C.E., Woolsey M.D., Martinez D.M., Barrett J.A., Miller A.L., Velligan D.I., Glahn D.C. Association of clinical symptoms and neurocognitive performance in bipolar disorder: a longitudinal study. Bipolar Disord. 2011, 13:118-123.
37. Chiu S., Widjaja F., Bates M.E., Voelbel G.T., Pandina G., Marble J., Blank J.A., Day J., Brule N., Hendren R.L. Anterior cingulate volume in pediatric bipolar disorder and autism. J. Affect. Disord. 2008, 105:93-99.
38. Chudal R., Sourander A., Polo-Kantola P., Hinkka-Yli-Salomaki S., Lehti V., Sucksdorff D., Gissler M., Brown A.S. Perinatal factors and the risk of bipolar disorder in Finland. J. Affect. Disord. 2013.
39. Connor C.M., Guo Y., Akbarian S. Cingulate white matter neurons in schizophrenia and bipolar disorder. Biol. Psychiatry 2009, 66:486-493.
40. Conway C.R., Sheline Y.I., Chibnall J.T., Bucholz R.D., Price J.L., Gangwani S., Mintun M.A. Brain blood-flow change with acute vagus nerve stimulation in treatment-refractory major depressive disorder. Brain Stimul. 2012, 5:163-171.
41. Cook S.C., Wellman C.L. Chronic stress alters dendritic morphology in rat medial prefrontal cortex. J. Neurobiol. 2004, 60:236-248.
42. Cotter D., Hudson L., Landau S. Evidence for orbitofrontal pathology in bipolar disorder and major depression, but not in schizophrenia. Bipolar Disord. 2005, 7:358-369.
43. Cotter D., Landau S., Beasley C., Stevenson R., Chana G., MacMillan L., Everall I. The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia. Biol. Psychiatry 2002, 51:377-386.
44. Cotter D., Mackay D., Chana G., Beasley C., Landau S., Everall I.P. Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder. Cereb. Cortex 2002, 12:386-394.
45. Cotter D., Mackay D., Landau S., Kerwin R., Everall I. Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Arch. Gen. Psychiatry 2001, 58:545-553.
46. Covington H.E., Lobo M.K., Maze I., Vialou V., Hyman J.M., Zaman S., LaPlant Q., Mouzon E., Ghose S., Tamminga C.A., Neve R.L., Deisseroth K., Nestler E.J. Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J. Neurosci. 2010, 30:16082-16090.
47. Czeh B., Muller-Keuker J.I., Rygula R., Abumaria N., Hiemke C., Domenici E., Fuchs E. Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment. Neuropsychopharmacology 2007, 32:1490-1503.
48. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008, 9:46-56.
49. Dean B., Gibbons A.S., Tawadros N., Brooks L., Everall I.P., Scarr E. Different changes in cortical tumor necrosis factor-alpha-related pathways in schizophrenia and mood disorders. Mol. Psychiatry 2013, 18:767-773.
50. Delaloye C., Moy G., de Bilbao F., Weber K., Baudois S., Haller S., Xekardaki A., Canuto A., Giardini U., Lovblad K.O., Gold G., Giannakopoulos P. Longitudinal analysis of cognitive performances and structural brain changes in late-life bipolar disorder. Int. J. Geriatr. Psychiatry 2011, 26:1309-1318.
51. Dickstein D.P., Milham M.P., Nugent A.C., Drevets W.C., Charney D.S., Pine D.S., Leibenluft E. Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry study. Arch. Gen. Psychiatry 2005, 62:734-741.
52. Dorph-Petersen K.A., Lewis D.A. Stereological approaches to identifying neuropathology in psychosis. Biol. Psychiatry 2011, 69:113-126.
53. Drevets W.C., Ongur D., Price J.L. Neuroimaging abnormalities in the subgenual prefrontal cortex: implications for the pathophysiology of familial mood disorders. Mol. Psychiatry 1998, 3:220-226. (190-221).
54. Drevets W.C., Price J.L., Simpson J.R., Todd R.D., Reich T., Vannier M., Raichle M.E. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 1997, 386:824-827.
55. Drevets W.C., Savitz J., Trimble M. The subgenual anterior cingulate cortex in mood disorders. CNS Spectr. 2008, 13:663-681.
56. Eastwood S.L., Harrison P.J. Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins. Brain Res. Bull. 2001, 55:569-578.
57. Farber N.B., Newcomer J.W., Olney J.W. The glutamate synapse in neuropsychiatric disorders. Focus on schizophrenia and Alzheimer's disease. Prog. Brain Res. 1998, 116:421-437.
58. Farrow T.F., Whitford T.J., Williams L.M., Gomes L., Harris A.W. Diagnosis-related regional gray matter loss over two years in first episode schizophrenia and bipolar disorder. Biol. Psychiatry 2005, 58:713-723.
59. Fjell A.M., Walhovd K.B. Structural brain changes in aging: courses, causes and cognitive consequences. Rev. Neurosci. 2010, 21:187-221.
60. Foland-Ross L.C., Thompson P.M., Sugar C.A., Madsen S.K., Shen J.K., Penfold C., Ahlf K., Rasser P.E., Fischer J., Yang Y., Townsend J., Bookheimer S.Y., Altshuler L.L. Investigation of cortical thickness abnormalities in lithium-free adults with bipolar I disorder using cortical pattern matching. Am. J. Psychiatry 2011.
61. Forester B.P., Finn C.T., Berlow Y.A., Wardrop M., Renshaw P.F., Moore C.M. Brain lithium, N-acetyl aspartate and myo-inositol levels in older adults with bipolar disorder treated with lithium: a lithium-7 and proton magnetic resonance spectroscopy study. Bipolar Disord. 2008, 10:691-700.
62. Fornito A., Malhi G.S., Lagopoulos J., Ivanovski B., Wood S.J., Saling M.M., Pantelis C., Yucel M. Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorder. Psychiatry Res. 2008, 162:123-132.
63. Frangou S. The Maudsley bipolar disorder project. Epilepsia 2005, 46(Suppl. 4):19-25.
64. Frangou S., Donaldson S., Hadjulis M., Landau S., Goldstein L.H. The Maudsley Bipolar Disorder Project: executive dysfunction in bipolar disorder I and its clinical correlates. Biol. Psychiatry 2005, 58:859-864.
65. Frazier J.A., Breeze J.L., Papadimitriou G., Kennedy D.N., Hodge S.M., Moore C.M., Howard J.D., Rohan M.P., Caviness V.S., Makris N. White matter abnormalities in children with and at risk for bipolar disorder. Bipolar Disord. 2007, 9:799-809.
66. Frey B.N., Stanley J.A., Nery F.G., Monkul E.S., Nicoletti M.A., Chen H.H., Hatch J.P., Caetano S.C., Ortiz O., Kapczinski F., Soares J.C. Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo 1H MRS study. Bipolar Disord. 2007, 9(Suppl. 1):119-127.
67. Frey B.N., Zunta-Soares G.B., Caetano S.C., Nicoletti M.A., Hatch J.P., Brambilla P., Mallinger A.G., Soares J.C. Illness duration and total brain gray matter in bipolar disorder: evidence for neurodegeneration?. Eur. Neuropsychopharmacol. 2008, 18:717-722.
68. Gigante A.D., Young L.T., Yatham L.N., Andreazza A.C., Nery F.G., Grinberg L.T., Heinsen H., Lafer B. Morphometric post-mortem studies in bipolar disorder: possible association with oxidative stress and apoptosis. Int. J. Neuropsychopharmacol. 2011, 14:1075-1089.
69. Gildengers A.G., Chisholm D., Butters M.A., Anderson S.J., Begley A., Holm M., Rogers J.C., Reynolds C.F., Mulsant B.H. Two-year course of cognitive function and instrumental activities of daily living in older adults with bipolar disorder: evidence for neuroprogression?. Psychol. Med. 2013, 43:801-811.
70. Gildengers A.G., Mulsant B.H., Begley A., Mazumdar S., Hyams A.V., Reynolds Iii C.F., Kupfer D.J., Butters M.A. The longitudinal course of cognition in older adults with bipolar disorder. Bipolar Disord. 2009, 11:744-752.
71. Glahn D.C., Bearden C.E., Barguil M., Barrett J., Reichenberg A., Bowden C.L., Soares J.C., Velligan D.I. The neurocognitive signature of psychotic bipolar disorder. Biol. Psychiatry 2007.
72. Gogtay N., Greenstein D., Lenane M., Clasen L., Sharp W., Gochman P., Butler P., Evans A., Rapoport J. Cortical brain development in nonpsychotic siblings of patients with childhood-onset schizophrenia. Arch. Gen. Psychiatry 2007, 64:772-780.
73. Gogtay N., Ordonez A., Herman D.H., Hayashi K.M., Greenstein D., Vaituzis C., Lenane M., Clasen L., Sharp W., Giedd J.N., Jung D., Nugent T.F., Toga A.W., Leibenluft E., Thompson P.M., Rapoport J.L. Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness. J. Child Psychol. Psychiatry 2007, 48:852-862.
74. Gos T., Steiner J., Bielau H., Dobrowolny H., Gunther K., Mawrin C., Krzyzanowski M., Hauser R., Brisch R., Bernstein H.G., Jankowski Z., Braun K., Bogerts B. Differences between unipolar and bipolar I depression in the quantitative analysis of glutamic acid decarboxylase-immunoreactive neuropil. Eur. Arch. Psychiatry Clin. Neurosci. 2012, 262:647-655.
75. Guidotti A., Auta J., Davis J.M., Di-Giorgi-Gerevini V., Dwivedi Y., Grayson D.R., Impagnatiello F., Pandey G., Pesold C., Sharma R., Uzunov D., Costa E. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch. Gen. Psychiatry 2000, 57:1061-1069.
76. Hafeman D.M., Chang K.D., Garrett A.S., Sanders E.M., Phillips M.L. Effects of medication on neuroimaging findings in bipolar disorder: an updated review. Bipolar Disord. 2012, 14:375-410.
77. Hajek T., Calkin C., Blagdon R., Slaney C., Alda M. Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders. Biol. Psychiatry 2013.
78. Harkavy-Friedman J.M., Keilp J.G., Grunebaum M.F., Sher L., Printz D., Burke A.K., Mann J.J., Oquendo M. Are BPI and BPII suicide attempters distinct neuropsychologically?. J. Affect. Disord. 2006, 94:255-259.
79. Harrison P.J. The neuropathology of primary mood disorder. Brain 2002, 125:1428-1449.
80. Hasler G., Fromm S., Carlson P.J., Luckenbaugh D.A., Waldeck T., Geraci M., Roiser J.P., Neumeister A., Meyers N., Charney D.S., Drevets W.C. Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects. Arch. Gen. Psychiatry 2008, 65:521-531.
81. Haukvik U.K., McNeil T., Lange E.H., Melle I., Dale A.M., Andreassen O.A., Agartz I. Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder. Psychol. Med. 2013, 1-11.
82. Haznedar M.M., Roversi F., Pallanti S., Baldini-Rossi N., Schnur D.B., Licalzi E.M., Tang C., Hof P.R., Hollander E., Buchsbaum M.S. Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses. Biol. Psychiatry 2005, 57:733-742.
83. Henry B.L., Minassian A., Paulus M.P., Geyer M.A., Perry W. Heart rate variability in bipolar mania and schizophrenia. J. Psychiatr. Res. 2010, 44:168-176.
84. Hercher C., Canetti L., Turecki G., Mechawar N. Anterior cingulate pyramidal neurons display altered dendritic branching in depressed suicides. J. Psychiatr. Res. 2010, 44:286-293.
85. Hirayasu Y., Shenton M.E., Salisbury D.F., Kwon J.S., Wible C.G., Fischer I.A., Yurgelun-Todd D., Zarate C., Kikinis R., Jolesz F.A., McCarley R.W. Subgenual cingulate cortex volume in first-episode psychosis. Am. J. Psychiatry 1999, 156:1091-1093.
86. Ho B.C., Andreasen N.C., Dawson J.D., Wassink T.H. Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia. Am. J. Psychiatry 2007, 164:1890-1899.
87. Houenou J., Wessa M., Douaud G., Leboyer M., Chanraud S., Perrin M., Poupon C., Martinot J.L., Paillere-Martinot M.L. Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex. Mol. Psychiatry 2007, 12:1001-1010.
88. Hsiao Y.L., Wu Y.S., Wu J.Y., Hsu M.H., Chen H.C., Lee S.Y., Lee I.H., Yeh T.L., Yang Y.K., Ko H.C., Lu R.B. Neuropsychological functions in patients with bipolar I and bipolar II disorder. Bipolar Disord. 2009, 11:547-554.
89. Irwin M.R., Cole S.W. Reciprocal regulation of the neural and innate immune systems. Nat. Rev. Immunol. 2011, 11:625-632.
90. James A., Hough M., James S., Burge L., Winmill L., Nijhawan S., Matthews P.M., Zarei M. Structural brain and neuropsychometric changes associated with pediatric bipolar disorder with psychosis. Bipolar Disord. 2011, 13:16-27.
91. Kafantaris V., Kingsley P., Ardekani B., Saito E., Lencz T., Lim K., Szeszko P. Lower orbital frontal white matter integrity in adolescents with bipolar I disorder. J. Am. Acad. Child Adolesc. Psychiatry 2009, 48:79-86.
92. Kalayci D., Ozdel O., Sozeri-Varma G., Kiroglu Y., Tumkaya S. A proton magnetic resonance spectroscopy study in schizoaffective disorder: comparison of bipolar disorder and schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 2012, 37:176-181.
93. Kalmar J.H., Wang F., Spencer L., Edmiston E., Lacadie C.M., Martin A., Constable R.T., Duncan J.S., Staib L.H., Papademetris X., Blumberg H.P. Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder. J. Int. Neuropsychol. Soc. 2009, 15:476-481.
94. Kapczinski F., Dias V.V., Kauer-Sant'Anna M., Frey B.N., Grassi-Oliveira R., Colom F., Berk M. Clinical implications of a staging model for bipolar disorders. Expert Rev. Neurother. 2009, 9:957-966.
95. Kaur S., Sassi R.B., Axelson D., Nicoletti M., Brambilla P., Monkul E.S., Hatch J.P., Keshavan M.S., Ryan N., Birmaher B., Soares J.C. Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder. Am. J. Psychiatry 2005, 162:1637-1643.
96. Kemp A.H., Quintana D.S., Felmingham K.L., Matthews S., Jelinek H.F. Depression, comorbid anxiety disorders, and heart rate variability in physically healthy, unmedicated patients: implications for cardiovascular risk. PLoS One 2012, 7:e30777.
97. Kessing L.V. Cognitive impairment in the euthymic phase of affective disorder. Psychol. Med. 1998, 28:1027-1038.
98. Kessing L.V., Andersen E.W., Andersen P.K. Predictors of recurrence in affective disorder - analyses accounting for individual heterogeneity. J. Affect. Disord. 2000, 57:139-145.
99. Kessing L.V., Sondergard L., Forman J.L., Andersen P.K. Lithium treatment and risk of dementia. Arch. Gen. Psychiatry 2008, 65:1331-1335.
100. Kim S., Webster M.J. Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders. Mol. Psychiatry 2010, 15:326-336.
101. Kingsbury A.E., Foster O.J., Nisbet A.P., Cairns N., Bray L., Eve D.J., Lees A.J., Marsden C.D. Tissue pH as an indicator of mRNA preservation in human post-mortem brain. Brain Res. Mol. Brain Res. 1995, 28:311-318.
102. Konopaske G.T., Dorph-Petersen K.A., Sweet R.A., Pierri J.N., Zhang W., Sampson A.R., Lewis D.A. Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biol. Psychiatry 2008, 63:759-765.
103. Koo M.S., Levitt J.J., Salisbury D.F., Nakamura M., Shenton M.E., McCarley R.W. A cross-sectional and longitudinal magnetic resonance imaging study of cingulate gyrus gray matter volume abnormalities in first-episode schizophrenia and first-episode affective psychosis. Arch. Gen. Psychiatry 2008, 65:746-760.
104. Korbo L. Glial cell loss in the hippocampus of alcoholics. Alcohol. Clin. Exp. Res. 1999, 23:164-168.
105. Lane R.D., McRae K., Reiman E.M., Chen K., Ahern G.L., Thayer J.F. Neural correlates of heart rate variability during emotion. Neuroimage 2009, 44:213-222.
106. Law A.J., Harrison P.J. The distribution and morphology of prefrontal cortex pyramidal neurons identified using anti-neurofilament antibodies SMI32, N200 and FNP7. Normative data and a comparison in subjects with schizophrenia, bipolar disorder or major depression. J. Psychiatr. Res. 2003, 37:487-499.
107. Lewandowski K.E., Cohen B.M., Ongur D. Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder. Psychol. Med. 2011, 41:225-241.
108. Lim C.S., Baldessarini R.J., Vieta E., Yucel M., Bora E., Sim K. Longitudinal neuroimaging and neuropsychological changes in bipolar disorder patients: review of the evidence. Neurosci. Biobehav. Rev. 2013, 37:418-435.
109. Lin A., Reniers R.L., Wood S.J. Clinical staging in severe mental disorder: evidence from neurocognition and neuroimaging. Br. J. Psychiatry Suppl. 2013, 54:s11-s17.
110. Liston C., Miller M.M., Goldwater D.S., Radley J.J., Rocher A.B., Hof P.R., Morrison J.H., McEwen B.S. Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting. J. Neurosci. 2006, 26:7870-7874.
111. Lisy M.E., Jarvis K.B., DelBello M.P., Mills N.P., Weber W.A., Fleck D., Strakowski S.M., Adler C.M. Progressive neurostructural changes in adolescent and adult patients with bipolar disorder. Bipolar Disord. 2011, 13:396-405.
112. Lopez-Jaramillo C., Lopera-Vasquez J., Gallo A., Ospina-Duque J., Bell V., Torrent C., Martinez-Aran A., Vieta E. Effects of recurrence on the cognitive performance of patients with bipolar I disorder: implications for relapse prevention and treatment adherence. Bipolar Disord. 2010, 12:557-567.
113. Lu L.H., Zhou X.J., Keedy S.K., Reilly J.L., Sweeney J.A. White matter microstructure in untreated first episode bipolar disorder with psychosis: comparison with schizophrenia. Bipolar Disord. 2011, 13:604-613.
114. Lyoo I.K., Sung Y.H., Dager S.R., Friedman S.D., Lee J.Y., Kim S.J., Kim N., Dunner D.L., Renshaw P.F. Regional cerebral cortical thinning in bipolar disorder. Bipolar Disord. 2006, 8:65-74.
115. MacDonald M.L., Naydenov A., Chu M., Matzilevich D., Konradi C. Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorder. Bipolar Disord. 2006, 8:255-264.
116. Mahon K., Burdick K.E., Wu J., Ardekani B.A., Szeszko P.R. Relationship between suicidality and impulsivity in bipolar I disorder: a diffusion tensor imaging study. Bipolar Disord. 2012, 14:80-89.
117. Manji H.K., Moore G.J., Chen G. Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic-depressive illness. Biol. Psychiatry 2000, 48:740-754.
118. Martinez-Aran A., Torrent C., Tabares-Seisdedos R., Salamero M., Daban C., Balanza-Martinez V., Sanchez-Moreno J., Manuel Goikolea J., Benabarre A., Colom F., Vieta E. Neurocognitive impairment in bipolar patients with and without history of psychosis. J. Clin. Psychiatry 2008, e1-e7.
119. Martinez-Aran A., Vieta E., Colom F., Torrent C., Sanchez-Moreno J., Reinares M., Benabarre A., Goikolea J.M., Brugue E., Daban C., Salamero M. Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcome. Bipolar Disord. 2004, 6:224-232.
120. Matsuo K., Nicoletti M.A., Peluso M.A., Hatch J.P., Nemoto K., Watanabe Y., Nery F.G., Monkul E.S., Zunta-Soares G.B., Bowden C.L., Soares J.C. Anterior cingulate volumes associated with trait impulsivity in individuals with bipolar disorder. Bipolar Disord. 2009, 11:628-636.
121. Matsuo K., Walss-Bass C., Nery F.G., Nicoletti M.A., Hatch J.P., Frey B.N., Monkul E.S., Zunta-Soares G.B., Bowden C.L., Escamilla M.A., Soares J.C. Neuronal correlates of brain-derived neurotrophic factor Val66Met polymorphism and morphometric abnormalities in bipolar disorder. Neuropsychopharmacology 2009, 34:1904-1913.
122. McDonald C., Bullmore E.T., Sham P.C., Chitnis X., Wickham H., Bramon E., Murray R.M. Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Arch. Gen. Psychiatry 2004, 61:974-984.
123. McIntosh A.M., Maniega S.M., Lymer G.K., McKirdy J., Hall J., Sussmann J.E., Bastin M.E., Clayden J.D., Johnstone E.C., Lawrie S.M. White matter tractography in bipolar disorder and schizophrenia. Biol. Psychiatry 2008, 64:1088-1092.
124. McNamara R.K., Nandagopal J.J., Strakowski S.M., DelBello M.P. Preventative strategies for early-onset bipolar disorder: towards a clinical staging model. CNS Drugs 2010, 24:983-996.
125. Miller A.H., Maletic V., Raison C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 2009, 65:732-741.
126. Mirakhur A., Moorhead T.W., Stanfield A.C., McKirdy J., Sussmann J.E., Hall J., Lawrie S.M., Johnstone E.C., McIntosh A.M. Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant. Biol. Psychiatry 2009, 66:293-297.
127. Molina V., Sanchez J., Sanz J., Reig S., Benito C., Leal I., Sarramea F., Rebolledo R., Palomo T., Desco M. Dorsolateral prefrontal N-acetyl-aspartate concentration in male patients with chronic schizophrenia and with chronic bipolar disorder. Eur. Psychiatry 2007, 22:505-512.
128. Moore G.J., Bebchuk J.M., Wilds I.B., Chen G., Manji H.K. Lithium-induced increase in human brain grey matter. Lancet 2000, 356:1241-1242.
129. Moore G.J., Cortese B.M., Glitz D.A., Zajac-Benitez C., Quiroz J.A., Uhde T.W., Drevets W.C., Manji H.K. A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients. J. Clin. Psychiatry 2009, 70:699-705.
130. Moore G.J., Galloway M.P. Magnetic resonance spectroscopy: neurochemistry and treatment effects in affective disorders. Psychopharmacol. Bull. 2002, 36:5-23.
131. Mosebach J., Keilhoff G., Gos T., Schiltz K., Schoeneck L., Dobrowolny H., Mawrin C., Muller S., Schroeter M.L., Bernstein H.G., Bogerts B., Steiner J. Increased nuclear Olig1-expression in the pregenual anterior cingulate white matter of patients with major depression: a regenerative attempt to compensate oligodendrocyte loss?. J. Psychiatr. Res. 2013.
132. Narita K., Suda M., Takei Y., Aoyama Y., Majima T., Kameyama M., Kosaka H., Amanuma M., Fukuda M., Mikuni M. Volume reduction of ventromedial prefrontal cortex in bipolar II patients with rapid cycling: a voxel-based morphometric study. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010.
133. Nosarti C., Reichenberg A., Murray R.M., Cnattingius S., Lambe M.P., Yin L., MacCabe J., Rifkin L., Hultman C.M. Preterm birth and psychiatric disorders in young adult life. Arch. Gen. Psychiatry 2012, 69:E1-E8.
134. Nugent A.C., Bain E.E., Thayer J.F., Sollers J.J., Drevets W.C. Heart rate variability during motor and cognitive tasks in females with major depressive disorder. Psychiatry Res. 2011, 191:1-8.
135. Nugent A.C., Milham M.P., Bain E.E., Mah L., Cannon D.M., Marrett S., Zarate C.A., Pine D.S., Price J.L., Drevets W.C. Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry. Neuroimage 2006, 30:485-497.
136. Nunes P.V., Forlenza O.V., Gattaz W.F. Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder. Br. J. Psychiatry 2007, 190:359-360.
137. O'Connor J.A., Hemby S.E. Elevated GRIA1 mRNA expression in Layer II/III and V pyramidal cells of the DLPFC in schizophrenia. Schizophr. Res. 2007, 97:277-288.
138. Ohira H., Matsunaga M., Osumi T., Fukuyama S., Shinoda J., Yamada J., Gidron Y. Vagal nerve activity as a moderator of brain-immune relationships. J. Neuroimmunol. 2013, 260:28-36.
139. Olney J.W., Newcomer J.W., Farber N.B. NMDA receptor hypofunction model of schizophrenia. J. Psychiatr. Res. 1999, 33:523-533.
140. Olvera R.L., Caetano S.C., Fonseca M., Nicoletti M., Stanley J.A., Chen H.H., Hatch J.P., Hunter K., Pliszka S.R., Soares J.C. Low levels of N-acetyl aspartate in the left dorsolateral prefrontal cortex of pediatric bipolar patients. J. Child Adolesc. Psychopharmacol. 2007, 17:461-473.
141. Olvet D.M., Burdick K.E., Cornblatt B.A. Assessing the potential to use neurocognition to predict who is at risk for developing bipolar disorder: a review of the literature. Cogn. Neuropsychiatry 2013, 18:129-145.
142. Ongur D., Drevets W.C., Price J.L. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:13290-13295.
143. Ongur D., Ferry A.T., Price J.L. Architectonic subdivision of the human orbital and medial prefrontal cortex. J. Comp. Neurol. 2003, 460:425-449.
144. Ongur D., Jensen J.E., Prescot A.P., Stork C., Lundy M., Cohen B.M., Renshaw P.F. Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania. Biol. Psychiatry 2008, 64:718-726.
145. Oppenheimer D.R. Diseases of the Basal Ganglia, Cerebellum, and Motor Neurons. Greenfield's Neuropathology 1984, 699-747. John Wiley, New York.
146. Padmos R.C., Hillegers M.H., Knijff E.M., Vonk R., Bouvy A., Staal F.J., de Ridder D., Kupka R.W., Nolen W.A., Drexhage H.A. A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch. Gen. Psychiatry 2008, 65:395-407.
147. Pavuluri M.N., West A., Hill S.K., Jindal K., Sweeney J.A. Neurocognitive function in pediatric bipolar disorder: 3-year follow-up shows cognitive development lagging behind healthy youths. J. Am. Acad. Child Adolesc. Psychiatry 2009, 48:299-307.
148. Pennington K., Beasley C.L., Dicker P., Fagan A., English J., Pariante C.M., Wait R., Dunn M.J., Cotter D.R. Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. Mol. Psychiatry 2008, 13:1102-1117.
149. Pillai J.J., Friedman L., Stuve T.A., Trinidad S., Jesberger J.A., Lewin J.S., Findling R.L., Swales T.P., Schulz S.C. Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder. Psychiatry Res. 2002, 114:51-56.
150. Price J.L., Drevets W.C. Neurocircuitry of mood disorders. Neuropsychopharmacology 2010, 35:192-216.
151. Radley J.J., Rocher A.B., Janssen W.G., Hof P.R., McEwen B.S., Morrison J.H. Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress. Exp. Neurol. 2005, 196:199-203.
152. Radley J.J., Rocher A.B., Miller M., Janssen W.G., Liston C., Hof P.R., McEwen B.S., Morrison J.H. Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. Cereb. Cortex 2006, 16:313-320.
153. Radley J.J., Rocher A.B., Rodriguez A., Ehlenberger D.B., Dammann M., McEwen B.S., Morrison J.H., Wearne S.L., Hof P.R. Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex. J. Comp. Neurol. 2008, 507:1141-1150.
154. Rajkowska G., Halaris A., Selemon L.D. Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder. Biol. Psychiatry 2001, 49:741-752.
155. Regenold W.T., Phatak P., Marano C.M., Gearhart L., Viens C.H., Hisley K.C. Myelin staining of deep white matter in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and unipolar major depression. Psychiatry Res. 2007, 151:179-188.
156. Robinson L.J., Thompson J.M., Gallagher P., Goswami U., Young A.H., Ferrier I.N., Moore P.B. A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J. Affect. Disord. 2006, 93:105-115.
157. Roiser J.P., Levy J., Fromm S.J., Nugent A.C., Talagala S.L., Hasler G., Henn F.A., Sahakian B.J., Drevets W.C. The effects of tryptophan depletion on neural responses to emotional words in remitted depression. Biol. Psychiatry 2009, 66:441-450.
158. Rolls E.T. The orbitofrontal cortex and reward. Cereb. Cortex 2000, 10:284-294.
159. Rolls E.T., Grabenhorst F. The orbitofrontal cortex and beyond: from affect to decision-making. Prog. Neurobiol. 2008, 86:216-244.
160. Rosas-Ballina M., Tracey K.J. Cholinergic control of inflammation. J. Intern. Med. 2009, 265:663-679.
161. Sakai T., Oshima A., Nozaki Y., Ida I., Haga C., Akiyama H., Nakazato Y., Mikuni M. Changes in density of calcium-binding-protein-immunoreactive GABAergic neurons in prefrontal cortex in schizophrenia and bipolar disorder. Neuropathology 2008, 28:143-150.
162. Sanchez-Moreno J., Martinez-Aran A., Tabares-Seisdedos R., Torrent C., Vieta E., Ayuso-Mateos J.L. Functioning and disability in bipolar disorder: an extensive review. Psychother. Psychosom. 2009, 78:285-297.
163. Sassi R.B., Stanley J.A., Axelson D., Brambilla P., Nicoletti M.A., Keshavan M.S., Ramos R.T., Ryan N., Birmaher B., Soares J.C. Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients. Am. J. Psychiatry 2005, 162:2109-2115.
164. Savitz J., Drevets W.C. Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide. Neurosci. Biobehav. Rev. 2009, 33:699-771.
165. Savitz J., Frank M.B., Victor T., Bebak M., Marino J.H., Bellgowan P.S., McKinney B.A., Bodurka J., Kent Teague T., Drevets W.C. Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. Brain Behav. Immun. 2013, 31:161-171.
166. 18F]fluorodeoxyglucose positron emission tomography study. Neuroimage Clin. 2013, 2:341-355.
167. Savitz J., Nugent A.C., Bogers W., Liu A., Sills R., Luckenbaugh D.A., Bain E.E., Price J.L., Zarate C., Manji H.K., Cannon D.M., Marrett S., Charney D.S., Drevets W.C. Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication. Neuroimage 2010, 49:2966-2976.
168. Savitz J., Solms M., Ramesar R. Neuropsychological dysfunction in bipolar affective disorder: a critical opinion. Bipolar Disord. 2005, 7:216-235.
169. Savitz J., van der Merwe L., Stein D.J., Solms M., Ramesar R. Neuropsychological status of bipolar I disorder: impact of psychosis. Br. J. Psychiatry 2009, 194:243-251.
170. Savitz J.B., Drevets W.C. Imaging phenotypes of major depressive disorder: genetic correlates. Neuroscience 2009, 164:300-330.
171. Savitz J.B., Nugent A.C., Bogers W., Roiser J.P., Bain E.E., Neumeister A., Zarate C.A., Manji H.K., Cannon D.M., Marrett S., Henn F., Charney D.S., Drevets W.C. Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study. Biol. Psychiatry 2011, 69:336-343.
172. Savitz J.B., Ramesar R.S. Personality: is it a viable endophenotype for genetic studies of bipolar affective disorder?. Bipolar Disord. 2006, 8:322-337.
173. Savitz J.B., Rauch S.L., Drevets W.C. Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play. Mol. Psychiatry 2013, 18:528-539.
174. Savitz J.B., Solms M., Ramesar R.S. Neurocognitive function as an endophenotype for genetic studies of bipolar affective disorder. Neuromolecular Med. 2005, 7:275-286.
175. Schneider M.R., DelBello M.P., McNamara R.K., Strakowski S.M., Adler C.M. Neuroprogression in bipolar disorder. Bipolar Disord. 2012, 14:356-374.
176. Selemon L.D., Lidow M.S., Goldman-Rakic P.S. Increased volume and glial density in primate prefrontal cortex associated with chronic antipsychotic drug exposure. Biol. Psychiatry 1999, 46:161-172.
177. Simonsen C., Sundet K., Vaskinn A., Birkenaes A.B., Engh J.A., Faerden A., Jonsdottir H., Ringen P.A., Opjordsmoen S., Melle I., Friis S., Andreassen O.A. Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophr. Bull. 2011, 37:73-83.
178. Singh M.K., Chang K.D., Chen M.C., Kelley R.G., Garrett A., Mitsunaga M.M., Bararpour L., Howe M., Reiss A.L., Gotlib I.H. Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder. Bipolar Disord. 2012, 14:585-596.
179. Sklar P., Gabriel S.B., McInnis M.G., Bennett P., Lim Y.M., Tsan G., Schaffner S., Kirov G., Jones I., Owen M., Craddock N., DePaulo J.R., Lander E.S. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol. Psychiatry 2002, 7:579-593.
180. Steiner J., Bielau H., Brisch R., Danos P., Ullrich O., Mawrin C., Bernstein H.G., Bogerts B. Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. J. Psychiatr. Res. 2008, 42:151-157.
181. Strakowski S.M., Woods B.T., Tohen M., Wilson D.R., Douglass A.W., Stoll A.L. MRI subcortical signal hyperintensities in mania at first hospitalization. Biol. Psychiatry 1993, 33:204-206.
182. Sullivan R.M., Gratton A. Lateralized effects of medial prefrontal cortex lesions on neuroendocrine and autonomic stress responses in rats. J. Neurosci. 1999, 19:2834-2840.
183. Sussmann J.E., Lymer G.K., McKirdy J., Moorhead T.W., Maniega S.M., Job D., Hall J., Bastin M.E., Johnstone E.C., Lawrie S.M., McIntosh A.M. White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging. Bipolar Disord. 2009, 11:11-18.
184. Thayer J.F., Ahs F., Fredrikson M., Sollers J.J., Wager T.D. A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci. Biobehav. Rev. 2012, 36:747-756.
185. Thompson M., Weickert C.S., Wyatt E., Webster M.J. Decreased glutamic acid decarboxylase(67) mRNA expression in multiple brain areas of patients with schizophrenia and mood disorders. J. Psychiatr. Res. 2009, 43:970-977.
186. Tkachev D., Mimmack M.L., Ryan M.M., Wayland M., Freeman T., Jones P.B., Starkey M., Webster M.J., Yolken R.H., Bahn S. Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet 2003, 362:798-805.
187. Torrent C., Martinez-Aran A., del Mar Bonnin C., Reinares M., Daban C., Sole B., Rosa A.R., Tabares-Seisdedos R., Popovic D., Salamero M., Vieta E. Long-term outcome of cognitive impairment in bipolar disorder. J. Clin. Psychiatry 2012, 73:e899-e905.
188. Torres-Platas S.G., Hercher C., Davoli M.A., Maussion G., Labonte B., Turecki G., Mechawar N. Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides. Neuropsychopharmacology 2011, 36:2650-2658.
189. Udupa K., Sathyaprabha T.N., Thirthalli J., Kishore K.R., Lavekar G.S., Raju T.R., Gangadhar B.N. Alteration of cardiac autonomic functions in patients with major depression: a study using heart rate variability measures. J. Affect. Disord. 2007, 100:137-141.
190. Uranova N.A., Vostrikov V.M., Orlovskaya D.D., Rachmanova V.I. Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium. Schizophr. Res. 2004, 67:269-275.
191. van Gorp W.G., Altshuler L., Theberge D.C., Wilkins J., Dixon W. Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence. A preliminary study. Arch. Gen. Psychiatry 1998, 55:41-46.
192. Veldic M., Guidotti A., Maloku E., Davis J.M., Costa E. In psychosis, cortical interneurons overexpress DNA-methyltransferase 1. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:2152-2157.
193. Versace A., Almeida J.R., Hassel S., Walsh N.D., Novelli M., Klein C.R., Kupfer D.J., Phillips M.L. Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics. Arch. Gen. Psychiatry 2008, 65:1041-1052.
194. Vostrikov V.M., Uranova N.A., Orlovskaya D.D. Deficit of perineuronal oligodendrocytes in the prefrontal cortex in schizophrenia and mood disorders. Schizophr. Res. 2007, 94:273-280.
195. Wang F., Jackowski M., Kalmar J.H., Chepenik L.G., Tie K., Qiu M., Gong G., Pittman B.P., Jones M.M., Shah M.P., Spencer L., Papademetris X., Constable R.T., Blumberg H.P. Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging. Br. J. Psychiatry 2008, 193:126-129.
196. Wang F., Kalmar J.H., He Y., Jackowski M., Chepenik L.G., Edmiston E.E., Tie K., Gong G., Shah M.P., Jones M., Uderman J., Constable R.T., Blumberg H.P. Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biol. Psychiatry 2009, 66:516-521.
197. Webster M.J., O'Grady J., Kleinman J.E., Weickert C.S. Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia. Neuroscience 2005, 133:453-461.
198. Wilke M., Kowatch R.A., DelBello M.P., Mills N.P., Holland S.K. Voxel-based morphometry in adolescents with bipolar disorder: first results. Psychiatry Res. 2004, 131:57-69.
199. Williams M.R., Hampton T., Pearce R.K., Hirsch S.R., Ansorge O., Thom M., Maier M. Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 2013, 263:41-52.
200. Woo T.U., Kim A.M., Viscidi E. Disease-specific alterations in glutamatergic neurotransmission on inhibitory interneurons in the prefrontal cortex in schizophrenia. Brain Res. 2008, 1218:267-277.
201. Woo T.U., Shrestha K., Amstrong C., Minns M.M., Walsh J.P., Benes F.M. Differential alterations of kainate receptor subunits in inhibitory interneurons in the anterior cingulate cortex in schizophrenia and bipolar disorder. Schizophr. Res. 2007, 96:46-61.
202. Woo T.U., Shrestha K., Lamb D., Minns M.M., Benes F.M. N-methyl-d-aspartate receptor and calbindin-containing neurons in the anterior cingulate cortex in schizophrenia and bipolar disorder. Biol. Psychiatry 2008, 64:803-809.
203. Woo T.U., Walsh J.P., Benes F.M. Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-d-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Arch. Gen. Psychiatry 2004, 61:649-657.
204. Woods B.T. Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. Am. J. Psychiatry 1998, 155:1661-1670.
205. Yatham L.N., Lyoo I.K., Liddle P., Renshaw P.F., Wan D., Lam R.W., Hwang J. A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naive first-episode mania. Bipolar Disord. 2007, 9:693-697.
206. Zabala A., Rapado M., Arango C., Robles O., de la Serna E., Gonzalez C., Rodriguez-Sanchez J.M., Andres P., Mayoral M., Bombin I. Neuropsychological functioning in early-onset first-episode psychosis: comparison of diagnostic subgroups. Eur. Arch. Psychiatry Clin. Neurosci. 2010, 260:225-233.
207. Zanelli J., Reichenberg A., Morgan K., Fearon P., Kravariti E., Dazzan P., Morgan C., Zanelli C., Demjaha A., Jones P.B., Doody G.A., Kapur S., Murray R.M. Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations. Am. J. Psychiatry 2010, 167:78-85.
208. Zimmerman M.E., DelBello M.P., Getz G.E., Shear P.K., Strakowski S.M. Anterior cingulate subregion volumes and executive function in bipolar disorder. Bipolar Disord. 2006, 8:281-288.
209. Zubieta J.K., Huguelet P., O'Neil R.L., Giordani B.J. Cognitive function in euthymic bipolar I disorder. Psychiatry Res. 2001, 102:9-20.